Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 7 March 1997:
Vol. 275. no. 5305, pp. 1465 - 1468
DOI: 10.1126/science.275.5305.1465
Prev | Table of Contents | Next

Reports

Oxidative Thymine Dimer Repair in the DNA Helix

Peter J. Dandliker, R. Erik Holmlin, Jacqueline K. Barton *

The metallointercalator Rh(phi)2DMB3+ (phi, 9,10-phenanthrenequinone diimine; DMB, 4,4'-dimethyl-2,2'-bipyridine) catalyzed the repair of a thymine dimer incorporated site-specifically in a 16-base pair DNA duplex by means of visible light. This repair could be accomplished with rhodium noncovalently bound to the duplex and at long range (16 to 26 angstroms), with the rhodium intercalator tethered to either end of the duplex assembly. This long-range repair was mediated by the DNA helix. Repair efficiency did not decrease with increasing distance between intercalated rhodium and the thymine dimer, but it diminished with disruption of the intervening pi -stack.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
*   To whom correspondence should be addressed.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A role for DNA-mediated charge transport in regulating p53: Oxidation of the DNA-bound protein from a distance.
K. E. Augustyn, E. J. Merino, and J. K. Barton (2007)
PNAS 104, 18907-18912
   Abstract »    Full Text »    PDF »
Complementary base-pair-facilitated electron tunneling for electrically pinpointing complementary nucleobases.
T. Ohshiro and Y. Umezawa (2006)
PNAS 103, 10-14
   Abstract »    Full Text »    PDF »
Supramolecular Structure and Dynamics Special Feature: Electrically monitoring DNA repair by photolyase.
M. C. DeRosa, A. Sancar, and J. K. Barton (2005)
PNAS 102, 10788-10792
   Abstract »    Full Text »    PDF »
From the Cover: Long-range oxidative damage to cytosines in duplex DNA.
F. Shao, M. A. O'Neill, and J. K. Barton (2004)
PNAS 101, 17914-17919
   Abstract »    Full Text »    PDF »
Long-range charge hopping in DNA.
M. Bixon, B. Giese, S. Wessely, T. Langenbacher, M. E. Michel-Beyerle, and J. Jortner (1999)
PNAS 96, 11713-11716
   Abstract »    Full Text »    PDF »
Femtosecond dynamics of DNA-mediated electron transfer.
C. Wan, T. Fiebig, S. O. Kelley, C. R. Treadway, J. K. Barton, and A. H. Zewail (1999)
PNAS 96, 6014-6019
   Abstract »    Full Text »    PDF »
Electron Transfer Between Bases in Double Helical DNA.
S. O. Kelley and J. K. Barton (1999)
Science 283, 375-381
   Abstract »    Full Text »
Charge transfer and transport in DNA.
J. Jortner, M. Bixon, T. Langenbacher, and M. E. Michel-Beyerle (1998)
PNAS 95, 12759-12765
   Abstract »    Full Text »    PDF »
A unified theory of carcinogenesis based on order-disorder transitions in DNA structure as studied in the human ovary and breast.
D. C. Malins, N. L. Polissar, S. Schaefer, Y. Su, and M. Vinson (1998)
PNAS 95, 7637-7642
   Abstract »    Full Text »    PDF »
Peptide nucleic acid-DNA duplexes: Long range hole migration from an internally linked anthraquinone.
B. Armitage, D. Ly, T. Koch, H. Frydenlund, H. Orum, H. G. Batz, and G. B. Schuster (1997)
PNAS 94, 12320-12325
   Abstract »    Full Text »    PDF »
Distance-Dependent Electron Transfer in DNA Hairpins.
F. D. Lewis, T. Wu, Y. Zhang, R. L. Letsinger, S. R. Greenfield, and M. R. Wasielewski (1997)
Science 277, 673-676
   Abstract »    Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)