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Science 4 July 1997:
Vol. 277. no. 5322, pp. 109 - 112
DOI: 10.1126/science.277.5322.109
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Reports

Modulation of Hepatic Gene Expression by Hepatocyte Nuclear Factor 1 

Eleni Ktistaki, Iannis Talianidis *

Hepatocyte nuclear factors 1 and 4 (HNF-1 and HNF-4) are liver-enriched transcription factors that function in the regulation of several liver-specific genes. HNF-1 activates genes containing promoters with HNF-1 binding sites. However, this factor negatively regulates its own expression and that of other HNF-4-dependent genes that lack HNF-1 binding sites in their promoter region. This repression is exerted by a direct interaction of HNF-1 with AF2, the main activation domain of HNF-4. The dual functions of gene activation and repression suggest that HNF-1 is a global regulator of the transcriptional network involved in the maintenance of hepatocyte-specific phenotype.

Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Post Office Box 1527, 711 10 Heraklion, Crete, Greece.
*   To whom correspondence should be addressed.

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