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Science 3 January 1997:
Vol. 275. no. 5296, pp. 86 - 88
DOI: 10.1126/science.275.5296.86
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Reports

Interaction of the Thiol-Dependent Reductase ERp57 with Nascent Glycoproteins

Jason D. Oliver, Fimme J. van der Wal, Neil J. Bulleid, Stephen High *

Calnexin and calreticulin interact specifically with newly synthesized glycoproteins in the endoplasmic reticulum (ER) and function as molecular chaperones. The carbohydrate-specific interactions between ER components and glycoproteins synthesized in isolated canine pancreatic microsomes were analyzed using a cross-linking approach. A carbohydrate-dependent interaction between newly synthesized glycoproteins, the thiol-dependent reductase ERp57, and either calnexin or calreticulin was identified. The interaction between ERp57 and the newly synthesized glycoproteins required trimming of the N-linked oligosaccharide side chain. Thus, it is likely that ERp57 functions as part of the glycoprotein-specific quality control machinery operating in the lumen of the ER.

School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT, UK.
*   To whom correspondence should be addressed. E-mail: shigh{at}fs2.scg.man.ac.uk

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