Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 13 December 1996:
Vol. 274. no. 5294, pp. 1850 - 1851
DOI: 10.1126/science.274.5294.1850
Prev | Table of Contents | Next

Perspectives

Donald M. Engelman

In this issue of Science, Song et al. (p. 1859) provide the first high-resolution x-ray view of a transmembrane protein that spontaneously inserts into the lipid bilayer. In his Perspective, Engelman discusses what these results mean for our understanding of protein insertion into membranes.

The author is in the Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. E-mail: don{at}paradigm.csb.yale.edu

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
T Cell Antigen Receptor Peptide-Lipid Membrane Interactions Using Surface Plasmon Resonance.
V. Bender, M. Ali, M. Amon, E. Diefenbach, and N. Manolios (2004)
J. Biol. Chem. 279, 54002-54007
   Abstract »    Full Text »    PDF »
Surfactant Releases Internal Calcium Stores in Neutrophils by G Protein-Activated Pathway.
M. E. Boston, G. C. Frech, E. Chacon-Cruz, E. S. Buescher, and D. G. Oelberg (2004)
Experimental Biology and Medicine 229, 99-107
   Abstract »    Full Text »    PDF »
A Dominant Negative Mutant of Helicobacter pylori Vacuolating Toxin (VacA) Inhibits VacA-induced Cell Vacuolation.
A. D. Vinion-Dubiel, M. S. McClain, D. M. Czajkowsky, H. Iwamoto, D. Ye, P. Cao, W. Schraw, G. Szabo, S. R. Blanke, Z. Shao, et al. (1999)
J. Biol. Chem. 274, 37736-37742
   Abstract »    Full Text »    PDF »
Water: Foldase activity in catalyzing polypeptide conformational rearrangements.
F. Xu and T. A. Cross (1999)
PNAS 96, 9057-9061
   Abstract »    Full Text »    PDF »
The Role of the Amino Terminus in the Kinetics and Assembly of alpha -Hemolysin of Staphylococcus aureus.
S. Vandana, M. Raje, and M. V. Krishnasastry (1997)
J. Biol. Chem. 272, 24858-24863
   Abstract »    Full Text »    PDF »
Insertion and Organization within Membranes of the delta -Endotoxin Pore-forming Domain, Helix 4-Loop-Helix 5, and Inhibition of Its Activity by a Mutant Helix 4 Peptide.
D. Gerber and Y. Shai (2000)
J. Biol. Chem. 275, 23602-23607
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)