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Science 27 June 1997:
Vol. 276. no. 5321, pp. 2045 - 2047
DOI: 10.1126/science.276.5321.2045
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Reports

Mutation in the alpha -Synuclein Gene Identified in Families with Parkinson's Disease

Mihael H. Polymeropoulos, * Christian Lavedan, dagger Elisabeth Leroy, dagger Susan E. Ide, Anindya Dehejia, Amalia Dutra, Brian Pike, Holly Root, Jeffrey Rubenstein, Rebecca Boyer, Edward S. Stenroos, Settara Chandrasekharappa, Aglaia Athanassiadou, Theodore Papapetropoulos, William G. Johnson, Alice M. Lazzarini, Roger C. Duvoisin, Giuseppe Di Iorio, Lawrence I. Golbe, Robert L. Nussbaum

Parkinson's disease (PD) is a common neurodegenerative disorder with a lifetime incidence of approximately 2 percent. A pattern of familial aggregation has been documented for the disorder, and it was recently reported that a PD susceptibility gene in a large Italian kindred is located on the long arm of human chromosome 4. A mutation was identified in the alpha -synuclein gene, which codes for a presynaptic protein thought to be involved in neuronal plasticity, in the Italian kindred and in three unrelated families of Greek origin with autosomal dominant inheritance for the PD phenotype. This finding of a specific molecular alteration associated with PD will facilitate the detailed understanding of the pathophysiology of the disorder.

M. H. Polymeropoulos, C. Lavedan, E. Leroy, S. E. Ide, A. Dehejia, J. Rubenstein, R. Boyer, R. L. Nussbaum, Laboratory of Genetic Disease Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-1430, USA.
S. Chandrasekharappa, B. Pike, H. Root, A. Dutra, Laboratory of Gene Transfer, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-1430, USA.
L. I. Golbe, W. G. Johnson, E. S. Stenroos, R. C. Duvoisin, A. M. Lazzarini, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.
G. Di Iorio, Instituto di Scienze Neurologiche, Faculta di Medicina, Seconda Universita degli Studi di Napoli, Naples, Italy.
T. Papapetropoulos and A. Athanassiadou, University of Patras Medical School, Patras, Greece.
*   To whom correspondence should be addressed.

dagger    These authors contributed equally in this work.

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Fuchs, A. Tichopad, Y. Golub, M. Munz, K. J. Schweitzer, B. Wolf, D. Berg, J. C. Mueller, and T. Gasser (2008)
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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M. Koch, M. Uyttenboogaart, M. Heerings, D. Heersema, J. Mostert, and J. De Keyser (2008)
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   Abstract »    PDF »
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S. Buttner, A. Bitto, J. Ring, M. Augsten, P. Zabrocki, T. Eisenberg, H. Jungwirth, S. Hutter, D. Carmona-Gutierrez, G. Kroemer, et al. (2008)
J. Biol. Chem. 283, 7554-7560
   Abstract »    Full Text »    PDF »
Ubiquitination of {alpha}-synuclein by Siah-1 promotes {alpha}-synuclein aggregation and apoptotic cell death.
J. T. Lee, T. C. Wheeler, L. Li, and L.-S. Chin (2008)
Hum. Mol. Genet. 17, 906-917
   Abstract »    Full Text »    PDF »
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S. Nuber, E. Petrasch-Parwez, B. Winner, J. Winkler, S. von Horsten, T. Schmidt, J. Boy, M. Kuhn, H. P. Nguyen, P. Teismann, et al. (2008)
J. Neurosci. 28, 2471-2484
   Abstract »    Full Text »    PDF »
{alpha}-Synuclein-induced Aggregation of Cytoplasmic Vesicles in Saccharomyces cerevisiae.
J. H. Soper, S. Roy, A. Stieber, E. Lee, R. B. Wilson, J. Q. Trojanowski, C. G. Burd, and V. M.-Y. Lee (2008)
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   Abstract »    Full Text »    PDF »
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J. Biol. Chem. 283, 3316-3328
   Abstract »    Full Text »    PDF »
Translation of Genetic Discoveries into Clinical Therapies.
D. G. Hackam and A. S. Hackam (2008)
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   Full Text »    PDF »
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K. Trinh, K. Moore, P. D. Wes, P. J. Muchowski, J. Dey, L. Andrews, and L. J. Pallanck (2008)
J. Neurosci. 28, 465-472
   Abstract »    Full Text »    PDF »
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J. Theuns and C. Van Broeckhoven (2008)
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   Full Text »    PDF »
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T. -B. Ahn, S. Y. Kim, J. Y. Kim, S. -S. Park, D. S. Lee, H. J.. Min, Y. K. Kim, S. E. Kim, J. -M. Kim, H. -J. Kim, et al. (2008)
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   Abstract »    Full Text »    PDF »
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C. Klein and M. G. Schlossmacher (2007)
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   Abstract »    Full Text »    PDF »
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W. S. Woods, J. M. Boettcher, D. H. Zhou, K. D. Kloepper, K. L. Hartman, D. T. Ladror, Z. Qi, C. M. Rienstra, and J. M. George (2007)
J. Biol. Chem. 282, 34555-34567
   Abstract »    Full Text »    PDF »
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R. Wassef, R. Haenold, A. Hansel, N. Brot, S. H. Heinemann, and T. Hoshi (2007)
J. Neurosci. 27, 12808-12816
   Abstract »    Full Text »    PDF »
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N. Exner, B. Treske, D. Paquet, K. Holmstrom, C. Schiesling, S. Gispert, I. Carballo-Carbajal, D. Berg, H.-H. Hoepken, T. Gasser, et al. (2007)
J. Neurosci. 27, 12413-12418
   Abstract »    Full Text »    PDF »
{gamma}-Synuclein and the progression of cancer.
M. Ahmad, S. Attoub, M. N. Singh, F. L. Martin, and O. M. A. El-Agnaf (2007)
FASEB J 21, 3419-3430
   Abstract »    Full Text »    PDF »
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J. R. Mazzulli, M. Armakola, M. Dumoulin, I. Parastatidis, and H. Ischiropoulos (2007)
J. Biol. Chem. 282, 31621-31630
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases.
W. Mandemakers, V. A. Morais, and B. De Strooper (2007)
J. Cell Sci. 120, 1707-1716
   Abstract »    Full Text »    PDF »
Assembly of Lysine 63-linked Ubiquitin Conjugates by Phosphorylated {alpha}-Synuclein Implies Lewy Body Biogenesis.
C. Liu, E. Fei, N. Jia, H. Wang, R. Tao, A. Iwata, N. Nukina, J. Zhou, and G. Wang (2007)
J. Biol. Chem. 282, 14558-14566
   Abstract »    Full Text »    PDF »
Identification of Novel Proteins Associated with Both {alpha}-Synuclein and DJ-1.
J. Jin, G. J. Li, J. Davis, D. Zhu, Y. Wang, C. Pan, and J. Zhang (2007)
Mol. Cell. Proteomics 6, 845-859
   Abstract »    Full Text »    PDF »
Thioredoxin Suppresses Parkin-associated Endothelin Receptor-like Receptor-induced Neurotoxicity and Extends Longevity in Drosophila.
Y. Umeda-Kameyama, M. Tsuda, C. Ohkura, T. Matsuo, Y. Namba, Y. Ohuchi, and T. Aigaki (2007)
J. Biol. Chem. 282, 11180-11187
   Abstract »    Full Text »    PDF »
Translocation of {alpha}-Synuclein Expressed in Escherichia coli.
G. Ren, X. Wang, S. Hao, H. Hu, and C.-c. Wang (2007)
J. Bacteriol. 189, 2777-2786
   Abstract »    Full Text »    PDF »
Aggregated {alpha}-Synuclein Mediates Dopaminergic Neurotoxicity In Vivo.
M. Periquet, T. Fulga, L. Myllykangas, M. G. Schlossmacher, and M. B. Feany (2007)
J. Neurosci. 27, 3338-3346
   Abstract »    Full Text »    PDF »
Over-expression of alpha-synuclein in human neural progenitors leads to specific changes in fate and differentiation.
B. L. Schneider, C. R. Seehus, E. E. Capowski, P. Aebischer, S.-C. Zhang, and C. N. Svendsen (2007)
Hum. Mol. Genet. 16, 651-666
   Abstract »    Full Text »    PDF »
DLB and PDD boundary issues: Diagnosis, treatment, molecular pathology, and biomarkers.
C. F. Lippa, J. E. Duda, M. Grossman, H. I. Hurtig, D. Aarsland, B. F. Boeve, D. J. Brooks, D. W. Dickson, B. Dubois, M. Emre, et al. (2007)
Neurology 68, 812-819
   Abstract »    Full Text »    PDF »
Emerging Roles for Ubiquitin and Protein Degradation in Neuronal Function.
J. J. Yi and M. D. Ehlers (2007)
Pharmacol. Rev. 59, 14-39
   Abstract »    Full Text »    PDF »
Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.
A. Eslamboli, M. Romero-Ramos, C. Burger, T. Bjorklund, N. Muzyczka, R. J. Mandel, H. Baker, R. M. Ridley, and D. Kirik (2007)
Brain 130, 799-815
   Abstract »    Full Text »    PDF »
Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and {alpha}-Synuclein.
S. Sarkar, J. E. Davies, Z. Huang, A. Tunnacliffe, and D. C. Rubinsztein (2007)
J. Biol. Chem. 282, 5641-5652
   Abstract »    Full Text »    PDF »


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