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Science 10 January 1997:
Vol. 275. no. 5297, pp. 209 - 213
DOI: 10.1126/science.275.5297.209
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Reports

A Synaptically Controlled, Associative Signal for Hebbian Plasticity in Hippocampal Neurons

Jeffrey C. Magee and Daniel Johnston

The role of back-propagating dendritic action potentials in the induction of long-term potentiation (LTP) was investigated in CA1 neurons by means of dendritic patch recordings and simultaneous calcium imaging. Pairing of subthreshold excitatory postsynaptic potentials (EPSPs) with back-propagating action potentials resulted in an amplification of dendritic action potentials and evoked calcium influx near the site of synaptic input. This pairing also induced a robust LTP, which was reduced when EPSPs were paired with non-back-propagating action potentials or when stimuli were unpaired. Action potentials thus provide a synaptically controlled, associative signal to the dendrites for Hebbian modifications of synaptic strength.

Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. E-mail: jmagee{at}ptp.bcm.tmc.edu

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