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Science 29 November 1996:
Vol. 274. no. 5292, pp. 1523 - 1527
DOI: 10.1126/science.274.5292.1523
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Reports

Myc and Max Homologs in Drosophila

Peter Gallant, Yuzuru Shiio, Pei Feng Cheng, Susan M. Parkhurst, Robert N. Eisenman *

The proteins encoded by the myc proto-oncogene family are involved in cell proliferation, apoptosis, differentiation, and neoplasia. Myc acts through dimerization with Max to bind DNA and activate transcription. Homologs of the myc and max genes were cloned from the fruit fly Drosophila melanogaster and their protein products (dMyc and dMax) were shown to heterodimerize, recognize the same DNA sequence as their vertebrate homologs, and activate transcription. The dMyc protein is likely encoded by the Drosophila gene diminutive (dm), a mutation in which results in small body size and female sterility caused by degeneration of the ovaries. These findings indicate a potential role for Myc in germ cell development and set the stage for genetic analysis of Myc and Max.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1124 Columbia Street, Seattle WA 98104, USA.
*   To whom correspondence should be addressed.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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A Myc Groucho complex integrates EGF and Notch signaling to regulate neural development.
A. Orian, J. J. Delrow, A. E. Rosales Nieves, M. Abed, D. Metzger, Z. Paroush, R. N. Eisenman, and S. M. Parkhurst (2007)
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The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth.
J. Secombe, L. Li, L. Carlos, and R. N. Eisenman (2007)
Genes & Dev. 21, 537-551
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Contribution of Growth and Cell Cycle Checkpoints to Radiation Survival in Drosophila.
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Genetics 174, 1963-1972
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V. H. Cowling, S. Chandriani, M. L. Whitfield, and M. D. Cole (2006)
Mol. Cell. Biol. 26, 4226-4239
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Of Myc and Mnt.
C. W. Hooker and P. J. Hurlin (2006)
J. Cell Sci. 119, 208-216
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Polycomb mediates Myc autorepression and its transcriptional control of many loci in Drosophila.
J. M. Goodliffe, E. Wieschaus, and M. D. Cole (2005)
Genes & Dev. 19, 2941-2946
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Human c-Myc Isoforms Differentially Regulate Cell Growth and Apoptosis in Drosophila melanogaster.
C. Benassayag, L. Montero, N. Colombie, P. Gallant, D. Cribbs, and D. Morello (2005)
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Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.
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The Transcriptional Repressor dMnt Is a Regulator of Growth in Drosophila melanogaster.
L. W. M. Loo, J. Secombe, J. T. Little, L.-S. Carlos, C. Yost, P.-F. Cheng, E. M. Flynn, B. A. Edgar, and R. N. Eisenman (2005)
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J. Cell Sci. 118, 1693-1704
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dMyc is required for larval growth and endoreplication in Drosophila.
S. B. Pierce, C. Yost, J. S. Britton, L. W. M. Loo, E. M. Flynn, B. A. Edgar, and R. N. Eisenman (2004)
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Development 131, 1411-1423
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Drosophila dMyc is required for ovary cell growth and endoreplication.
J. Z. Maines, L. M. Stevens, X. Tong, and D. Stein (2004)
Development 131, 775-786
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M. Lynch, C. Fitzgerald, K. A. Johnston, S. Wang, and E. V. Schmidt (2004)
J. Biol. Chem. 279, 3327-3339
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Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network.
A. Orian, B. van Steensel, J. Delrow, H. J. Bussemaker, L. Li, T. Sawado, E. Williams, L. W.M. Loo, S. M. Cowley, C. Yost, et al. (2003)
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Loss of Protooncogene c-Myc Function Impedes G1 Phase Progression Both before and after the Restriction Point.
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Natural alleles at a tomato fruit size quantitative trait locus differ by heterochronic regulatory mutations.
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M. Buszczak, X. Lu, W. A. Segraves, T. Y. Chang, and L. Cooley (2002)
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Characterization of the B lymphocyte-induced maturation protein-1 (Blimp-1) gene, mRNA isoforms and basal promoter.
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A. N. Billin, A. L. Eilers, K. L. Coulter, J. S. Logan, and D. E. Ayer (2000)
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N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation.
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Development 125, 3571-3584
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Integrating Genetic Approaches into the Discovery of Anticancer Drugs.
L. H. Hartwell, P. Szankasi, C. J. Roberts, A. W. Murray, and S. H. Friend (1997)
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Development 124, 4939-4947
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