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Science 22 August 1997:
Vol. 277. no. 5329, p. 1035
DOI: 10.1126/science.277.5329.1035
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AIDS RESEARCH:
Novel Campaign to Test Live HIV Vaccine

Jon Cohen

An AIDS vaccine that has had more success in monkey experiments than any other approach has never been tested in humans. The reason: many researchers believe the vaccine, based on a weakened, or attenuated, live virus, would be too risky. Now, the little-known International Association of Physicians in AIDS Care, convinced that the potential benefits outweigh the risks, is conducting an unusual campaign to recruit "a few hundred" volunteers for a safety study of this approach that the group hopes to organize by the year 2000.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Viral Phenotypes and Antibody Responses in Long-Term Survivors Infected with Attenuated Human Immunodeficiency Virus Type 1 Containing Deletions in the nef and Long Terminal Repeat Regions.
E. E. Verity, D. Zotos, K. Wilson, C. Chatfield, V. A. Lawson, D. E. Dwyer, A. Cunningham, J. Learmont, W. Dyer, J. Sullivan, et al. (2007)
J. Virol. 81, 9268-9278
   Abstract »    Full Text »    PDF »
Genetic Instability of Live, Attenuated Human Immunodeficiency Virus Type 1 Vaccine Strains.
B. Berkhout, K. Verhoef, J. L. B. van Wamel, and N. K. T. Back (1999)
J. Virol. 73, 1138-1145
   Abstract »    Full Text »    PDF »
Limited Protection from a Pathogenic Chimeric Simian-Human Immunodeficiency Virus Challenge following Immunization with Attenuated Simian Immunodeficiency Virus.
M. G. Lewis, J. Yalley-Ogunro, J. J. Greenhouse, T. P. Brennan, J. B. Jiang, T. C. VanCott, Y. Lu, G. A. Eddy, and D. L. Birx (1999)
J. Virol. 73, 1262-1270
   Abstract »    Full Text »    PDF »
Strong Human Immunodeficiency Virus (HIV)-Specific Cytotoxic T-Lymphocyte Activity in Sydney Blood Bank Cohort Patients Infected with nef-Defective HIV Type 1.
W. B. Dyer, G. S. Ogg, M.-A. Demoitie, X. Jin, A. F. Geczy, S. L. Rowland-Jones, A. J. McMichael, D. F. Nixon, and J. S. Sullivan (1999)
J. Virol. 73, 436-443
   Abstract »    Full Text »    PDF »


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