Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 15 November 1996:
Vol. 274. no. 5290, pp. 1109 - 1115
DOI: 10.1126/science.274.5290.1109
Prev | Table of Contents | Next

Articles

Patterning the Vertebrate Neuraxis

Andrew Lumsden and Robb Krumlauf

Neuraxial patterning is a continuous process that extends over a protracted period of development. During gastrulation a crude anteroposterior pattern, detectable by molecular markers, is conferred on the neuroectoderm by signals from the endomesoderm that are largely inseparable from those of neural induction itself. This coarse-grained pattern is subsequently reinforced and refined by diverse, locally acting mechanisms. Segmentation and long-range signaling from organizing centers are prominent among the emerging principles governing regional pattern.

A. Lumsden is in the Medical Research Council Brain Development Programme, Department of Developmental Neurobiology, United Medical and Dental Schools, Guy's Hospital, London SE1 9RT, UK. E-mail: a.lumsden{at}umds.ac.uk. R. Krumlauf is in the Division of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW17 1AA, UK. E-mail: r-krumla{at}nimr.mrc.ac.uk

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Developmental basis of the rostro-caudal organization of the brainstem respiratory rhythm generator.
J. Champagnat, M. P. Morin-Surun, G. Fortin, and M. Thoby-Brisson (2009)
Phil Trans R Soc B 364, 2469-2476
   Abstract »    Full Text »    PDF »
Transcriptional Control of Neuronal Migration in the Developing Mouse Brain.
S. Nobrega-Pereira and O. Marin (2009)
Cereb Cortex 19, i107-i113
   Abstract »    Full Text »    PDF »
Krox20 Controls the Transcription of Its Various Targets in the Developing Hindbrain According to Multiple Modes.
A. Desmazieres, P. Charnay, and P. Gilardi-Hebenstreit (2009)
J. Biol. Chem. 284, 10831-10840
   Abstract »    Full Text »    PDF »
Human ESC-derived Neural Rosettes and Neural Stem Cell Progression.
Y. Elkabetz and L. Studer (2009)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Reciprocal co-regulation of EGR2 and MECP2 is disrupted in Rett syndrome and autism.
S. E. Swanberg, R. P. Nagarajan, S. Peddada, D. H. Yasui, and J. M. LaSalle (2009)
Hum. Mol. Genet. 18, 525-534
   Abstract »    Full Text »    PDF »
Gene Networks in Development and Evolution Special Feature Sackler Colloquium: A regulatory module embedded in the coding region of Hoxa2 controls expression in rhombomere 2.
S. Tumpel, F. Cambronero, C. Sims, R. Krumlauf, and L. M. Wiedemann (2008)
PNAS 105, 20077-20082
   Abstract »    Full Text »    PDF »
Differential origin of reticulospinal drive to motoneurons innervating trunk and hindlimb muscles in the mouse revealed by optical recording.
K. Szokol, J. C. Glover, and M.-C. Perreault (2008)
J. Physiol. 586, 5259-5276
   Abstract »    Full Text »    PDF »
Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon.
D. Omodei, D. Acampora, P. Mancuso, N. Prakash, L. G. Di Giovannantonio, W. Wurst, and A. Simeone (2008)
Development 135, 3459-3470
   Abstract »    Full Text »    PDF »
Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors.
M. A. Wassef, D. Chomette, M. Pouilhe, A. Stedman, E. Havis, C. Desmarquet-Trin Dinh, S. Schneider-Maunoury, P. Gilardi-Hebenstreit, P. Charnay, and J. Ghislain (2008)
Development 135, 3369-3378
   Abstract »    Full Text »    PDF »
Control of Precerebellar Neuron Development by Olig3 bHLH Transcription Factor.
Z. Liu, H. Li, X. Hu, L. Yu, H. Liu, R. Han, R. Colella, G. D. Mower, Y. Chen, and M. Qiu (2008)
J. Neurosci. 28, 10124-10133
   Abstract »    Full Text »    PDF »
An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4.
X. Lampe, O. A. Samad, A. Guiguen, C. Matis, S. Remacle, J. J. Picard, F. M. Rijli, and R. Rezsohazy (2008)
Nucleic Acids Res. 36, 3214-3225
   Abstract »    Full Text »    PDF »
Six3 inactivation causes progressive caudalization and aberrant patterning of the mammalian diencephalon.
A. Lavado, O. V. Lagutin, and G. Oliver (2008)
Development 135, 441-450
   Abstract »    Full Text »    PDF »
Cornichon-like Protein Facilitates Secretion of HB-EGF and Regulates Proper Development of Cranial Nerves.
H. Hoshino, T. Uchida, T. Otsuki, S. Kawamoto, K. Okubo, M. Takeichi, and O. Chisaka (2007)
Mol. Biol. Cell 18, 1143-1152
   Abstract »    Full Text »    PDF »
Hox gene expression in the hemichordate Saccoglossus kowalevskii and the evolution of deuterostome nervous systems.
J. Aronowicz and C. J. Lowe (2006)
Integr. Comp. Biol. 46, 890-901
   Abstract »    Full Text »    PDF »
The roof plate regulates cerebellar cell-type specification and proliferation.
V. V. Chizhikov, A. G. Lindgren, D. S. Currle, M. F. Rose, E. S. Monuki, and K. J. Millen (2006)
Development 133, 2793-2804
   Abstract »    Full Text »    PDF »
Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system.
J. H. Baek, J. Hatakeyama, S. Sakamoto, T. Ohtsuka, and R. Kageyama (2006)
Development 133, 2467-2476
   Abstract »    Full Text »    PDF »
Otx2 controls identity and fate of glutamatergic progenitors of the thalamus by repressing GABAergic differentiation..
E. Puelles, D. Acampora, R. Gogoi, F. Tuorto, A. Papalia, F. Guillemot, S.-L. Ang, and A. Simeone (2006)
J. Neurosci. 26, 5955-5964
   Abstract »    Full Text »    PDF »
Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphants.
I. Foucher, M. Mione, A. Simeone, D. Acampora, L. Bally-Cuif, and C. Houart (2006)
Development 133, 1891-1900
   Abstract »    Full Text »    PDF »
A threshold requirement for Gbx2 levels in hindbrain development..
S. T. Waters and M. Lewandoski (2006)
Development 133, 1991-2000
   Abstract »    Full Text »    PDF »
Evolution of cis elements in the differential expression of two Hoxa2 coparalogous genes in pufferfish (Takifugu rubripes).
S. Tumpel, F. Cambronero, L. M. Wiedemann, and R. Krumlauf (2006)
PNAS 103, 5419-5424
   Abstract »    Full Text »    PDF »
Krox20 hindbrain cis-regulatory landscape: interplay between multiple long-range initiation and autoregulatory elements.
D. Chomette, M. Frain, S. Cereghini, P. Charnay, and J. Ghislain (2006)
Development 133, 1253-1262
   Abstract »    Full Text »    PDF »
Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon.
S. Scholpp, O. Wolf, M. Brand, and A. Lumsden (2006)
Development 133, 855-864
   Abstract »    Full Text »    PDF »
HoxD cluster scanning deletions identify multiple defects leading to paralysis in the mouse mutant Ironside.
B. Tarchini, T. H. N. Huynh, G. A. Cox, and D. Duboule (2005)
Genes & Dev. 19, 2862-2876
   Abstract »    Full Text »    PDF »
Ventromedial Hypothalamic Nucleus-Specific Enhancer of Ad4BP/SF-1 Gene.
Y. Shima, M. Zubair, S. Ishihara, Y. Shinohara, S. Oka, S. Kimura, S. Okamoto, Y. Minokoshi, S. Suita, and K.-i. Morohashi (2005)
Mol. Endocrinol. 19, 2812-2823
   Abstract »    Full Text »    PDF »
Hoxb1 Enhancer and Control of Rhombomere 4 Expression: Complex Interplay between PREP1-PBX1-HOXB1 Binding Sites.
E. Ferretti, F. Cambronero, S. Tumpel, E. Longobardi, L. M. Wiedemann, F. Blasi, and R. Krumlauf (2005)
Mol. Cell. Biol. 25, 8541-8552
   Abstract »    Full Text »    PDF »
Adult mouse brain gene expression patterns bear an embryologic imprint.
M. A. Zapala, I. Hovatta, J. A. Ellison, L. Wodicka, J. A. Del Rio, R. Tennant, W. Tynan, R. S. Broide, R. Helton, B. S. Stoveken, et al. (2005)
PNAS 102, 10357-10362
   Abstract »    Full Text »    PDF »
Otx2 Regulates Subtype Specification and Neurogenesis in the Midbrain.
B. Vernay, M. Koch, F. Vaccarino, J. Briscoe, A. Simeone, R. Kageyama, and S.-L. Ang (2005)
J. Neurosci. 25, 4856-4867
   Abstract »    Full Text »    PDF »
Role of the hindbrain in dorsoventral but not anteroposterior axial specification of the inner ear.
J. Bok, M. Bronner-Fraser, and D. K. Wu (2005)
Development 132, 2115-2124
   Abstract »    Full Text »    PDF »
New regulatory interactions and cellular responses in the isthmic organizer region revealed by altering Gbx2 expression.
J. Y. H. Li, Z. Lao, and A. L. Joyner (2005)
Development 132, 1971-1981
   Abstract »    Full Text »    PDF »
Wnt1 regulates neurogenesis and mediates lateral inhibition of boundary cell specification in the zebrafish hindbrain.
M. Amoyel, Y.-C. Cheng, Y.-J. Jiang, and D. G. Wilkinson (2005)
Development 132, 775-785
   Abstract »    Full Text »    PDF »
Direct crossregulation between retinoic acid receptor {beta} and Hox genes during hindbrain segmentation.
P. Serpente, S. Tumpel, N. B. Ghyselinck, K. Niederreither, L. M. Wiedemann, P. Dolle, P. Chambon, R. Krumlauf, and A. P. Gould (2005)
Development 132, 503-513
   Abstract »    Full Text »    PDF »
Segment-specific prevention of pioneer neuron apoptosis by cell-autonomous, postmitotic Hox gene activity.
I. Miguel-Aliaga and S. Thor (2004)
Development 131, 6093-6105
   Abstract »    Full Text »    PDF »
Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development.
N. Haubst, J. Berger, V. Radjendirane, J. Graw, J. Favor, G. F. Saunders, A. Stoykova, and M. Gotz (2004)
Development 131, 6131-6140
   Abstract »    Full Text »    PDF »
Compartmentalization of visual centers in the Drosophila brain requires Slit and Robo proteins.
T. D. Tayler, M. B. Robichaux, and P. A. Garrity (2004)
Development 131, 5935-5945
   Abstract »    Full Text »    PDF »
Induction of a Parafacial Rhythm Generator by Rhombomere 3 in the Chick Embryo.
A. P. Coutinho, C. Borday, J. Gilthorpe, S. Jungbluth, J. Champagnat, A. Lumsden, and G. Fortin (2004)
J. Neurosci. 24, 9383-9390
   Abstract »    Full Text »    PDF »
vhnf1 integrates global RA patterning and local FGF signals to direct posterior hindbrain development in zebrafish.
R. E. Hernandez, H. A. Rikhof, R. Bachmann, and C. B. Moens (2004)
Development 131, 4511-4520
   Abstract »    Full Text »    PDF »
Retinoic acid signalling specifies intermediate character in the developing telencephalon.
M. Marklund, M. Sjodal, B. C. Beehler, T. M. Jessell, T. Edlund, and L. Gunhaga (2004)
Development 131, 4323-4332
   Abstract »    Full Text »    PDF »
Integration of anteroposterior and dorsoventral regulation of Phox2b transcription in cranial motoneuron progenitors by homeodomain proteins.
O. A. Samad, M. J. Geisen, G. Caronia, I. Varlet, V. Zappavigna, J. Ericson, C. Goridis, and F. M. Rijli (2004)
Development 131, 4071-4083
   Abstract »    Full Text »    PDF »
Establishing neuronal circuitry: Hox genes make the connection.
J. Briscoe and D. G. Wilkinson (2004)
Genes & Dev. 18, 1643-1648
   Full Text »    PDF »
The zebrafish Iroquois gene iro7 positions the r4/r5 boundary and controls neurogenesis in the rostral hindbrain.
V. Lecaudey, I. Anselme, F. Rosa, and S. Schneider-Maunoury (2004)
Development 131, 3121-3131
   Abstract »    Full Text »    PDF »
Hox Gene Misexpression and Cell-Specific Lesions Reveal Functionality of Homeotically Transformed Neurons.
M. E. Hale, M. A. Kheirbek, J. E. Schriefer, and V. E. Prince (2004)
J. Neurosci. 24, 3070-3076
   Abstract »    Full Text »    PDF »
Segmental development of reticulospinal and branchiomotor neurons in lamprey: insights into the evolution of the vertebrate hindbrain.
Y. Murakami, M. Pasqualetti, Y. Takio, S. Hirano, F. M. Rijli, and S. Kuratani (2004)
Development 131, 983-995
   Abstract »    Full Text »    PDF »
Isthmus-to-midbrain transformation in the absence of midbrain-hindbrain organizer activity.
J. Jaszai, F. Reifers, A. Picker, T. Langenberg, and M. Brand (2003)
Development 130, 6611-6623
   Abstract »    Full Text »    PDF »
Neuronal defects in the hindbrain of Hoxa1, Hoxb1 and Hoxb2 mutants reflect regulatory interactions among these Hox genes.
A. Gavalas, C. Ruhrberg, J. Livet, C. E. Henderson, and R. Krumlauf (2003)
Development 130, 5663-5679
   Abstract »    Full Text »    PDF »
Nkx6.1 controls migration and axon pathfinding of cranial branchio-motoneurons.
M. Muller, N. Jabs, D. E. Lork, B. Fritzsch, and M. Sander (2003)
Development 130, 5815-5826
   Abstract »    Full Text »    PDF »
Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects.
Y. Ito, J. Y. Yeo, A. Chytil, J. Han, P. Bringas Jr, A. Nakajima, C. F. Shuler, H. L. Moses, and Y. Chai (2003)
Development 130, 5269-5280
   Abstract »    Full Text »    PDF »
Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon.
S. Scholpp, C. Lohs, and M. Brand (2003)
Development 130, 4881-4893
   Abstract »    Full Text »    PDF »
Glial Cells Generate Neurons--Master Control within CNS Regions: Developmental Perspectives on Neural Stem Cells.
M. Gotz (2003)
Neuroscientist 9, 379-397
   Abstract »    PDF »
Complementary roles for Nkx6 and Nkx2 class proteins in the establishment of motoneuron identity in the hindbrain.
A. Pattyn, A. Vallstedt, J. M. Dias, M. Sander, and J. Ericson (2003)
Development 130, 4149-4159
   Abstract »    Full Text »    PDF »
vhnf1 and Fgf signals synergize to specify rhombomere identity in the zebrafish hindbrain.
E. L. Wiellette and H. Sive (2003)
Development 130, 3821-3829
   Abstract »    Full Text »    PDF »
Somatic motoneurone specification in the hindbrain: the influence of somite-derived signals, retinoic acid and Hoxa3.
S. Guidato, F. Prin, and S. Guthrie (2003)
Development 130, 2981-2996
   Abstract »    Full Text »    PDF »
Joint regulation of the MAP1B promoter by HNF3{beta}/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors.
I. Foucher, M. L. Montesinos, M. Volovitch, A. Prochiantz, and A. Trembleau (2003)
Development 130, 1867-1876
   Abstract »    Full Text »    PDF »
Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors.
A. Pattyn, A. Vallstedt, J. M. Dias, O. A. Samad, R. Krumlauf, F. M. Rijli, J.-F. Brunet, and J. Ericson (2003)
Genes & Dev. 17, 729-737
   Abstract »    Full Text »    PDF »
Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning.
G. Davidson, B. Mao, I. del Barco Barrantes, and C. Niehrs (2003)
Development 129, 5587-5596
   Abstract »    Full Text »    PDF »
A sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo.
M. Ishibashi and A. P. McMahon (2003)
Development 129, 4807-4819
   Abstract »    Full Text »    PDF »
FGF3 and FGF8 mediate a rhombomere 4 signaling activity in the zebrafish hindbrain.
L. Maves, W. Jackman, and C. B. Kimmel (2003)
Development 129, 3825-3837
   Abstract »    Full Text »    PDF »
Knockdown of duplicated zebrafish hoxb1 genes reveals distinct roles in hindbrain patterning and a novel mechanism of duplicate gene retention.
J. M. McClintock, M. A. Kheirbek, and V. E. Prince (2003)
Development 129, 2339-2354
   Abstract »    Full Text »    PDF »
Requirement for downregulation of kreisler during late patterning of the hindbrain.
T. Theil, L. Ariza-McNaughton, M. Manzanares, J. Brodie, R. Krumlauf, and D. G. Wilkinson (2003)
Development 129, 1477-1485
   Abstract »    Full Text »    PDF »
spiel-ohne-grenzen/pou2 mediates regional competence to respond to Fgf8 during zebrafish early neural development.
G. Reim and M. Brand (2003)
Development 129, 917-933
   Abstract »    Full Text »    PDF »
The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by separate enhancers.
P. L. Pfeffer, B. Payer, G. Reim, M. P. di Magliano, and M. Busslinger (2003)
Development 129, 307-318
   Abstract »    Full Text »    PDF »
Signalling between the hindbrain and paraxial tissues dictates neural crest migration pathways.
P. A. Trainor, D. Sobieszczuk, D. Wilkinson, and R. Krumlauf (2003)
Development 129, 433-442
   Abstract »    Full Text »    PDF »
TGF-{beta} SIGNALING AND ITS FUNCTIONAL SIGNIFICANCE IN REGULATING THE FATE OF CRANIAL NEURAL CREST CELLS.
Y. Chai, Y. Ito, and J. Han (2003)
Critical Reviews in Oral Biology & Medicine 14, 78-88
   Abstract »    Full Text »    PDF »
Neural crest patterning: autoregulatory and crest-specific elements co-operate for Krox20 transcriptional control.
J. Ghislain, C. Desmarquet-Trin-Dinh, P. Gilardi-Hebenstreit, P. Charnay, and M. Frain (2003)
Development 130, 941-953
   Abstract »    Full Text »    PDF »
Fgfr1 regulates patterning of the pharyngeal region.
N. Trokovic, R. Trokovic, P. Mai, and J. Partanen (2003)
Genes & Dev. 17, 141-153
   Abstract »    Full Text »    PDF »
Arcuate Plan of Chick Midbrain Development.
T. A. Sanders, A. Lumsden, and C. W. Ragsdale (2002)
J. Neurosci. 22, 10742-10750
   Abstract »    Full Text »    PDF »
YY1 activates Msx2 gene independent of bone morphogenetic protein signaling.
D. P. Tan, K. Nonaka, G. H. Nuckolls, Y. H. Liu, R. E. Maxson, H. C. Slavkin, and L. Shum (2002)
Nucleic Acids Res. 30, 1213-1223
   Abstract »    Full Text »    PDF »
Role of the Isthmus and FGFs in Resolving the Paradox of Neural Crest Plasticity and Prepatterning.
P. A. Trainor, L. Ariza-McNaughton, and R. Krumlauf (2002)
Science 295, 1288-1291
   Abstract »    Full Text »    PDF »
Establishing the trochlear motor axon trajectory: role of the isthmic organiser and Fgf8.
C. Irving, A. Malhas, S. Guthrie, and I. Mason (2002)
Development 129, 5389-5398
   Abstract »    Full Text »    PDF »
Cues from neuroepithelium and surface ectoderm maintain neural crest-free regions within cranial mesenchyme of the developing chick.
J. P. Golding, M. Dixon, and M. Gassmann (2002)
Development 129, 1095-1105
   Abstract »    Full Text »    PDF »
Early subdivisions in the neural plate define distinct competence for inductive signals.
D. Kobayashi, M. Kobayashi, K. Matsumoto, T. Ogura, M. Nakafuku, and K. Shimamura (2002)
Development 129, 83-93
   Abstract »    Full Text »    PDF »
Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain.
S. Hitoshi, V. Tropepe, M. Ekker, and D. van der Kooy (2002)
Development 129, 233-244
   Abstract »    Full Text »    PDF »
Hindbrain patterning: Krox20 couples segmentation and specification of regional identity.
O. Voiculescu, E. Taillebourg, C. Pujades, C. Kress, S. Buart, P. Charnay, and S. Schneider-Maunoury (2001)
Development 128, 4967-4978
   Abstract »    Full Text »    PDF »
The transcription factor neurogenin 2 restricts cell migration from the cortex to the striatum.
P. Chapouton, C. Schuurmans, F. Guillemot, and M. Gotz (2001)
Development 128, 5149-5159
   Abstract »    Full Text »    PDF »
OTD/OTX2 functional equivalence depends on 5' and 3' UTR-mediated control of Otx2 mRNA for nucleo-cytoplasmic export and epiblast-restricted translation.
D. Acampora, P. P. Boyl, M. Signore, J. P. Martinez-Barbera, C. Ilengo, E. Puelles, A. Annino, H. Reichert, G. Corte, and A. Simeone (2001)
Development 128, 4801-4813
   Abstract »    Full Text »    PDF »
Antagonistic Effects of Smad2 Versus Smad7 Are Sensitive to Their Expression Level during Tooth Development.
Y. Ito, J. Zhao, A. Mogharei, C. F. Shuler, M. Weinstein, C. Deng, and Y. Chai (2001)
J. Biol. Chem. 276, 44163-44172
   Abstract »    Full Text »    PDF »
A morphogen gradient of Wnt/{beta}-catenin signalling regulates anteroposterior neural patterning in Xenopus.
C. Kiecker and C. Niehrs (2001)
Development 128, 4189-4201
   Abstract »    Full Text »    PDF »
The zebrafish buttonhead-like factor Bts1 is an early regulator of pax2.1 expression during mid-hindbrain development.
A. Tallafu{beta}, T. P. Wilm, M. Crozatier, P. Pfeffer, M. Wassef, and L. Bally-Cuif (2001)
Development 128, 4021-4034
   Abstract »    Full Text »    PDF »
Body patterning.
Y. Takahashi, N. Osumi, and N. H. Patel (2001)
PNAS
   Abstract »    Full Text »    PDF »
Initiation of facial motoneurone migration is dependent on rhombomeres 5 and 6.
M. Studer (2001)
Development 128, 3707-3716
   Abstract »    Full Text »    PDF »
Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo.
C. E. Erter, T. P. Wilm, N. Basler, C. V. E. Wright, and L. Solnica-Krezel (2001)
Development 128, 3571-3583
   Abstract »    Full Text »    PDF »
Independent regulation of initiation and maintenance phases of Hoxa3 expression in the vertebrate hindbrain involve auto- and cross-regulatory mechanisms.
M. Manzanares, S. Bel-Vialar, L. Ariza-McNaughton, E. Ferretti, H. Marshall, M. M. Maconochie, F. Blasi, and R. Krumlauf (2001)
Development 128, 3595-3607
   Abstract »    Full Text »    PDF »
Generation of a Novel Functional Neuronal Circuit in Hoxa1 Mutant Mice.
E. D. del Toro, V. Borday, M. Davenne, R. Neun, F. M. Rijli, and J. Champagnat (2001)
J. Neurosci. 21, 5637-5642
   Abstract »    Full Text »    PDF »
The Iroquois family of genes: from body building to neural patterning.
F. Cavodeassi, J. Modolell, and J. L. Gomez-Skarmeta (2001)
Development 128, 2847-2855
   Abstract »    Full Text »    PDF »
Synergy between Hoxa1 and Hoxb1: the relationship between arch patterning and the generation of cranial neural crest.
A. Gavalas, P. Trainor, L. Ariza-McNaughton, and R. Krumlauf (2001)
Development 128, 3017-3027
   Abstract »    Full Text »    PDF »
Vitamin A and the developing embryo.
M MADEN (2001)
Postgrad. Med. J. 77, 489-491
   Full Text »    PDF »
Boundary Formation and Compartition in the Avian Diencephalon.
C. W. Larsen, L. M. Zeltser, and A. Lumsden (2001)
J. Neurosci. 21, 4699-4711
   Abstract »    Full Text »    PDF »
Consequences of Hox gene duplication in the vertebrates: an investigation of the zebrafish Hox paralogue group 1 genes.
J. M. McClintock, R. Carlson, D. M. Mann, and V. E. Prince (2001)
Development 128, 2471-2484
   Abstract »    Full Text »    PDF »
Hoxd10 induction and regionalization in the developing lumbosacral spinal cord.
C. Lance-Jones, N. Omelchenko, A. Bailis, S. Lynch, and K. Sharma (2001)
Development 128, 2255-2268
   Abstract »    Full Text »    PDF »
Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice.
A. Ikeda, S. Ikeda, T. Gridley, P. M. Nishina, and J. K. Naggert (2001)
Hum. Mol. Genet. 10, 1325-1334
   Abstract »    Full Text »    PDF »
A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon.
C.-P. Heisenberg, C. Houart, M. Take-uchi, G.-J. Rauch, N. Young, P. Coutinho, I. Masai, L. Caneparo, M. L. Concha, R. Geisler, et al. (2001)
Genes & Dev. 15, 1427-1434
   Abstract »    Full Text »    PDF »
Krox-20 patterns the hindbrain through both cell-autonomous and non cell-autonomous mechanisms.
F. Giudicelli, E. Taillebourg, P. Charnay, and P. Gilardi-Hebenstreit (2001)
Genes & Dev. 15, 567-580
   Abstract »    Full Text »
Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes.
A. Grapin-Botton, A. R. Majithia, and D. A. Melton (2001)
Genes & Dev. 15, 444-454
   Abstract »    Full Text »
Vitronectin regulates Sonic hedgehog activity during cerebellum development through CREB phosphorylation.
S Pons, J. Trejo, J. Martinez-Morales, and E Marti (2001)
Development 128, 1481-1492
   Abstract »    PDF »
Monofocal origin of telencephalic oligodendrocytes in the anterior entopeduncular area of the chick embryo.
C Olivier, I Cobos, E. Perez Villegas, N Spassky, B Zalc, S Martinez, and J. Thomas (2001)
Development 128, 1757-1769
   Abstract »    PDF »
Role of cadherins in maintaining the compartment boundary between the cortex and striatum during development.
T Inoue, T Tanaka, M Takeichi, O Chisaka, S Nakamura, and N Osumi (2001)
Development 128, 561-569
   Abstract »    PDF »
Stem Cells and Neuronal Progenitors and Their Diversity in the CNS: Are Time and Place Important?.
F. M. Vaccarino (2000)
Neuroscientist 6, 338-352
   Abstract »    PDF »
Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma.
X. X. Tang, H. Zhao, M. E. Robinson, B. Cohen, A. Cnaan, W. London, S. L. Cohn, N.-K. V. Cheung, G. M. Brodeur, A. E. Evans, et al. (2000)
PNAS
   Abstract »    Full Text »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)