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Science 15 November 1996:
Vol. 274. no. 5290, pp. 1194 - 1197
DOI: 10.1126/science.274.5290.1194
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Reports

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

Caridad Rosette and Michael Karin *

Exposure of mammalian cells to ultraviolet (UV) light or high osmolarity strongly activates the c-Jun amino-terminal protein kinase (JNK) cascade, causing induction of many target genes. Exposure to UV light or osmotic shock induced clustering and internalization of cell surface receptors for epidermal growth factor (EGF), tumor necrosis factor (TNF), and interleukin-1 (IL-1). Activation of the EGF and TNF receptors was also detected biochemically. Whereas activation of each receptor alone resulted in modest activation of JNK, coadministration of EGF, IL-1, and TNF resulted in a strong synergistic response equal to that caused by exposure to osmotic shock or UV light. Inhibition of clustering or receptor down-regulation attenuated both the osmotic shock and UV responses. Physical stresses may perturb the cell surface or alter receptor conformation, thereby subverting signaling pathways normally used by growth factors and cytokines.

Department of Pharmacology, Program in Biomedical Sciences, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA.
*   To whom correspondence should be addressed.

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Mol. Pharmacol. 63, 512-523
   Abstract »    Full Text »    PDF »
A Single c-Jun N-terminal Kinase Isoform (JNK3-p54) Is an Effector in Both Neuronal Differentiation and Cell Death.
V. Waetzig and T. Herdegen (2003)
J. Biol. Chem. 278, 567-572
   Abstract »    Full Text »    PDF »
Inhibition of interferon-gamma expression by osmotic shrinkage of peripheral blood lymphocytes.
K. S. Lang, C. Weigert, S. Braedel, S. Fillon, M. Palmada, E. Schleicher, H.-G. Rammensee, and F. Lang (2003)
Am J Physiol Cell Physiol 284, C200-C208
   Abstract »    Full Text »    PDF »
Gadd45a Protects against UV Irradiation-induced Skin Tumors, and Promotes Apoptosis and Stress Signaling via MAPK and p53.
J. Hildesheim, D. V. Bulavin, M. R. Anver, W. G. Alvord, M. C. Hollander, L. Vardanian, and A. J. Fornace Jr. (2002)
Cancer Res. 62, 7305-7315
   Abstract »    Full Text »    PDF »
Inhibitory Effects of Sodium Salicylate and Acetylsalicylic Acid on UVB-induced Mouse Skin Carcinogenesis.
W. B. Bair III, N. Hart, J. Einspahr, G. Liu, Z. Dong, D. Alberts, and G. T. Bowden (2002)
Cancer Epidemiol. Biomarkers Prev. 11, 1645-1652
   Abstract »    Full Text »    PDF »
Damage Recovery Pathways in Saccharomyces cerevisiae Revealed by Genomic Phenotyping and Interactome Mapping.
T. J. Begley, A. S. Rosenbach, T. Ideker, and L. D. Samson (2002)
Mol. Cancer Res. 1, 103-112
   Abstract »    Full Text »    PDF »
p38 and Activating Transcription Factor-2 Involvement in Osteoblast Osmotic Response to Elevated Extracellular Glucose.
M. Zayzafoon, S. Botolin, and L. R. McCabe (2002)
J. Biol. Chem. 277, 37212-37218
   Abstract »    Full Text »    PDF »
PKC{alpha}-mediated ERK, JNK and p38 activation regulates the myogenic program in human rhabdomyosarcoma cells.
A. Mauro, C. Ciccarelli, P. De Cesaris, A. Scoglio, M. Bouche, M. Molinaro, A. Aquino, and B. M. Zani (2002)
J. Cell Sci. 115, 3587-3599
   Abstract »    Full Text »    PDF »
gamma -Synuclein Promotes Cancer Cell Survival and Inhibits Stress- and Chemotherapy Drug-induced Apoptosis by Modulating MAPK Pathways.
Z.-Z. Pan, W. Bruening, B. I. Giasson, V. M.-Y. Lee, and A. K. Godwin (2002)
J. Biol. Chem. 277, 35050-35060
   Abstract »    Full Text »    PDF »
Activation of the p38 Signaling Pathway by Heat Shock Involves the Dissociation of Glutathione S-Transferase Mu from Ask1.
S. Dorion, H. Lambert, and J. Landry (2002)
J. Biol. Chem. 277, 30792-30797
   Abstract »    Full Text »    PDF »
The Zinc Finger Domain of NEMO Is Selectively Required for NF-{kappa}B Activation by UV Radiation and Topoisomerase Inhibitors.
T. T. Huang, S. L. Feinberg, S. Suryanarayanan, and S. Miyamoto (2002)
Mol. Cell. Biol. 22, 5813-5825
   Abstract »    Full Text »    PDF »
Inhibition of JNK by Cellular Stress- and Tumor Necrosis Factor alpha -induced AKT2 through Activation of the NFkappa B Pathway in Human Epithelial Cells.
Z.-q. Yuan, R. I. Feldman, M. Sun, N. E. Olashaw, D. Coppola, G. E. Sussman, S. A. Shelley, S. V. Nicosia, and J. Q. Cheng (2002)
J. Biol. Chem. 277, 29973-29982
   Abstract »    Full Text »    PDF »
Ultraviolet-B Activates Components of the Systemin Signaling Pathway in Lycopersicon peruvianum Suspension-cultured Cells.
R. D. Yalamanchili and J. W. Stratmann (2002)
J. Biol. Chem. 277, 28424-28430
   Abstract »    Full Text »    PDF »
Invited Review: Cell Volume Control and Signal Transduction in Apoptosis.
M. Gomez-Angelats and J. A. Cidlowski (2002)
Toxicol Pathol 30, 541-551
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Impairment of macrophage survival by NaCl: implications for early pulmonary inflammation in cystic fibrosis.
G. S. Kerby, V. Cottin, F. J. Accurso, F. Hoffmann, E. D. Chan, V. A. Fadok, and D. W. H. Riches (2002)
Am J Physiol Lung Cell Mol Physiol 283, L188-L197
   Abstract »    Full Text »    PDF »
Activation of JNK1, RSK2, and MSK1 Is Involved in Serine 112 Phosphorylation of Bad by Ultraviolet B Radiation.
Q.-B. She, W.-Y. Ma, S. Zhong, and Z. Dong (2002)
J. Biol. Chem. 277, 24039-24048
   Abstract »    Full Text »    PDF »


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