Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 14 March 1997:
Vol. 275. no. 5306, pp. 1649 - 1652
DOI: 10.1126/science.275.5306.1649
Prev | Table of Contents | Next

Reports

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

Kaikobad Irani, Yong Xia, Jay L. Zweier, Steven J. Sollott, Channing J. Der, Eric R. Fearon, Maitrayee Sundaresan, Toren Finkel, Pascal J. Goldschmidt-Clermont *

NIH 3T3 fibroblasts stably transformed with a constitutively active isoform of p21Ras, H-RasV12 (v-H-Ras or EJ-Ras), produced large amounts of the reactive oxygen species superoxide (·O2-). ·O2- production was suppressed by the expression of dominant negative isoforms of Ras or Rac1, as well as by treatment with a farnesyltransferase inhibitor or with diphenylene iodonium, a flavoprotein inhibitor. The mitogenic activity of cells expressing H-RasV12 was inhibited by treatment with the chemical antioxidant N-acetyl-L-cysteine. Mitogen-activated protein kinase (MAPK) activity was decreased and c-Jun N-terminal kinase (JNK) was not activated in H-RasV12-transformed cells. Thus, H-RasV12-induced transformation can lead to the production of ·O2- through one or more pathways involving a flavoprotein and Rac1. The implication of a reactive oxygen species, probably ·O2-, as a mediator of Ras-induced cell cycle progression independent of MAPK and JNK suggests a possible mechanism for the effects of antioxidants against Ras-induced cellular transformation.

K. Irani, Y. Xia, J. L. Zweier, S. J. Sollott, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
C. J. Der, Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
E. R. Fearon, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
M. Sundaresan and T. Finkel, Cardiology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
P. J. Goldschmidt-Clermont, Division of Cardiology, Department of Medicine, and Department of Cell Biology and Anatomy, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
*   To whom correspondence should be addressed at Heart and Lung Institute, Ohio State University, Columbus, OH 43210, USA.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma.
Q. Ma, L. E. Cavallin, B. Yan, S. Zhu, E. M. Duran, H. Wang, L. P. Hale, C. Dong, E. Cesarman, E. A. Mesri, et al. (2009)
PNAS 106, 8683-8688
   Abstract »    Full Text »    PDF »
A Novel Human AlkB Homologue, ALKBH8, Contributes to Human Bladder Cancer Progression.
K. Shimada, M. Nakamura, S. Anai, M. De Velasco, M. Tanaka, K. Tsujikawa, Y. Ouji, and N. Konishi (2009)
Cancer Res. 69, 3157-3164
   Abstract »    Full Text »    PDF »
Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence.
P. Rai, T. T. Onder, J. J. Young, J. L. McFaline, B. Pang, P. C. Dedon, and R. A. Weinberg (2009)
PNAS 106, 169-174
   Abstract »    Full Text »    PDF »
Altered Detoxification Status and Increased Resistance to Oxidative Stress by K-Ras Transformation.
C. V. Recktenwald, R. Kellner, R. Lichtenfels, and B. Seliger (2008)
Cancer Res. 68, 10086-10093
   Abstract »    Full Text »    PDF »
CPEB regulation of human cellular senescence, energy metabolism, and p53 mRNA translation.
D. M. Burns and J. D. Richter (2008)
Genes & Dev. 22, 3449-3460
   Abstract »    Full Text »    PDF »
Transmembrane signaling pathway mediates oxidized low-density lipoprotein-induced expression of plasminogen activator inhibitor-1 in vascular endothelial cells.
G. V. Sangle, R. Zhao, and G. X. Shen (2008)
Am J Physiol Endocrinol Metab 295, E1243-E1254
   Abstract »    Full Text »    PDF »
Acetaminophen Is Cardioprotective Against H2O2-Induced Injury In Vivo.
K. M. Jaques-Robinson, R. Golfetti, S. S. Baliga, N. M. Hadzimichalis, and G. F. Merrill (2008)
Experimental Biology and Medicine 233, 1315-1322
   Abstract »    Full Text »    PDF »
Superoxide-mediated proteasomal degradation of Bcl-2 determines cell susceptibility to Cr(VI)-induced apoptosis.
N. Azad, A. K. V. Iyer, A. Manosroi, L. Wang, and Y. Rojanasakul (2008)
Carcinogenesis 29, 1538-1545
   Abstract »    Full Text »    PDF »
The Involvement of the Tyrosine Kinase c-Src in the Regulation of Reactive Oxygen Species Generation Mediated by NADPH Oxidase-1.
D. Gianni, B. Bohl, S. A. Courtneidge, and G. M. Bokoch (2008)
Mol. Biol. Cell 19, 2984-2994
   Abstract »    Full Text »    PDF »
Nox4 Oxidase Overexpression Specifically Decreases Endogenous Nox4 mRNA and Inhibits Angiotensin II-Induced Adventitial Myofibroblast Migration.
M. J. Haurani, M. E. Cifuentes, A. D. Shepard, and P. J. Pagano (2008)
Hypertension 52, 143-149
   Abstract »    Full Text »    PDF »
Dependence of Reactive Oxygen Species and FLICE Inhibitory Protein on Lipofectamine-Induced Apoptosis in Human Lung Epithelial Cells.
L. Kongkaneramit, N. Sarisuta, N. Azad, Y. Lu, A. K. V. Iyer, L. Wang, and Y. Rojanasakul (2008)
J. Pharmacol. Exp. Ther. 325, 969-977
   Abstract »    Full Text »    PDF »
The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation.
T. P. Rygiel, A. E. Mertens, K. Strumane, R. van der Kammen, and J. G. Collard (2008)
J. Cell Sci. 121, 1183-1192
   Abstract »    Full Text »    PDF »
Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair: implications for poor prognosis in AML.
A. Sallmyr, J. Fan, K. Datta, K.-T. Kim, D. Grosu, P. Shapiro, D. Small, and F. Rassool (2008)
Blood 111, 3173-3182
   Abstract »    Full Text »    PDF »
Tempol Protects against Oxidative Damage and Delays Epithelial Tumor Onset in Fanconi Anemia Mice.
Q.-S. Zhang, L. Eaton, E. R. Snyder, S. Houghtaling, J. B. Mitchell, M. Finegold, C. Van Waes, and M. Grompe (2008)
Cancer Res. 68, 1601-1608
   Abstract »    Full Text »    PDF »
The Fas Death Signaling Pathway Connecting Reactive Oxygen Species Generation and FLICE Inhibitory Protein Down-Regulation.
L. Wang, N. Azad, L. Kongkaneramit, F. Chen, Y. Lu, B.-H. Jiang, and Y. Rojanasakul (2008)
J. Immunol. 180, 3072-3080
   Abstract »    Full Text »    PDF »
Protein Carbonylation as a Novel Mechanism in Redox Signaling.
C. M. Wong, A. K. Cheema, L. Zhang, and Y. J. Suzuki (2008)
Circ. Res. 102, 310-318
   Abstract »    Full Text »    PDF »
Mechanisms of oxidant production in esophageal squamous cell and Barrett's cell lines.
L. A. Feagins, H. Y. Zhang, X. Zhang, K. Hormi-Carver, T. Thomas, L. S. Terada, S. J. Spechler, and R. F. Souza (2008)
Am J Physiol Gastrointest Liver Physiol 294, G411-G417
   Abstract »    Full Text »    PDF »
Involvement of Nox2 NADPH Oxidase in Adverse Cardiac Remodeling After Myocardial Infarction.
Y. H. Looi, D. J. Grieve, A. Siva, S. J. Walker, N. Anilkumar, A. C. Cave, M. Marber, M. J. Monaghan, and A. M. Shah (2008)
Hypertension 51, 319-325
   Abstract »    Full Text »    PDF »
Modulation of Reactive Oxygen Species in Pancreatic Cancer.
M. L.T. Teoh, W. Sun, B. J. Smith, L. W. Oberley, and J. J. Cullen (2007)
Clin. Cancer Res. 13, 7441-7450
   Abstract »    Full Text »    PDF »
DNA damage, cellular senescence and organismal ageing: causal or correlative?.
J.-H. Chen, C. N. Hales, and S. E. Ozanne (2007)
Nucleic Acids Res. 35, 7417-7428
   Abstract »    Full Text »    PDF »
Cancer stem cell: target for anti-cancer therapy.
C. Tang, B. T. Ang, and S. Pervaiz (2007)
FASEB J 21, 3777-3785
   Abstract »    Full Text »    PDF »
Nox1 Expression Determines Cellular Reactive Oxygen and Modulates c-fos-Induced Growth Factor, Interleukin-8, and Cav-1.
R. S. Arnold, J. He, A. Remo, D. Ritsick, Q. Yin-Goen, J. D. Lambeth, M. W. Datta, A. N. Young, and J. A. Petros (2007)
Am. J. Pathol. 171, 2021-2032
   Abstract »    Full Text »    PDF »
Cross-talk between aldosterone and angiotensin II in vascular smooth muscle cell senescence.
L.-J. Min, M. Mogi, J. Iwanami, J.-M. Li, A. Sakata, T. Fujita, K. Tsukuda, M. Iwai, and M. Horiuchi (2007)
Cardiovasc Res 76, 506-516
   Abstract »    Full Text »    PDF »
Constitutive NADPH oxidase and increased mitochondrial respiratory chain activity regulate chemokine gene expression.
L. A. Tephly and A. B. Carter (2007)
Am J Physiol Lung Cell Mol Physiol 293, L1143-L1155
   Abstract »    Full Text »    PDF »
DNA Binding Suppresses Human AIF-M2 Activity and Provides a Connection between Redox Chemistry, Reactive Oxygen Species, and Apoptosis.
M. Gong, S. Hay, K. R. Marshall, A. W. Munro, and N. S. Scrutton (2007)
J. Biol. Chem. 282, 30331-30340
   Abstract »    Full Text »    PDF »
MAP17 enhances the malignant behavior of tumor cells through ROS increase.
M. V. Guijarro, J. F.M. Leal, C. Blanco-Aparicio, S. Alonso, J. Fominaya, M. Lleonart, J. Castellvi, S. Ramon y Cajal, and A. Carnero (2007)
Carcinogenesis 28, 2096-2104
   Abstract »    Full Text »    PDF »
p66 Shc Tumor Levels Show a Strong Prognostic Correlation with Disease Outcome in Stage IIA Colon Cancer.
S. R. Grossman, S. Lyle, M. B. Resnick, E. Sabo, R. T. Lis, E. Rosinha, Q. Liu, C.-C. Hsieh, G. Bhat, A. R. Frackelton Jr., et al. (2007)
Clin. Cancer Res. 13, 5798-5804
   Abstract »    Full Text »    PDF »
Reactive Oxygen Species, DNA Damage, and Error-Prone Repair: A Model for Genomic Instability with Progression in Myeloid Leukemia?.
F. V. Rassool, T. J. Gaymes, N. Omidvar, N. Brady, S. Beurlet, M. Pla, M. Reboul, N. Lea, C. Chomienne, N. S.B. Thomas, et al. (2007)
Cancer Res. 67, 8762-8771
   Abstract »    Full Text »    PDF »
Fer-Mediated Cortactin Phosphorylation Is Associated with Efficient Fibroblast Migration and Is Dependent on Reactive Oxygen Species Generation during Integrin-Mediated Cell Adhesion.
W. Sangrar, Y. Gao, M. Scott, P. Truesdell, and P. A. Greer (2007)
Mol. Cell. Biol. 27, 6140-6152
   Abstract »    Full Text »    PDF »
Differential Expression and Oxidation of MKP-1 Modulates TNF-{alpha} Gene Expression.
L. A. Tephly and A. B. Carter (2007)
Am. J. Respir. Cell Mol. Biol. 37, 366-374
   Abstract »    Full Text »    PDF »
Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Inducible Factor-Dependent Extension of the Replicative Life Span during Hypoxia.
E. L. Bell, T. A. Klimova, J. Eisenbart, P. T. Schumacker, and N. S. Chandel (2007)
Mol. Cell. Biol. 27, 5737-5745
   Abstract »    Full Text »    PDF »
Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.
P. Newsholme, E. P. Haber, S. M. Hirabara, E. L. O. Rebelato, J. Procopio, D. Morgan, H. C. Oliveira-Emilio, A. R. Carpinelli, and R. Curi (2007)
J. Physiol. 583, 9-24
   Abstract »    Full Text »    PDF »
Selective cell death of oncogenic Akt-transduced brain cancer cells by etoposide through reactive oxygen species mediated damage.
S.-Y. Oh, Y.-W. Sohn, J.-W. Park, H.-J. Park, H.-M. Jeon, T.-K. Kim, J.-S. Lee, J.-E. Jung, X. Jin, Y. G. Chung, et al. (2007)
Mol. Cancer Ther. 6, 2178-2187
   Abstract »    Full Text »    PDF »
Involvement of oxidative and nitrosative stress in modulation of gene expression and functional responses by IFN{gamma}.
S. J. Prasanna, B. Saha, and D. Nandi (2007)
Int. Immunol.
   Abstract »    Full Text »    PDF »
The band mutation in Neurospora crassa is a dominant allele of ras-1 implicating RAS signaling in circadian output.
W. J. Belden, L. F. Larrondo, A. C. Froehlich, M. Shi, C.-H. Chen, J. J. Loros, and J. C. Dunlap (2007)
Genes & Dev. 21, 1494-1505
   Abstract »    Full Text »    PDF »
Nox1 Redox Signaling Mediates Oncogenic Ras-induced Disruption of Stress Fibers and Focal Adhesions by Down-regulating Rho.
M. Shinohara, W.-H. Shang, M. Kubodera, S. Harada, J. Mitsushita, M. Kato, H. Miyazaki, H. Sumimoto, and T. Kamata (2007)
J. Biol. Chem. 282, 17640-17648
   Abstract »    Full Text »    PDF »
Farnesyltransferase Inhibitor, Manumycin A, Prevents Atherosclerosis Development and Reduces Oxidative Stress in Apolipoprotein E-Deficient Mice.
M. Sugita, H. Sugita, and M. Kaneki (2007)
Arterioscler Thromb Vasc Biol 27, 1390-1395
   Abstract »    Full Text »    PDF »
Repression of Sestrin Family Genes Contributes to Oncogenic Ras-Induced Reactive Oxygen Species Up-regulation and Genetic Instability.
P. B. Kopnin, L. S. Agapova, B. P. Kopnin, and P. M. Chumakov (2007)
Cancer Res. 67, 4671-4678
   Abstract »    Full Text »    PDF »
Transcription activator structure reveals redox control of a replication initiation reaction.
C. M. Sanders, D. Sizov, P. R. Seavers, M. Ortiz-Lombardia, and A. A. Antson (2007)
Nucleic Acids Res. 35, 3504-3515
   Abstract »    Full Text »    PDF »
Stimulation of colonic mucosal growth associated with oxidized redox status in rats.
J. Tian, N. Washizawa, L. H. Gu, M. S. Levin, L. Wang, D. C. Rubin, S. Mwangi, S. Srinivasan, Y. Gao, D. P. Jones, et al. (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R1081-R1091
   Abstract »    Full Text »    PDF »
Low-Dose Irradiation of Nontransformed Cells Stimulates the Selective Removal of Precancerous Cells via Intercellular Induction of Apoptosis.
D. I. Portess, G. Bauer, M. A. Hill, and P. O'Neill (2007)
Cancer Res. 67, 1246-1253
   Abstract »    Full Text »    PDF »
Circadian Output, Input, and Intracellular Oscillators: Insights into the Circadian Systems of Single Cells.
J. J. Loros, J. C. Dunlap, L. F. Larrondo, M. Shi, W. J. Belden, V. D. Gooch, C.-H. Chen, C. L. Baker, A. Mehra, H. V. Colot, et al. (2007)
Cold Spring Harb Symp Quant Biol 72, 201-214
   Abstract »    PDF »
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology.
K. Bedard and K.-H. Krause (2007)
Physiol Rev 87, 245-313
   Abstract »    Full Text »    PDF »
Reactive Oxygen Species Mediate Caspase Activation and Apoptosis Induced by Lipoic Acid in Human Lung Epithelial Cancer Cells through Bcl-2 Down-Regulation.
J. Moungjaroen, U. Nimmannit, P. S. Callery, L. Wang, N. Azad, V. Lipipun, P. Chanvorachote, and Y. Rojanasakul (2006)
J. Pharmacol. Exp. Ther. 319, 1062-1069
   Abstract »    Full Text »    PDF »
Antioxidant actions contribute to the antihypertrophic effects of atrial natriuretic peptide in neonatal rat cardiomyocytes.
A. Laskowski, O. L. Woodman, A. H. Cao, G. R. Drummond, T. Marshall, D. M. Kaye, and R. H. Ritchie (2006)
Cardiovasc Res 72, 112-123
   Abstract »    Full Text »    PDF »
Specificity in reactive oxidant signaling: think globally, act locally.
L. S. Terada (2006)
J. Cell Biol. 174, 615-623
   Abstract »    Full Text »    PDF »
Ras mutation promotes p53 activation and apoptosis of skin keratinocytes.
Y. Zhao, L. Chaiswing, V. Bakthavatchalu, T. D. Oberley, and D. K. St. Clair (2006)
Carcinogenesis 27, 1692-1698
   Abstract »    Full Text »    PDF »
NADPH oxidase-dependent redox signalling in cardiac hypertrophy, remodelling and failure.
C. E. Murdoch, M. Zhang, A. C. Cave, and A. M. Shah (2006)
Cardiovasc Res 71, 208-215
   Abstract »    Full Text »    PDF »
Cyclin d1 determines mitochondrial function in vivo..
T. Sakamaki, M. C. Casimiro, X. Ju, A. A. Quong, S. Katiyar, M. Liu, X. Jiao, A. Li, X. Zhang, Y. Lu, et al. (2006)
Mol. Cell. Biol. 26, 5449-5469
   Abstract »    Full Text »    PDF »
Nox1-dependent Reactive Oxygen Generation Is Regulated by Rac1.
G. Cheng, B. A. Diebold, Y. Hughes, and J. D. Lambeth (2006)
J. Biol. Chem. 281, 17718-17726
   Abstract »    Full Text »    PDF »
Regulation of Late G1/S Phase Transition and APCCdh1 by Reactive Oxygen Species.
C. G. Havens, A. Ho, N. Yoshioka, and S. F. Dowdy (2006)
Mol. Cell. Biol. 26, 4701-4711
   Abstract »    Full Text »    PDF »
Regulation of the mitogen-activated protein kinase p44 ERK activity during anoxia/recovery in rainbow trout hypodermal fibroblasts.
C. G. Ossum, T. Wulff, and E. K. Hoffmann (2006)
J. Exp. Biol. 209, 1765-1776
   Abstract »    Full Text »    PDF »
Actions of a Histone Deacetylase Inhibitor NSC3852 (5-Nitroso-8-quinolinol) Link Reactive Oxygen Species to Cell Differentiation and Apoptosis in MCF-7 Human Mammary Tumor Cells.
A. Martirosyan, S. Leonard, X. Shi, B. Griffith, P. Gannett, and J. Strobl (2006)
J. Pharmacol. Exp. Ther. 317, 546-552
   Abstract »    Full Text »    PDF »
Adventitial delivery of dominant-negative p67phox attenuates neointimal hyperplasia of the rat carotid artery.
M. Weaver, J. Liu, D. Pimentel, D. J. Reddy, P. Harding, E. L. Peterson, and P. J. Pagano (2006)
Am J Physiol Heart Circ Physiol 290, H1933-H1941
   Abstract »    Full Text »    PDF »
The role of oxidants and free radicals in reperfusion injury.
J. L. Zweier and M.A. H. Talukder (2006)
Cardiovasc Res 70, 181-190
   Abstract »    Full Text »    PDF »
Chemical Enhancers of Cytokine Signaling that Suppress Microfilament Turnover and Tumor Cell Growth..
H.-J. Park, E. Partridge, P. Cheung, J. Pawling, R. Donovan, J. L. Wrana, and J. W. Dennis (2006)
Cancer Res. 66, 3558-3566
   Abstract »    Full Text »    PDF »
Rho GTPases and Leukocyte Adhesion Receptor Expression and Function in Endothelial Cells.
E. Cernuda-Morollon and A. J. Ridley (2006)
Circ. Res. 98, 757-767
   Abstract »    Full Text »    PDF »
Regulation of NADPH Oxidases: The Role of Rac Proteins.
P. L. Hordijk (2006)
Circ. Res. 98, 453-462
   Abstract »    Full Text »    PDF »
Redox-Sensitive Proteins Are Potential Targets of Garlic-Derived Mercaptocysteine Derivatives.
J. T. Pinto, B. F. Krasnikov, and A. J. L. Cooper (2006)
J. Nutr. 136, 835S-841S
   Abstract »    Full Text »    PDF »
Involvement of the Nicotinamide Adenosine Dinucleotide Phosphate Oxidase Isoform Nox2 in Cardiac Contractile Dysfunction Occurring in Response to Pressure Overload.
D. J. Grieve, J. A. Byrne, A. Siva, J. Layland, S. Johar, A. C. Cave, and A. M. Shah (2006)
J. Am. Coll. Cardiol. 47, 817-826
   Abstract »    Full Text »    PDF »
Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir..
J. Alexandre, C. Nicco, C. Chereau, A. Laurent, B. Weill, F. Goldwasser, and F. Batteux (2006)
J Natl Cancer Inst 98, 236-244
   Abstract »    Full Text »    PDF »
Rac1 Leads to Phosphorylation-dependent Increase in Stability of the p66shc Adaptor Protein: Role in Rac1-induced Oxidative Stress.
F. A. Khanday, T. Yamamori, I. Mattagajasingh, Z. Zhang, A. Bugayenko, A. Naqvi, L. Santhanam, N. Nabi, K. Kasuno, B. W. Day, et al. (2006)
Mol. Biol. Cell 17, 122-129
   Abstract »    Full Text »    PDF »
NADPH oxidase-derived reactive oxygen species in cardiac pathophysiology.
A. Cave, D. Grieve, S. Johar, M. Zhang, and A. M Shah (2005)
Phil Trans R Soc B 360, 2327-2334
   Abstract »    Full Text »    PDF »
Platelet-Derived Growth Factor-Induced p42/44 Mitogen-Activated Protein Kinase Activation and Cellular Growth Is Mediated by Reactive Oxygen Species in the Absence of TSC2/Tuberin.
G. A. Finlay, V. J. Thannickal, B. L. Fanburg, and D. J. Kwiatkowski (2005)
Cancer Res. 65, 10881-10890
   Abstract »    Full Text »    PDF »
Platelet-derived Growth Factor and Reactive Oxygen Species (ROS) Regulate Ras Protein Levels in Primary Human Fibroblasts via ERK1/2: AMPLIFICATION OF ROS AND Ras IN SYSTEMIC SCLEROSIS FIBROBLASTS.
S. Svegliati, R. Cancello, P. Sambo, M. Luchetti, P. Paroncini, G. Orlandini, G. Discepoli, R. Paterno, M. Santillo, C. Cuozzo, et al. (2005)
J. Biol. Chem. 280, 36474-36482
   Abstract »    Full Text »    PDF »
RAS mutation in acute myeloid leukemia is associated with distinct cytogenetic subgroups but does not influence outcome in patients younger than 60 years.
D. T. Bowen, M. E. Frew, R. Hills, R. E. Gale, K. Wheatley, M. J. Groves, S. E. Langabeer, P. D. Kottaridis, A. V. Moorman, A. K. Burnett, et al. (2005)
Blood 106, 2113-2119
   Abstract »    Full Text »    PDF »
Manganese Superoxide Dismutase Induces p53-Dependent Senescence in Colorectal Cancer Cells.
L. Behrend, A. Mohr, T. Dick, and R. M. Zwacka (2005)
Mol. Cell. Biol. 25, 7758-7769
   Abstract »    Full Text »    PDF »
Heparin-Binding Epidermal Growth Factor-Like Growth Factor Inhibits Cytokine-Induced NF-{kappa}B Activation and Nitric Oxide Production via Activation of the Phosphatidylinositol 3-Kinase Pathway.
V. B. Mehta and G. E. Besner (2005)
J. Immunol. 175, 1911-1918
   Abstract »    Full Text »    PDF »
Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor.
K. Matsushita, C. N. Morrell, R. J.A. Mason, M. Yamakuchi, F. A. Khanday, K. Irani, and C. J. Lowenstein (2005)
J. Cell Biol. 170, 73-79
   Abstract »    Full Text »    PDF »
A Rac Homolog Functions Downstream of Ras1 To Control Hyphal Differentiation and High-Temperature Growth in the Pathogenic Fungus Cryptococcus neoformans.
M. A. Vallim, C. B. Nichols, L. Fernandes, K. L. Cramer, and J. A. Alspaugh (2005)
Eukaryot. Cell 4, 1066-1078
   Abstract »    Full Text »    PDF »
Manganese Superoxide Dismutase Protects the Proliferative Capacity of Confluent Normal Human Fibroblasts.
E. H. Sarsour, M. Agarwal, T. K. Pandita, L. W. Oberley, and P. C. Goswami (2005)
J. Biol. Chem. 280, 18033-18041
   Abstract »    Full Text »    PDF »
Thrombin-Induced Oxidative Stress Contributes to the Death of Hippocampal Neurons In Vivo: Role of Microglial NADPH Oxidase.
S.-H. Choi, D. Y. Lee, S. U. Kim, and B. K. Jin (2005)
J. Neurosci. 25, 4082-4090
   Abstract »    Full Text »    PDF »
From The Cover: Proline suppresses apoptosis in the fungal pathogen Colletotrichum trifolii.
C. Chen and M. B. Dickman (2005)
PNAS 102, 3459-3464
   Abstract »    Full Text »    PDF »
Transgenic Expression of Dominant Negative Tuberin through a Strong Constitutive Promoter Results in a Tissue-specific Tuberous Sclerosis Phenotype in the Skin and Brain.
B. Govindarajan, D. J. Brat, M. Csete, W. D. Martin, E. Murad, K. Litani, C. Cohen, F. Cerimele, M. Nunnelley, B. Lefkove, et al. (2005)
J. Biol. Chem. 280, 5870-5874
   Abstract »    Full Text »    PDF »
Perivascular gene transfer of NADPH oxidase inhibitor suppresses angioplasty-induced neointimal proliferation of rat carotid artery.
H. M. Dourron, G. M. Jacobson, J. L. Park, J. Liu, D. J. Reddy, M. L. Scheel, and P. J. Pagano (2005)
Am J Physiol Heart Circ Physiol 288, H946-H953
   Abstract »    Full Text »    PDF »
Regulation of H2O2 generation in thyroid cells does not involve Rac1 activation.
N Fortemaison, F Miot, J E Dumont, and S Dremier (2005)
Eur. J. Endocrinol. 152, 127-133
   Abstract »    Full Text »    PDF »
Glycolytic Enzymes Can Modulate Cellular Life Span.
H. Kondoh, M. E. Lleonart, J. Gil, J. Wang, P. Degan, G. Peters, D. Martinez, A. Carnero, and D. Beach (2005)
Cancer Res. 65, 177-185
   Abstract »    Full Text »    PDF »
Membrane depolarization and NADPH oxidase activation in aortic endothelium during ischemia reflect altered mechanotransduction.
I. Matsuzaki, S. Chatterjee, K. DeBolt, Y. Manevich, Q. Zhang, and A. B. Fisher (2005)
Am J Physiol Heart Circ Physiol 288, H336-H343
   Abstract »    Full Text »    PDF »
The Nox Family of NAD(P)H Oxidases: Host Defense and Beyond.
M. Geiszt and T. L. Leto (2004)
J. Biol. Chem. 279, 51715-51718
   Full Text »    PDF »
Important role for Rac1 in regulating reactive oxygen species generation and pulmonary arterial smooth muscle cell growth.
S. Patil, M. Bunderson, J. Wilham, and S. M. Black (2004)
Am J Physiol Lung Cell Mol Physiol 287, L1314-L1322
   Abstract »    Full Text »    PDF »
Src Tyrosine Kinase Inhibitor PP2 Markedly Enhances Ras-independent Activation of Raf-1 Protein Kinase by Phorbol Myristate Acetate and H2O2.
M. Lee, J.-Y. Kim, and W. B. Anderson (2004)
J. Biol. Chem. 279, 48692-48701
   Abstract »    Full Text »    PDF »
Mutant K-rasV12 increases COX-2, peroxides and DNA damage in lung cells.
A. Maciag, G. Sithanandam, and L. M. Anderson (2004)
Carcinogenesis 25, 2231-2237
   Abstract »    Full Text »    PDF »
Human Polynucleotide Phosphorylase (hPNPaseold-35): A Potential Link between Aging and Inflammation.
D. Sarkar, I. V. Lebedeva, L. Emdad, D.-c. Kang, A. S. Baldwin Jr., and P. B. Fisher (2004)
Cancer Res. 64, 7473-7478
   Abstract »    Full Text »    PDF »
Induction of Hypoxia-inducible Factor 1 Activity by Muscarinic Acetylcholine Receptor Signaling.
K. Hirota, R. Fukuda, S. Takabuchi, S. Kizaka-Kondoh, T. Adachi, K. Fukuda, and G. L. Semenza (2004)
J. Biol. Chem. 279, 41521-41528
   Abstract »    Full Text »    PDF »
In vivo Detection of Gastric Cancer in Rats by Electron Paramagnetic Resonance Imaging.
T. Mikuni, G. He, S. Petryakov, M. M. Fallouh, Y. Deng, R. Ishihara, P. Kuppusamy, M. Tatsuta, and J. L. Zweier (2004)
Cancer Res. 64, 6495-6502
   Abstract »    Full Text »    PDF »
Activation of Ras-Ral Pathway Attenuates p53-independent DNA Damage G2 Checkpoint.
L. S. Agapova, J. L. Volodina, P. M. Chumakov, and B. P. Kopnin (2004)
J. Biol. Chem. 279, 36382-36389
   Abstract »    Full Text »    PDF »
Rap1 Signaling Is Required for Suppression of Ras-Generated Reactive Oxygen Species and Protection Against Oxidative Stress in T Lymphocytes.
P. H. J. Remans, S. I. Gringhuis, J. M. van Laar, M. E. Sanders, E. A. M. Papendrecht-van der Voort, F. J. T. Zwartkruis, E. W. N. Levarht, M. Rosas, P. J. Coffer, F. C. Breedveld, et al. (2004)
J. Immunol. 173, 920-931
   Abstract »    Full Text »    PDF »
High Levels of Catalase and Glutathione Peroxidase Activity Dampen H2O2 Signaling in Human Alveolar Macrophages.
A. B. Carter, L. A. Tephly, S. Venkataraman, L. W. Oberley, Y. Zhang, G. R. Buettner, D. R. Spitz, and G. W. Hunninghake (2004)
Am. J. Respir. Cell Mol. Biol. 31, 43-53
   Abstract »    Full Text »    PDF »
Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation.
R. A. Woo and R. Y.C. Poon (2004)
Genes & Dev. 18, 1317-1330
   Abstract »    Full Text »    PDF »
The Superoxide-Generating Oxidase Nox1 Is Functionally Required for Ras Oncogene Transformation.
J. Mitsushita, J. D. Lambeth, and T. Kamata (2004)
Cancer Res. 64, 3580-3585
   Abstract »    Full Text »    PDF »
HBP1 Repression of the p47phox Gene: Cell Cycle Regulation via the NADPH Oxidase.
S. P. Berasi, M. Xiu, A. S. Yee, and K. E. Paulson (2004)
Mol. Cell. Biol. 24, 3011-3024
   Abstract »    Full Text »    PDF »
Ras Induction of Superoxide Activates ERK-dependent Angiogenic Transcription Factor HIF-1{alpha} and VEGF-A Expression in Shock Wave-stimulated Osteoblasts.
F.-S. Wang, C.-J. Wang, Y.-J. Chen, P.-R. Chang, Y.-T. Huang, Y.-C. Sun, H.-C. Huang, Y.-J. Yang, and K. D. Yang (2004)
J. Biol. Chem. 279, 10331-10337
   Abstract »    Full Text »    PDF »
Potential Contributory Role of H-Ras, a Small G-Protein, in the Development of Retinopathy in Diabetic Rats.
R. A. Kowluru, A. Kowluru, S. Chakrabarti, and Z. Khan (2004)
Diabetes 53, 775-783
   Abstract »    Full Text »    PDF »
Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-{kappa}B, and cytokine expression.
D. Strassheim, K. Asehnoune, J.-S. Park, J.-Y. Kim, Q. He, D. Richter, S. Mitra, J. Arcaroli, K. Kuhn, and E. Abraham (2004)
Am J Physiol Cell Physiol 286, C683-C692
   Abstract »    Full Text »
Involvement of Reactive Oxygen Species in Toll-Like Receptor 4-Dependent Activation of NF-{kappa}B.
K. Asehnoune, D. Strassheim, S. Mitra, J. Y. Kim, and E. Abraham (2004)
J. Immunol. 172, 2522-2529
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)