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Science 6 December 1996:
Vol. 274. no. 5293, pp. 1739 - 1744
DOI: 10.1126/science.274.5293.1739
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Reports

Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV

Patrick S. Moore, Chris Boshoff, Robin A. Weiss, Yuan Chang *

Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome. vIL-6 was functional in B9 proliferation assays and primarily expressed in KSHV-infected hematopoietic cells rather than KS lesions. HIV-1 transmission studies showed that vMIP-I is similar to human MIP chemokines in its ability to inhibit replication of HIV-1 strains dependent on the CCR5 co-receptor. These viral genes may form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions.

P. S. Moore, School of Public Health and Y. Chang, Department of Pathology, Columbia University, New York, NY 10032, USA.
C. Boshoff and R. A. Weiss, Chester Beatty Laboratories, Institute of Cancer Research, London SW3 6JB, UK.
*   To whom correspondence should be addressed.

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   Abstract »    Full Text »    PDF »
Activation of NF-{kappa}B by the Human Herpesvirus 8 Chemokine Receptor ORF74: Evidence for a Paracrine Model of Kaposi's Sarcoma Pathogenesis.
S. Pati, M. Cavrois, H.-G. Guo, J. S. Foulke Jr., J. Kim, R. A. Feldman, and M. Reitz (2001)
J. Virol. 75, 8660-8673
   Abstract »    Full Text »    PDF »
DNA Binding and Modulation of Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus.
A. C. Garber, M. A. Shu, J. Hu, and R. Renne (2001)
J. Virol. 75, 7882-7892
   Abstract »    Full Text »    PDF »
Interleukin 8 Is an Autocrine Growth Factor and a Surrogate Marker for Kaposi's Sarcoma.
R. Masood, J. Cai, A. Tulpule, T. Zheng, A. Hamilton, S. Sharma, B. M. Espina, D. L. Smith, and P. S. Gill (2001)
Clin. Cancer Res. 7, 2693-2702
   Abstract »    Full Text »    PDF »
Inhibition of p53 Tumor Suppressor by Viral Interferon Regulatory Factor.
H. Nakamura, M. Li, J. Zarycki, and J. U. Jung (2001)
J. Virol. 75, 7572-7582
   Abstract »    Full Text »    PDF »
Transcription Pattern of Human Herpesvirus 8 Open Reading Frame K3 in Primary Effusion Lymphoma and Kaposi's Sarcoma.
P. Rimessi, A. Bonaccorsi, M. Sturzl, M. Fabris, E. Brocca-Cofano, A. Caputo, G. Melucci-Vigo, M. Falchi, A. Cafaro, E. Cassai, et al. (2001)
J. Virol. 75, 7161-7174
   Abstract »    Full Text »
Spindle Cell Conversion by Kaposi's Sarcoma-Associated Herpesvirus: Formation of Colonies and Plaques with Mixed Lytic and Latent Gene Expression in Infected Primary Dermal Microvascular Endothelial Cell Cultures.
D. M. Ciufo, J. S. Cannon, L. J. Poole, F. Y. Wu, P. Murray, R. F. Ambinder, and G. S. Hayward (2001)
J. Virol. 75, 5614-5626
   Abstract »    Full Text »
Transcription Program of Human Herpesvirus 8 (Kaposi's Sarcoma-Associated Herpesvirus).
M. Paulose-Murphy, N.-K. Ha, C. Xiang, Y. Chen, L. Gillim, R. Yarchoan, P. Meltzer, M. Bittner, J. Trent, and S. Zeichner (2001)
J. Virol. 75, 4843-4853
   Abstract »    Full Text »
Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus.
D. A. Davis, A. S. Rinderknecht, J. P. Zoeteweij, Y. Aoki, E. L. Read-Connole, G. Tosato, A. Blauvelt, and R. Yarchoan (2001)
Blood 97, 3244-3250
   Abstract »    Full Text »    PDF »
Detection of Direct Binding of Human Herpesvirus 8-Encoded Interleukin-6 (vIL-6) to both gp130 and IL-6 Receptor (IL-6R) and Identification of Amino Acid Residues of vIL-6 Important for IL-6R-Dependent and -Independent Signaling.
H. Li, H. Wang, and J. Nicholas (2001)
J. Virol. 75, 3325-3334
   Abstract »    Full Text »
{beta}-Chemokine Induction of Activation Protein-1 and Cyclic AMP Responsive Element Activation in Human Myeloid Cells.
Y.-M. Yang, W. C. Hatch, Z.-Y. Liu, B. Du, and J. E. Groopman (2001)
Cell Growth Differ. 12, 211-221
   Abstract »    Full Text »
Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders.
Y. Aoki, R. Yarchoan, K. Wyvill, S.-i. Okamoto, R. F. Little, and G. Tosato (2001)
Blood 97, 2173-2176
   Abstract »    Full Text »    PDF »
Structure of an Extracellular gp130 Cytokine Receptor Signaling Complex.
D.-c. Chow, X.-l. He, A. L. Snow, S. Rose-John, and K. C. Garcia (2001)
Science 291, 2150-2155
   Abstract »    Full Text »
Spontaneous Activation of the Lytic Cycle in Cells Infected with a Recombinant Kaposi's Sarcoma-Associated Virus.
H.-J. Delecluse, M. Kost, R. Feederle, L. Wilson, and W. Hammerschmidt (2001)
J. Virol. 75, 2921-2928
   Abstract »    Full Text »
Internal Ribosome Entry Site Regulates Translation of Kaposi's Sarcoma-Associated Herpesvirus FLICE Inhibitory Protein.
W. Low, M. Harries, H. Ye, M.-Q. Du, C. Boshoff, and M. Collins (2001)
J. Virol. 75, 2938-2945
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Latently Expressed Human Herpesvirus 8-Encoded Interferon Regulatory Factor 2 Inhibits Double-Stranded RNA-Activated Protein Kinase.
P. M. Pitha (2001)
J. Virol. 75, 2345-2352
   Abstract »    Full Text »
Kaposi's Sarcoma-Associated Herpesvirus Latent and Lytic Gene Expression as Revealed by DNA Arrays.
R. G. Jenner, M. M. Albà, C. Boshoff, and P. Kellam (2001)
J. Virol. 75, 891-902
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Kaposi's Sarcoma-Associated Herpesvirus LANA2 Is a B-Cell-Specific Latent Viral Protein That Inhibits p53.
C. Rivas, A.-E. Thlick, C. Parravicini, P. S. Moore, and Y. Chang (2001)
J. Virol. 75, 429-438
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Modulation of Cellular and Viral Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus.
R. Renne, C. Barry, D. Dittmer, N. Compitello, P. O. Brown, and D. Ganem (2001)
J. Virol. 75, 458-468
   Abstract »    Full Text »
The chemokine receptor CCR8 mediates human endothelial cell chemotaxis induced by I-309 and Kaposi sarcoma herpesvirus-encoded vMIP-I and by lipoprotein(a)-stimulated endothelial cell conditioned medium.
N. S. Haque, J. T. Fallon, M. B. Taubman, and P. C. Harpel (2001)
Blood 97, 39-45
   Abstract »    Full Text »    PDF »
DNA binding and transcription activation by chicken interferon regulatory factor-3 (chIRF-3).
C. E. Grant, D. L. May, and R. G. Deeley (2000)
Nucleic Acids Res. 28, 4790-4799
   Abstract »    Full Text »    PDF »


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