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Science 14 February 1997:
Vol. 275. no. 5302, pp. 943 - 944
DOI: 10.1126/science.275.5302.943
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Perspectives

Leonard Guarente

A mutant Caenorhabditis elegans worm, defective in the gene clk-1, lives an extraordinarily long time. In this issue, Ewbank et al. (p. 980) report the sequence of clk-1 and find that it is homologous to the yeast gene CAT5/COQ7, whose product regulates the transcription of genes that control yeast metabolism. In his Perspective, Guarente describes how these findings fit into a model of aging in which life-span is determined by the accumulation of damage to the organism, perhaps at a rate proportional to metabolism, and the counteracting repair of such damage.

The author is in the Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. E-mail: leng{at}mit.edu

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mitotic and Postmitotic Senescence in Plants.
S. Gan (2003)
Sci. Aging Knowl. Environ. 2003, re7-7
   Abstract »    Full Text »    PDF »
Link between aging and the nucleolus.
L. Guarente (1997)
Genes & Dev. 11, 2449-2455
   Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)