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Science 3 January 1997:
Vol. 275. no. 5296, pp. 77 - 79
DOI: 10.1126/science.275.5296.77
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Reports

The Inverse Association Between Tuberculin Responses and Atopic Disorder

Taro Shirakawa, Tadao Enomoto, Shin-ichiro Shimazu, Julian M. Hopkin *

Human immune responses are heterogeneous and may involve antagonism between T helper (TH) lymphocyte subsets and their cytokines. Atopy is characterized by immediate immunoglobulin E (IgE)-mediated hypersensitivity to agents such as dust mites and pollen, and it underlies the increasingly prevalent disorder asthma. Among Japanese schoolchildren, there was a strong inverse association between delayed hypersensitivity to Mycobacterium tuberculosis and atopy. Positive tuberculin responses predicted a lower incidence of asthma, lower serum IgE levels, and cytokine profiles biased toward TH1 type. Exposure and response to M. tuberculosis may, by modification of immune profiles, inhibit atopic disorder.

T. Shirakawa and J. M. Hopkin, Lung Research Laboratory, Osler Chest Unit, Churchill Hospital, Oxford OX3 7LJ, UK.
T. Enomoto, Department of Otolaryngology, Japanese Red Cross Society, Wakayama Medical Center, Wakayama, Japan.
S. Shimazu, Department of Pediatrics, National Waka-yama Hospital, Wakayama, Japan.
*   To whom correspondence should be addressed. E-mail: jhopkin{at}immsvr.jr2.ox.ac.uk

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IL-18 Gene Transfer by Adenovirus Prevents the Development of and Reverses Established Allergen-Induced Airway Hyperreactivity.
D. M. Walter, C. P. Wong, R. H. DeKruyff, G. J. Berry, S. Levy, and D. T. Umetsu (2001)
J. Immunol. 166, 6392-6398
   Abstract »    Full Text »    PDF »
The Effect of Delipidated Deglycolipidated (DDMV) and Heat-killed Mycobacterium vaccae in Asthma.
P. M. SHIRTCLIFFE, S. E. EASTHOPE, S. CHENG, M. WEATHERALL, P. L. J. TAN, G. LE GROS, and R. BEASLEY (2001)
Am. J. Respir. Crit. Care Med. 163, 1410-1414
   Abstract »    Full Text »
Modulation of Inhaled Antigen-Induced IgE Tolerance by Ongoing Th2 Responses in the Lung.
S. D. Hurst, B. W. P. Seymour, T. Muchamuel, V. P. Kurup, and R. L. Coffman (2001)
J. Immunol. 166, 4922-4930
   Abstract »    Full Text »    PDF »
Allergy markers in respiratory epidemiology.
S. Baldacci, E. Omenaas, and M.P. Oryszczyn (2001)
Eur. Respir. J. 17, 773-790
   Abstract »    Full Text »    PDF »
Prenatal risk factors of wheezing at the age of four years in Tanzania.
J Sunyer, C Mendendez, P J Ventura, J J Aponte, D Schellenberg, E Kahigwa, C Acosta, J M Antó, and P L Alonso (2001)
Thorax 56, 290-295
   Abstract »    Full Text »
Interference between Host Resistance to Listeria monocytogenes Infection and Ovalbumin-Induced Allergic Responses in Mice.
D. Mizuki, T. Miura, S. Sasaki, M. Mizuki, H. Madarame, and A. Nakane (2001)
Infect. Immun. 69, 1883-1888
   Abstract »    Full Text »    PDF »
Delayed Hypersensitivity to Tuberculin, Total Immunoglobulin E, Specific Sensitization, and Atopic Manifestation in Longitudinally Followed Early Bacille Calmette-Guerin-Vaccinated and Nonvaccinated Children.
C. Grüber, M. Kulig, R. Bergmann, I. Guggenmoos-Holzmann, U. Wahn, and the MAS-90 Study Group (2001)
Pediatrics 107, 36e-36
   Abstract »    Full Text »
Asthma.
W. W. Busse and R. F. Lemanske (2001)
N. Engl. J. Med. 344, 350-362
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