Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 21 March 1997:
Vol. 275. no. 5307, pp. 1752 - 0
DOI: 10.1126/science.275.5307.1752
Prev | Table of Contents | Next

Perspectives

Mark Peifer

Three reports [Korinek et al. (p. 1784), Morin et al. (p. 1787), and Rubinfeld et al. (p. 1790)] in this issue provide new evidence about the molecular pathway that goes awry in colon cancer and melanoma. The protein beta-catenin, previously known to be associated with the colon-cancer-causing adenomatous polyposis coli protein, is shown to be an oncogene in its own right. In his Perspective, Peifer discusses the normal functions of these proteins in mammals and flies and how their dysfunction can lead to cancer.

The author is in the Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA. E-mail: peifer{at}unc.edu of Enhanced Perspectives

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Review of the Molecular Mechanisms of Chemically Induced Neoplasia in Rat and Mouse Models in National Toxicology Program Bioassays and Their Relevance to Human Cancer.
M. J. Hoenerhoff, H. H. Hong, T.-v. Ton, S. A. Lahousse, and R. C. Sills (2009)
Toxicol Pathol 37, 835-848
   Abstract »    Full Text »    PDF »
Hyaluronan-mediated CD44 Interaction with p300 and SIRT1 Regulates {beta}-Catenin Signaling and NF{kappa}B-specific Transcription Activity Leading to MDR1 and Bcl-xL Gene Expression and Chemoresistance in Breast Tumor Cells.
L. Y. W. Bourguignon, W. Xia, and G. Wong (2009)
J. Biol. Chem. 284, 2657-2671
   Abstract »    Full Text »    PDF »
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-{beta}-catenin and Wnt-RhoA-Rac1 pathways.
V. A. de Jesus Perez, T.-P. Alastalo, J. C. Wu, J. D. Axelrod, J. P. Cooke, M. Amieva, and M. Rabinovitch (2009)
J. Cell Biol. 184, 83-99
   Abstract »    Full Text »    PDF »
Hyaluronan-CD44 Interaction with Neural Wiskott-Aldrich Syndrome Protein (N-WASP) Promotes Actin Polymerization and ErbB2 Activation Leading to beta-Catenin Nuclear Translocation, Transcriptional Up-regulation, and Cell Migration in Ovarian Tumor Cells.
L. Y. W. Bourguignon, K. Peyrollier, E. Gilad, and A. Brightman (2007)
J. Biol. Chem. 282, 1265-1280
   Abstract »    Full Text »    PDF »
Functional Interaction between Peroxisome Proliferator-Activated Receptor {gamma} and {beta}-Catenin.
J. Liu, H. Wang, Y. Zuo, and S. R. Farmer (2006)
Mol. Cell. Biol. 26, 5827-5837
   Abstract »    Full Text »    PDF »
Physiological and Functional Interactions between Tcf4 and Daxx in Colon Cancer Cells.
S.-L. Tzeng, Y.-W. Cheng, C.-H. Li, Y.-S. Lin, H.-C. Hsu, and J.-J. Kang (2006)
J. Biol. Chem. 281, 15405-15411
   Abstract »    Full Text »    PDF »
Protein-tyrosine Phosphatase PCP-2 Inhibits beta-Catenin Signaling and Increases E-cadherin-dependent Cell Adhesion.
H.-X. Yan, W. Yang, R. Zhang, L. Chen, L. Tang, B. Zhai, S.-Q. Liu, H.-F. Cao, X.-B. Man, H.-P. Wu, et al. (2006)
J. Biol. Chem. 281, 15423-15433
   Abstract »    Full Text »    PDF »
HIC-5 Is a Novel Repressor of Lymphoid Enhancer Factor/T-cell Factor-driven Transcription.
S. M. Ghogomu, S. van Venrooy, M. Ritthaler, D. Wedlich, and D. Gradl (2006)
J. Biol. Chem. 281, 1755-1764
   Abstract »    Full Text »    PDF »
Integrin-linked Kinase Regulates the Nuclear Entry of the c-Jun Coactivator {alpha}-NAC and Its Coactivation Potency.
I. Quelo, C. Gauthier, G. E. Hannigan, S. Dedhar, and R. St-Arnaud (2004)
J. Biol. Chem. 279, 43893-43899
   Abstract »    Full Text »    PDF »
Peroxisome Proliferator-activated Receptor {gamma} Activation Can Regulate {beta}-Catenin Levels via a Proteasome-mediated and Adenomatous Polyposis Coli-independent Pathway.
C. Sharma, A. Pradeep, L. Wong, A. Rana, and B. Rana (2004)
J. Biol. Chem. 279, 35583-35594
   Abstract »    Full Text »    PDF »
Deoxycholic Acid Activates {beta}-Catenin Signaling Pathway and Increases Colon Cell Cancer Growth and Invasiveness.
R. Pai, A. S. Tarnawski, and T. Tran (2004)
Mol. Biol. Cell 15, 2156-2163
   Abstract »    Full Text »    PDF »
o-Nitrotoluene-induced large intestinal tumors in B6C3F1 mice model human colon cancer in their molecular pathogenesis.
R.C. Sills, H.L. Hong, G. Flake, C. Moomaw, N. Clayton, G.A. Boorman, J. Dunnick, and T.R. Devereux (2004)
Carcinogenesis 25, 605-612
   Abstract »    Full Text »    PDF »
{beta}-Catenin Regulation during the Cell Cycle: Implications in G2/M and Apoptosis.
D. Olmeda, S. Castel, S. Vilaro, and A. Cano (2003)
Mol. Biol. Cell 14, 2844-2860
   Abstract »    Full Text »    PDF »
Azoxymethane-induced beta-catenin-accumulated crypts in colonic mucosa of rodents as an intermediate biomarker for colon carcinogenesis.
Y. Hirose, T. Kuno, Y. Yamada, K. Sakata, M. Katayama, K. Yoshida, Z. Qiao, K. Hata, N. Yoshimi, and H. Mori (2003)
Carcinogenesis 24, 107-111
   Abstract »    Full Text »    PDF »
Association of Human Polyomavirus JCV with Colon Cancer: Evidence for Interaction of Viral T-Antigen and {beta}-Catenin.
S. Enam, L. Del Valle, C. Lara, D.-D. Gan, C. Ortiz-Hidalgo, J. P. Palazzo, and K. Khalili (2002)
Cancer Res. 62, 7093-7101
   Abstract »    Full Text »    PDF »
Src-dependent, neutrophil-mediated vascular hyperpermeability and beta -catenin modification.
J. H. Tinsley, E. E. Ustinova, W. Xu, and S. Y. Yuan (2002)
Am J Physiol Cell Physiol 283, C1745-C1751
   Abstract »    Full Text »    PDF »
Nr-CAM is a target gene of the beta -catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis.
M. E. Conacci-Sorrell, T. Ben-Yedidia, M. Shtutman, E. Feinstein, P. Einat, and A. Ben-Ze'ev (2002)
Genes & Dev. 16, 2058-2072
   Abstract »    Full Text »    PDF »
The p120ctn-binding partner Kaiso is a bi-modal DNA-binding protein that recognizes both a sequence-specific consensus and methylated CpG dinucleotides.
J. M. Daniel, C. M. Spring, H. C. Crawford, A. B. Reynolds, and A. Baig (2002)
Nucleic Acids Res. 30, 2911-2919
   Abstract »    Full Text »    PDF »
ATP Depletion Of Tubular Cells Causes Dissociation of the Zonula Adherens and Nuclear Translocation of {beta}-Catenin and LEF-1.
V. R. Price, C. A. Reed, W. Lieberthal, and J. H. Schwartz (2002)
J. Am. Soc. Nephrol. 13, 1152-1161
   Abstract »    Full Text »    PDF »
Functional Diversity of Xenopus Lymphoid Enhancer Factor/T-cell Factor Transcription Factors Relies on Combinations of Activating and Repressing Elements.
D. Gradl, A. Konig, and D. Wedlich (2002)
J. Biol. Chem. 277, 14159-14171
   Abstract »    Full Text »    PDF »
Down-Regulation of {beta}-Catenin by Activated p53.
E. Sadot, B. Geiger, M. Oren, and A. Ben-Ze'ev (2001)
Mol. Cell. Biol. 21, 6768-6781
   Abstract »    Full Text »    PDF »
Variable beta -catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment.
T. Brabletz, A. Jung, S. Reu, M. Porzner, F. Hlubek, L. A. Kunz-Schughart, R. Knuechel, and T. Kirchner (2001)
PNAS 98, 10356-10361
   Abstract »    Full Text »    PDF »
Caveolin-1 Expression Negatively Regulates Cell Cycle Progression by Inducing G0/G1 Arrest via a p53/p21WAF1/Cip1-dependent Mechanism.
F. Galbiati, D. Volonte', J. Liu, F. Capozza, P. G. Frank, L. Zhu, R. G. Pestell, and M. P. Lisanti (2001)
Mol. Biol. Cell 12, 2229-2244
   Abstract »    Full Text »    PDF »
Reduced Expression of Plakoglobin Correlates with Adverse Outcome in Patients with Neuroblastoma.
R. Amitay, D. Nass, D. Meitar, I. Goldberg, B. Davidson, L. Trakhtenbrot, F. Brok-Simoni, A. Ben-Ze'ev, G. Rechavi, and Y. Kaufmann (2001)
Am. J. Pathol. 159, 43-49
   Abstract »    Full Text »    PDF »
Increased {beta}-Catenin Expression and Nuclear Translocation Accompany Cellular Hyperproliferation in Vivo.
J. H. Sellin, S. Umar, J. Xiao, and A. P. Morris (2001)
Cancer Res. 61, 2899-2906
   Abstract »    Full Text »
Frequent Deletions and Mutations of the {beta}-Catenin Gene Are Associated with Overexpression of Cyclin D1 and Fibronectin and Poorly Differentiated Histology in Childhood Hepatoblastoma.
H. Takayasu, H. Horie, E. Hiyama, T. Matsunaga, Y. Hayashi, Y. Watanabe, S. Suita, M. Kaneko, F. Sasaki, K. Hashizume, et al. (2001)
Clin. Cancer Res. 7, 901-908
   Abstract »    Full Text »
{beta}-Catenin Dysregulation in Thyroid Neoplasms : Down-Regulation, Aberrant Nuclear Expression, and CTNNB1 Exon 3 Mutations Are Markers for Aggressive Tumor Phenotypes and Poor Prognosis.
G. Garcia-Rostan, R. L. Camp, A. Herrero, M. L. Carcangiu, D. L. Rimm, and G. Tallini (2001)
Am. J. Pathol. 158, 987-996
   Abstract »    Full Text »    PDF »
Gas6 Induces Growth, {beta}-Catenin Stabilization, and T-Cell Factor Transcriptional Activation in Contact-Inhibited C57 Mammary Cells.
S. Goruppi, C. Chiaruttini, M. E. Ruaro, B. Varnum, and C. Schneider (2001)
Mol. Cell. Biol. 21, 902-915
   Abstract »    Full Text »    PDF »
A Possible Role for the Wnt~1 Pathway in Oral Carcinogenesis.
L. Lo Muzio (2001)
Critical Reviews in Oral Biology & Medicine 12, 152-165
   Abstract »    Full Text »    PDF »
Posttranslational Truncation and Inactivation of Human E-Cadherin Distinguishes Prostate Cancer from Matched Normal Prostate.
M. G. Rashid, M. G. Sanda, C. J. Vallorosi, J. Rios-Doria, M. A. Rubin, and M. L. Day (2001)
Cancer Res. 61, 489-492
   Abstract »    Full Text »
Exocyst Is Involved in Cystogenesis and Tubulogenesis and Acts by Modulating Synthesis and Delivery of Basolateral Plasma Membrane and Secretory Proteins.
J. H. Lipschutz, W. Guo, L. E. O'Brien, Y. H. Nguyen, P. Novick, and K. E. Mostov (2000)
Mol. Biol. Cell 11, 4259-4275
   Abstract »    Full Text »
{beta}-Catenin, an Inducer of Uncontrolled Cell Proliferation and Migration in Malignancies, Is Localized in the Cytoplasm of Vascular Endothelium during Neovascularization after Myocardial Infarction.
W. M. Blankesteijn, M. E. van Gijn, Y. P. G. Essers-Janssen, M. J. A. P. Daemen, and J. F. M. Smits (2000)
Am. J. Pathol. 157, 877-883
   Abstract »    Full Text »    PDF »
The Human T-Cell Transcription Factor-4 Gene: Structure, Extensive Characterization of Alternative Splicings, and Mutational Analysis in Colorectal Cancer Cell Lines.
A. Duval, S. Rolland, E. Tubacher, H. Bui, G. Thomas, and R. Hamelin (2000)
Cancer Res. 60, 3872-3879
   Abstract »    Full Text »
Expression of prostaglandin endoperoxide H synthase-2 induced by nitric oxide in conditionally immortalized murine colonic epithelial cells.
J. M. MEI, N. G. HORD, D. F. WINTERSTEIN, S. P. DONALD, and J. M. PHANG (2000)
FASEB J 14, 1188-1201
   Abstract »    Full Text »
A beta-catenin/engrailed chimera selectively suppresses Wnt signaling.
W. Montross, H Ji, and P. McCrea (2000)
J. Cell Sci. 113, 1759-1770
   Abstract »    PDF »
WISP-1 is a Wnt-1- and beta -catenin-responsive oncogene.
L. Xu, R. B. Corcoran, J. W. Welsh, D. Pennica, and A. J. Levine (2000)
Genes & Dev. 14, 585-595
   Abstract »    Full Text »
Secreted Frizzled-related Protein-1 Binds Directly to Wingless and Is a Biphasic Modulator of Wnt Signaling.
A. Uren, F. Reichsman, V. Anest, W. G. Taylor, K. Muraiso, D. P. Bottaro, S. Cumberledge, and J. S. Rubin (2000)
J. Biol. Chem. 275, 4374-4382
   Abstract »    Full Text »    PDF »
Truncation of the beta -Catenin Binding Domain of E-cadherin Precedes Epithelial Apoptosis during Prostate and Mammary Involution.
C. J. Vallorosi, K. C. Day, X. Zhao, M. G. Rashid, M. A. Rubin, K. R. Johnson, M. J. Wheelock, and M. L. Day (2000)
J. Biol. Chem. 275, 3328-3334
   Abstract »    Full Text »    PDF »
Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression.
H. Schumann, J. Holtz, H.-R. Zerkowski, and M. Hatzfeld (2000)
Cardiovasc Res 45, 720-728
   Abstract »    Full Text »    PDF »
Plakoglobin and beta-catenin: protein interactions, regulation and biological roles.
J Zhurinsky, M Shtutman, and A Ben-Ze'ev (2000)
J. Cell Sci. 113, 3127-3139
   Abstract »    PDF »
decapentaplegic is a direct target of dTcf repression in the Drosophila visceral mesoderm.
X Yang, M van Beest, H Clevers, T Jones, D. Hursh, and M. Mortin (2000)
Development 127, 3695-3702
   Abstract »    PDF »
Functional interaction between E-cadherin and alphav-containing integrins in carcinoma cells.
M von Schlippe, J. Marshall, P Perry, M Stone, A. Zhu, and I. Hart (2000)
J. Cell Sci. 113, 425-437
   Abstract »    PDF »
Analysis of E-Cadherin in Diffuse-Type Gastric Cancer Using a Mutation-Specific Monoclonal Antibody.
K.-F. Becker, E. Kremmer, M. Eulitz, I. Becker, G. Handschuh, C. Schuhmacher, W. Muller, H. E. Gabbert, A. Ochiai, S. Hirohashi, et al. (1999)
Am. J. Pathol. 155, 1803-1809
   Abstract »    Full Text »    PDF »
H-Ras Activation Promotes Cytoplasmic Accumulation and Phosphoinositide 3-Oh Kinase Association of {beta}-Catenin in Epidermal Keratinocytes.
J. Espada, M. Perez-Moreno, V. M.M. Braga, P. Rodriguez-Viciana, and A. Cano (1999)
J. Cell Biol. 146, 967-980
   Abstract »    Full Text »    PDF »
Exogenous Expression of {beta}-Catenin Regulates Contact Inhibition, Anchorage-Independent Growth, Anoikis, and Radiation-Induced Cell Cycle Arrest.
K. Orford, C. C. Orford, and S. W. Byers (1999)
J. Cell Biol. 146, 855-868
   Abstract »    Full Text »    PDF »
Genetically Tailored Preventive Strategies: an Effective Plan for the Twenty-first Century?.
F. P. Li and A. S. Whittemore (1999)
Cancer Epidemiol. Biomarkers Prev. 8, 649-658
   Abstract »    Full Text »
Differential Activity of Diethylstilbestrol versus Estradiol As Neonatal Endocrine Disruptors in the Female Hamster (Mesocricetus auratus) Reproductive Tract.
W. J. Hendry III, B. L. DeBrot, X. Zheng, W. S. Branham, and D. M. Sheehan (1999)
Biol Reprod 61, 91-100
   Abstract »    Full Text »
Colorectal Cancer: Molecules and Populations.
J. D. Potter (1999)
J Natl Cancer Inst 91, 916-932
   Abstract »    Full Text »    PDF »
beta -Trcp couples beta -catenin phosphorylation-degradation and regulates Xenopus axis formation.
C. Liu, Y. Kato, Z. Zhang, V. M. Do, B. A. Yankner, and X. He (1999)
PNAS 96, 6273-6278
   Abstract »    Full Text »    PDF »
The cyclin D1 gene is a target of the beta -catenin/LEF-1 pathway.
M. Shtutman, J. Zhurinsky, I. Simcha, C. Albanese, M. D'Amico, R. Pestell, and A. Ben-Ze'ev (1999)
PNAS 96, 5522-5527
   Abstract »    Full Text »    PDF »
The Catenin p120ctn Interacts with Kaiso, a Novel BTB/POZ Domain Zinc Finger Transcription Factor.
J. M. Daniel and A. B. Reynolds (1999)
Mol. Cell. Biol. 19, 3614-3623
   Abstract »    Full Text »    PDF »
Direct Interaction of Alzheimer's Disease-related Presenilin 1 with Armadillo Protein p0071.
B. Stahl, A. Diehlmann, and T. C. Sudhof (1999)
J. Biol. Chem. 274, 9141-9148
   Abstract »    Full Text »    PDF »
E-cadherin Mediates Aggregation-dependent Survival of Prostate and Mammary Epithelial Cells through the Retinoblastoma Cell Cycle Control Pathway.
M. L. Day, X. Zhao, C. J. Vallorosi, M. Putzi, C. T. Powell, C. Lin, and K. C. Day (1999)
J. Biol. Chem. 274, 9656-9664
   Abstract »    Full Text »    PDF »
The Cadherin-Catenin System: Implications for Growth and Differentiation of Endocrine Tissues.
E. Pötter, C. Bergwitz, and G. Brabant (1999)
Endocr. Rev. 20, 207-239
   Abstract »    Full Text »
Differential expression of prostaglandin endoperoxide H synthase-2 and formation of activated ß-catenin–LEF-1 transcription complex in mouse colonic epithelial cells contrasting in Apc.
J.M. Mei, N.G. Hord, D.F. Winterstein, S.P. Donald, and J.M. Phang (1999)
Carcinogenesis 20, 737-740
   Abstract »    Full Text »    PDF »
Frequent Mutation and Nuclear Localization of {beta}-Catenin in Anaplastic Thyroid Carcinoma.
G. Garcia-Rostan, G. Tallini, A. Herrero, T. G. D'Aquila, M. L. Carcangiu, and D. L. Rimm (1999)
Cancer Res. 59, 1811-1815
   Abstract »    Full Text »    PDF »
A Mouse Mammary Tumor Virus-Wnt-1 Transgene Induces Mammary Gland Hyperplasia and Tumorigenesis in Mice Lacking Estrogen Receptor-{{alpha}}.
W. P. Bocchinfuso, W. P. Hively, J. F. Couse, H. E. Varmus, and K. S. Korach (1999)
Cancer Res. 59, 1869-1876
   Abstract »    Full Text »    PDF »
Ubiquitin-dependent degradation of Ikappa Balpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.
S. Hatakeyama, M. Kitagawa, K. Nakayama, M. Shirane, M. Matsumoto, K. Hattori, H. Higashi, H. Nakano, K. Okumura, K. Onoe, et al. (1999)
PNAS 96, 3859-3863
   Abstract »    Full Text »    PDF »
Identification of a Second Major Tumor-Specific Antigen Recognized by CTLs on Mouse Mastocytoma P815.
J. Bilsborough, A. Van Pel, C. Uyttenhove, T. Boon, and B. J. Van den Eynde (1999)
J. Immunol. 162, 3534-3540
   Abstract »    Full Text »    PDF »
Target genes of beta -catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas.
B. Mann, M. Gelos, A. Siedow, M. L. Hanski, A. Gratchev, M. Ilyas, W. F. Bodmer, M. P. Moyer, E. O. Riecken, H. J. Buhr, et al. (1999)
PNAS 96, 1603-1608
   Abstract »    Full Text »    PDF »
Conserved Mechanism of PLAG1 Activation in Salivary Gland Tumors with and without Chromosome 8q12 Abnormalities: Identification of SII as a New Fusion Partner Gene.
A.-K. Astrom, M. L. Voz, K. Kas, E. Roijer, B. Wedell, N. Mandahl, W. V. de Ven, J. Mark, and G. Stenman (1999)
Cancer Res. 59, 918-923
   Abstract »    Full Text »    PDF »
Administration of an unconjugated bile acid increases duodenal tumors in a murine model of familial adenomatous polyposis.
N. N. Mahmoud, A. J. Dannenberg, R. T. Bilinski, J. R. Mestre, A. Chadburn, M. Churchill, C. Martucci, and M. M. Bertagnolli (1999)
Carcinogenesis 20, 299-303
   Abstract »    Full Text »    PDF »
The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro.
J. T. Winston, P. Strack, P. Beer-Romero, C. Y. Chu, S. J. Elledge, and J. W. Harper (1999)
Genes & Dev. 13, 270-283
   Abstract »    Full Text »
Cadherin function in junctional complex rearrangement and posttranslational control of cadherin expression.
M. L. Troxell, Y.-T. Chen, N. Cobb, W. J. Nelson, and J. A. Marrs (1999)
Am J Physiol Cell Physiol 276, C404-C418
   Abstract »    Full Text »    PDF »
Childhood Hepatoblastomas Frequently Carry a Mutated Degradation Targeting Box of the {beta}-Catenin Gene.
A. Koch, D. Denkhaus, S. Albrecht, I. Leuschner, D. von Schweinitz, and T. Pietsch (1999)
Cancer Res. 59, 269-273
   Abstract »    Full Text »    PDF »
Genotype-Phenotype Correlation in Murine Apc Mutation: Differences in Enterocyte Migration and Response to Sulindac.
N. N. Mahmoud, R. T. Bilinski, M. R. Churchill, W. Edelmann, R. Kucherlapati, and M. M. Bertagnolli (1999)
Cancer Res. 59, 353-359
   Abstract »    Full Text »    PDF »
Cytoplasmic Redistribution of E-Cadherin-Catenin Adhesion Complex Is Associated with Down-Regulated Tyrosine Phosphorylation of E-Cadherin in Human Bronchopulmonary Carcinomas.
B. Nawrocki, M. Polette, J. Van Hengel, J.-M. Tournier, F. Van Roy, and P. Birembaut (1998)
Am. J. Pathol. 153, 1521-1530
   Abstract »    Full Text »    PDF »
A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta -catenin signals.
S. Tanaka, T. Akiyoshi, M. Mori, J. R. Wands, and K. Sugimachi (1998)
PNAS 95, 10164-10169
   Abstract »    Full Text »    PDF »
Somatic mutations of the beta -catenin gene are frequent in mouse and human hepatocellular carcinomas.
A. d. L. Coste, B. Romagnolo, P. Billuart, C.-A. Renard, M.-A. Buendia, O. Soubrane, M. Fabre, J. Chelly, C. Beldjord, A. Kahn, et al. (1998)
PNAS 95, 8847-8851
   Abstract »    Full Text »    PDF »
E-cadherin Regulates Anchorage-independent Growth and Survival in Oral Squamous Cell Carcinoma Cells.
S. S. Kantak and R. H. Kramer (1998)
J. Biol. Chem. 273, 16953-16961
   Abstract »    Full Text »    PDF »
Differential Nuclear Translocation and Transactivation Potential of {beta}-Catenin and Plakoglobin.
I. Simcha, M. Shtutman, D. Salomon, J. Zhurinsky, E. Sadot, B. Geiger, and A. Ben-Ze'ev (1998)
J. Cell Biol. 141, 1433-1448
   Abstract »    Full Text »    PDF »
Wnt-1 Induces Growth, Cytosolic beta -Catenin, and Tcf/Lef Transcriptional Activation in Rat-1 Fibroblasts.
C. S. Young, M. Kitamura, S. Hardy, and J. Kitajewski (1998)
Mol. Cell. Biol. 18, 2474-2485
   Abstract »    Full Text »    PDF »
Axil, a Member of the Axin Family, Interacts with Both Glycogen Synthase Kinase 3beta and beta -Catenin and Inhibits Axis Formation of Xenopus Embryos.
H. Yamamoto, S. Kishida, T. Uochi, S. Ikeda, S. Koyama, M. Asashima, and A. Kikuchi (1998)
Mol. Cell. Biol. 18, 2867-2875
   Abstract »    Full Text »    PDF »
Activation of Adenomatous Polyposis Coli (APC) Gene Expression by the DNA-alkylating Agent N-MethylN'-nitro-N-nitrosoguanidine Requires p53.
S. Narayan and A. S. Jaiswal (1997)
J. Biol. Chem. 272, 30619-30622
   Abstract »    Full Text »    PDF »
Regulation of {beta}-Catenin Levels and Localization by Overexpression of Plakoglobin and Inhibition of the Ubiquitin-Proteasome System.
D. Salomon, P. A. Sacco, S. G. Roy, I. Simcha, K. R. Johnson, M. J. Wheelock, and A. Ben-Ze'ev (1997)
J. Cell Biol. 139, 1325-1335
   Abstract »    Full Text »    PDF »
Antagonism of Cell Adhesion by an {alpha}-Catenin Mutant, and of the Wnt-signaling Pathway by {alpha}-Catenin in Xenopus Embryos.
R. N.M. Sehgal, B. M. Gumbiner, and L. F. Reichardt (1997)
J. Cell Biol. 139, 1033-1046
   Abstract »    Full Text »    PDF »
A CASP-8 Mutation Recognized by Cytolytic T Lymphocytes on a Human Head and Neck Carcinoma.
S. Mandruzzato, F. Brasseur, G. Andry, T. Boon, and P. v. d. Bruggen (1997)
J. Exp. Med. 186, 785-793
   Abstract »    Full Text »    PDF »
Regulation of Lef-mediated Transcription and p53-dependent Pathway by Associating beta -Catenin with CBP/p300.
M. Miyagishi, R. Fujii, M. Hatta, E. Yoshida, N. Araya, A. Nagafuchi, S. Ishihara, T. Nakajima, and A. Fukamizu (2000)
J. Biol. Chem. 275, 35170-35175
   Abstract »    Full Text »    PDF »
Role of the Adenomatous Polyposis Coli Gene Product in Human Cardiac Development and Disease.
M. Rezvani and C.-C. Liew (2000)
J. Biol. Chem. 275, 18470-18475
   Abstract »    Full Text »    PDF »
Caveolin-1 Expression Inhibits Wnt/beta -Catenin/Lef-1 Signaling by Recruiting beta -Catenin to Caveolae Membrane Domains.
F. Galbiati, D. Volonte', A. M. C. Brown, D. E. Weinstein, A. Ben-Ze'ev, R. G. Pestell, and M. P. Lisanti (2000)
J. Biol. Chem. 275, 23368-23377
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)