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Science 11 July 1997:
Vol. 277. no. 5323, pp. 242 - 245
DOI: 10.1126/science.277.5323.242
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Reports

Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice

Per Lindahl, Bengt R. Johansson, Per Levéen, * Christer Betsholtz dagger

Platelet-derived growth factor (PDGF)-B-deficient mouse embryos were found to lack microvascular pericytes, which normally form part of the capillary wall, and they developed numerous capillary microaneurysms that ruptured at late gestation. Endothelial cells of the sprouting capillaries in the mutant mice appeared to be unable to attract PDGF-Rbeta -positive pericyte progenitor cells. Pericytes may contribute to the mechanical stability of the capillary wall. Comparisons made between PDGF null mouse phenotypes suggest a general role for PDGFs in the development of myofibroblasts.

P. Lindahl, P. Levéen, C. Betsholtz, Department of Medical Biochemistry, University of Göteborg, Medicinaregatan 9A, S-413 90 Göteborg, Sweden.
B. R. Johansson, Department of Anatomy and Cell Biology, University of Göteborg, Medicinaregatan 9A, S-413 90 Göteborg, Sweden.
*   Present address: Wallenberg Neurocenter, University of Lund, Sölve-gantan 17, S-223 62 Lund, Sweden.

dagger    To whom correspondence should be addressed. E-mail: christer.betsholtz{at}medkem.gu.se

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Hepatocyte growth factor mediates angiopoietin-induced smooth muscle cell recruitment.
H. Kobayashi, L. M. DeBusk, Y. O. Babichev, D. J. Dumont, and P. C. Lin (2006)
Blood 108, 1260-1266
   Abstract »    Full Text »    PDF »
Local Controlled Intramyocardial Delivery of Platelet-Derived Growth Factor Improves Postinfarction Ventricular Function Without Pulmonary Toxicity.
P. C.H. Hsieh, C. MacGillivray, J. Gannon;, F. U. Cruz, and R. T. Lee (2006)
Circulation 114, 637-644
   Abstract »    Full Text »    PDF »
Receptor for advanced glycation end products is involved in impaired angiogenic response in diabetes..
T. Shoji, H. Koyama, T. Morioka, S. Tanaka, A. Kizu, K. Motoyama, K. Mori, S. Fukumoto, A. Shioi, N. Shimogaito, et al. (2006)
Diabetes 55, 2245-2255
   Abstract »    Full Text »    PDF »
Microarray analysis of blood microvessels from PDGF-B and PDGF-R{beta} mutant mice identifies novel markers for brain pericytes.
C. Bondjers, L. He, M. Takemoto, J. Norlin, N. Asker, M. Hellstrom, P. Lindahl, and C. Betsholtz (2006)
FASEB J 20, 1703-1705
   Abstract »    Full Text »    PDF »
Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries.
H. C. Nystrom, P. Lindblom, A. Wickman, I. Andersson, J. Norlin, J. Faldt, P. Lindahl, O. Skott, M. Bjarnegard, S. M. Fitzgerald, et al. (2006)
Cardiovasc Res 71, 557-565
   Abstract »    Full Text »    PDF »
New Insights to Vascular Smooth Muscle Cell and Pericyte Differentiation of Mouse Embryonic Stem Cells In Vitro.
H. Lindskog, E. Athley, E. Larsson, S. Lundin, M. Hellstrom, and P. Lindahl (2006)
Arterioscler Thromb Vasc Biol 26, 1457-1464
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Inhibition of Platelet-Derived Growth Factor B Signaling Enhances the Efficacy of Anti-Vascular Endothelial Growth Factor Therapy in Multiple Models of Ocular Neovascularization.
N. Jo, C. Mailhos, M. Ju, E. Cheung, J. Bradley, K. Nishijima, G. S. Robinson, A. P. Adamis, and D. T. Shima (2006)
Am. J. Pathol. 168, 2036-2053
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Angiotensinogen Modulates Renal Vasculature Growth.
M. Brand, N. Lamande, C. D. Sigmund, E. Larger, P. Corvol, and J.-M. Gasc (2006)
Hypertension 47, 1067-1074
   Abstract »    Full Text »    PDF »
The Role of PDGF Receptor Inhibitors and PI3-Kinase Signaling in the Pathogenesis of Corneal Neovascularization.
S. Dell, S. Peters, P. Muther, N. Kociok, and A. M. Joussen (2006)
Invest. Ophthalmol. Vis. Sci. 47, 1928-1937
   Abstract »    Full Text »    PDF »
Neovasculogenic therapy to augment perfusion and preserve viability in ischemic cardiomyopathy..
P. Atluri, G. P. Liao, C. M. Panlilio, V. M. Hsu, M. J. Leskowitz, K. J. Morine, J. E. Cohen, M. F. Berry, E. E. Suarez, D. A. Murphy, et al. (2006)
Ann. Thorac. Surg. 81, 1728-1736
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Flow perturbation is linked to endothelial par signaling..
W. Ruf (2006)
Arterioscler Thromb Vasc Biol 26, 962-964
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Contribution of individual targets to the antitumor efficacy of the multitargeted receptor tyrosine kinase inhibitor SU11248.
O. Potapova, A. D. Laird, M. A. Nannini, A. Barone, G. Li, K. G. Moss, J. M. Cherrington, and D. B. Mendel (2006)
Mol. Cancer Ther. 5, 1280-1289
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New Assignments for Multitasking Signal Transduction Inhibitors.
Z. Zhang and K. E. Meier (2006)
Mol. Pharmacol. 69, 1510-1512
   Abstract »    Full Text »    PDF »
Physiological pathway of differentiation of hematopoietic stem cell population into mural cells.
Y. Yamada and N. Takakura (2006)
J. Exp. Med. 203, 1055-1065
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Somite-derived cells replace ventral aortic hemangioblasts and provide aortic smooth muscle cells of the trunk.
C. Pouget, R. Gautier, M.-A. Teillet, and T. Jaffredo (2006)
Development 133, 1013-1022
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A molecular mimic demonstrates that phosphorylated human prolactin is a potent anti-angiogenic hormone..
E. Ueda, U. Ozerdem, Y.-H. Chen, M. Yao, K. T. Huang, H. Sun, M. Martins-Green, P. Bartolini, and A. M Walker (2006)
Endocr. Relat. Cancer 13, 95-111
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Administration of Hematopoietic Cytokines in the Subacute Phase After Cerebral Infarction Is Effective for Functional Recovery Facilitating Proliferation of Intrinsic Neural Stem/Progenitor Cells and Transition of Bone Marrow-Derived Neuronal Cells.
H. Kawada, S. Takizawa, T. Takanashi, Y. Morita, J. Fujita, K. Fukuda, S. Takagi, H. Okano, K. Ando, and T. Hotta (2006)
Circulation 113, 701-710
   Abstract »    Full Text »    PDF »
Ocular versus Extraocular Neovascularization: Mirror Images or Vague Resemblances.
P. A. Campochiaro and the First ARVO/Pfizer Institute Working Group (2006)
Invest. Ophthalmol. Vis. Sci. 47, 462-474
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Review of the Effects of Anti-Angiogenic Compounds on the Epiphyseal Growth Plate.
A. P. Hall, F. R. Westwood, and P. F. Wadsworth (2006)
Toxicol Pathol 34, 131-147
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