Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 31 January 1997:
Vol. 275. no. 5300, pp. 674 - 678
DOI: 10.1126/science.275.5300.674
Prev | Table of Contents | Next

Reports

NMDA Channel Regulation by Channel-Associated Protein Tyrosine Kinase Src

Xian-Min Yu, Rand Askalan, Gary J. Keil II, Michael W. Salter *

The N-methyl-D-aspartate (NMDA) receptor mediates synaptic transmission and plasticity in the central nervous system (CNS) and is regulated by tyrosine phosphorylation. In membrane patches excised from mammalian central neurons, the endogenous tyrosine kinase Src was shown to regulate the activity of NMDA channels. The action of Src required a sequence [Src(40-58)] within the noncatalytic, unique domain of Src. In addition, Src coprecipitated with NMDA receptor proteins. Finally, endogenous Src regulated the function of NMDA receptors at synapses. Thus, NMDA receptor regulation by Src may be important in development, plasticity, and pathology in the CNS.

Division of Neuroscience, Hospital for Sick Children, Department of Physiology, University of Toronto, Toronto, Ontario, M5G 1X8 Canada.
*   To whom correspondence should be addressed. E-mail: mike.salter{at}utoronto.ca

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Supramolecular Assemblies and Localized Regulation of Voltage-Gated Ion Channels.
S. Dai, D. D. Hall, and J. W. Hell (2009)
Physiol Rev 89, 411-452
   Abstract »    Full Text »    PDF »
Sodium Channel Activation Augments NMDA Receptor Function and Promotes Neurite Outgrowth in Immature Cerebrocortical Neurons.
J. George, S. M. Dravid, A. Prakash, J. Xie, J. Peterson, S. V. Jabba, D. G. Baden, and T. F. Murray (2009)
J. Neurosci. 29, 3288-3301
   Abstract »    Full Text »    PDF »
A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1{beta}.
S. Balosso, M. Maroso, M. Sanchez-Alavez, T. Ravizza, A. Frasca, T. Bartfai, and A. Vezzani (2008)
Brain 131, 3256-3265
   Abstract »    Full Text »    PDF »
Neuroprotection of GluR5-containing Kainate Receptor Activation against Ischemic Brain Injury through Decreasing Tyrosine Phosphorylation of N-Methyl-D-aspartate Receptors Mediated by Src Kinase.
J. Xu, Y. Liu, and G.-Y. Zhang (2008)
J. Biol. Chem. 283, 29355-29366
   Abstract »    Full Text »    PDF »
Postsynaptic Density-95 (PSD-95) and Calcineurin Control the Sensitivity of N-Methyl-D-aspartate Receptors to Calpain Cleavage in Cortical Neurons.
E. Y. Yuen, Y. Ren, and Z. Yan (2008)
Mol. Pharmacol. 74, 360-370
   Abstract »    Full Text »    PDF »
Control of Excitatory Synaptic Transmission by C-terminal Src Kinase.
J. Xu, M. Weerapura, M. K. Ali, M. F. Jackson, H. Li, G. Lei, S. Xue, C. L. Kwan, M. F. Manolson, K. Yang, et al. (2008)
J. Biol. Chem. 283, 17503-17514
   Abstract »    Full Text »    PDF »
Bradykinin Enhances AMPA and NMDA Receptor Activity in Spinal Cord Dorsal Horn Neurons by Activating Multiple Kinases to Produce Pain Hypersensitivity.
T. Kohno, H. Wang, F. Amaya, G. J. Brenner, J.-K. Cheng, R.-R. Ji, and C. J. Woolf (2008)
J. Neurosci. 28, 4533-4540
   Abstract »    Full Text »    PDF »
Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death.
B. P. Head, H. H. Patel, Y. M. Tsutsumi, Y. Hu, T. Mejia, R. C. Mora, P. A. Insel, D. M. Roth, J. C. Drummond, and P. M. Patel (2008)
FASEB J 22, 828-840
   Abstract »    Full Text »    PDF »
Cdk5 Regulates the Phosphorylation of Tyrosine 1472 NR2B and the Surface Expression of NMDA Receptors.
S. Zhang, L. Edelmann, J. Liu, J. E. Crandall, and M. A. Morabito (2008)
J. Neurosci. 28, 415-424
   Abstract »    Full Text »    PDF »
PREGS Induces LTP in the Hippocampal Dentate Gyrus of Adult Rats Via the Tyrosine Phosphorylation International Cooperative Research CREB Signaling.
L. Chen, Y. Miyamoto, K. Furuya, N. Mori, and M. Sokabe (2007)
J Neurophysiol 98, 1538-1548
   Abstract »    Full Text »    PDF »
Synapsin Phosphorylation by Src Tyrosine Kinase Enhances Src Activity in Synaptic Vesicles.
F. Onofri, M. Messa, V. Matafora, G. Bonanno, A. Corradi, A. Bachi, F. Valtorta, and F. Benfenati (2007)
J. Biol. Chem. 282, 15754-15767
   Abstract »    Full Text »    PDF »
Neuregulin1 (NRG1) Signaling through Fyn Modulates NMDA Receptor Phosphorylation: Differential Synaptic Function in NRG1+/- Knock-Outs Compared with Wild-Type Mice.
M. Bjarnadottir, D. L. Misner, S. Haverfield-Gross, S. Bruun, V. G. Helgason, H. Stefansson, A. Sigmundsson, D. R. Firth, B. Nielsen, R. Stefansdottir, et al. (2007)
J. Neurosci. 27, 4519-4529
   Abstract »    Full Text »    PDF »
Reelin Signaling Facilitates Maturation of CA1 Glutamatergic Synapses.
S. Qiu and E. J. Weeber (2007)
J Neurophysiol 97, 2312-2321
   Abstract »    Full Text »    PDF »
Differential Reelin-Induced Enhancement of NMDA and AMPA Receptor Activity in the Adult Hippocampus.
S. Qiu, L. F. Zhao, K. M. Korwek, and E. J. Weeber (2006)
J. Neurosci. 26, 12943-12955
   Abstract »    Full Text »    PDF »
c-Src Control of Chloride Channel Support for Osteoclast HCl Transport and Bone Resorption.
J. C. Edwards, C. Cohen, W. Xu, and P. H. Schlesinger (2006)
J. Biol. Chem. 281, 28011-28022
   Abstract »    Full Text »    PDF »
Experimental colitis modulates the functional properties of NMDA receptors in dorsal root ganglia neurons.
J. Li, J. A. McRoberts, H. S. Ennes, M. Trevisani, P. Nicoletti, Y. Mittal, and E. A. Mayer (2006)
Am J Physiol Gastrointest Liver Physiol 291, G219-G228
   Abstract »    Full Text »    PDF »
Loss of Synaptic D1 Dopamine/N-Methyl-D-aspartate Glutamate Receptor Complexes in L-DOPA-Induced Dyskinesia in the Rat.
C. Fiorentini, M. C. Rizzetti, C. Busi, S. Bontempi, G. Collo, P. Spano, and C. Missale (2006)
Mol. Pharmacol. 69, 805-812
   Abstract »    Full Text »    PDF »
Binding of Src to Na+/K+-ATPase Forms a Functional Signaling Complex.
J. Tian, T. Cai, Z. Yuan, H. Wang, L. Liu, M. Haas, E. Maksimova, X.-Y. Huang, and Z.-J. Xie (2006)
Mol. Biol. Cell 17, 317-326
   Abstract »    Full Text »    PDF »
{alpha}7 Neuronal Nicotinic Acetylcholine Receptors Are Negatively Regulated by Tyrosine Phosphorylation and Src-Family Kinases.
E. Charpantier, A. Wiesner, K.-H. Huh, R. Ogier, J.-C. Hoda, G. Allaman, M. Raggenbass, D. Feuerbach, D. Bertrand, and C. Fuhrer (2005)
J. Neurosci. 25, 9836-9849
   Abstract »    Full Text »    PDF »
Reelin Modulates NMDA Receptor Activity in Cortical Neurons.
Y. Chen, U. Beffert, M. Ertunc, T.-S. Tang, E. T. Kavalali, I. Bezprozvanny, and J. Herz (2005)
J. Neurosci. 25, 8209-8216
   Abstract »    Full Text »    PDF »
Bradykinin Produces Pain Hypersensitivity by Potentiating Spinal Cord Glutamatergic Synaptic Transmission.
H. Wang, T. Kohno, F. Amaya, G. J. Brenner, N. Ito, A. Allchorne, R.-R. Ji, and C. J. Woolf (2005)
J. Neurosci. 25, 7986-7992
   Abstract »    Full Text »    PDF »
Association/Dissociation of a Channel-Kinase Complex Underlies State-Dependent Modulation.
N. S. Magoski and L. K. Kaczmarek (2005)
J. Neurosci. 25, 8037-8047
   Abstract »    Full Text »    PDF »
Modulation of Protein Tyrosine Phosphatase Activity Alters the Subunit Assembly in Native N-Methyl-D-aspartate Receptor Complex.
K. Ferrani-Kile and S. W. Leslie (2005)
J. Pharmacol. Exp. Ther. 314, 86-93
   Abstract »    Full Text »    PDF »
NMDA Receptor Subunit-Dependent [Ca2+] Signaling in Individual Hippocampal Dendritic Spines.
A. Sobczyk, V. Scheuss, and K. Svoboda (2005)
J. Neurosci. 25, 6037-6046
   Abstract »    Full Text »    PDF »
Reelin, Very-Low-Density Lipoprotein Receptor, and Apolipoprotein E Receptor 2 Control Somatic NMDA Receptor Composition during Hippocampal Maturation In Vitro.
M. Sinagra, D. Verrier, D. Frankova, K. M. Korwek, J. Blahos, E. J. Weeber, O. J. Manzoni, and P. Chavis (2005)
J. Neurosci. 25, 6127-6136
   Abstract »    Full Text »    PDF »
ATP stimulates GRK-3 phosphorylation and {beta}-arrestin-2-dependent internalization of P2X7 receptor.
Y.-H. Feng, L. Wang, Q. Wang, X. Li, R. Zeng, and G. I. Gorodeski (2005)
Am J Physiol Cell Physiol 288, C1342-C1356
   Abstract »    Full Text »    PDF »
Somatostatin-Induced Activation and Up-Regulation of N-Methyl-D-aspartate Receptor Function: Mediation through Calmodulin-Dependent Protein Kinase II, Phospholipase C, Protein Kinase C, and Tyrosine Kinase in Hippocampal Noradrenergic Nerve Endings.
A. Pittaluga, M. Feligioni, F. Longordo, M. Arvigo, and M. Raiteri (2005)
J. Pharmacol. Exp. Ther. 313, 242-249
   Abstract »    Full Text »    PDF »
Hippocampal Synaptic Modulation by the Phosphotyrosine Adapter Protein ShcC/N-Shc via Interaction with the NMDA Receptor.
Y. Miyamoto, L. Chen, M. Sato, M. Sokabe, T. Nabeshima, T. Pawson, R. Sakai, and N. Mori (2005)
J. Neurosci. 25, 1826-1835
   Abstract »    Full Text »    PDF »
Prion-associated Increases in Src-family Kinases.
R. R. Nixon (2005)
J. Biol. Chem. 280, 2455-2462
   Abstract »    Full Text »    PDF »
A Functional Interaction of Sodium and Calcium in the Regulation of NMDA Receptor Activity by Remote NMDA Receptors.
W.-K. Xin, C. L. Kwan, X.-H. Zhao, J. Xu, R. P. Ellen, C. A. G. McCulloch, and X.-M. Yu (2005)
J. Neurosci. 25, 139-148
   Abstract »    Full Text »    PDF »
Pharmacology of Brain Na+/Ca2+ Exchanger: From Molecular Biology to Therapeutic Perspectives.
L. Annunziato, G. Pignataro, and G. F. Di Renzo (2004)
Pharmacol. Rev. 56, 633-654
   Abstract »    Full Text »    PDF »
Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions of Src Family Tyrosine Kinases to Feeding Triggered Either by NMDA Injection or by Food Deprivation.
A. M. Khan, H. H. Cheung, E. R. Gillard, J. A. Palarca, D. S. Welsbie, J. W. Gurd, and B. G. Stanley (2004)
J. Neurosci. 24, 10603-10615
   Abstract »    Full Text »    PDF »
Group I Metabotropic Glutamate Receptor NMDA Receptor Coupling and Signaling Cascade Mediate Spinal Dorsal Horn NMDA Receptor 2B Tyrosine Phosphorylation Associated with Inflammatory Hyperalgesia.
W. Guo, F. Wei, S. Zou, M. T. Robbins, S. Sugiyo, T. Ikeda, J.-C. Tu, P. F. Worley, R. Dubner, and K. Ren (2004)
J. Neurosci. 24, 9161-9173
   Abstract »    Full Text »    PDF »
Signaling Cascades Regulating NMDA Receptor Sensitivity to Ethanol.
D. Ron (2004)
Neuroscientist 10, 325-336
   Abstract »    PDF »
Regulation of an Aplysia Bag Cell Neuron Cation Channel by Closely Associated Protein Kinase A and a Protein Phosphatase.
N. S. Magoski (2004)
J. Neurosci. 24, 6833-6841
   Abstract »    Full Text »    PDF »
Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2.
J. R. Gingrich, K. A. Pelkey, S. R. Fam, Y. Huang, R. S. Petralia, R. J. Wenthold, and M. W. Salter (2004)
PNAS 101, 6237-6242
   Abstract »    Full Text »    PDF »
Regulation of the Neuronal Nicotinic Acetylcholine Receptor by Src Family Tyrosine Kinases.
K. Wang, J. T. Hackett, M. E. Cox, M. van Hoek, J. M. Lindstrom, and S. J. Parsons (2004)
J. Biol. Chem. 279, 8779-8786
   Abstract »    Full Text »    PDF »
Phosphorylation of Vanilloid Receptor 1 by Ca2+/Calmodulin-dependent Kinase II Regulates Its Vanilloid Binding.
J. Jung, J. S. Shin, S.-Y. Lee, S. W. Hwang, J. Koo, H. Cho, and U. Oh (2004)
J. Biol. Chem. 279, 7048-7054
   Abstract »    Full Text »    PDF »
Differential Calcium-Dependent Modulation of NMDA Currents in CA1 and CA3 Hippocampal Pyramidal Cells.
A. A. Grishin, C. E. Gee, U. Gerber, and P. Benquet (2004)
J. Neurosci. 24, 350-355
   Abstract »    Full Text »    PDF »
Dopamine D1-Dependent Trafficking of Striatal N-Methyl-D-aspartate Glutamate Receptors Requires Fyn Protein Tyrosine Kinase but Not DARPP-32.
A. W. Dunah, A. C. Sirianni, A. A. Fienberg, E. Bastia, M. A. Schwarzschild, and David. G. Standaert (2004)
Mol. Pharmacol. 65, 121-129
   Abstract »    Full Text »    PDF »
Identification of PSD-93 as a Substrate for the Src Family Tyrosine Kinase Fyn.
S. Nada, T. Shima, H. Yanai, H. Husi, S. G. N. Grant, M. Okada, and T. Akiyama (2003)
J. Biol. Chem. 278, 47610-47621
   Abstract »    Full Text »    PDF »
Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1.
M. Cammalleri, R. Lutjens, F. Berton, A. R. King, C. Simpson, W. Francesconi, and P. P. Sanna (2003)
PNAS 100, 14368-14373
   Abstract »    Full Text »    PDF »
Regulation of a TRPM7-like Current in Rat Brain Microglia.
X. Jiang, E. W. Newell, and L. C. Schlichter (2003)
J. Biol. Chem. 278, 42867-42876
   Abstract »    Full Text »    PDF »
Therapeutic implications of central and peripheral neurologic mechanisms in migraine.
C. Waeber and M. A. Moskowitz (2003)
Neurology 61, S9-20
   Full Text »
Interleukin-1{beta} Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases.
B. Viviani, S. Bartesaghi, F. Gardoni, A. Vezzani, M. M. Behrens, T. Bartfai, M. Binaglia, E. Corsini, M. Di Luca, C. L. Galli, et al. (2003)
J. Neurosci. 23, 8692-8700
   Abstract »    Full Text »    PDF »
H-Ras Modulates N-Methyl-D-aspartate Receptor Function via Inhibition of Src Tyrosine Kinase Activity.
C. Thornton, R. Yaka, S. Dinh, and D. Ron (2003)
J. Biol. Chem. 278, 23823-23829
   Abstract »    Full Text »    PDF »
A Conditional Deletion of the NR1 Subunit of the NMDA Receptor in Adult Spinal Cord Dorsal Horn Reduces NMDA Currents and Injury-Induced Pain.
S. M. South, T. Kohno, B. K. Kaspar, D. Hegarty, B. Vissel, C. T. Drake, M. Ohata, S. Jenab, A. W. Sailer, S. Malkmus, et al. (2003)
J. Neurosci. 23, 5031-5040
   Abstract »    Full Text »    PDF »
Focal Adhesion Kinase Is Required, But Not Sufficient, for the Induction of Long-Term Potentiation in Dentate Gyrus Neurons In Vivo.
Y. C. Yang, Y. L. Ma, S. K. Chen, C. W. Wang, and E. H. Y. Lee (2003)
J. Neurosci. 23, 4072-4080
   Abstract »    Full Text »    PDF »
Phosphorylation-dependent Regulation of Kv2.1 Channel Activity at Tyrosine 124 by Src and by Protein-tyrosine Phosphatase epsilon.
Z. Tiran, A. Peretz, B. Attali, and A. Elson (2003)
J. Biol. Chem. 278, 17509-17514
   Abstract »    Full Text »    PDF »
Scaffolding of Fyn Kinase to the NMDA Receptor Determines Brain Region Sensitivity to Ethanol.
R. Yaka, K. Phamluong, and D. Ron (2003)
J. Neurosci. 23, 3623-3632
   Abstract »    Full Text »    PDF »
Interaction of the Tyrosine Kinase Pyk2 with the N-Methyl-D-aspartate Receptor Complex via the Src Homology 3 Domains of PSD-95 and SAP102.
G. K. Seabold, A. Burette, I. A. Lim, R. J. Weinberg, and J. W. Hell (2003)
J. Biol. Chem. 278, 15040-15048
   Abstract »    Full Text »    PDF »
Tyrosine Dephosphorylation and Ethanol Inhibition of N-Methyl-D-aspartate Receptor Function.
R. M. Alvestad, D. R. Grosshans, S. J. Coultrap, T. Nakazawa, T. Yamamoto, and M. D. Browning (2003)
J. Biol. Chem. 278, 11020-11025
   Abstract »    Full Text »    PDF »
Platelet-derived Growth Factor Induces the beta -gamma -Secretase-mediated Cleavage of Alzheimer's Amyloid Precursor Protein through a Src-Rac-dependent Pathway.
D. Gianni, N. Zambrano, M. Bimonte, G. Minopoli, L. Mercken, F. Talamo, A. Scaloni, and T. Russo (2003)
J. Biol. Chem. 278, 9290-9297
   Abstract »    Full Text »    PDF »
Pituitary Adenylate Cyclase-activating Polypeptide (PACAP(1-38)) Enhances N-Methyl-D-aspartate Receptor Function and Brain-derived Neurotrophic Factor Expression via RACK1.
R. Yaka, D.-Y. He, K. Phamluong, and D. Ron (2003)
J. Biol. Chem. 278, 9630-9638
   Abstract »    Full Text »    PDF »
Muscarinic Potentiation of GABAA Receptor Currents Is Gated by Insulin Signaling in the Prefrontal Cortex.
X.-H. Ma, P. Zhong, Z. Gu, J. Feng, and Z. Yan (2003)
J. Neurosci. 23, 1159-1168
   Abstract »    Full Text »    PDF »
Excitatory Amino Acid Receptors of the Electrosensory System: The NR1/NR2B N-Methyl-D-Aspartate Receptor.
E. Harvey-Girard and R. J. Dunn (2003)
J Neurophysiol 89, 822-832
   Abstract »    Full Text »    PDF »
A Site in the Fourth Membrane-associated Domain of the N-Methyl-D-aspartate Receptor Regulates Desensitization and Ion Channel Gating.
H. Ren, Y. Honse, B. J. Karp, R. H. Lipsky, and R. W. Peoples (2003)
J. Biol. Chem. 278, 276-283
   Abstract »    Full Text »    PDF »
Beyond Neurons: Evidence That Immune and Glial Cells Contribute to Pathological Pain States.
L. R. Watkins and S. F. Maier (2002)
Physiol Rev 82, 981-1011
   Abstract »    Full Text »    PDF »
Huntington's disease: A randomized, controlled trial using the NMDA-antagonist amantadine.
L. Verhagen Metman, M. J. Morris, C. Farmer, M. Gillespie, K. Mosby, J. Wuu, and T. N. Chase (2002)
Neurology 59, 694-699
   Abstract »    Full Text »    PDF »
N-terminal Tyrosine Residues within the Potassium Channel Kir3 Modulate GTPase Activity of Galpha i.
D. L. Ippolito, P. A. Temkin, S. L. Rogalski, and C. Chavkin (2002)
J. Biol. Chem. 277, 32692-32696
   Abstract »    Full Text »    PDF »
Receptor for Activated C Kinase-1 Facilitates Protein Kinase C-Dependent Phosphorylation and Functional Modulation of GABAA Receptors with the Activation of G-Protein-Coupled Receptors.
N. J. Brandon, J. N. Jovanovic, T. G. Smart, and S. J. Moss (2002)
J. Neurosci. 22, 6353-6361
   Abstract »    Full Text »    PDF »
Tyrosine Phosphorylation of the NR2B Subunit of the NMDA Receptor in the Spinal Cord during the Development and Maintenance of Inflammatory Hyperalgesia.
W. Guo, S. Zou, Y. Guan, T. Ikeda, M. Tal, R. Dubner, and K. Ren (2002)
J. Neurosci. 22, 6208-6217
   Abstract »    Full Text »    PDF »
Neurotrophin modulation of voltage-gated potassium channels in rat through TrkB receptors is time and sensory experience dependent.
K Tucker and D. Fadool (2002)
J. Physiol. 542, 413-429
   Abstract »    Full Text »    PDF »
Metabotropic Glutamate Receptor 1-Induced Upregulation of NMDA Receptor Current: Mediation through the Pyk2/Src-Family Kinase Pathway in Cortical Neurons.
V. Heidinger, P. Manzerra, X. Q. Wang, U. Strasser, S.-P. Yu, D. W. Choi, and M. M. Behrens (2002)
J. Neurosci. 22, 5452-5461
   Abstract »    Full Text »    PDF »
Striatal Enriched Phosphatase 61 Dephosphorylates Fyn at Phosphotyrosine 420.
T.-H. Nguyen, J. Liu, and P. J. Lombroso (2002)
J. Biol. Chem. 277, 24274-24279
   Abstract »    Full Text »    PDF »
NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1.
R. Yaka, C. Thornton, A. J. Vagts, K. Phamluong, A. Bonci, and D. Ron (2002)
PNAS 99, 5710-5715
   Abstract »    Full Text »    PDF »
Regulation of an ERG K+ Current by Src Tyrosine Kinase.
F. S. Cayabyab and L. C. Schlichter (2002)
J. Biol. Chem. 277, 13673-13681
   Abstract »    Full Text »    PDF »
Protein Kinase Modulation of a Neuronal Cation Channel Requires Protein-Protein Interactions Mediated by an Src homology 3 Domain.
N. S. Magoski, G. F. Wilson, and L. K. Kaczmarek (2002)
J. Neurosci. 22, 1-9
   Abstract »    Full Text »    PDF »
Human cervical cancer cells use Ca2+ signalling, protein tyrosine phosphorylation and MAP kinase in regulatory volume decrease.
M.-R. Shen, C.-Y. Chou, J. A Browning, R. J Wilkins, and J C. Ellory (2001)
J. Physiol. 537, 347-362
   Abstract »    Full Text »    PDF »
Central neural mechanisms mediating human visceral hypersensitivity.
S. Sarkar, A. R. Hobson, P. L. Furlong, C. J. Woolf, D. G. Thompson, and Q. Aziz (2001)
Am J Physiol Gastrointest Liver Physiol 281, G1196-G1202
   Abstract »    Full Text »    PDF »
Regulation of ion channels by protein tyrosine phosphorylation.
M. J. Davis, X. Wu, T. R. Nurkiewicz, J. Kawasaki, P. Gui, M. A. Hill, and E. Wilson (2001)
Am J Physiol Heart Circ Physiol 281, H1835-H1862
   Abstract »    Full Text »    PDF »
Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway.
R. Bi, M. R. Foy, R.-M. Vouimba, R. F. Thompson, and M. Baudry (2001)
PNAS
   Abstract »    Full Text »    PDF »
Effects of protein tyrosine kinase and protein tyrosine phosphatase on apical K+ channels in the TAL.
R.-M. Gu, Y. Wei, J. R. Falck, U. M. Krishna, and W.-H. Wang (2001)
Am J Physiol Cell Physiol 281, C1188-C1195
   Abstract »    Full Text »    PDF »
Regulation of NMDA receptors by cyclin-dependent kinase-5.
B.-S. Li, M.-K. Sun, L. Zhang, S. Takahashi, W. Ma, L. Vinade, A. B. Kulkarni, R. O. Brady, and H. C. Pant (2001)
PNAS
   Abstract »    Full Text »    PDF »
Modulation of Excitability in Aplysia Tail Sensory Neurons by Tyrosine Kinases.
A. L. Purcell and T. J. Carew (2001)
J Neurophysiol 85, 2398-2411
   Abstract »    Full Text »    PDF »
Src, Fyn, and Yes Are Not Required for Neuromuscular Synapse Formation But Are Necessary for Stabilization of Agrin-Induced Clusters of Acetylcholine Receptors.
C. L. Smith, P. Mittaud, E. D. Prescott, C. Fuhrer, and S. J. Burden (2001)
J. Neurosci. 21, 3151-3160
   Abstract »    Full Text »    PDF »
Cellular and Molecular Mechanisms of Estrogen Regulation of Memory Function and Neuroprotection Against Alzheimer's Disease: Recent Insights and Remaining Challenges.
R. D. Brinton (2001)
Learn. Mem. 8, 121-133
   Abstract »    Full Text »    PDF »
Hippocampal Synaptic Plasticity Involves Competition between Ca2+/Calmodulin-Dependent Protein Kinase II and Postsynaptic Density 95 for Binding to the NR2A Subunit of the NMDA Receptor.
F. Gardoni, L. H. Schrama, A. Kamal, W. H. Gispen, F. Cattabeni, and M. Di Luca (2001)
J. Neurosci. 21, 1501-1509
   Abstract »    Full Text »    PDF »
Tyrosine Decaging Leads to Substantial Membrane Trafficking during Modulation of an Inward Rectifier Potassium Channel.
Y. Tong, G. S. Brandt, M. Li, G. Shapovalov, E. Slimko, A. Karschin, D. A. Dougherty, and H. A. Lester (2001)
J. Gen. Physiol. 117, 103-118
   Abstract »    Full Text »    PDF »
Negative Control of Store-Operated Ca2+ Influx by B Cell Receptor Cross-Linking.
A. Hashimoto, K. Hirose, T. Kurosaki, and M. Iino (2001)
J. Immunol. 166, 1003-1008
   Abstract »    Full Text »    PDF »
Enhanced Phosphorylation of NMDA Receptor 1 Subunits in Spinal Cord Dorsal Horn and Spinothalamic Tract Neurons after Intradermal Injection of Capsaicin in Rats.
X. Zou, Q. Lin, and W. D. Willis (2000)
J. Neurosci. 20, 6989-6997
   Abstract »    Full Text »    PDF »
A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus.
P. P. Sanna, F. Berton, M. Cammalleri, M. K. Tallent, G. R. Siggins, F. E. Bloom, and W. Francesconi (2000)
PNAS
   Abstract »    Full Text »
Neuronal Plasticity: Increasing the Gain in Pain.
C. J. Woolf and M. W. Salter (2000)
Science 288, 1765-1768
   Abstract »    Full Text »    PDF »
Interactions of Cyclic Nucleotide-Gated Channel Subunits and Protein Tyrosine Kinase Probed with Genistein.
E. Molokanova, A. Savchenko, and R. H. Kramer (2000)
J. Gen. Physiol. 115, 685-696
   Abstract »    Full Text »    PDF »
AMPA receptor blockade improves levodopa-induced dyskinesia in MPTP monkeys.
S. Konitsiotis, P. J. Blanchet, L. Verhagen, E. Lamers, and T. N. Chase (2000)
Neurology 54, 1589-1595
   Abstract »    Full Text »    PDF »
Regulation of Long-Term Potentiation by H-Ras through NMDA Receptor Phosphorylation.
T. Manabe, A. Aiba, A. Yamada, T. Ichise, H. Sakagami, H. Kondo, and M. Katsuki (2000)
J. Neurosci. 20, 2504-2511
   Abstract »    Full Text »    PDF »
Brain Aging and Midlife Tofu Consumption.
L. R. White, H. Petrovitch, G. W. Ross, K. Masaki, J. Hardman, J. Nelson, D. Davis, and W. Markesbery (2000)
J. Am. Coll. Nutr. 19, 242-255
   Abstract »    Full Text »    PDF »
Alterations in Subunit Expression, Composition, and Phosphorylation of Striatal N-Methyl-D-Aspartate Glutamate Receptors in a Rat 6-Hydroxydopamine Model of Parkinson's Disease.
A. W. Dunah, Y. Wang, R. P. Yasuda, K. Kameyama, R. L. Huganir, B. B. Wolfe, and D. G. Standaert (2000)
Mol. Pharmacol. 57, 342-352
   Abstract »    Full Text »
Protein tyrosine kinase is required for the induction of long-term potentiation in the rat hippocampus.
C.-C. Huang and K.-S. Hsu (1999)
J. Physiol. 520, 783-796
   Abstract »    Full Text »    PDF »
Platelet-derived Growth Factor Receptor-induced Feed-forward Inhibition of Excitatory Transmission between Hippocampal Pyramidal Neurons.
S. Lei, W.-Y. Lu, Z.-G. Xiong, B. A. Orser, C. F. Valenzuela, and J. F. MacDonald (1999)
J. Biol. Chem. 274, 30617-30623
   Abstract »    Full Text »    PDF »
Neurotrophins: Peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity.
R. J. Mannion, M. Costigan, I. Decosterd, F. Amaya, Q.-P. Ma, J. C. Holstege, R.-R. Ji, A. Acheson, R. M. Lindsay, G. A. Wilkinson, et al. (1999)
PNAS 96, 9385-9390
   Abstract »    Full Text »    PDF »
Ret-dependent and -independent Mechanisms of Glial Cell Line-derived Neurotrophic Factor Signaling in Neuronal Cells.
M. Trupp, R. Scott, S. R. Whittemore, and C. F. Ibanez (1999)
J. Biol. Chem. 274, 20885-20894
   Abstract »    Full Text »    PDF »
Src, a molecular switch governing gain control of synaptic transmission mediated by N-methyl-D-aspartate receptors.
X.-M. Yu and M. W. Salter (1999)
PNAS 96, 7697-7704
   Abstract »    Full Text »    PDF »
Transcriptional and posttranslational plasticity and the generation of inflammatory pain.
C. J. Woolf and M. Costigan (1999)
PNAS 96, 7723-7730
   Abstract »    Full Text »    PDF »
Growth factor-mediated Fyn signaling regulates alpha -amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression in rodent neocortical neurons.
M. Narisawa-Saito, A. J. Silva, T. Yamaguchi, T. Hayashi, T. Yamamoto, and H. Nawa (1999)
PNAS 96, 2461-2466
   Abstract »    Full Text »    PDF »
The Glutamate Receptor Ion Channels.
R. Dingledine, K. Borges, D. Bowie, and S. F. Traynelis (1999)
Pharmacol. Rev. 51, 7-62
   Abstract »    Full Text »    PDF »
Reg1ulatory Role and Molecular Interactions of a Cell-Surface Heparan Sulfate Proteoglycan (N-syndecan) in Hippocampal Long-Term Potentiation.
S. E. Lauri, S. Kaukinen, T. Kinnunen, A. Ylinen, S. Imai, K. Kaila, T. Taira, and H. Rauvala (1999)
J. Neurosci. 19, 1226-1235
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)