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Science 10 January 1997:
Vol. 275. no. 5297, pp. 203 - 206
DOI: 10.1126/science.275.5297.203
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Reports

Regulation of Cell Cycle Synchronization by decapentaplegic During Drosophila Eye Development

Andrea Penton, Scott B. Selleck, F. Michael Hoffmann *

In the developing Drosophila eye, differentiation is coordinated with synchronized progression through the cell cycle. Signaling mediated by the transforming growth factor-beta -related gene decapentaplegic (dpp) was required for the synchronization of the cell cycle but not for cell fate specification. DPP may affect cell cycle synchronization by promoting cell cycle progression through the G2-M phases. This synchronization is critical for the precise assembly of the eye.

A. Penton and F. M. Hoffmann, McArdle Laboratory for Cancer Research and Laboratory of Genetics, University of Wisconsin Medical School, Madison, WI 53706, USA.
S. B. Selleck, Arizona Research Laboratories Division of Neurobiology and Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721, USA.
*   To whom correspondence should be addressed.

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