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Science 15 August 1997:
Vol. 277. no. 5328, pp. 965 - 968
DOI: 10.1126/science.277.5328.965
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Reports

AIB1, a Steroid Receptor Coactivator Amplified in Breast and Ovarian Cancer

Sarah L. Anzick, Juha Kononen, Robert L. Walker, David O. Azorsa, Minna M. Tanner, Xin-Yuan Guan, Guido Sauter, Olli-P. Kallioniemi, Jeffrey M. Trent, Paul S. Meltzer *

Members of the recently recognized SRC-1 family of transcriptional coactivators interact with steroid hormone receptors to enhance ligand-dependent transcription. AIB1, a member of the SRC-1 family, was cloned during a search on the long arm of chromosome 20 for genes whose expression and copy number were elevated in human breast cancers. AIB1 amplification and overexpression were observed in four of five estrogen receptor-positive breast and ovarian cancer cell lines. Subsequent evaluation of 105 unselected specimens of primary breast cancer found AIB1 amplification in approximately 10 percent and high expression in 64 percent of the primary tumors analyzed. AIB1 protein interacted with estrogen receptors in a ligand-dependent fashion, and transfection of AIB1 resulted in enhancement of estrogen-dependent transcription. These observations identify AIB1 as a nuclear receptor coactivator whose altered expression may contribute to development of steroid-dependent cancers.

S. L. Anzick, J. Kononen, R. L. Walker, D. D. Azorsa, X.-Y. Guan, O.-P. Kallioniemi, J. M. Trent, P. S. Meltzer, Laboratory of Cancer Genetics, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
M. M. Tanner, Laboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere and Tampere University Hospital, Post Office Box 607, FIN-33101 Tampere, Finland.
G. Sauter, Institute for Pathology, University of Basel, Schönbeinstrasse 40 4003 Basel, Switzerland.
*   To whom correspondence should be addressed. E-mail: pmeltzer{at}nhgri.nih.gov

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The N-Terminal A/B Domain of the Thyroid Hormone Receptor-{beta}2 Isoform Influences Ligand-Dependent Recruitment of Coactivators to the Ligand-Binding Domain.
H. Tian, M. A. Mahajan, C. T. Wong, I. Habeos, and H. H. Samuels (2006)
Mol. Endocrinol. 20, 2036-2051
   Abstract »    Full Text »    PDF »
Protein Disulfide Isomerase Serves as a Molecular Chaperone to Maintain Estrogen Receptor {alpha} Structure and Function.
J. R. Schultz-Norton, W. H. McDonald, J. R. Yates, and A. M. Nardulli (2006)
Mol. Endocrinol. 20, 1982-1995
   Abstract »    Full Text »    PDF »
AIB1 Promotes DNA Replication by JNK Repression and AKT Activation during Cellular Stress.
K. Horiguchi, S. Arai, T. Nishihara, and J.-i. Nishikawa (2006)
J. Biochem. 140, 409-419
   Abstract »    Full Text »    PDF »
Molecular Inversion Probe Analysis of Gene Copy Alterations Reveals Distinct Categories of Colorectal Carcinoma.
H. Ji, J. Kumm, M. Zhang, K. Farnam, K. Salari, M. Faham, J. M. Ford, and R. W. Davis (2006)
Cancer Res. 66, 7910-7919
   Abstract »    Full Text »    PDF »
The SWI/SNF Chromatin Remodeling Subunit BAF57 Is a Critical Regulator of Estrogen Receptor Function in Breast Cancer Cells.
J. M. Garcia-Pedrero, E. Kiskinis, M. G. Parker, and B. Belandia (2006)
J. Biol. Chem. 281, 22656-22664
   Abstract »    Full Text »    PDF »
Coordinated Regulation of AIB1 Transcriptional Activity by Sumoylation and Phosphorylation.
H. Wu, L. Sun, Y. Zhang, Y. Chen, B. Shi, R. Li, Y. Wang, J. Liang, D. Fan, G. Wu, et al. (2006)
J. Biol. Chem. 281, 21848-21856
   Abstract »    Full Text »    PDF »
Extranuclear expression of hormone receptors in primary breast cancer.
R. Kim, M. Kaneko, K. Arihiro, M. Emi, K. Tanabe, S. Murakami, A. Osaki, and K. Inai (2006)
Ann. Onc. 17, 1213-1220
   Abstract »    Full Text »    PDF »
Loss of B-cell translocation gene-2 in estrogen receptor-positive breast carcinoma is associated with tumor grade and overexpression of cyclin d1 protein..
H. Kawakubo, E. Brachtel, T. Hayashida, G. Yeo, J. Kish, A. Muzikansky, P. D. Walden, and S. Maheswaran (2006)
Cancer Res. 66, 7075-7082
   Abstract »    Full Text »    PDF »
Hic-5/ARA55, a LIM Domain-Containing Nuclear Receptor Coactivator Expressed in Prostate Stromal Cells..
M. D. Heitzer and D. B. DeFranco (2006)
Cancer Res. 66, 7326-7333
   Abstract »    Full Text »    PDF »
Identification of the MLL2 Complex as a Coactivator for Estrogen Receptor {alpha}.
R. Mo, S. M. Rao, and Y.-J. Zhu (2006)
J. Biol. Chem. 281, 15714-15720
   Abstract »    Full Text »    PDF »
Transcriptional Intermediary Factor 1{alpha} Mediates Physical Interaction and Functional Synergy between the Coactivator-Associated Arginine Methyltransferase 1 and Glucocorticoid Receptor-Interacting Protein 1 Nuclear Receptor Coactivators.
C. Teyssier, C.-Y. Ou, K. Khetchoumian, R. Losson, and M. R. Stallcup (2006)
Mol. Endocrinol. 20, 1276-1286
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The Genomic Analysis of the Impact of Steroid Receptor Coactivators Ablation on Hepatic Metabolism.
J.-W. Jeong, I. Kwak, K. Y. Lee, L. D. White, X.-P. Wang, F. C. Brunicardi, B. W. O'Malley, and F. J. DeMayo (2006)
Mol. Endocrinol. 20, 1138-1152
   Abstract »    Full Text »    PDF »
Short photoperiod-induced ovarian regression is mediated by apoptosis in Siberian hamsters (Phodopus sungorus)..
C S Moffatt-Blue, J J Sury, and K. A Young (2006)
Reproduction 131, 771-782
   Abstract »    Full Text »    PDF »
Development and therapeutic options for the treatment of raloxifene-stimulated breast cancer in athymic mice..
R. M. O'Regan, C. Osipo, E. Ariazi, E. S. Lee, K. Meeke, C. Morris, A. Bertucci, M. A.B. Sarker, R. Grigg, and V. C. Jordan (2006)
Clin. Cancer Res. 12, 2255-2263
   Abstract »    Full Text »    PDF »
The joint effect of smoking and AIB1 on breast cancer risk in BRCA1 mutation carriers.
S. Colilla, P. W. Kantoff, S. L. Neuhausen, A. K. Godwin, M. B. Daly, S. A. Narod, J. E. Garber, H. T. Lynch, M. Brown, B. L. Weber, et al. (2006)
Carcinogenesis 27, 599-605
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Steroid Receptor Coactivator-1-Deficient Mice Exhibit Altered Hypothalamic-Pituitary-Adrenal Axis Function.
J. N. Winnay, J. Xu, B. W. O'Malley, and G. D. Hammer (2006)
Endocrinology 147, 1322-1332
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3-Phosphoinositide-Dependent Protein Kinase-1 Activates the Peroxisome Proliferator-Activated Receptor-{gamma} and Promotes Adipocyte Differentiation.
Y. Yin, H. Yuan, C. Wang, N. Pattabiraman, M. Rao, R. G. Pestell, and R. I. Glazer (2006)
Mol. Endocrinol. 20, 268-278
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Differential Recruitment of p160 Coactivators by Glucocorticoid Receptor between Schwann Cells and Astrocytes.
J. Grenier, A. Trousson, A. Chauchereau, J. Cartaud, M. Schumacher, and C. Massaad (2006)
Mol. Endocrinol. 20, 254-267
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The AIB1 Polyglutamine Repeat Does Not Modify Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
A. B. Spurdle, A. C. Antoniou, L. Kelemen, H. Holland, S. Peock, M. R. Cook, P. L. Smith, M. H. Greene, J. Simard, M. Plourde, et al. (2006)
Cancer Epidemiol. Biomarkers Prev. 15, 76-79
   Abstract »    Full Text »    PDF »
Mechanism of Action of Hic-5/Androgen Receptor Activator 55, a LIM Domain-Containing Nuclear Receptor Coactivator.
M. D Heitzer and D. B. DeFranco (2006)
Mol. Endocrinol. 20, 56-64
   Abstract »    Full Text »    PDF »


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