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Science 11 April 1997:
Vol. 276. no. 5310, pp. 264 - 266
DOI: 10.1126/science.276.5310.264
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Reports

Separate Neural Bases of Two Fundamental Memory Processes in the Human Medial Temporal Lobe

John D. E. Gabrieli, James B. Brewer, John E. Desmond, Gary H. Glover

The participation of medial temporal-lobe structures in memory performance was examined by functional magnetic resonance imaging of local blood oxygenation level-dependent signals. Signals were measured during encoding into memory complex scenes or line drawings and during retrieval from memory of previously studied line drawings or words. Encoding tasks yielded increased signals for unfamiliar information in a posterior medial-temporal region that were focused in the parahippocampal cortex. Retrieval tasks yielded increased signals for successfully remembered information in an anterior medial-temporal region that were focused in the subiculum. These results indicate that separate components of the human medial temporal-lobe memory system are active during distinct memory processes.

J. D. E. Gabrieli, Department of Psychology and Neuroscience Program, Stanford University, Stanford, CA 94305, USA.
J. B. Brewer, Neuroscience Program and School of Medicine, Stanford University, Stanford, CA 94305, USA.
J. E. Desmond, Department of Psychology, Stanford University, Stanford, CA 94305, USA.
G. H. Glover, Department of Radiology, Stanford University, Stanford, CA 94305, USA.

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