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Science 27 June 1997:
Vol. 276. no. 5321, pp. 2037 - 2039
DOI: 10.1126/science.276.5321.2037
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Reports

In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography

Guillermo J. Tearney, Mark E. Brezinski, * Brett E. Bouma, Stephen A. Boppart, Costas Pitris, James F. Southern, James G. Fujimoto

Current medical imaging technologies allow visualization of tissue anatomy in the human body at resolutions ranging from 100 micrometers to 1 millimeter. These technologies are generally not sensitive enough to detect early-stage tissue abnormalities associated with diseases such as cancer and atherosclerosis, which require micrometer-scale resolution. Here, optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1 millimeter in diameter. This method, referred to as "optical biopsy," was used to obtain cross-sectional images of the rabbit gastrointestinal and respiratory tracts at 10-micrometer resolution.

G. J. Tearney, B. E. Bouma, S. A. Boppart, C. Pitris, J. G. Fujimoto, Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Building 36-357, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
M. E. Brezinski, Cardiac Unit, Massachusetts General Hospital (Harvard Medical School), Knight Catheterization Laboratory, Fruit Street, Boston, MA 02114, USA.
J. F. Southern, Department of Pathology, Sinai Samaritan Hospital, Milwaukee, WI 53233, USA.
*   To whom correspondence should be addressed at Building 36-357, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA. E-mail: mebrezin{at}mit.edu

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