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Science 22 August 1997:
Vol. 277. no. 5329, pp. 1091 - 1093
DOI: 10.1126/science.277.5329.1091
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Reports

A Macrophage Invasion Mechanism of Pathogenic Mycobacteria

Jeffrey S. Schorey, Michael C. Carroll, Eric J. Brown *

Tuberculosis is the leading cause of death due to an infectious organism, killing an estimated 3 million people annually. Mycobacterium tuberculosis, the causative agent of tuberculosis, and other pathogenic mycobacteria require entry into host macrophages to initiate infection. An invasion mechanism was defined that was shared among pathogenic mycobacteria including M. tuberculosis, M. leprae, and M. avium but not by nonpathogenic mycobacteria or nonmycobacterial intramacrophage pathogens. This pathway required the association of the complement cleavage product C2a with mycobacteria resulting in the formation of a C3 convertase. The mycobacteria-associated C2a cleaved C3, resulting in C3b opsonization of the mycobacteria and recognition by macrophages.

J. S. Schorey, Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
M. C. Carroll, Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
E. J. Brown, Division of Infectious Diseases, Department of Internal Medicine, and Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
*   To whom correspondence should be addressed.

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