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Science 18 July 1997:
Vol. 277. no. 5324, p. 332
DOI: 10.1126/science.277.5324.332
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Perspectives

IMMUNOLOGY:
Update: Antigen Presentation: A Balanced Diet

Michael Brenner and Steven Porcelli

CD1 molecules are distant cousins of major histocompatibility complex (MHC) molecules; both are located on the cell surface, and MHC binds or "displays" foreign peptides so that the immune system can recognize and eliminate them. In their Perspective, Brenner and Porcelli discuss the crystal structure of CD1, reported by Zeng et al. in this issue. The new work shows how the structure of CD1 is specialized for presenting another class of antigens--lipids.

The authors are in the Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. E-mail (M.B.): emontes{at}bics.bwh.harvard.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Essential Role for CD40 Ligand Interactions in T Lymphocyte-Mediated Modulation of the Murine Immune Response to Pneumococcal Capsular Polysaccharides.
A. Jeurissen, M. Wuyts, A. Kasran, S. Ramdien-Murli, L. Boon, J. L. Ceuppens, and X. Bossuyt (2002)
J. Immunol. 168, 2773-2781
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Dendritic Cells: Immune Regulators in Health and Disease.
M. F. Lipscomb and B. J. Masten (2002)
Physiol Rev 82, 97-130
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Characterization of a 34-kDa soybean binding protein for the syringolide elicitors.
C. Ji, C. Boyd, D. Slaymaker, Y. Okinaka, Y. Takeuchi, S. L. Midland, J. J. Sims, E. Herman, and N. Keen (1998)
PNAS 95, 3306-3311
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Induction of an Antigen-specific, CD1-restricted Cytotoxic T Lymphocyte Response In vivo.
D. J. Lee, A. Abeyratne, D. A. Carson, and M. Corr (1998)
J. Exp. Med. 187, 433-438
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Presentation of the Same Glycolipid by Different CD1 Molecules.
A. Shamshiev, H.-J. Gober, A. Donda, Z. Mazorra, L. Mori, and G. De Libero (2002)
J. Exp. Med. 195, 1013-1021
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