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Science 17 January 1997:
Vol. 275. no. 5298, pp. 281 - 0
DOI: 10.1126/science.275.5298.281h
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Proteins that have been tagged in the cell by the protein ubiquitin are recognized and degraded. Musti et al. (p. 400) report that such regulated destruction contributes to the control of the activity of the transcription factor and proto-oncogene c-Jun. When the c-Jun protein is phosphorylated by mitogen-activated protein kinases, not only is its DNA binding and transcriptional activation enhanced but its ubiquitination is also inhibited. In this manner, the transcription of genes regulated by growth factors and other stimuli that activate c-Jun is enhanced by the reduced degradation of the transcription factor.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)