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Science 30 May 1997:
Vol. 276. no. 5317, pp. 1418 - 1420
DOI: 10.1126/science.276.5317.1418
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Reports

STAT3 as an Adapter to Couple Phosphatidylinositol 3-Kinase to the IFNAR1 Chain of the Type I Interferon Receptor

Lawrence M. Pfeffer, *dagger Jerald E. Mullersman, Susan R. Pfeffer, Aruna Murti, Wei Shi, Chuan He Yang *

STAT (signal transducers and activators of transcription) proteins undergo cytokine-dependent phosphorylation on serine and tyrosine. STAT3, a transcription factor for acute phase response genes, was found to act as an adapter molecule in signal transduction from the type I interferon receptor. STAT3 bound to a conserved sequence in the cytoplasmic tail of the IFNAR1 chain of the receptor and underwent interferon-dependent tyrosine phosphorylation. The p85 regulatory subunit of phosphatidylinositol 3-kinase, which activates a series of serine kinases, bound to phosphorylated STAT3 and subsequently underwent tyrosine phosphorylation. Thus, STAT3 acts as an adapter to couple another signaling pathway to the interferon receptor.

Department of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed.

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C. H. Yang, A. Murti, S. R. Pfeffer, L. Basu, J. G. Kim, and L. M. Pfeffer (2000)
PNAS 97, 13631-13636
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Science. ISSN 0036-8075 (print), 1095-9203 (online)