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Science 14 February 1997:
Vol. 275. no. 5302, pp. 977 - 979
DOI: 10.1126/science.275.5302.977
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Reports

Immunoglobulin E Production in the Absence of Interleukin-4-Secreting CD1-Dependent Cells

Stephen T. Smiley, Mark H. Kaplan, Michael J. Grusby *

A lymphocyte population that expresses surface markers found on T cells and natural killer (NK) cells secretes large amounts of interleukin-4 (IL-4) immediately after T cell receptor ligation. These NK-like T cells are thus thought to be important for the initiation of type 2 T helper cell (TH2) responses. CD1-deficient mice were found to lack this lymphocyte subset, but they could nevertheless mount a protypical TH2 response; after immunization with antibody to immunoglobulin D (IgD), CD1-deficient mice produced IgE. Thus, although dependent on CD1 for their development, IL-4-secreting NK-like T cells are not required for TH2 responses.

S. T. Smiley and M. H. Kaplan, Department of Cancer Biology, Harvard School of Public Health (HSPH), Boston, MA 02115, USA.
M. J. Grusby, Department of Cancer Biology, HSPH, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
*   To whom correspondence should be addressed.

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MHC-II-Independent CD4+ T Cells Induce Colitis in Immunodeficient RAG-/- Hosts.
Z. Trobonjaca, F. Leithauser, P. Moller, H. Bluethmann, Y. Koezuka, H. R. MacDonald, and J. Reimann (2001)
J. Immunol. 166, 3804-3812
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Defective development of NK1.1+ T-cell antigen receptor {alpha}{beta}+ cells in zeta-associated protein 70 null mice with an accumulation of NK1.1+ CD3{-} NK-like cells in the thymus.
K. Iwabuchi, C. Iwabuchi, S. Tone, D. Itoh, N. Tosa, I. Negishi, K. Ogasawara, T. Uede, and K. Onoe (2001)
Blood 97, 1765-1775
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Involvement of CD1 in Peripheral Deletion of T Lymphocytes Is Independent of NK T Cells.
T. Dao, M. Exley, W. Z. Mehal, S. M. A. Tahir, S. Snapper, M. Taniguchi, S. P. Balk, and I. N. Crispe (2001)
J. Immunol. 166, 3090-3097
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Requirement for natural killer T (NKT) cells in the induction of allograft tolerance.
K.-i. Seino, K. Fukao, K. Muramoto, K. Yanagisawa, Y. Takada, S. Kakuta, Y. Iwakura, L. Van Kaer, K. Takeda, T. Nakayama, et al. (2001)
PNAS
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Activation-induced expression of CD1d antigen on mature T cells.
M. del C. Salamone, G. A. Rabinovich, A. K. Mendiguren, G. V. Salamone, and L. Fainboim (2001)
J. Leukoc. Biol. 69, 207-214
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Activation of V{alpha}14+ Natural Killer T Cells by {alpha}-Galactosylceramide Results in Development of Th1 Response and Local Host Resistance in Mice Infected with Cryptococcus neoformans.
K. Kawakami, Y. Kinjo, S. Yara, Y. Koguchi, K. Uezu, T. Nakayama, M. Taniguchi, and A. Saito (2001)
Infect. Immun. 69, 213-220
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NK T Cell-Derived IL-10 Is Essential for the Differentiation of Antigen-Specific T Regulatory Cells in Systemic Tolerance.
K.-H. Sonoda, D. E. Faunce, M. Taniguchi, M. Exley, S. Balk, and J. Stein-Streilein (2001)
J. Immunol. 166, 42-50
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Costimulation-Dependent Modulation of Experimental Autoimmune Encephalomyelitis by Ligand Stimulation of V{{alpha}}14 NK T Cells.
E. Pal, T. Tabira, T. Kawano, M. Taniguchi, S. Miyake, and T. Yamamura (2001)
J. Immunol. 166, 662-668
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NKT lymphocyte ontogeny and function are impaired in low antibody-producer Biozzi mice: gene mapping in the interval-specific congenic