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Science 15 November 1996:
Vol. 274. no. 5290, pp. 1208 - 1211
DOI: 10.1126/science.274.5290.1208
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Reports

High Mutation Frequencies Among Escherichia coli and Salmonella Pathogens

J. Eugene LeClerc, Baoguang Li, William L. Payne, Thomas A. Cebula *

Here it is reported that the incidence of mutators among isolates of pathogenic Escherichia coli and Salmonella enterica is high (over 1 percent). These findings counter the theory, founded on studies with laboratory-attenuated strains, that suggests mutators are rare among bacterial populations. Defects in methyl-directed mismatch repair underlie all mutator phenotypes described here. Of nine independently derived hypermutable strains, seven contained a defective mutS allele. Because these mutant alleles increase the mutation rate and enhance recombination among diverse species, these studies may help explain both the rapid emergence of antibiotic resistance and the penetrance of virulence genes within the prokaryotic community.

Molecular Biology Branch, Center for Food Safety and Applied Nutrition (HFS-235), Food and Drug Administration, Washington, DC 20204, USA.
*   To whom correspondence should be addressed. E-mail: tac{at}vax8.cfsan.fda.gov

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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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Detection of simple mutations and polymorphisms in large genomic regions.
E. V. Sokurenko, V. Tchesnokova, A. T. Yeung, C. A. Oleykowski, E. Trintchina, K. T. Hughes, R. A. Rashid, J. M. Brint, S. L. Moseley, and S. Lory (2001)
Nucleic Acids Res. 29, e111
   Abstract »    Full Text »    PDF »
Mutation frequency and biological cost of antibiotic resistance in Helicobacter pylori.
B. Bjorkholm, M. Sjolund, P. G. Falk, O. G. Berg, L. Engstrand, and D. I. Andersson (2001)
PNAS
   Abstract »    Full Text »    PDF »
Role of Genomic Typing in Taxonomy, Evolutionary Genetics, and Microbial Epidemiology.
A. van Belkum, M. Struelens, A. de Visser, H. Verbrugh, and M. Tibayrenc (2001)
Clin. Microbiol. Rev. 14, 547-560
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Microsatellites in the Eukaryotic DNA Mismatch Repair Genes as Modulators of Evolutionary Mutation Rate.
D. K. Chang, D. Metzgar, C. Wills, and C. R. Boland (2001)
Genome Res. 11, 1145-1146
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Amplification of Mutator Cells in a Population as a Result of Horizontal Transfer.
P. Funchain, A. Yeung, J. Stewart, W. M. Clendenin, and J. H. Miller (2001)
J. Bacteriol. 183, 3737-3741
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Use of Mutator Strains for Characterization of Novel Antimicrobial Agents.
A. J. O'Neill, I. Chopra, J. L. Martínez, and F. Baquero (2001)
Antimicrob. Agents Chemother. 45, 1599-1600
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