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Science 22 August 1997:
Vol. 277. no. 5329, pp. 1094 - 1097
DOI: 10.1126/science.277.5329.1094
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Reports

Functional Role of High-Affinity Anandamide Transport, as Revealed by Selective Inhibition

M. Beltramo, N. Stella, A. Calignano, S. Y. Lin, A. Makriyannis, D. Piomelli *

Anandamide, an endogenous ligand for central cannabinoid receptors, is released from neurons on depolarization and rapidly inactivated. Anandamide inactivation is not completely understood, but it may occur by transport into cells or by enzymatic hydrolysis. The compound N-(4-hydroxyphenyl)arachidonylamide (AM404) was shown to inhibit high-affinity anandamide accumulation in rat neurons and astrocytes in vitro, an indication that this accumulation resulted from carrier-mediated transport. Although AM404 did not activate cannabinoid receptors or inhibit anandamide hydrolysis, it enhanced receptor-mediated anandamide responses in vitro and in vivo. The data indicate that carrier-mediated transport may be essential for termination of the biological effects of anandamide, and may represent a potential drug target.

M. Beltramo, N. Stella, D. Piomelli, The Neurosciences Institute, 10640 J. J. Hopkins Drive, San Diego, CA 92121, USA.
A. Calignano, School of Pharmacy, University of Naples, Italy 80131.
S. Y. Lin and A. Makriyannis, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USA.
*   To whom correspondence should be addressed. E-mail: piomelli{at}nsi.edu

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »
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   Abstract »    Full Text »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »
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   Abstract »    Full Text »
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