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Science 27 June 1997:
Vol. 276. no. 5321, pp. 2027 - 2030
DOI: 10.1126/science.276.5321.2027
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Reports

Bacterial Interference Caused by Autoinducing Peptide Variants

Guangyong Ji, Ronald Beavis, Richard P. Novick *

The synthesis of virulence factors and other extracellular proteins by Staphylococcus aureus is globally controlled by the agr locus, which encodes a two-component signaling pathway whose activating ligand is an agr-encoded autoinducing peptide. The cognate peptides produced by some strains inhibit the expression of agr in other strains, and the amino acid sequences of peptide and receptor are markedly different between such strains, suggesting a hypervariability-generating mechanism. Cross-inhibition of gene expression represents a type of bacterial interference that could be correlated with the ability of one strain to exclude others from infection or colonization sites, or both.

Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA.
*   To whom correspondence should be addressed.

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Mob Psychology.
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   Abstract »    Full Text »    PDF »
Transcription Profiling-Based Identification of Staphylococcus aureus Genes Regulated by the agr and/or sarA Loci.
P. M. Dunman, E. Murphy, S. Haney, D. Palacios, G. Tucker-Kellogg, S. Wu, E. L. Brown, R. J. Zagursky, D. Shlaes, and S. J. Projan (2001)
J. Bacteriol. 183, 7341-7353
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agr Expression Precedes Escape of Internalized Staphylococcus aureus from the Host Endosome.
S. N. A. Qazi, E. Counil, J. Morrissey, C. E. D. Rees, A. Cockayne, K. Winzer, W. C. Chan, P. Williams, and P. J. Hill (2001)
Infect. Immun. 69, 7074-7082
   Abstract »    Full Text »    PDF »
Genetic Variation among Hospital Isolates of Methicillin-Sensitive Staphylococcus aureus: Evidence for Horizontal Transfer of Virulence Genes.
P. C. L. Moore and J. A. Lindsay (2001)
J. Clin. Microbiol. 39, 2760-2767
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Detection of Differential Gene Expression in Biofilm-Forming versus Planktonic Populations of Staphylococcus aureus Using Micro-Representational-Difference Analysis.
P. Becker, W. Hufnagle, G. Peters, and M. Herrmann (2001)
Appl. Envir. Microbiol. 67, 2958-2965
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The languages of bacteria.
S. Schauder and B. L. Bassler (2001)
Genes & Dev. 15, 1468-1480
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Characterization of fsr, a Regulator Controlling Expression of Gelatinase and Serine Protease in Enterococcus faecalis OG1RF.
X. Qin, K. V. Singh, G. M. Weinstock, and B. E. Murray (2001)
J. Bacteriol. 183, 3372-3382
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Crystal structure of the SarR protein from Staphylococcus aureus.
Y. Liu, A. Manna, R. Li, W. E. Martin, R. C. Murphy, A. L. Cheung, and G. Zhang (2001)
PNAS
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Pheromone Cross-Inhibition between Staphylococcus aureus and Staphylococcus epidermidis.
M. Otto, H. Echner, W. Voelter, and F. Gotz (2001)
Infect. Immun. 69, 1957-1960
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Characterization of sarR, a Modulator of sar Expression in Staphylococcus aureus.
A. Manna and A. L. Cheung (2001)
Infect. Immun. 69, 885-896
   Abstract »    Full Text »    PDF »
Specificity and Genetic Polymorphism of the Bacillus Competence Quorum-Sensing System.
P. Tortosa, L. Logsdon, B. Kraigher, Y. Itoh, I. Mandic-Mulec, and D. Dubnau (2001)
J. Bacteriol. 183, 451-460
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