Science 20 December 1996: Vol. 274. no. 5295, pp. 2086 - 2089 DOI: 10.1126/science.274.5295.2086

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Endosomes: A legitimate platform for the signaling train.

J. E. Murphy, B. E. Padilla, B. Hasdemir, G. S. Cottrell, and N. W. Bunnett (2009)
PNAS 106, 17615-17622
 |  Abstract »  |  Full Text »  |  PDF »

Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling.

F. K. Mardakheh, M. Yekezare, L. M. Machesky, and J. K. Heath (2009)
J. Cell Biol. 187, 265-277
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TAK1-Mediated Serine/Threonine Phosphorylation of Epidermal Growth Factor Receptor via p38/Extracellular Signal-Regulated Kinase: NF-{kappa}B-Independent Survival Pathways in Tumor Necrosis Factor Alpha Signaling.

M. Nishimura, M.-S. Shin, P. Singhirunnusorn, S. Suzuki, M. Kawanishi, K. Koizumi, I. Saiki, and H. Sakurai (2009)
Mol. Cell. Biol. 29, 5529-5539
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Cell Proliferation and Epidermal Growth Factor Signaling in Non-small Cell Lung Adenocarcinoma Cell Lines Are Dependent on Rin1.

J. C. Tomshine, S. R. Severson, D. A. Wigle, Z. Sun, D. A. T. Beleford, V. Shridhar, and B. F. Horazdovsky (2009)
J. Biol. Chem. 284, 26331-26339
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B Cell Antigen Receptor Endocytosis and Antigen Presentation to T Cells Require Vav and Dynamin.

S. Malhotra, S. Kovats, W. Zhang, and K. M. Coggeshall (2009)
J. Biol. Chem. 284, 24088-24097
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{beta}-Arrestin Mediates {beta}1-Adrenergic Receptor-Epidermal Growth Factor Receptor Interaction and Downstream Signaling.

D. G. Tilley, I.-M. Kim, P. A. Patel, J. D. Violin, and H. A. Rockman (2009)
J. Biol. Chem. 284, 20375-20386
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Rab GTPase Regulation of VEGFR2 Trafficking and Signaling in Endothelial Cells.

H. M. Jopling, A. F. Odell, N. M. Hooper, I. C. Zachary, J. H. Walker, and S. Ponnambalam (2009)
Arterioscler Thromb Vasc Biol 29, 1119-1124
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Systems Biological Analysis of Epidermal Growth Factor Receptor Internalization Dynamics for Altered Receptor Levels.

H. Schmidt-Glenewinkel, E. Reinz, R. Eils, and N. R. Brady (2009)
J. Biol. Chem. 284, 17243-17252
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Knockdown of GnT-Va expression inhibits ligand-induced downregulation of the epidermal growth factor receptor and intracellular signaling by inhibiting receptor endocytosis.

H.-B. Guo, H. Johnson, M. Randolph, I. Lee, and M. Pierce (2009)
Glycobiology 19, 547-559
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Rab7 Regulates Late Endocytic Trafficking Downstream of Multivesicular Body Biogenesis and Cargo Sequestration.

P. A. Vanlandingham and B. P. Ceresa (2009)
J. Biol. Chem. 284, 12110-12124
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Epidermal Growth Factor Receptor 1 (EGFR1) and Its Variant EGFRvIII Regulate TATA-Binding Protein Expression through Distinct Pathways.

J. A. Fromm, S. A. S. Johnson, and D. L. Johnson (2008)
Mol. Cell. Biol. 28, 6483-6495
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A comparative cell biological analysis reveals only limited functional homology between the NS5A proteins of hepatitis C virus and GB virus B.

J. Mankouri, A. Milward, K. R. Pryde, L. Warter, A. Martin, and M. Harris (2008)
J. Gen. Virol. 89, 1911-1920
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Critical Role for Endocytosis in the Regulation of Signaling by the Kaposi's Sarcoma-Associated Herpesvirus K1 Protein.

C. C. Tomlinson and B. Damania (2008)
J. Virol. 82, 6514-6523
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EGF Transregulates Opioid Receptors through EGFR-mediated GRK2 Phosphorylation and Activation.

Y. Chen, H. Long, Z. Wu, X. Jiang, and L. Ma (2008)
Mol. Biol. Cell 19, 2973-2983
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Endocytosis of Prion Protein Is Required for ERK1/2 Signaling Induced by Stress-Inducible Protein 1.

F. A. Caetano, M. H. Lopes, G. N. M. Hajj, C. F. Machado, C. Pinto Arantes, A. C. Magalhaes, M. D. P. B. Vieira, T. A. Americo, A. R. Massensini, S. A. Priola, et al. (2008)
J. Neurosci. 28, 6691-6702
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eena Promotes Myeloid Proliferation through Stimulating ERK1/2 Phosphorylation in Zebrafish.

H.-Y. Le, Y. Zhang, H. Liu, L.-H. Ma, Y. Jin, Q.-H. Huang, Y. Chen, M. Deng, Z. Chen, S.-J. Chen, et al. (2008)
J. Biol. Chem. 283, 17652-17661
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The Relative Distribution of Membranous and Cytoplasmic Met Is a Prognostic Indicator in Stage I and II Colon Cancer.

F. Ginty, S. Adak, A. Can, M. Gerdes, M. Larsen, H. Cline, R. Filkins, Z. Pang, Q. Li, and M. C. Montalto (2008)
Clin. Cancer Res. 14, 3814-3822
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Disrupted RabGAP Function of the p85 Subunit of Phosphatidylinositol 3-Kinase Results in Cell Transformation.

M. D. Chamberlain, T. Chan, J. C. Oberg, A. D. Hawrysh, K. M. James, A. Saxena, J. Xiang, and D. H. Anderson (2008)
J. Biol. Chem. 283, 15861-15868
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Regulation of clathrin-mediated endocytosis by p53..

Y. Endo, A. Sugiyama, S.-A. Li, K. Ohmori, H. Ohata, Y. Yoshida, M. Shibuya, K. Takei, M. Enari, and Y. Taya (2008)
Genes Cells 13, 375-386
 |  Abstract »  |  Full Text »  |  PDF »

Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.

M. Sundvall, A. Korhonen, I. Paatero, E. Gaudio, G. Melino, C. M. Croce, R. I. Aqeilan, and K. Elenius (2008)
PNAS 105, 4162-4167
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Insulin-Like Growth Factor Type-I Receptor-Dependent Phosphorylation of Extracellular Signal-Regulated Kinase 1/2 but not Akt (Protein Kinase B) Can Be Induced by Picropodophyllin.

R. Vasilcanu, D. Vasilcanu, B. Sehat, S. Yin, A. Girnita, M. Axelson, and L. Girnita (2008)
Mol. Pharmacol. 73, 930-939
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Muscle-Specific Receptor Tyrosine Kinase Endocytosis in Acetylcholine Receptor Clustering in Response to Agrin.

D. Zhu, Z. Yang, Z. Luo, S. Luo, W. C. Xiong, and L. Mei (2008)
J. Neurosci. 28, 1688-1696
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Clustering of Genetically Defined Allele Classes in the Caenorhabditis elegans DAF-2 Insulin/IGF-1 Receptor.

D. S. Patel, A. Garza-Garcia, M. Nanji, J. J. McElwee, D. Ackerman, P. C. Driscoll, and D. Gems (2008)
Genetics 178, 931-946
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NCAM is ubiquitylated, endocytosed and recycled in neurons.

S. Diestel, D. Schaefer, H. Cremer, and B. Schmitz (2007)
J. Cell Sci. 120, 4035-4049
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Insulin-like Growth Factor Type-I Receptor Internalization and Recycling Mediate the Sustained Phosphorylation of Akt.

R. J. Romanelli, A. P. LeBeau, C. G. Fulmer, D. A. Lazzarino, A. Hochberg, and T. L. Wood (2007)
J. Biol. Chem. 282, 22513-22524
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Trk-signaling endosomes are generated by Rac-dependent macroendocytosis.

G. Valdez, P. Philippidou, J. Rosenbaum, W. Akmentin, Y. Shao, and S. Halegoua (2007)
PNAS 104, 12270-12275
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GAPex-5 Mediates Ubiquitination, Trafficking, and Degradation of Epidermal Growth Factor Receptor.

X. Su, C. Kong, and P. D. Stahl (2007)
J. Biol. Chem. 282, 21278-21284
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Signaling from plant endosomes: compartments with something to say!.

N. Raikhel and G. Hicks (2007)
Genes & Dev. 21, 1578-1580
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Endosomal signaling of plant steroid receptor kinase BRI1.

N. Geldner, D. L. Hyman, X. Wang, K. Schumacher, and J. Chory (2007)
Genes & Dev. 21, 1598-1602
 |  Abstract »  |  Full Text »  |  PDF »

Screening of differentially expressed transcripts in infectious bursal disease virus-induced apoptotic chicken embryonic fibroblasts by using cDNA microarrays.

R. T.-Y. Wong, C.-C. Hon, F. Zeng, and F. C.-C. Leung (2007)
J. Gen. Virol. 88, 1785-1796
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The Membrane-proximal Portion of CD3 {epsilon} Associates with the Serine/Threonine Kinase GRK2.

L. M. DeFord-Watts, J. A. Young, L. A. Pitcher, and N. S. C. van Oers (2007)
J. Biol. Chem. 282, 16126-16134
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Receptor-mediated Endocytosis Involves Tyrosine Phosphorylation of Cortactin.

J. Zhu, D. Yu, X.-C. Zeng, K. Zhou, and X. Zhan (2007)
J. Biol. Chem. 282, 16086-16094
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The role played by endocytosis in albumin-induced secretion of TGF-beta1 by proximal tubular epithelial cells.

R. Diwakar, A. L. Pearson, P. Colville-Nash, N. J. Brunskill, and M. E. C. Dockrell (2007)
Am J Physiol Renal Physiol 292, F1464-F1470
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Epidermal Growth Factor Directs Sex-specific Steroid Signaling through Src Activation.

T. Hitosugi, K. Sasaki, M. Sato, Y. Suzuki, and Y. Umezawa (2007)
J. Biol. Chem. 282, 10697-10706
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SEL-2, the C. elegans neurobeachin/LRBA homolog, is a negative regulator of lin-12/Notch activity and affects endosomal traffic in polarized epithelial cells.

N. de Souza, L. G. Vallier, H. Fares, and I. Greenwald (2007)
Development 134, 691-702
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Altered endocytosis of epidermal growth factor receptor in androgen receptor positive prostate cancer cell lines.

L. Bonaccorsi, D. Nosi, M. Muratori, L. Formigli, G. Forti, and E. Baldi (2007)
J. Mol. Endocrinol. 38, 51-66
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GIPC Is Recruited by APPL to Peripheral TrkA Endosomes and Regulates TrkA Trafficking and Signaling.

T. Varsano, M.-Q. Dong, I. Niesman, H. Gacula, X. Lou, T. Ma, J. R. Testa, J. R. Yates III, and M. G. Farquhar (2006)
Mol. Cell. Biol. 26, 8942-8952
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The Fps/Fes kinase regulates the inflammatory response to endotoxin through down-regulation of TLR4, NF-{kappa}B activation, and TNF-{alpha} secretion in macrophages.

S. A. Parsons and P. A. Greer (2006)
J. Leukoc. Biol. 80, 1522-1528
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Sorting Nexin 1 Down-Regulation Promotes Colon Tumorigenesis.

L. N. Nguyen, M. S. Holdren, A. P. Nguyen, M. H. Furuya, M. Bianchini, E. Levy, J. Mordoh, A. Liu, G. D. Guncay, J. S. Campbell, et al. (2006)
Clin. Cancer Res. 12, 6952-6959
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TIRC7 Inhibits T Cell Proliferation by Modulation of CTLA-4 Expression.

G.-C. Bulwin, T. Heinemann, V. Bugge, M. Winter, A. Lohan, M. Schlawinsky, A. Schulze, S. Walter, R. Sabat, R. Schulein, et al. (2006)
J. Immunol. 177, 6833-6841
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Intersectin Regulates Epidermal Growth Factor Receptor Endocytosis, Ubiquitylation, and Signaling.

N. P. Martin, R. P. Mohney, S. Dunn, M. Das, E. Scappini, and J. P. O'Bryan (2006)
Mol. Pharmacol. 70, 1643-1653
 |  Abstract »  |  Full Text »  |  PDF »

Abl Tyrosine Kinase Regulates Endocytosis of the Epidermal Growth Factor Receptor.

B. Tanos and A. M. Pendergast (2006)
J. Biol. Chem. 281, 32714-32723
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Stat-mediated Signaling Induced by Type I and Type II Interferons (IFNs) Is Differentially Controlled through Lipid Microdomain Association and Clathrin-dependent Endocytosis of IFN Receptors.

M. Marchetti, M.-N. Monier, A. Fradagrada, K. Mitchell, F. Baychelier, P. Eid, L. Johannes, and C. Lamaze (2006)
Mol. Biol. Cell 17, 2896-2909
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The ESCRT-III Subunit hVps24 Is Required for Degradation but Not Silencing of the Epidermal Growth Factor Receptor.

K. G. Bache, S. Stuffers, L. Malerod, T. Slagsvold, C. Raiborg, D. Lechardeur, S. Walchli, G. L. Lukacs, A. Brech, and H. Stenmark (2006)
Mol. Biol. Cell 17, 2513-2523
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Differential Regulation of Interleukin 5-stimulated Signaling Pathways by Dynamin.

M. M. Gorska, O. Cen, Q. Liang, S. J. Stafford, and R. Alam (2006)
J. Biol. Chem. 281, 14429-14439
 |  Abstract »  |  Full Text »  |  PDF »

The Adaptor Protein soc-1/Gab1 Modifies Growth Factor Receptor Output in Caenorhabditis elegans.

N. A. Hopper (2006)
Genetics 173, 163-175
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RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells..

J. Kalesnikoff, E. J. Rios, C.-C. Chen, S. Nakae, B. A. Zabel, E. C. Butcher, M. Tsai, S.-Y. Tam, and S. J. Galli (2006)
PNAS 103, 2659-2664
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Internalization and Desensitization of the Oxytocin Receptor Is Inhibited by Dynamin and Clathrin Mutants in Human Embryonic Kidney 293 Cells.

M. P. Smith, V. J. Ayad, S. J. Mundell, C. A. McArdle, E. Kelly, and A. Lopez Bernal (2006)
Mol. Endocrinol. 20, 379-388
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Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis.

K. Tsujita, S. Suetsugu, N. Sasaki, M. Furutani, T. Oikawa, and T. Takenawa (2006)
J. Cell Biol. 172, 269-279
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rab7 Activity Affects Epidermal Growth Factor:Epidermal Growth Factor Receptor Degradation by Regulating Endocytic Trafficking from the Late Endosome.

B. P. Ceresa and S. J. Bahr (2006)
J. Biol. Chem. 281, 1099-1106
 |  Abstract »  |  Full Text »  |  PDF »

The Small GTPase Rab7 Controls the Endosomal Trafficking and Neuritogenic Signaling of the Nerve Growth Factor Receptor TrkA.

S. Saxena, C. Bucci, J. Weis, and A. Kruttgen (2005)
J. Neurosci. 25, 10930-10940
 |  Abstract »  |  Full Text »  |  PDF »

Initial entry of IRAP into the insulin-responsive storage compartment occurs prior to basal or insulin-stimulated plasma membrane recycling.

G. Liu, J. C. Hou, R. T. Watson, and J. E. Pessin (2005)
Am J Physiol Endocrinol Metab 289, E746-E752
 |  Abstract »  |  Full Text »  |  PDF »

Rho mediates endocytosis of epidermal growth factor receptor through phosphorylation of endophilin A1 by Rho-kinase.

T. Kaneko, A. Maeda, M. Takefuji, H. Aoyama, M. Nakayama, S. Kawabata, Y. Kawano, A. Iwamatsu, M. Amano, and K. Kaibuchi (2005)
Genes Cells 10, 973-987
 |  Abstract »  |  Full Text »  |  PDF »

Heterotrimeric G Protein-independent Signaling of a G Protein-coupled Receptor: DIRECT BINDING OF ARNO/CYTOHESIN-2 TO THE CARBOXYL TERMINUS OF THE A2A ADENOSINE RECEPTOR IS NECESSARY FOR SUSTAINED ACTIVATION OF THE ERK/MAP KINASE PATHWAY.

I. Gsandtner, C. Charalambous, E. Stefan, E. Ogris, M. Freissmuth, and J. Zezula (2005)
J. Biol. Chem. 280, 31898-31905
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Internalization of gonadotropin-releasing hormone receptors (GnRHRs): does arrestin binding to the C-terminal tail target GnRHRs for dynamin-dependent internalization?.

J. N Hislop, C. J Caunt, K. R Sedgley, E. Kelly, S. Mundell, L. D Green, and C. A McArdle (2005)
J. Mol. Endocrinol. 35, 177-189
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Cationic cell-penetrating peptides interfere with TNF signalling by induction of TNF receptor internalization.

M. Fotin-Mleczek, S. Welte, O. Mader, F. Duchardt, R. Fischer, H. Hufnagel, P. Scheurich, and R. Brock (2005)
J. Cell Sci. 118, 3339-3351
 |  Abstract »  |  Full Text »  |  PDF »

Autocrine, Mitogenic Pheromone Receptor Loop of the Ciliate Euplotes raikovi: Pheromone-Induced Receptor Internalization.

A. Vallesi, P. Ballarini, B. Di Pretoro, C. Alimenti, C. Miceli, and P. Luporini (2005)
Eukaryot. Cell 4, 1221-1227
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Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain.

B. L. Lua and B. C. Low (2005)
J. Cell Sci. 118, 2707-2721
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Evidence That Dystroglycan Is Associated with Dynamin and Regulates Endocytosis.

Y. Zhan, M. R. Tremblay, N. Melian, and S. Carbonetto (2005)
J. Biol. Chem. 280, 18015-18024
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PGE2-induced hypertrophy of cardiac myocytes involves EP4 receptor-dependent activation of p42/44 MAPK and EGFR transactivation.

M. Mendez and M. C. LaPointe (2005)
Am J Physiol Heart Circ Physiol 288, H2111-H2117
 |  Abstract »  |  Full Text »  |  PDF »

Plasticity of B Cell Receptor Internalization upon Conditional Depletion of Clathrin.

A. Stoddart, A. P. Jackson, and F. M. Brodsky (2005)
Mol. Biol. Cell 16, 2339-2348
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Cortactin Overexpression Inhibits Ligand-Induced Down-regulation of the Epidermal Growth Factor Receptor.

P. Timpson, D. K. Lynch, D. Schramek, F. Walker, and R. J. Daly (2005)
Cancer Res. 65, 3273-3280
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Sensitivity, principal component and flux analysis applied to signal transduction: the case of epidermal growth factor mediated signaling.

G. Liu, M. T. Swihart, and S. Neelamegham (2005)
Bioinformatics 21, 1194-1202
 |  Abstract »  |  Full Text »  |  PDF »

Parathyroid Hormone Receptor Trafficking Contributes to the Activation of Extracellular Signal-regulated Kinases but Is Not Required for Regulation of cAMP Signaling.

C. A. Syme, P. A. Friedman, and A. Bisello (2005)
J. Biol. Chem. 280, 11281-11288
 |  Abstract »  |  Full Text »  |  PDF »

Contribution of Phospholipase D in Endothelin-1-Mediated Extracellular Signal-Regulated Kinase Activation and Proliferation in Rat Uterine Leiomyoma Cells.

P. Robin, S. Chouayekh, C. Bole-Feysot, D. Leiber, and Z. Tanfin (2005)
Biol Reprod 72, 69-77
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Apc Deficiency Is Associated with Increased Egfr Activity in the Intestinal Enterocytes and Adenomas of C57BL/6J-Min/+ Mice.

A. E. Moran, D. H. Hunt, S. H. Javid, M. Redston, A. M. Carothers, and M. M. Bertagnolli (2004)
J. Biol. Chem. 279, 43261-43272
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{alpha}-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Subtype Glutamate Receptor (AMPAR) Endocytosis Is Essential for N-Methyl-D-aspartate-induced Neuronal Apoptosis.

Y. Wang, W. Ju, L. Liu, S. Fam, S. D'Souza, C. Taghibiglou, M. Salter, and Y. T. Wang (2004)
J. Biol. Chem. 279, 41267-41270
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Functional Genomics of Lung Disease.

J. A. Whitsett, C. J. Bachurski, K. C. Barnes, P. A. Bunn Jr., L. M. Case, D. N. Cook, D. Crooks, M. W. Duncan, L. Dwyer-Nield, R. C. Elston, et al. (2004)
Am. J. Respir. Cell Mol. Biol. 31, S1-S81
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Regulation of Gonadotropin-Releasing Hormone Receptors by Protein Kinase C: Inside Out Signalling and Evidence for Multiple Active Conformations.

C. J. Caunt, J. N. Hislop, E. Kelly, A.-L. Matharu, L. D. Green, K. R. Sedgley, A. R. Finch, and C. A. McArdle (2004)
Endocrinology 145, 3594-3602
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase C-{gamma}1 is a guanine nucleotide exchange factor for dynamin-1 and enhances dynamin-1-dependent epidermal growth factor receptor endocytosis.

J. H. Choi, J. B. Park, S. S. Bae, S. Yun, H. S. Kim, W.-P. Hong, I.-S. Kim, J. H. Kim, M. Y. Han, S. H. Ryu, et al. (2004)
J. Cell Sci. 117, 3785-3795
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The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling.

L. Zhang, O. Gjoerup, and T. M. Roberts (2004)
PNAS 101, 10296-10301
 |  Abstract »  |  Full Text »  |  PDF »

Comparative Studies of Molecular Mechanisms of Dopamine D2 and D3 Receptors for the Activation of Extracellular Signal-regulated Kinase.

S. Beom, D. Cheong, G. Torres, M. G. Caron, and K.-M. Kim (2004)
J. Biol. Chem. 279, 28304-28314
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Phospholipase D Elevates the Level of MDM2 and Suppresses DNA Damage-Induced Increases in p53.

L. Hui, T. Abbas, R. M. Pielak, T. Joseph, J. Bargonetti, and D. A. Foster (2004)
Mol. Cell. Biol. 24, 5677-5686
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Fibroblast growth factor 2 endocytosis in endothelial cells proceed via syndecan-4-dependent activation of Rac1 and a Cdc42-dependent macropinocytic pathway.

E. Tkachenko, E. Lutgens, R.-V. Stan, and M. Simons (2004)
J. Cell Sci. 117, 3189-3199
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HIP1 and HIP1r Stabilize Receptor Tyrosine Kinases and Bind 3-Phosphoinositides via Epsin N-terminal Homology Domains.

T. S. Hyun, D. S. Rao, D. Saint-Dic, L. E. Michael, P. D. Kumar, S. V. Bradley, I. F. Mizukami, K. I. Oravecz-Wilson, and T. S. Ross (2004)
J. Biol. Chem. 279, 14294-14306
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Sorting of Ligand-activated Epidermal Growth Factor Receptor to Lysosomes Requires Its Actin-binding Domain.

W. Stoorvogel, S. Kerstens, I. Fritzsche, J. C. d. Hartigh, R. Oud, M. A. G. van der Heyden, J. Voortman, and P. M. P. van Bergen en Henegouwen (2004)
J. Biol. Chem. 279, 11562-11569
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Calcium-sensing Receptor-mediated ERK1/2 Activation Requires G{alpha}i2 Coupling and Dynamin-independent Receptor Internalization.

D. M. Holstein, K. A. Berg, L. M. F. Leeb-Lundberg, M. S. Olson, and C. Saunders (2004)
J. Biol. Chem. 279, 10060-10069
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Regulation of Internalization and Mitogen-Activated Protein Kinase Activation by Two Isoforms of the Dopamine D2 Receptor.

S. J. Kim, M. Y. Kim, E. J. Lee, Y. S. Ahn, and J.-H. Baik (2004)
Mol. Endocrinol. 18, 640-652
 |  Abstract »  |  Full Text »  |  PDF »

Platelet-derived Growth Factor Receptor-mediated Signal Transduction from Endosomes.

Y. Wang, S. D. Pennock, X. Chen, A. Kazlauskas, and Z. Wang (2004)
J. Biol. Chem. 279, 8038-8046
 |  Abstract »  |  Full Text »  |  PDF »

Antibodies Directed against Lewis-Y Antigen Inhibit Signaling of Lewis-Y Modified ErbB Receptors.

M. Klinger, H. Farhan, H. Just, H. Drobny, G. Himmler, H. Loibner, G. C. Mudde, M. Freissmuth, and V. Sexl (2004)
Cancer Res. 64, 1087-1093
 |  Abstract »  |  Full Text »  |  PDF »

Estrogen-Induced {micro}-Opioid Receptor Internalization in the Medial Preoptic Nucleus Is Mediated via Neuropeptide Y-Y1 Receptor Activation in the Arcuate Nucleus of Female Rats.

R. H. Mills, R. K. Sohn, and P. E Micevych (2004)
J. Neurosci. 24, 947-955
 |  Abstract »  |  Full Text »  |  PDF »

Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development.

V. Dammai, B. Adryan, K. R. Lavenburg, and T. Hsu (2003)
Genes & Dev. 17, 2812-2824
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Insulin Analog With Unique Properties: LysB3,GluB29 Insulin Induces Prominent Activation of Insulin Receptor Substrate 2, but Marginal Phosphorylation of Insulin Receptor Substrate 1.

I. Rakatzi, S. Ramrath, D. Ledwig, O. Dransfeld, T. Bartels, G. Seipke, and J. Eckel (2003)
Diabetes 52, 2227-2238
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase D in Cell Proliferation and Cancer.

D. A. Foster and L. Xu (2003)
Mol. Cancer Res. 1, 789-800
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of Cell Proliferation by Endosomal Epidermal Growth Factor Receptor As Revealed through Two Distinct Phases of Signaling.

S. Pennock and Z. Wang (2003)
Mol. Cell. Biol. 23, 5803-5815
 |  Abstract »  |  Full Text »  |  PDF »

Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis.

L. Duan, Y. Miura, M. Dimri, B. Majumder, I. L. Dodge, A. L. Reddi, A. Ghosh, N. Fernandes, P. Zhou, K. Mullane-Robinson, et al. (2003)
J. Biol. Chem. 278, 28950-28960
 |  Abstract »  |  Full Text »  |  PDF »

Internalization of the thrombopoietin receptor is regulated by 2 cytoplasmic motifs.

D. D. Dahlen, V. C. Broudy, and J. G. Drachman (2003)
Blood 102, 102-108
 |  Abstract »  |  Full Text »  |  PDF »

Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors.

B. N Kholodenko (2003)
J. Exp. Biol. 206, 2073-2082
 |  Abstract »  |  Full Text »  |  PDF »

Rat mammary carcinogenesis induced by in situ expression of constitutive Raf kinase activity is prevented by tethering Raf to the plasma membrane.

D. R. McFarlin and M. N. Gould (2003)
Carcinogenesis 24, 1149-1153
 |  Abstract »  |  Full Text »  |  PDF »

How does an axon grow?.

J. L. Goldberg (2003)
Genes & Dev. 17, 941-958
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Endosomal Dynamics of Met Determine Signaling Output.

D. E. Hammond, S. Carter, J. McCullough, S. Urbe, G. Vande Woude, and M. J. Clague (2003)
Mol. Biol. Cell 14, 1346-1354
 |  Abstract »  |  Full Text »  |  PDF »

A Dynamin-Cortactin-Arp2/3 Complex Mediates Actin Reorganization in Growth Factor-stimulated Cells.

E. W. Krueger, J. D. Orth, H. Cao, and M. A. McNiven (2003)
Mol. Biol. Cell 14, 1085-1096
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Receptor Tyrosine Kinase Signaling by Protein Tyrosine Phosphatase-1B.

F. G. Haj, B. Markova, L. D. Klaman, F. D. Bohmer, and B. G. Neel (2003)
J. Biol. Chem. 278, 739-744
 |  Abstract »  |  Full Text »  |  PDF »

Increased Expression of Epidermal Growth Factor Receptor Induces Sequestration of Extracellular Signal-Related Kinases and Selective Attenuation of Specific Epidermal Growth Factor-Mediated Signal Transduction Pathways.

A. A. Habib, S. J. Chun, B. G. Neel, and T. Vartanian (2003)
Mol. Cancer Res. 1, 219-233
 |  Abstract »  |  Full Text »

Internalization of Inactive EGF Receptor into Endosomes and the Subsequent Activation of Endosome-Associated EGF Receptors.

Y. Wang, S. Pennock, X. Chen, and Z. Wang (2002)
Sci. STKE 2002, pl17
 |  Abstract »  |  Full Text »  |  PDF »

Neuronal Leucine-rich Repeat Protein-3 Amplifies MAPK Activation by Epidermal Growth Factor through a Carboxyl-terminal Region Containing Endocytosis Motifs.

K. Fukamachi, Y. Matsuoka, H. Ohno, T. Hamaguchi, and H. Tsuda (2002)
J. Biol. Chem. 277, 43549-43552
 |  Abstract »  |  Full Text »  |  PDF »

HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.

R. R. Singaraja, S. Hadano, M. Metzler, S. Givan, C. L. Wellington, S. Warby, A. Yanai, C.-A. Gutekunst, B. R. Leavitt, H. Yi, et al. (2002)
Hum. Mol. Genet. 11, 2815-2828
 |  Abstract »  |  Full Text »  |  PDF »

Endosomal Signaling of Epidermal Growth Factor Receptor Stimulates Signal Transduction Pathways Leading to Cell Survival.

Y. Wang, S. Pennock, X. Chen, and Z. Wang (2002)
Mol. Cell. Biol. 22, 7279-7290
 |  Abstract »  |  Full Text »  |  PDF »

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