Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 August 1997:
Vol. 277. no. 5328, pp. 955 - 959
DOI: 10.1126/science.277.5328.955
Prev | Table of Contents | Next

Reports

Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

Toru M. Nakamura, Gregg B. Morin, Karen B. Chapman, Scott L. Weinrich, William H. Andrews, Joachim Lingner, * Calvin B. Harley, Thomas R. Cech dagger

Catalytic protein subunits of telomerase from the ciliate Euplotes aediculatus and the yeast Saccharomyces cerevisiae contain reverse transcriptase motifs. Here the homologous genes from the fission yeast Schizosaccharomyces pombe and human are identified. Disruption of the S. pombe gene resulted in telomere shortening and senescence, and expression of mRNA from the human gene correlated with telomerase activity in cell lines. Sequence comparisons placed the telomerase proteins in the reverse transcriptase family but revealed hallmarks that distinguish them from retroviral and retrotransposon relatives. Thus, the proposed telomerase catalytic subunits are phylogenetically conserved and represent a deep branch in the evolution of reverse transcriptases.

T. M. Nakamura, J. Lingner, T. R. Cech, Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309-0215, USA.
G. B. Morin, K. B. Chapman, S. L. Weinrich, W. H. Andrews, C. B. Harley, Geron Corporation, 230 Constitution Drive, Menlo Park, CA 94025, USA.
*   Present address: Swiss Institute for Experimental Cancer Research, 1066 Epalinges/VD, Switzerland.

dagger    To whom correspondence should be addressed.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Deregulated GSK3{beta} Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse Transcriptase and Telomerase.
W. Mai, K. Kawakami, A. Shakoori, S. Kyo, K. Miyashita, K. Yokoi, M. Jin, T. Shimasaki, Y. Motoo, and T. Minamoto (2009)
Clin. Cancer Res. 15, 6810-6819
   Abstract »    Full Text »    PDF »
Telomeres and Telomerase in Sarcomas.
T. MATSUO, S. SHIMOSE, T. KUBO, J. FUJIMORI, Y. YASUNAGA, and M. OCHI (2009)
Anticancer Res 29, 3833-3836
   Abstract »    Full Text »    PDF »
Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells.
R. T. Calado, W. T. Yewdell, K. L. Wilkerson, J. A. Regal, S. Kajigaya, C. A. Stratakis, and N. S. Young (2009)
Blood 114, 2236-2243
   Abstract »    Full Text »    PDF »
Chromosome End Maintenance by Telomerase.
J. L. Osterhage and K. L. Friedman (2009)
J. Biol. Chem. 284, 16061-16065
   Abstract »    Full Text »    PDF »
Telomere-Maintenance Mechanisms in Soft-Tissue Malignant Fibrous Histiocytomas.
T. Matsuo, J. W. Shay, W. E. Wright, E. Hiyama, S. Shimose, T. Kubo, T. Sugita, Y. Yasunaga, and M. Ochi (2009)
J. Bone Joint Surg. Am. 91, 928-937
   Abstract »    Full Text »    PDF »
Increased Human Telomerase Reverse Transcriptase (hTERT) mRNA Expression but not Telomerase Activity is Related to Survival in Curatively Resected Non-small Cell Lung Cancer.
R. METZGER, D. VALLBOHMER, C. MULLER-TIDOW, H. HIGASHI, E. BOLLSCHWEILER, U. WARNECKE-EBERZ, J. BRABENDER, S. E. BALDUS, H. XI, W. E. BERDEL, et al. (2009)
Anticancer Res 29, 1157-1162
   Abstract »    Full Text »    PDF »
MCAF1/AM Is Involved in Sp1-mediated Maintenance of Cancer-associated Telomerase Activity.
L. Liu, K. Ishihara, T. Ichimura, N. Fujita, S. Hino, S. Tomita, S. Watanabe, N. Saitoh, T. Ito, and M. Nakao (2009)
J. Biol. Chem. 284, 5165-5174
   Abstract »    Full Text »    PDF »
Silencing PinX1 Compromises Telomere Length Maintenance As Well As Tumorigenicity in Telomerase-Positive Human Cancer Cells.
B. Zhang, Y. X. Bai, H. H. Ma, F. Feng, R. Jin, Z. L. Wang, J. Lin, S. P. Sun, P. Yang, X. X. Wang, et al. (2009)
Cancer Res. 69, 75-83
   Abstract »    Full Text »    PDF »
Telomerase Reverse Transcriptase (TERT) Expression in Canine Mammary Tissues: A Specific Marker for Malignancy?.
M. ZAVLARIS, K. ANGELOPOULOU, I. VLEMMAS, and N. PAPAIOANNOU (2009)
Anticancer Res 29, 319-325
   Abstract »    Full Text »    PDF »
Genetic Hypervariability in Two Distinct Deuterostome Telomerase Reverse Transcriptase Genes and their Early Embryonic Functions.
T. B. Wells, G. Zhang, Z. Harley, and H. Vaziri (2009)
Mol. Biol. Cell 20, 464-480
   Abstract »    Full Text »    PDF »
Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller.
K. Tomita and J. P. Cooper (2008)
Genes & Dev. 22, 3461-3474
   Abstract »    Full Text »    PDF »
Cell-Restricted Immortalization by Human Papillomavirus Correlates with Telomerase Activation and Engagement of the hTERT Promoter by Myc.
X. Liu, A. Dakic, R. Chen, G. L. Disbrow, Y. Zhang, Y. Dai, and R. Schlegel (2008)
J. Virol. 82, 11568-11576
   Abstract »    Full Text »    PDF »
Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes.
S. R. Fauce, B. D. Jamieson, A. C. Chin, R. T. Mitsuyasu, S. T. Parish, H. L. Ng, C. M. Ramirez Kitchen, O. O. Yang, C. B. Harley, and R. B. Effros (2008)
J. Immunol. 181, 7400-7406
   Abstract »    Full Text »    PDF »
Relationship Between Tumor and Plasma Levels of hTERT mRNA in Patients with Colorectal Cancer: Implications for Monitoring of Neoplastic Disease.
L. Terrin, E. Rampazzo, S. Pucciarelli, M. Agostini, R. Bertorelle, G. Esposito, P. DelBianco, D. Nitti, and A. De Rossi (2008)
Clin. Cancer Res. 14, 7444-7451
   Abstract »    Full Text »    PDF »
Latent Membrane Protein 1 of Epstein-Barr Virus Activates the hTERT Promoter and Enhances Telomerase Activity in B Lymphocytes.
L. Terrin, J. Dal Col, E. Rampazzo, P. Zancai, M. Pedrotti, G. Ammirabile, S. Bergamin, S. Rizzo, R. Dolcetti, and A. De Rossi (2008)
J. Virol. 82, 10175-10187
   Abstract »    Full Text »    PDF »
Review: Cardiogenic potential of endothelial progenitor cells.
S. Murasawa and T. Asahara (2008)
Therapeutic Advances in Cardiovascular Disease 2, 341-348
   Abstract »    PDF »
Telomere Shortening in Familial and Sporadic Pulmonary Fibrosis.
J. T. Cronkhite, C. Xing, G. Raghu, K. M. Chin, F. Torres, R. L. Rosenblatt, and C. K. Garcia (2008)
Am. J. Respir. Crit. Care Med. 178, 729-737
   Abstract »    Full Text »    PDF »
A genome-wide association study identifies an association of a common variant in TERT with susceptibility to idiopathic pulmonary fibrosis.
T Mushiroda, S Wattanapokayakit, A Takahashi, T Nukiwa, S Kudoh, T Ogura, H Taniguchi, M Kubo, N Kamatani, Y Nakamura, et al. (2008)
J. Med. Genet. 45, 654-656
   Abstract »    Full Text »    PDF »
Phylogenetic profiles reveal evolutionary relationships within the "twilight zone" of sequence similarity.
G. S. Chang, Y. Hong, K. D. Ko, G. Bhardwaj, E. C. Holmes, R. L. Patterson, and D. B. van Rossum (2008)
PNAS 105, 13474-13479
   Abstract »    Full Text »    PDF »
Short telomeres are a risk factor for idiopathic pulmonary fibrosis.
J. K. Alder, J. J.-L. Chen, L. Lancaster, S. Danoff, S.-c. Su, J. D. Cogan, I. Vulto, M. Xie, X. Qi, R. M. Tuder, et al. (2008)
PNAS 105, 13051-13056
   Abstract »    Full Text »    PDF »
Induced telomerase activity in primary aortic endothelial cells by low-LET {gamma}-radiation is mediated through NF-{kappa}B activation.
M NATARAJAN, S MOHAN, R KONOPINSKI, R A OTTO, and T S HERMAN (2008)
Br. J. Radiol. 81, 711-720
   Abstract »    Full Text »    PDF »
NFX1 Interacts with mSin3A/Histone Deacetylase To Repress hTERT Transcription in Keratinocytes.
M. Xu, W. Luo, D. J. Elzi, C. Grandori, and D. A. Galloway (2008)
Mol. Cell. Biol. 28, 4819-4828
   Abstract »    Full Text »    PDF »
Multiple Mechanisms of Telomere Maintenance Exist and Differentially Affect Clinical Outcome in Diffuse Malignant Peritoneal Mesothelioma.
R. Villa, M. G. Daidone, R. Motta, L. Venturini, C. De Marco, A. Vannelli, S. Kusamura, D. Baratti, M. Deraco, A. Costa, et al. (2008)
Clin. Cancer Res. 14, 4134-4140
   Abstract »    Full Text »    PDF »
A tandem repeat of human telomerase reverse transcriptase (hTERT) and risk of breast cancer development and metastasis in Chinese women.
Y. Wang, Z. Hu, J. Liang, Z. Wang, J. Tang, S. Wang, X. Wang, J. Qin, X. Wang, and H. Shen (2008)
Carcinogenesis 29, 1197-1201
   Abstract »    Full Text »    PDF »
Amplification of Telomerase Reverse Transcriptase Gene in Human Mammary Epithelial Cells with Limiting Telomerase RNA Expression Levels.
Y. Cao, L. I. Huschtscha, A. S. Nouwens, H. A. Pickett, A. A. Neumann, A. C-M. Chang, C. D. Toouli, T. M. Bryan, and R. R. Reddel (2008)
Cancer Res. 68, 3115-3123
   Abstract »    Full Text »    PDF »
Multistep regulation of telomerase during differentiation of HL60 cells.
O. Yamada, K. Ozaki, M. Nakatake, M. Akiyama, K. Kawauchi, and R. Matsuoka (2008)
J. Leukoc. Biol. 83, 1240-1248
   Abstract »    Full Text »    PDF »
Telomeres and Aging.
G. Aubert and P. M. Lansdorp (2008)
Physiol Rev 88, 557-579
   Abstract »    Full Text »    PDF »
Recombination-Based Telomere Maintenance Is Dependent on Tel1-MRN and Rap1 and Inhibited by Telomerase, Taz1, and Ku in Fission Yeast.
L. Subramanian, B. A. Moser, and T. M. Nakamura (2008)
Mol. Cell. Biol. 28, 1443-1455
   Abstract »    Full Text »    PDF »
SIRT1 Acts as a Nutrient-sensitive Growth Suppressor and Its Loss Is Associated with Increased AMPK and Telomerase Activity.
S. R. Narala, R. C. Allsopp, T. B. Wells, G. Zhang, P. Prasad, M. J. Coussens, D. J. Rossi, I. L. Weissman, and H. Vaziri (2008)
Mol. Biol. Cell 19, 1210-1219
   Abstract »    Full Text »    PDF »
Regulation of Telomerase and Telomeres: Human Tumor Viruses Take Control.
M. Bellon and C. Nicot (2008)
J Natl Cancer Inst 100, 98-108
   Abstract »    Full Text »    PDF »
Human diseases of telomerase dysfunction: insights into tissue aging.
C. K. Garcia, W. E. Wright, and J. W. Shay (2007)
Nucleic Acids Res. 35, 7406-7416
   Abstract »    Full Text »    PDF »
Detailed Technical Analysis of Urine RNA-Based Tumor Diagnostics Reveals ETS2/Urokinase Plasminogen Activator to Be a Novel Marker for Bladder Cancer.
M. Hanke, I. Kausch, G. Dahmen, D. Jocham, and J. M. Warnecke (2007)
Clin. Chem. 53, 2070-2077
   Abstract »    Full Text »    PDF »
Myc and Human Papillomavirus Type 16 E7 Genes Cooperate To Immortalize Human Keratinocytes.
X. Liu, G. L. Disbrow, H. Yuan, V. Tomaic, and R. Schlegel (2007)
J. Virol. 81, 12689-12695
   Abstract »    Full Text »    PDF »
Characterization of Drosophila Telomeric Retroelement TAHRE: Transcription, Transpositions, and RNAi-based Regulation of Expression.
S. Shpiz, D. Kwon, A. Uneva, M. Kim, M. Klenov, Y. Rozovsky, P. Georgiev, M. Savitsky, and A. Kalmykova (2007)
Mol. Biol. Evol. 24, 2535-2545
   Abstract »    Full Text »    PDF »
Tumor-specific Activation of Human Telomerase Reverses Transcriptase Promoter Activity by Activating Enhancer-binding Protein-2beta in Human Lung Cancer Cells.
W.-G. Deng, G. Jayachandran, G. Wu, K. Xu, J. A. Roth, and L. Ji (2007)
J. Biol. Chem. 282, 26460-26470
   Abstract »    Full Text »    PDF »
Vaccination of Patients With Advanced Non-Small-Cell Lung Cancer With an Optimized Cryptic Human Telomerase Reverse Transcriptase Peptide.
I. Bolonaki, A. Kotsakis, E. Papadimitraki, D. Aggouraki, G. Konsolakis, A. Vagia, C. Christophylakis, I. Nikoloudi, E. Magganas, A. Galanis, et al. (2007)
J. Clin. Oncol. 25, 2727-2734
   Abstract »    Full Text »    PDF »
Functional Characterization of Yeast Telomerase RNA Dimerization.
C. L. Gipson, Z.-T. Xin, S. C. Danzy, T. G. Parslow, and H. Ly (2007)
J. Biol. Chem. 282, 18857-18863
   Abstract »    Full Text »    PDF »
Immunohistochemichal expression of biomarkers: a comparative study between diagnostic bronchial biopsies and surgical specimens of non-small-cell lung cancer.
L Taillade, F Penault-Llorca, T Boulet, P Fouret, S Michiels, E Taranchon, G Mountzios, P Validire, J Domont, P Girard, et al. (2007)
Ann. Onc. 18, 1043-1050
   Abstract »    Full Text »    PDF »
Cdc13 Telomere Capping Decreases Mec1 Association but Does Not Affect Tel1 Association with DNA Ends.
Y. Hirano and K. Sugimoto (2007)
Mol. Biol. Cell 18, 2026-2036
   Abstract »    Full Text »    PDF »
Fission Yeast Taz1 and RPA Are Synergistically Required to Prevent Rapid Telomere Loss.
T. Kibe, Y. Ono, K. Sato, and M. Ueno (2007)
Mol. Biol. Cell 18, 2378-2387
   Abstract »    Full Text »    PDF »
Adult-onset pulmonary fibrosis caused by mutations in telomerase.
K. D. Tsakiri, J. T. Cronkhite, P. J. Kuan, C. Xing, G. Raghu, J. C. Weissler, R. L. Rosenblatt, J. W. Shay, and C. K. Garcia (2007)
PNAS 104, 7552-7557
   Abstract »    Full Text »    PDF »
Human Telomerase Exists in Two Distinct Active Complexes In Vivo.
H. Mizuno, S. Khurts, T. Seki, Y. Hirota, S. Kaneko, and S. Murakami (2007)
J. Biochem. 141, 641-652
   Abstract »    Full Text »    PDF »
Characterization of Physical and Functional Anchor Site Interactions in Human Telomerase.
H. D. M. Wyatt, D. A. Lobb, and T. L. Beattie (2007)
Mol. Cell. Biol. 27, 3226-3240
   Abstract »    Full Text »    PDF »
Protein Composition of Catalytically Active Human Telomerase from Immortal Cells.
S. B. Cohen, M. E. Graham, G. O. Lovrecz, N. Bache, P. J. Robinson, and R. R. Reddel (2007)
Science 315, 1850-1853
   Abstract »    Full Text »    PDF »
Telomerase Mutations in Families with Idiopathic Pulmonary Fibrosis.
M. Y. Armanios, J. J.-L. Chen, J. D. Cogan, J. K. Alder, R. G. Ingersoll, C. Markin, W. E. Lawson, M. Xie, I. Vulto, J. A. Phillips III, et al. (2007)
N. Engl. J. Med. 356, 1317-1326
   Abstract »    Full Text »    PDF »
The Telomerase Reverse Transcriptase (hTERT) Gene Is a Direct Target of the Histone Methyltransferase SMYD3.
C. Liu, X. Fang, Z. Ge, M. Jalink, S. Kyo, M. Bjorkholm, A. Gruber, J. Sjoberg, and D. Xu (2007)
Cancer Res. 67, 2626-2631
   Abstract »    Full Text »    PDF »
p53-dependent integration of telomere and growth factor deprivation signals.
A. Beliveau, E. Bassett, A. T. Lo, J. Garbe, M. A. Rubio, M. J. Bissell, J. Campisi, and P. Yaswen (2007)
PNAS 104, 4431-4436
   Abstract »    Full Text »    PDF »
A Novel Regulator of Telomerase: S100A8 MEDIATES DIFFERENTIATION-DEPENDENT AND CALCIUM-INDUCED INHIBITION OF TELOMERASE ACTIVITY IN THE HUMAN EPIDERMAL KERATINOCYTE LINE HaCaT.
S. Rosenberger, I. S. Thorey, S. Werner, and P. Boukamp (2007)
J. Biol. Chem. 282, 6126-6135
   Abstract »    Full Text »    PDF »
The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity.
W. C. Drosopoulos and V. R. Prasad (2007)
Nucleic Acids Res. 35, 1155-1168
   Abstract »    Full Text »    PDF »
Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene.
S. Renaud, D. Loukinov, Z. Abdullaev, I. Guilleret, F. T. Bosman, V. Lobanenkov, and J. Benhattar (2007)
Nucleic Acids Res. 35, 1245-1256
   Abstract »    Full Text »    PDF »
Telomere Length, Telomerase Activity, and Expressions of Human Telomerase mRNA Component (hTERC) and Human Telomerase Reverse Transcriptase (hTERT) mRNA in Pulmonary Neuroendocrine Tumors.
Y. Nishio, K. Nakanishi, Y. Ozeki, S.-X. Jiang, T. Kameya, A. Hebisawa, M. Mukai, W. D. Travis, T. J. Franks, and T. Kawai (2007)
Jpn. J. Clin. Oncol. 37, 16-22
   Abstract »    Full Text »    PDF »
Real-Time RT-PCR Quantification of Human Telomerase Reverse Transcriptase Splice Variants in Tumor Cell Lines and Non-Small Cell Lung Cancer.
E. Mavrogiannou, A. Strati, A. Stathopoulou, E. G. Tsaroucha, L. Kaklamanis, and E. S. Lianidou (2007)
Clin. Chem. 53, 53-61
   Abstract »    Full Text »    PDF »
Nucleostemin Delays Cellular Senescence and Negatively Regulates TRF1 Protein Stability.
Q. Zhu, H. Yasumoto, and R. Y. L. Tsai (2006)
Mol. Cell. Biol. 26, 9279-9290
   Abstract »    Full Text »    PDF »
Immunogenic HLA-B7-restricted peptides of hTRT.
X. Cortez-Gonzalez, J. Sidney, O. Adotevi, A. Sette, F. Millard, F. Lemonnier, P. Langlade-Demoyen, and M. Zanetti (2006)
Int. Immunol. 18, 1707-1718
   Abstract »    Full Text »    PDF »
Canonical TTAGG-repeat telomeres and telomerase in the honey bee, Apis mellifera.
H. M. Robertson and K. H.J. Gordon (2006)
Genome Res. 16, 1345-1351
   Abstract »    Full Text »    PDF »
Regulation and Effects of Modulation of Telomerase Reverse Transcriptase Expression in Primordial Germ Cells During Development.
M. Coussens, Y. Yamazaki, S. Moisyadi, R. Suganuma, R. Yanagimachi, and R. Allsopp (2006)
Biol Reprod 75, 785-791
   Abstract »    Full Text »    PDF »
Organization of chromosome ends in the rice blast fungus, Magnaporthe oryzae.
C. Rehmeyer, W. Li, M. Kusaba, Y.-S. Kim, D. Brown, C. Staben, R. Dean, and M. Farman (2006)
Nucleic Acids Res. 34, 4685-4701
   Abstract »    Full Text »    PDF »
Low-Dose Etoposide Enhances Telomerase-Dependent Adenovirus-Mediated Cytosine Deaminase Gene Therapy through Augmentation of Adenoviral Infection and Transgene Expression in a Syngeneic Bladder Tumor Model..
G.-S. Shieh, A.-L. Shiau, Y.-T. Yo, P.-R. Lin, C.-C. Chang, T.-S. Tzai, and C.-L. Wu (2006)
Cancer Res. 66, 9957-9966
   Abstract »    Full Text »    PDF »
The Biochemical Role of the Heat Shock Protein 90 Chaperone Complex in Establishing Human Telomerase Activity.
B. R. Keppler, A. T. Grady, and M. B. Jarstfer (2006)
J. Biol. Chem. 281, 19840-19848
   Abstract »    Full Text »    PDF »
Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths.
Y.-L. Wu, C. Dudognon, E. Nguyen, J. Hillion, F. Pendino, I. Tarkanyi, J. Aradi, M. Lanotte, J.-H. Tong, G.-Q. Chen, et al. (2006)
J. Cell Sci. 119, 2797-2806
   Abstract »    Full Text »    PDF »
Assembly of Mutant-Template Telomerase RNA into Catalytically Active Telomerase Ribonucleoprotein That Can Act on Telomeres Is Required for Apoptosis and Cell Cycle Arrest in Human Cancer Cells.
A. Goldkorn and E. H. Blackburn (2006)
Cancer Res. 66, 5763-5771
   Abstract »    Full Text »    PDF »
Immunogenic HLA-B*0702-Restricted Epitopes Derived from Human Telomerase Reverse Transcriptase That Elicit Antitumor Cytotoxic T-Cell Responses..
O. Adotevi, K. Mollier, C. Neuveut, S. Cardinaud, E. Boulanger, B. Mignen, W.-H. Fridman, M. Zanetti, P. Charneau, E. Tartour, et al. (2006)
Clin. Cancer Res. 12, 3158-3167
   Abstract »    Full Text »    PDF »
Involvement of Topoisomerase III in Telomere-Telomere Recombination.
H.-J. Tsai, W.-H. Huang, T.-K. Li, Y.-L. Tsai, K.-J. Wu, S.-F. Tseng, and S.-C. Teng (2006)
J. Biol. Chem. 281, 13717-13723
   Abstract »    Full Text »    PDF »
Mutations in dyskeratosis congenita: their impact on telomere length and the diversity of clinical presentation.
T. J. Vulliamy, A. Marrone, S. W. Knight, A. Walne, P. J. Mason, and I. Dokal (2006)
Blood 107, 2680-2685
   Abstract »    Full Text »    PDF »
Regulation of Cellular Immortalization and Steady-State Levels of the Telomerase Reverse Transcriptase through Its Carboxy-Terminal Domain..
E. J. Middleman, J. Choi, A. S. Venteicher, P. Cheung, and S. E. Artandi (2006)
Mol. Cell. Biol. 26, 2146-2159
   Abstract »    Full Text »    PDF »
Multiple Oncogenic Changes (K-RASV12, p53 Knockdown, Mutant EGFRs, p16 Bypass, Telomerase) Are Not Sufficient to Confer a Full Malignant Phenotype on Human Bronchial Epithelial Cells.
M. Sato, M. B. Vaughan, L. Girard, M. Peyton, W. Lee, D. S. Shames, R. D. Ramirez, N. Sunaga, A. F. Gazdar, J. W. Shay, et al. (2006)
Cancer Res. 66, 2116-2128
   Abstract »    Full Text »    PDF »
Frequency of telomerase-specific CD8+ T lymphocytes in patients with cancer.
G. Filaci, M. Fravega, M. Setti, P. Traverso, E. Millo, D. Fenoglio, S. Negrini, F. Ferrera, A. Romagnoli, M. Basso, et al. (2006)
Blood 107, 1505-1512
   Abstract »    Full Text »    PDF »
Visualization of Telomerase Reverse Transcriptase (hTERT) Promoter Activity Using a Trimodality Fusion Reporter Construct.
P. Padmanabhan, J. Otero, P. Ray, R. Paulmurugan, A. R. Hoffman, S. S. Gambhir, S. Biswal, and G. A. Ulaner (2006)
J. Nucl. Med. 47, 270-277
   Abstract »    Full Text »    PDF »
Saccharomyces cerevisiae Est3p dimerizes in vitro and dimerization contributes to efficient telomere replication in vivo.
C.-P. Yang, Y.-B. Chen, F.-L. Meng, and J.-Q. Zhou (2006)
Nucleic Acids Res. 34, 407-416
   Abstract »    Full Text »    PDF »
Mitogen-Activated Protein Kinase Cascade-Mediated Histone H3 Phosphorylation Is Critical for Telomerase Reverse Transcriptase Expression/Telomerase Activation Induced by Proliferation.
Z. Ge, C. Liu, M. Bjorkholm, A. Gruber, and D. Xu (2006)
Mol. Cell. Biol. 26, 230-237
   Abstract »    Full Text »    PDF »
High Telomerase RNA Expression Level Is an Adverse Prognostic Factor for Favorable-Histology Wilms' Tumor.
J. S. Dome, C. A. Bockhold, S. M. Li, S. D. Baker, D. M. Green, E. J. Perlman, D. A. Hill, and N. E. Breslow (2005)
J. Clin. Oncol. 23, 9138-9145
   Abstract »    Full Text »    PDF »
The effect of TERC haploinsufficiency on the inheritance of telomere length.
F. Goldman, R. Bouarich, S. Kulkarni, S. Freeman, H.-Y. Du, L. Harrington, P. J. Mason, A. Londono-Vallejo, and M. Bessler (2005)
PNAS 102, 17119-17124
   Abstract »    Full Text »    PDF »
Differential transcriptional regulation of human telomerase in a cellular model representing important genetic alterations in esophageal squamous carcinogenesis.
M. Quante, S. Heeg, A. von Werder, G. Goessel, C. Fulda, M. Doebele, H. Nakagawa, R. Beijersbergen, H. E. Blum, and O. G. Opitz (2005)
Carcinogenesis 26, 1879-1889
   Abstract »    Full Text »    PDF »
Haploinsufficiency of telomerase reverse transcriptase leads to anticipation in autosomal dominant dyskeratosis congenita.
M. Armanios, J.-L. Chen, Y.-P. C. Chang, R. A. Brodsky, A. Hawkins, C. A. Griffin, J. R. Eshleman, A. R. Cohen, A. Chakravarti, A. Hamosh, et al. (2005)
PNAS 102, 15960-15964
   Abstract »    Full Text »    PDF »
Function of AP-1 in Transcription of the Telomerase Reverse Transcriptase Gene (TERT) in Human and Mouse Cells.
M. Takakura, S. Kyo, M. Inoue, W. E. Wright, and J. W. Shay (2005)
Mol. Cell. Biol. 25, 8037-8043
   Abstract »    Full Text »    PDF »
Quantitative and Spatial Measurements of Telomerase Reverse Transcriptase Expression within Normal and Malignant Human Breast Tissues.
W. C. Hines, A. M. Fajardo, N. E. Joste, M. Bisoffi, and J. K. Griffith (2005)
Mol. Cancer Res. 3, 503-509
   Abstract »    Full Text »    PDF »
Potential of telomerase expression and activity in cervical specimens as a diagnostic tool.
S Bravaccini, M A Sanchini, A Amadori, L Medri, L Saragoni, D Calistri, F Monti, A Volpi, and D Amadori (2005)
J. Clin. Pathol. 58, 911-914
   Abstract »    Full Text »    PDF »
The Telomerase Activity of Adult Mouse Testis Resides in the Spermatogonial {alpha}6-Integrin-Positive Side Population Enriched in Germinal Stem Cells.
L. Riou, H. Bastos, B. Lassalle, M. Coureuil, J. Testart, F. D. Boussin, I. Allemand, and P. Fouchet (2005)
Endocrinology 146, 3926-3932
   Abstract »    Full Text »    PDF »
Telomere structure and shortening in telomerase-deficient Trypanosoma brucei.
O. Dreesen, B. Li, and G. A. M. Cross (2005)
Nucleic Acids Res. 33, 4536-4543
   Abstract »    Full Text »    PDF »
Transformation of Human and Murine Fibroblasts without Viral Oncoproteins.
J. S. Boehm, M. T. Hession, S. E. Bulmer, and W. C. Hahn (2005)
Mol. Cell. Biol. 25, 6464-6474
   Abstract »    Full Text »    PDF »
Expression of human telomerase catalytic protein in gallbladder carcinogenesis.
B Luzar, M Poljak, A Cor, U Klopcic, and V Ferlan-Marolt (2005)
J. Clin. Pathol. 58, 820-825
   Abstract »    Full Text »    PDF »
hTERT Extends Proliferative Lifespan and Prevents Oxidative Stress-Induced Apoptosis in Human Lens Epithelial Cells.
X.-Q. Huang, J. Wang, J.-P. Liu, H. Feng, W.-B. Liu, Q. Yan, Y. Liu, S.-M. Sun, M. Deng, L. Gong, et al. (2005)
Invest. Ophthalmol. Vis. Sci. 46, 2503-2513
   Abstract »    Full Text »    PDF »
Cellular and Gene Expression Responses Involved in the Rapid Growth Inhibition of Human Cancer Cells by RNA Interference-mediated Depletion of Telomerase RNA.
S. Li, J. Crothers, C. M. Haqq, and E. H. Blackburn (2005)
J. Biol. Chem. 280, 23709-23717
   Abstract »    Full Text »    PDF »
Human Telomerase Reverse Transcriptase Immortalizes Bovine Lens Epithelial Cells and Suppresses Differentiation through Regulation of the ERK Signaling Pathway.
J. Wang, H. Feng, X.-Q. Huang, H. Xiang, Y.-W. Mao, J.-P. Liu, Q. Yan, W.-B. Liu, Y. Liu, M. Deng, et al. (2005)
J. Biol. Chem. 280, 22776-22787
   Abstract »    Full Text »    PDF »
Differential Expression of Full-length Telomerase Reverse Transcriptase mRNA and Telomerase Activity between Normal and Malignant Renal Tissues.
Y. Fan, Z. Liu, X. Fang, Z. Ge, N. Ge, Y. Jia, P. Sun, F. Lou, M. Bjorkholm, A. Gruber, et al. (2005)
Clin. Cancer Res. 11, 4331-4337
   Abstract »    Full Text »    PDF »
Mutations in TERT, the Gene for Telomerase Reverse Transcriptase, in Aplastic Anemia.
H. Yamaguchi, R. T. Calado, H. Ly, S. Kajigaya, G. M. Baerlocher, S. J. Chanock, P. M. Lansdorp, and N. S. Young (2005)
N. Engl. J. Med. 352, 1413-1424
   Abstract »    Full Text »    PDF »
The E6AP Ubiquitin Ligase Is Required for Transactivation of the hTERT Promoter by the Human Papillomavirus E6 Oncoprotein.
X. Liu, H. Yuan, B. Fu, G. L. Disbrow, T. Apolinario, V. Tomaic, M. L. Kelley, C. C. Baker, J. Huibregtse, and R. Schlegel (2005)
J. Biol. Chem. 280, 10807-10816
   Abstract »    Full Text »    PDF »
The unusually large Plasmodium telomerase reverse-transcriptase localizes in a discrete compartment associated with the nucleolus.
L. M. Figueiredo, E. P. C. Rocha, L. Mancio-Silva, C. Prevost, D.èl. Hernandez-Verdun, and A. Scherf (2005)
Nucleic Acids Res. 33, 1111-1122
   Abstract »    Full Text »    PDF »
Protein coding potential of retroviruses and other transposable elements in vertebrate genomes.
E. M. Zdobnov, Món. Campillos, E. D. Harrington, D. Torrents, and P. Bork (2005)
Nucleic Acids Res. 33, 946-954
   Abstract »    Full Text »    PDF »
Extrachromosomal Telomeric Circles Contribute to Rad52-, Rad50-, and Polymerase {delta}-Mediated Telomere-Telomere Recombination in Saccharomyces cerevisiae.
C.-Y. Lin, H.-H. Chang, K.-J. Wu, S.-F. Tseng, C.-C. Lin, C.-P. Lin, and S.-C. Teng (2005)
Eukaryot. Cell 4, 327-336
   Abstract »    Full Text »    PDF »
Identification of two distinct elements mediating activation of telomerase (hTERT) gene expression in association with cell growth in human T cells.
Y. Matsumura-Arioka, K. Ohtani, T. Hara, R. Iwanaga, and M. Nakamura (2005)
Int. Immunol. 17, 207-215
   Abstract »    Full Text »    PDF »
Telomerase and Cancer Stem Cells.
M. ARMANIOS and C.W. GREIDER (2005)
Cold Spring Harb Symp Quant Biol 70, 205-208
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)