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Science 20 December 1996:
Vol. 274. no. 5295, pp. 2054 - 2057
DOI: 10.1126/science.274.5295.2054
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Reports

Late Complications of Immune Deviation Therapy in a Nonhuman Primate

Claude P. Genain, * Kristina Abel, Nicole Belmar, François Villinger, Daniel P. Rosenberg, Christopher Linington, Cedric S. Raine, Stephen L. Hauser

The administration of antigens in soluble form can induce antigen-specific immune tolerance and suppress experimental autoimmune diseases. In a marmoset model of multiple sclerosis induced by myelin oligodendrocyte glycoprotein (MOG), marmosets tolerized to MOG were protected against acute disease, but after tolerization treatment a lethal demyelinating disorder emerged. In these animals, MOG-specific T cell proliferative responses were transiently suppressed, cytokine production was shifted from a T helper type 1 (TH1) to a TH2 pattern, and titers of autoantibodies to MOG were enhanced. Thus, immune deviation can increase concentrations of pathogenic autoantibodies and in some circumstances exacerbate autoimmune disease.

C. P. Genain, K. Abel, N. Belmar, D. P. Rosenberg, S. L. Hauser, Department of Neurology, University of California, San Francisco, CA 94143, USA.
F. Villinger, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
C. Linington, Department of Neuroimmunology, Max Planck Institut für Psychiatrie, Martinsried, Germany.
C. S. Raine, Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
*   To whom correspondence should be addressed.

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