Science 22 November 1996: Vol. 274. no. 5291, pp. 1383 - 1385 DOI: 10.1126/science.274.5291.1383

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Autoimmune disease and risk for Parkinson disease: A population-based case-control study.

K. Rugbjerg, S. Friis, B. Ritz, E. S. Schernhammer, L. Korbo, and J. H. Olsen (2009)
Neurology 73, 1462-1468
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Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans.

T. Morris, M. Stables, A. Hobbs, P. de Souza, P. Colville-Nash, T. Warner, J. Newson, G. Bellingan, and D. W. Gilroy (2009)
J. Immunol. 183, 2089-2096
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Activation of Liver X Receptors Prevents Statin-induced Death of 3T3-L1 Preadipocytes.

L. Madsen, R. K. Petersen, K. R. Steffensen, L. M. Pedersen, P. Hallenborg, T. Ma, L. Froyland, S. O. Doskeland, J.-A. Gustafsson, and K. Kristiansen (2008)
J. Biol. Chem. 283, 22723-22736
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Effects of isoproterenol treatment for 7 days on inflammatory mediators in the rat aorta.

A. P. C. Davel, L. E. Fukuda, L. L. De Sa, C. D. Munhoz, C. Scavone, D. Sanz-Rosa, V. Cachofeiro, V. Lahera, and L. V. Rossoni (2008)
Am J Physiol Heart Circ Physiol 295, H211-H219
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Impaired Adult Neurogenesis Associated with Short-Term Memory Defects in NF-{kappa}B p50-Deficient Mice.

S. Denis-Donini, A. Dellarole, P. Crociara, M. T. Francese, V. Bortolotto, G. Quadrato, P. L. Canonico, M. Orsetti, P. Ghi, M. Memo, et al. (2008)
J. Neurosci. 28, 3911-3919
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Blockade of Tumor Growth Due to Matrix Metalloproteinase-9 Inhibition Is Mediated by Sequential Activation of 1-Integrin, ERK, and NF-{kappa}B.

P. Bhoopathi, C. Chetty, S. Kunigal, S. K. Vanamala, J. S. Rao, and S. S. Lakka (2008)
J. Biol. Chem. 283, 1545-1552
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Nonsteroidal anti-inflammatory drugs may protect against Parkinson disease.

A. D. Wahner, J. M. Bronstein, Y. M. Bordelon, and B. Ritz (2007)
Neurology 69, 1836-1842
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Acute Intracerebroventricular Administration of Palmitoylethanolamide, an Endogenous Peroxisome Proliferator-Activated Receptor-{alpha} Agonist, Modulates Carrageenan-Induced Paw Edema in Mice.

G. D'Agostino, G. La Rana, R. Russo, O. Sasso, A. Iacono, E. Esposito, G. M. Raso, S. Cuzzocrea, J. Lo Verme, D. Piomelli, et al. (2007)
J. Pharmacol. Exp. Ther. 322, 1137-1143
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Salicylate-Based Anti-Inflammatory Drugs Inhibit the Early Lesion of Diabetic Retinopathy.

L. Zheng, S. J. Howell, D. A. Hatala, K. Huang, and T. S. Kern (2007)
Diabetes 56, 337-345
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Effects of Triflusal and Aspirin in a Rat Model of Cerebral Ischemia.

S. N. Whitehead, N. A. Bayona, G. Cheng, G. V. Allen, V. C. Hachinski, and D. F. Cechetto (2007)
Stroke 38, 381-387
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Emerging Mechanisms of Immunosuppression in Oral Cancers.

A. Jewett, C. Head, and N.A. Cacalano (2006)
Journal of Dental Research 85, 1061-1073
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Aspirin and Salicylate Suppress Polymorphonuclear Apoptosis Delay Mediated by Proinflammatory Stimuli.

S. Negrotto, E. Malaver, M. E. Alvarez, N. Pacienza, L. P. D'Atri, R. G. Pozner, R. M. Gomez, and M. Schattner (2006)
J. Pharmacol. Exp. Ther. 319, 972-979
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Aspirin Induces Apoptosis through the Inhibition of Proteasome Function.

P. Dikshit, M. Chatterjee, A. Goswami, A. Mishra, and N. R. Jana (2006)
J. Biol. Chem. 281, 29228-29235
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Aspirin reduces the outcome of anticancer therapy in Meth A-bearing mice through activation of AKT-glycogen synthase kinase signaling.

A. di Palma, G. Matarese, V. Leone, T. Di Matola, F. Acquaviva, A. M. Acquaviva, and P. Ricchi (2006)
Mol. Cancer Ther. 5, 1318-1324
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Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of HO-1 and HO-2 to cytoprotection.

H. Parfenova, S. Basuroy, S. Bhattacharya, D. Tcheranova, Y. Qu, R. F. Regan, and C. W. Leffler (2006)
Am J Physiol Cell Physiol 290, C1399-C1410
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Inhibition of Cardiac Hypertrophy by Triflusal (4-Trifluoromethyl Derivative of Salicylate) and Its Active Metabolite.

A. Planavila, R. Rodriguez-Calvo, A. F. de Arriba, R. M. Sanchez, J. C. Laguna, M. Merlos, and M. Vazquez-Carrera (2006)
Mol. Pharmacol. 69, 1174-1181
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Premorbid antiplatelet use and ischemic stroke outcomes.

N. Sanossian, J. L. Saver, V. Rajajee, S. L. Selco, D. Kim, T. Razinia, and B. Ovbiagele (2006)
Neurology 66, 319-323
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Low K+ Promotes NF-{kappa}B/DNA Binding in Neuronal Apoptosis Induced by K+ Loss.

Y. Tao, D. Yan, Q. Yang, R. Zeng, and Y. Wang (2006)
Mol. Cell. Biol. 26, 1038-1050
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PROSTAGLANDINS AND CANCER.

D Wang and R N DuBois (2006)
Gut 55, 115-122
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Interaction Between a Rat Model of Cerebral Ischemia and {beta}-Amyloid Toxicity: II. Effects of Triflusal.

S. Whitehead, G. Cheng, V. Hachinski, and D. F. Cechetto (2005)
Stroke 36, 1782-1789
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Accelerated Prion Disease in the Absence of Interleukin-10.

A. M. Thackray, A. N. McKenzie, M. A. Klein, A. Lauder, and R. Bujdoso (2004)
J. Virol. 78, 13697-13707
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Agents with Selective Estrogen Receptor (ER) Modulator Activity Induce Apoptosis In vitro and In vivo in ER-Negative Glioma Cells.

A.-M. Hui, W. Zhang, W. Chen, D. Xi, B. Purow, G. C. Friedman, and H. A. Fine (2004)
Cancer Res. 64, 9115-9123
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Susceptibility to neoplastic and non-neoplastic pulmonary diseases in mice: genetic similarities.

A. K. Bauer, A. M. Malkinson, and S. R. Kleeberger (2004)
Am J Physiol Lung Cell Mol Physiol 287, L685-L703
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Switching leukemia cell phenotype between life and death.

S. J. Tucker, C. Rae, A. F. Littlejohn, A. Paul, and D. J. MacEwan (2004)
PNAS 101, 12940-12945
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Effect of NF-{kappa}B Inhibition on TNF-{alpha}-Induced Apoptosis in Human RPE Cells.

P. Yang, B. S. McKay, J. B. Allen, and G. J. Jaffe (2004)
Invest. Ophthalmol. Vis. Sci. 45, 2438-2446
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Immunolocalization and Activation of Transcription Factor Nuclear Factor {kappa}B in Dysimmune Neuropathies and Familial Amyloidotic Polyneuropathy.

A. Mazzeo, M. Aguennouz, C. Messina, and G. Vita (2004)
Arch Neurol 61, 1097-1102
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Role of Tumor Necrosis Factor-{alpha} in Methamphetamine-Induced Drug Dependence and Neurotoxicity.

A. Nakajima, K. Yamada, T. Nagai, T. Uchiyama, Y. Miyamoto, T. Mamiya, J. He, A. Nitta, M. Mizuno, M. H. Tran, et al. (2004)
J. Neurosci. 24, 2212-2225
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Aspirin and the Risk of Hodgkin's Lymphoma in a Population-Based Case-Control Study.

E. T. Chang, T. Zheng, E. G. Weir, M. Borowitz, R. B. Mann, D. Spiegelman, and N. E. Mueller (2004)
J Natl Cancer Inst 96, 305-315
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Specific Inhibition of I{kappa}B Kinase Reduces Hyperalgesia in Inflammatory and Neuropathic Pain Models in Rats.

I. Tegeder, E. Niederberger, R. Schmidt, S. Kunz, H. Guhring, O. Ritzeler, M. Michaelis, and G. Geisslinger (2004)
J. Neurosci. 24, 1637-1645
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Expression of the Angiogenic Factor Thymidine Phosphorylase in THP-1 Monocytes: Induction by Autocrine Tumor Necrosis Factor-{alpha} and Inhibition by Aspirin.

G. H. Zhu and E. L. Schwartz (2003)
Mol. Pharmacol. 64, 1251-1258
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Forebrain-Specific Neuronal Inhibition of Nuclear Factor-{kappa}B Activity Leads to Loss of Neuroprotection.

V. Fridmacher, B. Kaltschmidt, B. Goudeau, D. Ndiaye, F. M. Rossi, J. Pfeiffer, C. Kaltschmidt, A. Israel, and S. Memet (2003)
J. Neurosci. 23, 9403-9408
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Reciprocal Inhibition of p53 and Nuclear Factor-{kappa}B Transcriptional Activities Determines Cell Survival or Death in Neurons.

C. Culmsee, J. Siewe, V. Junker, M. Retiounskaia, S. Schwarz, S. Camandola, S. El-Metainy, H. Behnke, M. P. Mattson, and J. Krieglstein (2003)
J. Neurosci. 23, 8586-8595
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Aspirin Protects Caco-2 Cells from Apoptosis after Serum Deprivation through the Activation of a Phosphatidylinositol 3-Kinase/AKT/p21Cip/WAF1Pathway.

P. Ricchi, A. D. Palma, T. D. Matola, A. Apicella, R. Fortunato, R. Zarrilli, and A. M. Acquaviva (2003)
Mol. Pharmacol. 64, 407-414
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Nonsteroidal Anti-inflammatory Drugs Protect Against Parkinson Neurodegeneration: Can an NSAID a Day Keep Parkinson Disease Away?.

M. Schiess (2003)
Arch Neurol 60, 1043-1044
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Nonsteroidal Anti-inflammatory Drugs and the Risk of Parkinson Disease.

H. Chen, S. M. Zhang, M. A. Hernan, M. A. Schwarzschild, W. C. Willett, G. A. Colditz, F. E. Speizer, and A. Ascherio (2003)
Arch Neurol 60, 1059-1064
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BRCA1 Augments Transcription by the NF-{kappa}B Transcription Factor by Binding to the Rel Domain of the p65/RelA Subunit.

M. Benezra, N. Chevallier, D. J. Morrison, T. K. MacLachlan, W. S. El-Deiry, and J. D. Licht (2003)
J. Biol. Chem. 278, 26333-26341
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Activation of p38 Plays a Pivotal Role in the Inhibitory Effect of Lipopolysaccharide and Interleukin-1{beta} on Long Term Potentiation in Rat Dentate Gyrus.

A. Kelly, E. Vereker, Y. Nolan, M. Brady, C. Barry, C. E. Loscher, K. H. G. Mills, and M. A. Lynch (2003)
J. Biol. Chem. 278, 19453-19462
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From Calcium to NF-{kappa}B Signaling Pathways in Neurons.

A. Lilienbaum and A. Israel (2003)
Mol. Cell. Biol. 23, 2680-2698
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The Novel Neuroprotective Action of Sulfasalazine through Blockade of NMDA Receptors.

B. R. Ryu, Y. A. Lee, S. J. Won, J.-H. Noh, S.-Y. Chang, J.-M. Chung, J. S. Choi, C. K. Joo, S. H. Yoon, and B. J. Gwag (2003)
J. Pharmacol. Exp. Ther. 305, 48-56
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Activation of nuclear factor-{kappa}B in inflammatory myopathies and Duchenne muscular dystrophy.

M.C. Monici, M. Aguennouz, A. Mazzeo, C. Messina, and G. Vita (2003)
Neurology 60, 993-997
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Temporal pattern of NF{kappa}B activation influences apoptotic cell fate in a stimuli-dependent fashion.

C. Fan, J. Yang, and J. F. Engelhardt (2003)
J. Cell Sci. 115, 4843-4853
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Aspirin Inhibits p44/42 Mitogen-Activated Protein Kinase and Is Protective Against Hypoxia/Reoxygenation Neuronal Damage.

N. Vartiainen, G. Goldsteins, V. Keksa-Goldsteine, P. H. Chan, and J. Koistinaho (2003)
Stroke 34, 752-757
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Regulation of RelA (p65) Function by the Large Subunit of Replication Factor C.

L. A. Anderson and N. D. Perkins (2003)
Mol. Cell. Biol. 23, 721-732
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Role of p38 MAPK in CYP2E1-dependent Arachidonic Acid Toxicity.

D. Wu and A. I. Cederbaum (2003)
J. Biol. Chem. 278, 1115-1124
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Blockade of Phencyclidine-Induced Cortical Apoptosis and Deficits in Prepulse Inhibition by M40403, a Superoxide Dismutase Mimetic.

C. Wang, J. McInnis, J. B. West, J. Bao, N. Anastasio, J. A. Guidry, Y. Ye, D. Salvemini, and K. M. Johnson (2003)
J. Pharmacol. Exp. Ther. 304, 266-271
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Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice.

L. R. Kisley, B. S. Barrett, L. D. Dwyer-Nield, A. K. Bauer, D. C. Thompson, and A. M. Malkinson (2002)
Carcinogenesis 23, 1653-1660
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Constitutive Nuclear Factor-kappa B Activity Is Required for Central Neuron Survival.

A. L. Bhakar, L.-L. Tannis, C. Zeindler, M. P. Russo, C. Jobin, D. S. Park, S. MacPherson, and P. A. Barker (2002)
J. Neurosci. 22, 8466-8475
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THE BIOLOGIC ROLE FOR NUCLEAR FACTOR-KAPPAB IN DISEASE AND ITS POTENTIAL INVOLVEMENT IN MUCOSAL INJURY ASSOCIATED WITH ANTI-NEOPLASTIC THERAPY.

S. T. Sonis (2002)
Critical Reviews in Oral Biology & Medicine 13, 380-389
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Suppression of Japanese encephalitis virus infection by non-steroidal anti-inflammatory drugs.

C.-J. Chen, S.-L. Raung, M.-D. Kuo, and Y.-M. Wang (2002)
J. Gen. Virol. 83, 1897-1905
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Opposing Roles for NF-kappa B/Rel Factors p65 and c-Rel in the Modulation of Neuron Survival Elicited by Glutamate and Interleukin-1beta.

M. Pizzi, F. Goffi, F. Boroni, M. Benarese, S. E. Perkins, H.-C. Liou, and P. Spano (2002)
J. Biol. Chem. 277, 20717-20723
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The Role of Superoxide and Nuclear Factor-kappa B Signaling in N-Methyl-D-aspartate-Induced Necrosis and Apoptosis.

J. McInnis, C. Wang, N. Anastasio, M. Hultman, Y. Ye, D. Salvemini, and K. M. Johnson (2002)
J. Pharmacol. Exp. Ther. 301, 478-487
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Neutrophil-derived Glutamate Regulates Vascular Endothelial Barrier Function.

C. D. Collard, K. A. Park, M. C. Montalto, S. Alapati, J. A. Buras, G. L. Stahl, and S. P. Colgan (2002)
J. Biol. Chem. 277, 14801-14811
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beta -Amyloid precursor protein transgenic mice that harbor diffuse Abeta deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation.

M. Koistinaho, M. I. Kettunen, G. Goldsteins, R. Keinanen, A. Salminen, M. Ort, J. Bures, D. Liu, R. A. Kauppinen, L. S. Higgins, et al. (2002)
PNAS
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Inhibition of Glutamate Release via Recovery of ATP Levels Accounts for a Neuroprotective Effect of Aspirin in Rat Cortical Neurons Exposed to Oxygen-Glucose Deprivation.

J. De Cristobal, A. Cardenas, I. Lizasoain, J. C. Leza, P. Fernandez-Tome, P. Lorenzo, and M. A. Moro (2002)
Stroke 33, 261-267
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Prior Aspirin Use on Stroke Severity in the Trial of Org 10172 in Acute Stroke Treatment (TOAST).

J. L. Wilterdink, B. Bendixen, H. P. Adams Jr, R. F. Woolson, W. R. Clarke, and M. D. Hansen (2001)
Stroke 32, 2836-2840
 |  Abstract »  |  Full Text »  |  PDF »

NFkappa B Activation Is Required for the Neuroprotective Effects of Pigment Epithelium-derived Factor (PEDF) on Cerebellar Granule Neurons.

T. Yabe, D. Wilson, and J. P. Schwartz (2001)
J. Biol. Chem. 276, 43313-43319
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Nuclear factor-{kappa}B decoy attenuates neuronal damage after global brain ischemia: A future strategy for brain protection during circulatory arrest.

T. Ueno, Y. Sawa, S. Kitagawa-Sakakida, M. Nishimura, R. Morishita, Y. Kaneda, E. Kohmura, T. Yoshimine, and H. Matsuda (2001)
J. Thorac. Cardiovasc. Surg. 122, 720-727
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Cyclooxygenase-independent actions of cyclooxygenase inhibitors.

I. TEGEDER, J. PFEILSCHIFTER, and G. GEISSLINGER (2001)
FASEB J 15, 2057-2072
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Triflusal Posttreatment Inhibits Glial Nuclear Factor-{kappa}B, Downregulates the Glial Response, and Is Neuroprotective in an Excitotoxic Injury Model in Postnatal Brain.

L. Acarin, B. Gonzalez, and B. Castellano (2001)
Stroke 32, 2394-2402
 |  Abstract »  |  Full Text »  |  PDF »

Salicylates Inhibit Flavivirus Replication Independently of Blocking Nuclear Factor Kappa B Activation.

C.-L. Liao, Y.-L. Lin, B.-C. Wu, C.-H. Tsao, M.-C. Wang, C.-I Liu, Y.-L. Huang, J.-H. Chen, J.-P. Wang, and L.-K. Chen (2001)
J. Virol. 75, 7828-7839
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Tumor Necrosis Factor Receptor Deletion Reduces Nuclear Factor-{kappa}B Activation, Cellular Inhibitor of Apoptosis Protein 2 Expression, and Functional Recovery after Traumatic Spinal Cord Injury.

G.-M. Kim, J. Xu, J. Xu, S.-K. Song, P. Yan, G. Ku, X. M. Xu, and C. Y. Hsu (2001)
J. Neurosci. 21, 6617-6625
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Platelet glycoprotein IIb/IIIa antagonists for acute ischemic stroke.

J. Bogousslavsky and J. R. Leclerc (2001)
Neurology 57, S53-57
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Endotoxin stimulated cytokine production in rat vascular smooth muscle cells.

K. Detmer, Z. Wang, D. Warejcka, S. K. Leeper-Woodford, and W. H. Newman (2001)
Am J Physiol Heart Circ Physiol 281, H661-H668
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Activation of the Nuclear Factor-{kappa}B Is a Key Event in Brain Tolerance.

N. Blondeau, C. Widmann, M. Lazdunski, and C. Heurteaux (2001)
J. Neurosci. 21, 4668-4677
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Aspirin Inhibits In Vitro Maturation and In Vivo Immunostimulatory Function of Murine Myeloid Dendritic Cells.

H. Hackstein, A. E. Morelli, A. T. Larregina, R. W. Ganster, G. D. Papworth, A. J. Logar, S. C. Watkins, L. D. Falo, and A. W. Thomson (2001)
J. Immunol. 166, 7053-7062
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Interleukin-10 Prevents Glutamate-Mediated Cerebellar Granule Cell Death by Blocking Caspase-3-Like Activity.

A. Bachis, A. M. Colangelo, S. Vicini, P. P. Doe, M. A. De Bernardi, G. Brooker, and I. Mocchetti (2001)
J. Neurosci. 21, 3104-3112
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Prostaglandin A1 Protects Striatal Neurons against Excitotoxic Injury in Rat Striatum.

Z.-H. Qin, Y. Wang, R.-W. Chen, X. Wang, M. Ren, D.-M. Chuang, and T. N. Chase (2001)
J. Pharmacol. Exp. Ther. 297, 78-87
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Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice.

C. Iadecola, K. Niwa, S. Nogawa, X. Zhao, M. Nagayama, E. Araki, S. Morham, and M. E. Ross (2001)
PNAS 98, 1294-1299
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Roles of Nuclear Factor-kappa B, p53, and p21/WAF1 in Daunomycin-Induced Cell Cycle Arrest and Apoptosis.

A.-C. Hellin, M. Bentires-Alj, M. Verlaet, V. Benoit, J. Gielen, V. Bours, and M.-P. Merville (2000)
J. Pharmacol. Exp. Ther. 295, 870-878
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Luteinizing Hormone-Releasing Hormone Induces Nuclear Factor {kappa}B-Activation and Inhibits Apoptosis in Ovarian Cancer Cells.

C. Gründker, K. Schulz, A. R. Günthert, and G. Emons (2000)
J. Clin. Endocrinol. Metab. 85, 3815-3820
 |  Abstract »  |  Full Text »

A D-Amino Acid Peptide Inhibitor of NF-{kappa}B Nuclear Localization Is Efficacious in Models of Inflammatory Disease.

S. M. Fujihara, J. S. Cleaveland, L. S. Grosmaire, K. K. Berry, K. A. Kennedy, J. J. Blake, J. Loy, B. M. Rankin, J. A. Ledbetter, and S. G. Nadler (2000)
J. Immunol. 165, 1004-1012
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Mechanisms of N-Methyl-D-aspartate-Induced Apoptosis in Phencyclidine-Treated Cultured Forebrain Neurons.

C. Wang, J. A. Kaufmann, M. G. Sanchez-Ross, and K. M. Johnson (2000)
J. Pharmacol. Exp. Ther. 294, 287-295
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Does the Insulin-Like Growth Factor System Interact with Prostaglandins and Proinflammatory Cytokines During Neurodegeneration?.

B. R. Lackey, S. L. Gray, and D. M. Henricks (2000)
Experimental Biology and Medicine 224, 20-27
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Nuclear Factor-{{kappa}}B/Rel Is Apoptogenic in Cytokine Withdrawal-induced Programmed Cell Death.

U. S. Sohur, C.-L. Chen, D. J. Hicks, F. E. Yull, and L. D. Kerr (2000)
Cancer Res. 60, 1202-1205
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Oxidative stress and Alzheimer disease1.

Y. Christen (2000)
Am. J. Clinical Nutrition 71, 621s-629s
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Corticotropin-Releasing Hormone-Mediated Neuroprotection against Oxidative Stress Is Associated with the Increased Release of Non-amyloidogenic Amyloid {beta} Precursor Protein and with the Suppression of Nuclear Factor-{kappa}B.

F. Lezoualc’h, S. Engert, B. Berning, and C. Behl (2000)
Mol. Endocrinol. 14, 147-159
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Aspirin Reduces Apolipoprotein(a) (Apo(a)) Production in Human Hepatocytes by Suppression of Apo(a) Gene Transcription.

A. Kagawa, H. Azuma, M. Akaike, Y. Kanagawa, and T. Matsumoto (1999)
J. Biol. Chem. 274, 34111-34115
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High Level Calcineurin Activity Predisposes Neuronal Cells to Apoptosis.

A. Asai, J.-h. Qiu, Y. Narita, S. Chi, N. Saito, N. Shinoura, H. Hamada, Y. Kuchino, and T. Kirino (1999)
J. Biol. Chem. 274, 34450-34458
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Salicylic Acid and Aspirin Inhibit the Activity of RSK2 Kinase and Repress RSK2-Dependent Transcription of Cyclic AMP Response Element Binding Protein- and NF-{kappa}B-Responsive Genes.

M. A. Stevenson, M.-J. Zhao, A. Asea, C. N. Coleman, and S. K. Calderwood (1999)
J. Immunol. 163, 5608-5616
 |  Abstract »  |  Full Text »  |  PDF »

Risk Factors for Early Death in Acute Ischemic Stroke and Intracerebral Hemorrhage : A Prospective Hospital-Based Study in Asia.

K. S. Wong (1999)
Stroke 30, 2326-2330
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Factor-{kappa}B and Cell Death After Experimental Intracerebral Hemorrhage in Rats • Editorial Comment.

S. L. Hickenbottom, J. C. Grotta, R. Strong, L. A. Denner, J. Aronowski, and R. L. Macdonald (1999)
Stroke 30 , 2472-2478
 |  Abstract »  |  Full Text »  |  PDF »

Lack of the p50 Subunit of Nuclear Factor-kappa B Increases the Vulnerability of Hippocampal Neurons to Excitotoxic Injury.

Z. Yu, D. Zhou, A. J. Bruce-Keller, M. S. Kindy, and M. P. Mattson (1999)
J. Neurosci. 19, 8856-8865
 |  Abstract »  |  Full Text »  |  PDF »

Ischemic Cell Death in Brain Neurons.

P. Lipton (1999)
Physiol Rev 79, 1431-1568
 |  Abstract »  |  Full Text »  |  PDF »

Sulindac Inhibits Activation of the NF-kappa B Pathway.

Y. Yamamoto, M.-J. Yin, K.-M. Lin, and R. B. Gaynor (1999)
J. Biol. Chem. 274, 27307-27314
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Nuclear Factor-{{kappa}}B Activation Confers Sensitivity to Tumor Necrosis Factor-{{alpha}} by Impairment of Cell Cycle Progression in Human Glioma Cells.

G. Otsuka, T. Nagaya, K. Saito, M. Mizuno, J. Yoshida, and H. Seo (1999)
Cancer Res. 59, 4446-4452
 |  Abstract »  |  Full Text »  |  PDF »

Antiplatelet treatment does not reduce the severity of subsequent stroke.

J. Sivenius, L. Cunha, H.-C. Diener, C. Forbes, M. Laakso, A. Lowenthal, P. Smets, and P. Riekkinen Sr. (1999)
Neurology 53, 825
 |  Abstract »  |  Full Text »  |  PDF »

Intrastriatal Dopamine Injection Induces Apoptosis Through Oxidation-Involved Activation of Transcription Factors AP-1 and NF-kappa B in Rats.

Y. Luo, A. Hattori, J. Munoz, Z.-H. Qin, and G. S. Roth (1999)
Mol. Pharmacol. 56, 254-264
 |  Abstract »  |  Full Text »

Inhibition of Cytokine Gene Expression by Sodium Salicylate in a Macrophage Cell Line through an NF-kappa B-Independent Mechanism.

S. Lemay, T. V. Lebedeva, and A. K. Singh (1999)
Clin. Vaccine Immunol. 6, 567-572
 |  Abstract »  |  Full Text »  |  PDF »

Review : Gene Expression after Cerebral Ischemia.

S. I. Savitz and D. M. Rosenbaum (1999)
Neuroscientist 5, 238-253
 |  Abstract »  |  PDF »

Induction of Stromelysin Gene Expression by Tumor Necrosis Factor alpha  Is Inhibited by Dexamethasone, Salicylate, and N-Acetylcysteine in Synovial Fibroblasts.

I. Morin, W. Q. Li, S. Su, M. Ahmad, and M. Zafarullah (1999)
J. Pharmacol. Exp. Ther. 289, 1634-1640
 |  Abstract »  |  Full Text »

Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappa B.

B. N. Cronstein, M. C. Montesinos, and G. Weissmann (1999)
PNAS 96, 6377-6381
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Factor kappa B Nuclear Translocation Upregulates c-Myc and p53 Expression during NMDA Receptor-Mediated Apoptosis in Rat Striatum.

Z.-H. Qin, R.-W. Chen, Y. Wang, M. Nakai, D.-M. Chuang, and T. N. Chase (1999)
J. Neurosci. 19, 4023-4033
 |  Abstract »  |  Full Text »  |  PDF »

Differential Inhibitory Actions by Glucocorticoid and Aspirin on Cytokine-Induced Nitric Oxide Production in Vascular Smooth Muscle Cells.

K. Katsuyama, M. Shichiri, H. Kato, T. Imai, F. Marumo, and Y. Hirata (1999)
Endocrinology 140, 2183-2190
 |  Abstract »  |  Full Text »

Inhibition of Cyclooxygenase-2 Expression by 4-Trifluoromethyl Derivatives of Salicylate, Triflusal, and Its Deacetylated Metabolite, 2-Hydroxy-4-trifluoromethylbenzoic Acid.

A. F. de Arriba, F. Cavalcanti, A. Miralles, Y. Bayón, A. Alonso, M. Merlos, J. García-Rafanell, and J. Forn (1999)
Mol. Pharmacol. 55, 753-760
 |  Abstract »  |  Full Text »

Activation of Serum Response Factor by RhoA Is Mediated by the Nuclear Factor-kappa B and C/EBP Transcription Factors.

S. Montaner, R. Perona, L. Saniger, and J. C. Lacal (1999)
J. Biol. Chem. 274, 8506-8515
 |  Abstract »  |  Full Text »  |  PDF »

The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro.

J. T. Winston, P. Strack, P. Beer-Romero, C. Y. Chu, S. J. Elledge, and J. W. Harper (1999)
Genes & Dev. 13, 270-283
 |  Abstract »  |  Full Text »

An Essential Role for Nuclear Factor {kappa}B in Promoting Double Positive Thymocyte Apoptosis.

T. Hettmann, J. DiDonato, M. Karin, and J. M. Leiden (1999)
J. Exp. Med. 189, 145-158
 |  Abstract »  |  Full Text »  |  PDF »

Nerve Growth Factor-Dependent Activation of NF-kappa B Contributes to Survival of Sympathetic Neurons.

S. B. Maggirwar, P. D. Sarmiere, S. Dewhurst, and R. S. Freeman (1998)
J. Neurosci. 18, 10356-10365
 |  Abstract »  |  Full Text »  |  PDF »

Modes of action of aspirin-like drugs: Salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion.

M. H. Pillinger, C. Capodici, P. Rosenthal, N. Kheterpal, S. Hanft, M. R. Philips, and G. Weissmann (1998)
PNAS 95, 14540-14545
 |  Abstract »  |  Full Text »  |  PDF »

Paclitaxel (Taxol)-induced Gene Expression and Cell Death Are Both Mediated by the Activation of c-Jun NH2-terminal Kinase (JNK/SAPK).

L.-F. Lee, G. Li, D. J. Templeton, and J. P.-Y. Ting (1998)
J. Biol. Chem. 273, 28253-28260
 |  Abstract »  |  Full Text »  |  PDF »

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