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Science 8 August 1997:
Vol. 277. no. 5327, pp. 818 - 821
DOI: 10.1126/science.277.5327.818
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Reports

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

James P. Sheridan, * Scot A. Marsters, * Robert M. Pitti, * Austin Gurney, Maya Skubatch, Daryl Baldwin, Lakshmi Ramakrishnan, Christa L. Gray, Kevin Baker, William I. Wood, Audrey D. Goddard, Paul Godowski, Avi Ashkenazi dagger

TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4. Two additional TRAIL receptors were identified. The receptor designated death receptor 5 (DR5) contained a cytoplasmic death domain and induced apoptosis much like DR4. The receptor designated decoy receptor 1 (DcR1) displayed properties of a glycophospholipid-anchored cell surface protein. DcR1 acted as a decoy receptor that inhibited TRAIL signaling. Thus, a cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli.

J. P. Sheridan, S. A. Marsters, R. M. Pitti, M. Skubatch, A. Ashkenazi, Department of Molecular Oncology, Genentech, South San Francisco, CA 94080-4918, USA.
A. Gurney, D. Baldwin, L. Ramakrishnan, C. L. Gray, K. Baker, W. I. Wood, A. D. Goddard, P. Godowski, Department of Molecular Biology, Genentech, South San Francisco, CA 94080-4918, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed. E-mail: aa{at}gene.com

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   Abstract »    Full Text »    PDF »
Bortezomib Abolishes Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance via a p21-Dependent Mechanism in Human Bladder and Prostate Cancer Cells.
L. M. Lashinger, K. Zhu, S. A. Williams, M. Shrader, C. P.N. Dinney, and D. J. McConkey (2005)
Cancer Res. 65, 4902-4908
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Contribution of Epigenetic Silencing of Tumor Necrosis Factor-Related Apoptosis Inducing Ligand Receptor 1 (DR4) to TRAIL Resistance and Ovarian Cancer.
P. Horak, D. Pils, G. Haller, I. Pribill, M. Roessler, S. Tomek, R. Horvat, R. Zeillinger, C. Zielinski, and M. Krainer (2005)
Mol. Cancer Res. 3, 335-343
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Resistance and Susceptibility of Human Uveal Melanoma Cells to TRAIL-Induced Apoptosis.
H. Li, J. Y. Niederkorn, S. Neelam, and H. Alizadeh (2005)
Arch Ophthalmol 123, 654-661
   Abstract »    Full Text »    PDF »
A Study of TRAIL Receptors in Squamous Cell Carcinoma of the Head and Neck.
M. S. Teng, M. S. Brandwein-Gensler, M. S. Teixeira, J. A. Martignetti, and D. C. Duffey (2005)
Arch Otolaryngol Head Neck Surg 131, 407-412
   Abstract »    Full Text »    PDF »
Identification of GPI anchor attachment signals by a Kohonen self-organizing map.
N. Fankhauser and P. Maser (2005)
Bioinformatics 21, 1846-1852
   Abstract »    Full Text »    PDF »
Enhanced Apoptosis and Tumor Regression Induced by a Direct Agonist Antibody to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor 2.
K. Motoki, E. Mori, A. Matsumoto, M. Thomas, T. Tomura, R. Humphreys, V. Albert, M. Muto, H. Yoshida, M. Aoki, et al. (2005)
Clin. Cancer Res. 11, 3126-3135
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Dengue virus-induced apoptosis in hepatic cells is partly mediated by Apo2 ligand/tumour necrosis factor-related apoptosis-inducing ligand.
T. Matsuda, A. Almasan, M. Tomita, K. Tamaki, M. Saito, M. Tadano, H. Yagita, T. Ohta, and N. Mori (2005)
J. Gen. Virol. 86, 1055-1065
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E1A Sensitizes Cancer Cells to TRAIL-Induced Apoptosis through Enhancement of Caspase Activation.
R. Shao, D.-F. Lee, Y. Wen, Y. Ding, W. Xia, B. Ping, H. Yagita, B. Spohn, and M.-C. Hung (2005)
Mol. Cancer Res. 3, 219-226
   Abstract »    Full Text »    PDF »
Predominant Bcl-XL Knockdown Disables Antiapoptotic Mechanisms: Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Based Triple Chemotherapy Overcomes Chemoresistance in Pancreatic Cancer Cells In vitro.
J. Bai, J. Sui, A. Demirjian, C. M. Vollmer Jr., W. Marasco, and M. P. Callery (2005)
Cancer Res. 65, 2344-2352
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Linking of N-Myc to Death Receptor Machinery in Neuroblastoma Cells.
H. Cui, T. Li, and H.-F. Ding (2005)
J. Biol. Chem. 280, 9474-9481
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The Mouse Cell Surface Protein TOSO Regulates Fas/Fas Ligand-induced Apoptosis through Its Binding to Fas-associated Death Domain.
Y. Song and C. O. Jacob (2005)
J. Biol. Chem. 280, 9618-9626
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DR5 Knockout Mice Are Compromised in Radiation-Induced Apoptosis.
N. Finnberg, J. J. Gruber, P. Fei, D. Rudolph, A. Bric, S.-H. Kim, T. F. Burns, H. Ajuha, R. Page, G. S. Wu, et al. (2005)
Mol. Cell. Biol. 25, 2000-2013
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Resistance to Apo2 Ligand (Apo2L)/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Mediated Apoptosis and Constitutive Expression of Apo2L/TRAIL in Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines.
T. Matsuda, A. Almasan, M. Tomita, J.-n. Uchihara, M. Masuda, K. Ohshiro, N. Takasu, H. Yagita, T. Ohta, and N. Mori (2005)
J. Virol. 79, 1367-1378
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Selective Inhibition of Inflammatory Gene Expression in Activated T Lymphocytes: A Mechanism of Immune Suppression by Thiopurines.
C. W. Thomas, G. M. Myhre, R. Tschumper, R. Sreekumar, D. Jelinek, D. J. McKean, J. J. Lipsky, W. J. Sandborn, and L. J. Egan (2005)
J. Pharmacol. Exp. Ther. 312, 537-545
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Receptor-selective Mutants of Apoptosis-inducing Ligand 2/Tumor Necrosis Factor-related Apoptosis-inducing Ligand Reveal a Greater Contribution of Death Receptor (DR) 5 than DR4 to Apoptosis Signaling.
R. F. Kelley, K. Totpal, S. H. Lindstrom, M. Mathieu, K. Billeci, L. DeForge, R. Pai, S. G. Hymowitz, and A. Ashkenazi (2005)
J. Biol. Chem. 280, 2205-2212
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Fas-associated Protein with Death Domain (FADD)-independent Recruitment of c-FLIPL to Death Receptor 5.
T.-G. Jin, A. Kurakin, N. Benhaga, K. Abe, M. Mohseni, F. Sandra, K. Song, B. K. Kay, and R. Khosravi-Far (2004)
J. Biol. Chem. 279, 55594-55601
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The C-terminal Tails of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) and Fas Receptors Have Opposing Functions in Fas-associated Death Domain (FADD) Recruitment and Can Regulate Agonist-specific Mechanisms of Receptor Activation.
L. R. Thomas, R. L. Johnson, J. C. Reed, and A. Thorburn (2004)
J. Biol. Chem. 279, 52479-52486
   Abstract »    Full Text »    PDF »
Partial Contribution of Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)/TRAIL Receptor Pathway to Antitumor Effects of Interferon-{alpha}/5-Fluorouracil against Hepatocellular Carcinoma.
T. Yamamoto, H. Nagano, M. Sakon, H. Wada, H. Eguchi, M. Kondo, B. Damdinsuren, H. Ota, M. Nakamura, H. Wada, et al. (2004)
Clin. Cancer Res. 10, 7884-7895
   Abstract »    Full Text »    PDF »
T cells support osteoclastogenesis in an in vitro model derived from human multiple myeloma bone disease: the role of the OPG/TRAIL interaction.
S. Colucci, G. Brunetti, R. Rizzi, A. Zonno, G. Mori, G. Colaianni, D. Del Prete, R. Faccio, A. Liso, S. Capalbo, et al. (2004)
Blood 104, 3722-3730
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Reduced Apoptosis and Ameliorated Listeriosis in TRAIL-Null Mice.
S.-J. Zheng, J. Jiang, H. Shen, and Y. H. Chen (2004)
J. Immunol. 173, 5652-5658
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Activated human NK and CD8+ T cells express both TNF-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors but are resistant to TRAIL-mediated cytotoxicity.
P. Mirandola, C. Ponti, G. Gobbi, I. Sponzilli, M. Vaccarezza, L. Cocco, G. Zauli, P. Secchiero, F. A. Manzoli, and M. Vitale (2004)
Blood 104, 2418-2424
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Associations of Serum TRAIL Concentrations, Anthropometric Variables, and Serum Lipid Parameters in Healthy Adults.
J. W. Choi, J. S. Song, and S. H. Pai (2004)
Ann. Clin. Lab. Sci. 34, 400-404
   Abstract »    Full Text »    PDF »
Persistent c-FLIP(L) Expression Is Necessary and Sufficient to Maintain Resistance to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Mediated Apoptosis in Prostate Cancer.
X. Zhang, T.-G. Jin, H. Yang, W. C. DeWolf, R. Khosravi-Far, and A. F. Olumi (2004)
Cancer Res. 64, 7086-7091
   Abstract »    Full Text »    PDF »
Sodium butyrate sensitizes TRAIL-mediated apoptosis by induction of transcription from the DR5 gene promoter through Sp1 sites in colon cancer cells.
Y.-H. Kim, J.-W. Park, J.-Y. Lee, and T. K. Kwon (2004)
Carcinogenesis 25, 1813-1820
   Abstract »    Full Text »    PDF »


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