Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 21 March 1997:
Vol. 275. no. 5307, pp. 1781 - 1784
DOI: 10.1126/science.275.5307.1781
Prev | Table of Contents | Next

Reports

SBF Cell Cycle Regulator as a Target of the Yeast PKC-MAP Kinase Pathway

Kevin Madden, Yi-Jun Sheu, Kristin Baetz, Brenda Andrews, Michael Snyder *

Protein kinase C (PKC) signaling is highly conserved among eukaryotes and has been implicated in the regulation of cellular processes such as cell proliferation and growth. In the budding yeast, PKC1 functions to activate the SLT2(MPK1) mitogen-activated protein (MAP) kinase cascade, which is required for the maintenance of cell integrity during asymmetric cell growth. Genetic studies, coimmunoprecipitation experiments, and analysis of protein phosphorylation in vivo and in vitro indicate that the SBF transcription factor (composed of Swi4p and Swi6p), an important regulator of gene expression at the G1 to S phase cell cycle transition, is a target of the Slt2p(Mpk1p) MAP kinase. These studies provide evidence for a direct role of the PKC1 pathway in the regulation of the yeast cell cycle and cell growth and indicate that conserved signaling pathways can act to control key regulators of cell division.

K. Madden, Y.-J. Sheu, M. Snyder, Department of Biology, Yale University, Post Office Box B208103, New Haven, CT 06520-8103, USA.
K. Baetz and B. Andrews, Department of Molecular and Medical Genetics, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.
*   To whom correspondence should be addressed.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mechanism of Mpk1 Mitogen-Activated Protein Kinase Binding to the Swi4 Transcription Factor and Its Regulation by a Novel Caffeine-Induced Phosphorylation.
A. W. Truman, K.-Y. Kim, and D. E. Levin (2009)
Mol. Cell. Biol. 29, 6449-6461
   Abstract »    Full Text »    PDF »
Our Paths Might Cross: the Role of the Fungal Cell Wall Integrity Pathway in Stress Response and Cross Talk with Other Stress Response Pathways.
B. B. Fuchs and E. Mylonakis (2009)
Eukaryot. Cell 8, 1616-1625
   Abstract »    Full Text »    PDF »
Slt2 and Rim101 Contribute Independently to the Correct Assembly of the Chitin Ring at the Budding Yeast Neck in Saccharomyces cerevisiae.
A. Gomez, J. Perez, A. Reyes, A. Duran, and C. Roncero (2009)
Eukaryot. Cell 8, 1449-1459
   Abstract »    Full Text »    PDF »
Integrating Proteomic, Transcriptional, and Interactome Data Reveals Hidden Components of Signaling and Regulatory Networks.
S.-s. C. Huang and E. Fraenkel (2009)
Science Signaling 2, ra40
   Abstract »    Full Text »    PDF »
The Unfolded Protein Response Is Induced by the Cell Wall Integrity Mitogen-activated Protein Kinase Signaling Cascade and Is Required for Cell Wall Integrity in Saccharomyces cerevisiae.
T. Scrimale, L. Didone, K. L. de Mesy Bentley, and D. J. Krysan (2009)
Mol. Biol. Cell 20, 164-175
   Abstract »    Full Text »    PDF »
Yeast Mpk1 Mitogen-Activated Protein Kinase Activates Transcription through Swi4/Swi6 by a Noncatalytic Mechanism That Requires Upstream Signal.
K.-Y. Kim, A. W. Truman, and D. E. Levin (2008)
Mol. Cell. Biol. 28, 2579-2589
   Abstract »    Full Text »    PDF »
Susceptibility of Cryptococcus neoformans to Photodynamic Inactivation Is Associated with Cell Wall Integrity.
B. B. Fuchs, G. P. Tegos, M. R. Hamblin, and E. Mylonakis (2007)
Antimicrob. Agents Chemother. 51, 2929-2936
   Abstract »    Full Text »    PDF »
Up-regulation of the Cell Integrity Pathway in Saccharomyces cerevisiae Suppresses Temperature Sensitivity of the pgs1{Delta} Mutant.
Q. Zhong, G. Li, J. Gvozdenovic-Jeremic, and M. L. Greenberg (2007)
J. Biol. Chem. 282, 15946-15953
   Abstract »    Full Text »    PDF »
In the Yeast Heat Shock Response, Hsf1-Directed Induction of Hsp90 Facilitates the Activation of the Slt2 (Mpk1) Mitogen-Activated Protein Kinase Required for Cell Integrity.
A. W. Truman, S. H. Millson, J. M. Nuttall, M. Mollapour, C. Prodromou, and P. W. Piper (2007)
Eukaryot. Cell 6, 744-752
   Abstract »    Full Text »    PDF »
Cdc37p Is Required for Stress-Induced High-Osmolarity Glycerol and Protein Kinase C Mitogen-Activated Protein Kinase Pathway Functionality by Interaction with Hog1p and Slt2p (Mpk1p).
P. Hawle, D. Horst, J. P. Bebelman, X. X. Yang, M. Siderius, and S. M. van der Vies (2007)
Eukaryot. Cell 6, 521-532
   Abstract »    Full Text »    PDF »
Mpt5p, a Stress Tolerance- and Lifespan-Promoting PUF Protein in Saccharomyces cerevisiae, Acts Upstream of the Cell Wall Integrity Pathway.
M. S. Stewart, S. A. Krause, J. McGhie, and J. V. Gray (2007)
Eukaryot. Cell 6, 262-270
   Abstract »    Full Text »    PDF »
The Cdc34/SCF Ubiquitination Complex Mediates Saccharomyces cerevisiae Cell Wall Integrity.
X. Varelas, D. Stuart, M. J. Ellison, and C. Ptak (2006)
Genetics 174, 1825-1839
   Abstract »    Full Text »    PDF »
Cell Wall Assembly in Saccharomyces cerevisiae.
G. Lesage and H. Bussey (2006)
Microbiol. Mol. Biol. Rev. 70, 317-343
   Abstract »    Full Text »    PDF »
Regulation of the Cell Cycle by Protein Phosphatase 2A in Saccharomyces cerevisiae.
Y. Jiang (2006)
Microbiol. Mol. Biol. Rev. 70, 440-449
   Abstract »    Full Text »    PDF »
The Saccharomyces cerevisiae 14-3-3 Proteins Are Required for the G1/S Transition, Actin Cytoskeleton Organization and Cell Wall Integrity.
F. Lottersberger, A. Panza, G. Lucchini, S. Piatti, and M. P. Longhese (2006)
Genetics 173, 661-675
   Abstract »    Full Text »    PDF »
Characterization of the Yeast Amphiphysins Rvs161p and Rvs167p Reveals Roles for the Rvs Heterodimer In Vivo.
H. Friesen, C. Humphries, Y. Ho, O. Schub, K. Colwill, and B. Andrews (2006)
Mol. Biol. Cell 17, 1306-1321
   Abstract »    Full Text »    PDF »
Identification of Mitogen-Activated Protein Kinase Signaling Pathways That Confer Resistance to Endoplasmic Reticulum Stress in Saccharomyces cerevisiae.
Y. Chen, D. E. Feldman, C. Deng, J. A. Brown, A. F. De Giacomo, A. F. Gaw, G. Shi, Q. T. Le, J. M. Brown, and A. C. Koong (2005)
Mol. Cancer Res. 3, 669-677
   Abstract »    Full Text »    PDF »
Functional Connection Between the Clb5 Cyclin, the Protein Kinase C Pathway and the Swi4 Transcription Factor in Saccharomyces cerevisiae.
E. Queralt and J. C. Igual (2005)
Genetics 171, 1485-1498
   Abstract »    Full Text »    PDF »
TFIID and Spt-Ada-Gcn5-Acetyltransferase Functions Probed by Genome-wide Synthetic Genetic Array Analysis Using a Saccharomyces cerevisiae taf9-ts Allele.
E. Milgrom, R. W. West Jr., C. Gao, and W.-C. W. Shen (2005)
Genetics 171, 959-973
   Abstract »    Full Text »    PDF »
Implication of Pkc1p protein kinase C in sustaining Cln2p level and polarized bud growth in response to calcium signaling in Saccharomyces cerevisiae.
M. Mizunuma, D. Hirata, and T. Miyakawa (2005)
J. Cell Sci. 118, 4219-4229
   Abstract »    Full Text »    PDF »
The Rgd1p Rho GTPase-Activating Protein and the Mid2p Cell Wall Sensor Are Required at Low pH for Protein Kinase C Pathway Activation and Cell Survival in Saccharomyces cerevisiae.
S. Claret, X. Gatti, F. Doignon, D. Thoraval, and M. Crouzet (2005)
Eukaryot. Cell 4, 1375-1386
   Abstract »    Full Text »    PDF »
Cell Wall Integrity Signaling in Saccharomyces cerevisiae.
D. E. Levin (2005)
Microbiol. Mol. Biol. Rev. 69, 262-291
   Abstract »    Full Text »    PDF »
Molecular Analysis Reveals Localization of Saccharomyces cerevisiae Protein Kinase C to Sites of Polarized Growth and Pkc1p Targeting to the Nucleus and Mitotic Spindle.
V. Denis and M. S. Cyert (2005)
Eukaryot. Cell 4, 36-45
   Abstract »    Full Text »    PDF »
Scw10p, a cell-wall glucanase/transglucosidase important for cell-wall stability in Saccharomyces cerevisiae.
S. Sestak, I. Hagen, W. Tanner, and S. Strahl (2004)
Microbiology 150, 3197-3208
   Abstract »    Full Text »    PDF »
A Temperature-Sensitive dcw1 Mutant of Saccharomyces cerevisiae Is Cell Cycle Arrested with Small Buds Which Have Aberrant Cell Walls.
H. Kitagaki, K. Ito, and H. Shimoi (2004)
Eukaryot. Cell 3, 1297-1306
   Abstract »    Full Text »    PDF »
Discovery of Cercosporamide, a Known Antifungal Natural Product, as a Selective Pkc1 Kinase Inhibitor through High-Throughput Screening.
A. Sussman, K. Huss, L.-C. Chio, S. Heidler, M. Shaw, D. Ma, G. Zhu, R. M. Campbell, T.-S. Park, P. Kulanthaivel, et al. (2004)
Eukaryot. Cell 3, 932-943
   Abstract »    Full Text »    PDF »
The Global Transcriptional Response to Transient Cell Wall Damage in Saccharomyces cerevisiae and Its Regulation by the Cell Integrity Signaling Pathway.
R. Garcia, C. Bermejo, C. Grau, R. Perez, J. M. Rodriguez-Pena, J. Francois, C. Nombela, and J. Arroyo (2004)
J. Biol. Chem. 279, 15183-15195
   Abstract »    Full Text »    PDF »
Saccharomyces cerevisiae SSD1-V Confers Longevity by a Sir2p-Independent Mechanism.
M. Kaeberlein, A. A. Andalis, G. B. Liszt, G. R. Fink, and L. Guarente (2004)
Genetics 166, 1661-1672
   Abstract »    Full Text »    PDF »
The PXL1 Gene of Saccharomyces cerevisiae Encodes a Paxillin-like Protein Functioning in Polarized Cell Growth.
N. A. Mackin, T. J. Sousou, and S. E. Erdman (2004)
Mol. Biol. Cell 15, 1904-1917
   Abstract »    Full Text »    PDF »
Clb6/Cdc28 and Cdc14 Regulate Phosphorylation Status and Cellular Localization of Swi6.
M. Geymonat, A. Spanos, G. P. Wells, S. J. Smerdon, and S. G. Sedgwick (2004)
Mol. Cell. Biol. 24, 2277-2285
   Abstract »    Full Text »    PDF »
Response of the Saccharomyces cerevisiae Mpk1 Mitogen-Activated Protein Kinase Pathway to Increases in Internal Turgor Pressure Caused by Loss of Ppz Protein Phosphatases.
S. Merchan, D. Bernal, R. Serrano, and L. Yenush (2004)
Eukaryot. Cell 3, 100-107
   Abstract »    Full Text »    PDF »
The Yeast Protein Kinase C Cell Integrity Pathway Mediates Tolerance to the Antifungal Drug Caspofungin through Activation of Slt2p Mitogen-Activated Protein Kinase Signaling.
C. Reinoso-Martin, C. Schuller, M. Schuetzer-Muehlbauer, and K. Kuchler (2003)
Eukaryot. Cell 2, 1200-1210
   Abstract »    Full Text »    PDF »
Lipid Hydroperoxides Activate the Mitogen-activated Protein Kinase Mpk1p in Saccharomyces cerevisiae.
N. Alic, V. J. Higgins, A. Pichova, M. Breitenbach, and I. W. Dawes (2003)
J. Biol. Chem. 278, 41849-41855
   Abstract »    Full Text »    PDF »
Detection of regulatory circuits by integrating the cellular networks of protein-protein interactions and transcription regulation.
E. Yeger-Lotem and H. Margalit (2003)
Nucleic Acids Res. 31, 6053-6061
   Abstract »    Full Text »    PDF »
Ask10p Mediates the Oxidative Stress-Induced Destruction of the Saccharomyces cerevisiae C-Type Cyclin Ume3p/Srb11p.
T. J. Cohen, K. Lee, L. H. Rutkowski, and R. Strich (2003)
Eukaryot. Cell 2, 962-970
   Abstract »    Full Text »    PDF »
Mitogen-activated Protein Kinase Stimulation of Ca2+ Signaling Is Required for Survival of Endoplasmic Reticulum Stress in Yeast.
M. Bonilla and K. W. Cunningham (2003)
Mol. Biol. Cell 14, 4296-4305
   Abstract »    Full Text »    PDF »
G1 Transcription Factors Are Differentially Regulated in Saccharomyces cerevisiae by the Swi6-Binding Protein Stb1.
M. Costanzo, O. Schub, and B. Andrews (2003)
Mol. Cell. Biol. 23, 5064-5077
   Abstract »    Full Text »    PDF »
Feedback Inhibition on Cell Wall Integrity Signaling by Zds1 Involves Gsk3 Phosphorylation of a cAMP-dependent Protein Kinase Regulatory Subunit.
G. Griffioen, S. Swinnen, and J. M. Thevelein (2003)
J. Biol. Chem. 278, 23460-23471
   Abstract »    Full Text »    PDF »
Genome-wide Analysis of the Response to Cell Wall Mutations in the Yeast Saccharomyces cerevisiae.
A. Lagorce, N. C. Hauser, D. Labourdette, C. Rodriguez, H. Martin-Yken, J. Arroyo, J. D. Hoheisel, and J. Francois (2003)
J. Biol. Chem. 278, 20345-20357
   Abstract »    Full Text »    PDF »
Mitogen-Activated Protein Kinase in Pfiesteria piscicida and Its Growth Rate-Related Expression.
S. Lin and H. Zhang (2003)
Appl. Envir. Microbiol. 69, 343-349
   Abstract »    Full Text »    PDF »
Complex transcriptional circuitry at the G1/S transition in Saccharomyces cerevisiae.
C. E. Horak, N. M. Luscombe, J. Qian, P. Bertone, S. Piccirrillo, M. Gerstein, and M. Snyder (2002)
Genes & Dev. 16, 3017-3033
   Abstract »    Full Text »    PDF »
Maintenance of Mating Cell Integrity Requires the Adhesin Fig2p.
M. Zhang, D. Bennett, and S. E. Erdman (2002)
Eukaryot. Cell 1, 811-822
   Abstract »    Full Text »    PDF »
The Yeast Paf1-RNA Polymerase II Complex Is Required for Full Expression of a Subset of Cell Cycle-Regulated Genes.
S. E. Porter, T. M. Washburn, M. Chang, and J. A. Jaehning (2002)
Eukaryot. Cell 1, 830-842
   Abstract »    Full Text »    PDF »
Sit4 Is Required for Proper Modulation of the Biological Functions Mediated by Pkc1 and the Cell Integrity Pathway in Saccharomyces cerevisiae.
M. Angeles de la Torre-Ruiz, J. Torres, J. Arino, and E. Herrero (2002)
J. Biol. Chem. 277, 33468-33476
   Abstract »    Full Text »    PDF »
Dissection of a Complex Phenotype by Functional Genomics Reveals Roles for the Yeast Cyclin-Dependent Protein Kinase Pho85 in Stress Adaptation and Cell Integrity.
D. Huang, J. Moffat, and B. Andrews (2002)
Mol. Cell. Biol. 22, 5076-5088
   Abstract »    Full Text »    PDF »
Regulation of the Saccharomyces cerevisiae Slt2 Kinase Pathway by the Stress-inducible Sdp1 Dual Specificity Phosphatase.
J.-S. Hahn and D. J. Thiele (2002)
J. Biol. Chem. 277, 21278-21284
   Abstract »    Full Text »    PDF »
Osmotic Stress Signaling and Osmoadaptation in Yeasts.
S. Hohmann (2002)
Microbiol. Mol. Biol. Rev. 66, 300-372
   Abstract »    Full Text »    PDF »
Yeast RSC Function Is Required for Organization of the Cellular Cytoskeleton via an Alternative PKC1 Pathway.
B. Chai, J.-m. Hsu, J. Du, and B. C. Laurent (2002)
Genetics 161, 575-584
   Abstract »    Full Text »    PDF »
Genetic Interactions of Yeast Eukaryotic Translation Initiation Factor 5A (eIF5A) Reveal Connections to Poly(A)-Binding Protein and Protein Kinase C Signaling.
S. R. Valentini, J. M. Casolari, C. C. Oliveira, P. A. Silver, and A. E. McBride (2002)
Genetics 160, 393-405
   Abstract »    Full Text »    PDF »
Rho5p downregulates the yeast cell integrity pathway.
H.-P. Schmitz, S. Huppert, A. Lorberg, and J. J. Heinisch (2002)
J. Cell Sci. 115, 3139-3148
   Abstract »    Full Text »    PDF »
Saccharomyces cerevisiae MPT5 and SSD1 Function in Parallel Pathways to Promote Cell Wall Integrity.
M. Kaeberlein and L. Guarente (2002)
Genetics 160, 83-95
   Abstract »    Full Text »    PDF »
Transcriptional Coregulation by the Cell Integrity Mitogen-Activated Protein Kinase Slt2 and the Cell Cycle Regulator Swi4.
K. Baetz, J. Moffat, J. Haynes, M. Chang, and B. Andrews (2001)
Mol. Cell. Biol. 21, 6515-6528
   Abstract »    Full Text »    PDF »
Asf1 links Rad53 to control of chromatin assembly.
F. Hu, A. A. Alcasabas, and S. J. Elledge (2001)
Genes & Dev. 15, 1061-1066
   Abstract »    Full Text »
Characterization of the Promoter of PRS1 in Saccharomyces cerevisiae Identifies Three Regions Potentially Involved in Control of Expression.
Y. Hernando, A. T. Carter, S. Sickinger, and M. Schweizer (2001)
J. Bacteriol. 183, 795-799
   Abstract »    Full Text »    PDF »
Genetic Evidence for a Morphogenetic Function of the Saccharomyces cerevisiae Pho85 Cyclin-Dependent Kinase.
M. E. Lenburg and E. K. O'Shea (2001)
Genetics 157, 39-51
   Abstract »    Full Text »
Suppression of sorbitol dependence in a strain bearing a mutation in the SRB1/PSA1/VIG9 gene encoding GDP-mannose pyrophosphorylase by PDE2 overexpression suggests a role for the Ras/cAMP signal-transduction pathway in the control of yeast cell-wall biogenesis.
G. C. Tomlin, G. E. Hamilton, D. C. J. Gardner, R. M. Walmsley, L. I. Stateva, and S. G. Oliver (2000)
Microbiology 146, 2133-2146
   Abstract »    Full Text »    PDF »
Functional Interaction Between the PKC1 Pathway and CDC31 Network of SPB Duplication Genes.
W. Khalfan, I. Ivanovska, and M. D. Rose (2000)
Genetics 155, 1543-1559
   Abstract »    Full Text »
Repression of Ribosome and tRNA Synthesis in Secretion-Defective Cells Is Signaled by a Novel Branch of the Cell Integrity Pathway.
Y. Li, R. D. Moir, I. K. Sethy-Coraci, J. R. Warner, and I. M. Willis (2000)
Mol. Cell. Biol. 20, 3843-3851
   Abstract »    Full Text »    PDF »
A Yeast taf17 Mutant Requires the Swi6 Transcriptional Activator for Viability and Shows Defects in Cell Cycle-Regulated Transcription.
N. Macpherson, V. Measday, L. Moore, and B. Andrews (2000)
Genetics 154, 1561-1576
   Abstract »    Full Text »
Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles.
C. J. Roberts, B. Nelson, M. J. Marton, R. Stoughton, M. R. Meyer, H. A. Bennett, Y. D. He, H. Dai, W. L. Walker, T. R. Hughes, et al. (2000)
Science 287, 873-880
   Abstract »    Full Text »
Sbe2p and Sbe22p, Two Homologous Golgi Proteins Involved in Yeast Cell Wall Formation.
B. Santos and M. Snyder (2000)
Mol. Biol. Cell 11, 435-452
   Abstract »    Full Text »
Type 1 protein phosphatase is required for maintenance of cell wall integrity, morphogenesis and cell cycle progression in Saccharomyces cerevisiae.
P. Andrews and M. Stark (2000)
J. Cell Sci. 113, 507-520
   Abstract »    PDF »
Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase.
D. Huang, G. Patrick, J. Moffat, L.-H. Tsai, and B. Andrews (1999)
PNAS 96, 14445-14450
   Abstract »    Full Text »    PDF »
Differential Regulation of the Cell Wall Integrity Mitogen-Activated Protein Kinase Pathway in Budding Yeast by the Protein Tyrosine Phosphatases Ptp2 and Ptp3.
C. P. Mattison, S. S. Spencer, K. A. Kresge, J. Lee, and I. M. Ota (1999)
Mol. Cell. Biol. 19, 7651-7660
   Abstract »    Full Text »    PDF »
Morphogenesis is coordinated with nuclear division in germinating Aspergillus nidulans conidiospores.
S. D. Harris (1999)
Microbiology 145, 2747-2756
   Abstract »    Full Text »    PDF »
Association of the Cell Cycle Transcription Factor Mbp1 with the Skn7 Response Regulator in Budding Yeast.
N. Bouquin, A. L. Johnson, B. A. Morgan, and L. H. Johnston (1999)
Mol. Biol. Cell 10, 3389-3400
   Abstract »    Full Text »
Regulation of Transcription at the Saccharomyces cerevisiae Start Transition by Stb1, a Swi6-Binding Protein.
Y. Ho, M. Costanzo, L. Moore, R. Kobayashi, and B. J. Andrews (1999)
Mol. Cell. Biol. 19, 5267-5278
   Abstract »    Full Text »    PDF »
Protein Kinase C Enables the Regulatory Circuit That Connects Membrane Synthesis to Ribosome Synthesis in Saccharomyces cerevisiae.
C. R. Nierras and J. R. Warner (1999)
J. Biol. Chem. 274, 13235-13241
   Abstract »    Full Text »    PDF »
A Complex Containing RNA Polymerase II, Paf1p, Cdc73p, Hpr1p, and Ccr4p Plays a Role in Protein Kinase C Signaling.
M. Chang, D. French-Cornay, H.-y. Fan, H. Klein, C. L. Denis, and J. A. Jaehning (1999)
Mol. Cell. Biol. 19, 1056-1067
   Abstract »    Full Text »    PDF »
POG1, a Novel Yeast Gene, Promotes Recovery From Pheromone Arrest via the G1 Cyclin CLN2.
M. A. Leza and E. A. Elion (1999)
Genetics 151, 531-543
   Abstract »    Full Text »
The MSN1 and NHP6A Genes Suppress SWI6 Defects in Saccharomyces cerevisiae.
J. Sidorova and L. Breeden (1999)
Genetics 151, 45-55
   Abstract »    Full Text »
MAP Kinase Pathways in the Yeast Saccharomyces cerevisiae.
M. C. Gustin, J. Albertyn, M. Alexander, and K. Davenport (1998)
Microbiol. Mol. Biol. Rev. 62, 1264-1300
   Abstract »    Full Text »    PDF »
Identification of Kel1p, a Kelch Domain-containing Protein Involved in Cell Fusion and Morphology in Saccharomyces cerevisiae.
J. Philips and I. Herskowitz (1998)
J. Cell Biol. 143, 375-389
   Abstract »    Full Text »    PDF »
Spa2p Interacts with Cell Polarity Proteins and Signaling Components Involved in Yeast Cell Morphogenesis.
Y.-J. Sheu, B. Santos, N. Fortin, C. Costigan, and M. Snyder (1998)
Mol. Cell. Biol. 18, 4053-4069
   Abstract »    Full Text »    PDF »
Swi5 Controls a Novel Wave of Cyclin Synthesis in Late Mitosis.
B. L. Aerne, A. L. Johnson, J. H. Toyn, and L. H. Johnston (1998)
Mol. Biol. Cell 9, 945-956
   Abstract »    Full Text »
The Spa2-related protein, Sph1p, is important for polarized growth in yeast.
T Roemer, L Vallier, Y. Sheu, and M Snyder (1998)
J. Cell Sci. 111, 479-494
   Abstract »    PDF »
sn-1,2-Diacylglycerol Levels in the Fungus Neurospora crassa Display Circadian Rhythmicity.
M. Ramsdale and P. L. Lakin-Thomas (2000)
J. Biol. Chem. 275, 27541-27550
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)