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Science 4 July 1997:
Vol. 277. no. 5322, pp. 105 - 109
DOI: 10.1126/science.277.5322.105
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Reports

Control of Filament Formation in Candida albicans by the Transcriptional Repressor TUP1

Burkhard R. Braun, Alexander D. Johnson

The pathogenic yeast Candida albicans regulates its cellular morphology in response to environmental conditions. Ellipsoidal, single cells (blastospores) predominate in rich media, whereas filaments composed of elongated cells that are attached end-to-end form in response to starvation, serum, and other conditions. The TUP1 gene, which encodes a general transcriptional repressor in Saccharomyces cerevisiae, was isolated from C. albicans and disrupted. The resulting tup1 mutant strain of C. albicans grew exclusively as filaments under all conditions tested. TUP1 was epistatic to the transcriptional activator CPH1, previously found to promote filamentous growth. The results suggest a model where TUP1 represses genes responsible for initiating filamentous growth and this repression is lifted under inducing environmental conditions.

Department of Microbiology and Immunology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0414, USA.

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Invasive Lesions Containing Filamentous Forms Produced by a Candida albicans Mutant That Is Defective in Filamentous Growth in Culture.
P. J. Riggle, K. A. Andrutis, X. Chen, S. R. Tzipori, and C. A. Kumamoto (1999)
Infect. Immun. 67, 3649-3652
   Abstract »    Full Text »    PDF »
A G1 Cyclin Is Necessary for Maintenance of Filamentous Growth in Candida albicans.
J. D. J. Loeb, M. Sepulveda-Becerra, I. Hazan, and H. Liu (1999)
Mol. Cell. Biol. 19, 4019-4027
   Abstract »    Full Text »    PDF »
MHY1 Encodes a C2H2-Type Zinc Finger Protein That Promotes Dimorphic Transition in the Yeast Yarrowia lipolytica.
C. A. R. Hurtado and R. A. Rachubinski (1999)
J. Bacteriol. 181, 3051-3057
   Abstract »    Full Text »
Role of the Mitogen-Activated Protein Kinase Hog1p in Morphogenesis and Virulence of Candida albicans.
R. A. Monge, F. Navarro-García, G. Molero, R. Diez-Orejas, M. Gustin, J. Pla, M. Sánchez, and C. Nombela (1999)
J. Bacteriol. 181, 3058-3068
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Rapid Hypothesis Testing with Candida albicans through Gene Disruption with Short Homology Regions.
R. B. Wilson, D. Davis, and A. P. Mitchell (1999)
J. Bacteriol. 181, 1868-1874
   Abstract »    Full Text »
A New Member of the Sin3 Family of Corepressors Is Essential for Cell Viability and Required for Retroelement Propagation in Fission Yeast.
V. D. Dang, M. J. Benedik, K. Ekwall, J. Choi, R. C. Allshire, and H. L. Levin (1999)
Mol. Cell. Biol. 19, 2351-2365
   Abstract »    Full Text »    PDF »
A MADS Box Protein Consensus Binding Site Is Necessary and Sufficient for Activation of the Opaque-Phase-Specific Gene OP4 of Candida albicans.
S. R. Lockhart, M. Nguyen, T. Srikantha, and D. R. Soll (1998)
J. Bacteriol. 180, 6607-6616
   Abstract »    Full Text »


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