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Science 17 January 1997:
Vol. 275. no. 5298, pp. 400 - 402
DOI: 10.1126/science.275.5298.400
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Reports

Reduced Ubiquitin-Dependent Degradation of c-Jun After Phosphorylation by MAP Kinases

Anna Maria Musti, * Mathias Treier, dagger Dirk Bohmann ddagger

The proto-oncogene-encoded transcription factor c-Jun activates genes in response to a number of inducers that act through mitogen-activated protein kinase (MAPK) signal transduction pathways. The activation of c-Jun after phosphorylation by MAPK is accompanied by a reduction in c-Jun ubiquitination and consequent stabilization of the protein. These results illustrate the relevance of regulated protein degradation in the signal-dependent control of gene expression.

European Molecular Biology Laboratory, Meyerhofstr. 1, 69117 Heidelberg, Germany.

*   On leave from Centro Endocrinologia ed Oncologia Sperimentale, CNR, Naples, Italy.

dagger    Present address: Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093-0648, USA.

ddagger    To whom correspondence should be addressed.

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T. P. Shanley, N. Vasi, A. Denenberg, and H. R. Wong (2001)
J. Immunol. 166, 966-972
   Abstract »    Full Text »    PDF »
Drosophila puckered regulates Fos/Jun levels during follicle cell morphogenesis.
L. Dobens, E Martin-Blanco, A Martinez-Arias, F. Kafatos, and L. Raftery (2001)
Development 128, 1845-1856
   Abstract »    PDF »
C-Jun Activation-Dependent Tumorigenic Transformation Induced Paradoxically by Overexpression or Block of S-Adenosylmethionine Decarboxylase.
A. Paasinen-Sohns, M. Kielosto, E. Kaariainen, T. Eloranta, A. Laine, O. A. Janne, M. J. Birrer, and E. Holtta (2000)
J. Cell Biol. 151, 801-810
   Abstract »    Full Text »    PDF »
Hypoxia Activates Jun-N-Terminal Kinase, Extracellular Signal-Regulated Protein Kinase, and p38 Kinase in Pulmonary Arteries.
N. Jin, N. Hatton, D. R. Swartz, X.-l. Xia, M. A. Harrington, S. H. Larsen, and R. A. Rhoades (2000)
Am. J. Respir. Cell Mol. Biol. 23, 593-601
   Abstract »    Full Text »
Herpes Simplex Virus Type 1 ICP0 Protein Does Not Accumulate in the Nucleus of Primary Neurons in Culture.
X.-P. Chen, J. Li, M. Mata, J. Goss, D. Wolfe, J. C. Glorioso, and D. J. Fink (2000)
J. Virol. 74, 10132-10141
   Abstract »    Full Text »    PDF »
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.
R. Sears, F. Nuckolls, E. Haura, Y. Taya, K. Tamai, and J. R. Nevins (2000)
Genes & Dev. 14, 2501-2514
   Abstract »    Full Text »
BCR-ABL Prevents c-Jun-Mediated and Proteasome-Dependent FUS (TLS) Proteolysis through a Protein Kinase Cbeta II-Dependent Pathway.
D. Perrotti, A. Iervolino, V. Cesi, M. Cirinna, S. Lombardini, E. Grassilli, S. Bonatti, P. P. Claudio, and B. Calabretta (2000)
Mol. Cell. Biol. 20, 6159-6169
   Abstract »    Full Text »    PDF »
Keratins Turn over by Ubiquitination in a Phosphorylation-Modulated Fashion.
N.-O. Ku and M. B. Omary (2000)
J. Cell Biol. 149, 547-552
   Abstract »    Full Text »    PDF »
c-Jun and p53 Activity Is Modulated by SUMO-1 Modification.
S. Muller, M. Berger, F. Lehembre, J.-S. Seeler, Y. Haupt, and A. Dejean (2000)
J. Biol. Chem. 275, 13321-13329
   Abstract »    Full Text »    PDF »
Stability of the ATF2 Transcription Factor Is Regulated by Phosphorylation and Dephosphorylation.
S. Y. Fuchs, I. Tappin, and Z.'e. Ronai (2000)
J. Biol. Chem. 275, 12560-12564
   Abstract »    Full Text »    PDF »
Connexin Expression and Turnover : Implications for Cardiac Excitability.
J. E. Saffitz, J. G. Laing, and K. A. Yamada (2000)
Circ. Res. 86, 723-728
   Abstract »    Full Text »    PDF »
Insulin-Like Growth Factor I-Induced Degradation of Insulin Receptor Substrate 1 Is Mediated by the 26S Proteasome and Blocked by Phosphatidylinositol 3'-Kinase Inhibition.
A. V. Lee, J. L. Gooch, S. Oesterreich, R. L. Guler, and D. Yee (2000)
Mol. Cell. Biol. 20, 1489-1496
   Abstract »    Full Text »    PDF »
Posttranslational Modification of Bcl-2 Facilitates Its Proteasome-Dependent Degradation: Molecular Characterization of the Involved Signaling Pathway.
K. Breitschopf, J. Haendeler, P. Malchow, A. M. Zeiher, and S. Dimmeler (2000)
Mol. Cell. Biol. 20, 1886-1896
   Abstract »    Full Text »    PDF »
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.
R. Ravi, B. Mookerjee, Z. M. Bhujwalla, C. H. Sutter, D. Artemov, Q. Zeng, L. E. Dillehay, A. Madan, G. L. Semenza, and A. Bedi (2000)
Genes & Dev. 14, 34-44
   Abstract »    Full Text »
Reduced MAP Kinase Phosphatase-1 Degradation After p42/p44MAPK-Dependent Phosphorylation.
J. Brondello, J. Pouysségur, and F. R. McKenzie (1999)
Science 286, 2514-2517
   Abstract »    Full Text »
Degradation of the Basic Helix-Loop-Helix/Per-ARNT-Sim Homology Domain Dioxin Receptor Via the Ubiquitin/Proteasome Pathway.
B. J. Roberts and M. L. Whitelaw (1999)
J. Biol. Chem. 274, 36351-36356
   Abstract »    Full Text »    PDF »
COP9 Signalosome-directed c-Jun Activation/Stabilization Is Independent of JNK.
M. Naumann, D. Bech-Otschir, X. Huang, K. Ferrell, and W. Dubiel (1999)
J. Biol. Chem. 274, 35297-35300
   Abstract »    Full Text »    PDF »
p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1alpha (HIF-1alpha ) and Enhance the Transcriptional Activity of HIF-1.
D. E. Richard, E. Berra, E. Gothie, D. Roux, and J. Pouyssegur (1999)
J. Biol. Chem. 274, 32631-32637
   Abstract »    Full Text »    PDF »
Characterization of the mUBC9-binding Sites Required for E2A Protein Degradation.
G. S. Huggins, M. T. Chin, N. E. S. Sibinga, S.-L. Lee, E. Haber, and M.-E. Lee (1999)
J. Biol. Chem. 274, 28690-28696
   Abstract »    Full Text »    PDF »
Signal Transduction by MAP Kinases: Regulation by Phosphorylation-Dependent Switches.
A. J. Whitmarsh and R. J. Davis (1999)
Sci. STKE 1999, pe1
   Abstract »    Full Text »    PDF »


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