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Science 8 November 1996:
Vol. 274. no. 5289, pp. 990 - 992
DOI: 10.1126/science.274.5289.990
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Reports

Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95

Arul M. Chinnaiyan, * Karen O'Rourke, * Guo-Liang Yu, * Robert H. Lyons, Manish Garg, D. Roxanne Duan, Lily Xing, Reiner Gentz, Jian Ni, dagger Vishva M. Dixit dagger ddagger

Tumor necrosis factor receptor-1 (TNFR-1) and CD95 (also called Fas or APO-1) are cytokine receptors that engage the apoptosis pathway through a region of intracellular homology, designated the "death domain." Another death domain-containing member of the TNFR family, death receptor 3 (DR3), was identified and was shown to induce both apoptosis and activation of nuclear factor kappa B. Expression of DR3 appears to be restricted to tissues enriched in lymphocytes. DR3 signal transduction is mediated by a complex of intracellular signaling molecules including TRADD, TRAF2, FADD, and FLICE. Thus, DR3 likely plays a role in regulating lymphocyte homeostasis.

A. M. Chinnaiyan, K. O'Rourke, M. Garg, V. M. Dixit, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
G.-L. Yu, D. R. Duan, L. Xing, R. Gentz, J. Ni, Human Genome Sciences Inc., 9620 Medical Center Drive, Suite 300, Rockville, MD 20850-3338, USA.
R. H. Lyons, Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
*   These authors contributed equally to this report.

dagger    These authors share senior authorship.

ddagger    To whom correspondence should be addressed.

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J. Biol. Chem. 273, 27548-27556
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Thymic Expression of the Transcription Factor Nur77 Rescues the T Cell But Not the B Cell Abnormality of gld/gld Mice.
F. K.-M. Chan and A. C. Astar Winoto (1998)
J. Immunol. 161, 4252-4256
   Abstract »    Full Text »    PDF »
p38 MAPK Is Required for CD40-Induced Gene Expression and Proliferation in B Lymphocytes.
A. Craxton, G. Shu, J. D. Graves, J. Saklatvala, E. G. Krebs, and E. A. Clark (1998)
J. Immunol. 161, 3225-3236
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Tumor necrosis factor receptor-associated factors (TRAFs)---a family of adapter proteins that regulates life and death.
R. H. Arch, R. W. Gedrich, and C. B. Thompson (1998)
Genes & Dev. 12, 2821-2830
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Apoptosis Induced by Drosophila Reaper and Grim in a Human System. ATTENUATION BY INHIBITOR OF APOPTOSIS PROTEINS (cIAPs).
J. V. McCarthy and V. M. Dixit (1998)
J. Biol. Chem. 273, 24009-24015
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Dual Signaling of the Fas Receptor: Initiation of Both Apoptotic and Necrotic Cell Death Pathways.
D. Vercammen, G. Brouckaert, G. Denecker, M. Van de Craen, W. Declercq, W. Fiers, and P. Vandenabeele (1998)
J. Exp. Med. 188, 919-930
   Abstract »    Full Text »    PDF »
BRE: a modulator of TNF-{alpha} action.
C. Gu, A. Castellino, J. Y-h. Chan, and M. V. Chao (1998)
FASEB J 12, 1101-1108
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Death Receptors: Signaling and Modulation.
A. Ashkenazi and V. M. Dixit (1998)
Science 281, 1305-1308
   Abstract »    Full Text »
Antibodies to TR2 (Herpesvirus Entry Mediator), a New Member of the TNF Receptor Superfamily, Block T Cell Proliferation, Expression of Activation Markers, and Production of Cytokines.
J. A. Harrop, M. Reddy, K. Dede, M. Brigham-Burke, S. Lyn, K. B. Tan, C. Silverman, C. Eichman, R. DiPrinzio, J. Spampanato, et al. (1998)
J. Immunol. 161, 1786-1794
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Lipopolysaccharide Mediates Endothelial Apoptosis by a FADD-dependent Pathway.
K.-B. Choi, F. Wong, J. M. Harlan, P. M. Chaudhary, L. Hood, and A. Karsan (1998)
J. Biol. Chem. 273, 20185-20188
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Molecular Cloning and Characterization of the Mouse tag7 Gene Encoding a Novel Cytokine.
S. L. Kiselev, O. S. Kustikova, E. V. Korobko, E. B. Prokhortchouk, A. A. Kabishev, E. M. Lukanidin, and G. P. Georgiev (1998)
J. Biol. Chem. 273, 18633-18639
   Abstract »    Full Text »    PDF »
RIP2 Is a Novel NF-kappa B-activating and Cell Death-inducing Kinase.
J. V. McCarthy, J. Ni, and V. M. Dixit (1998)
J. Biol. Chem. 273, 16968-16975
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TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption.
B. S. Kwon, S. Wang, N. Udagawa, V. Haridas, Z. H. Lee, K. K. Kim, K.-o. Oh, J. Greene, Y. Li, J. Su, et al. (1998)
FASEB J 12, 845-854
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Cooperation of Both TNF Receptors in Inducing Apoptosis: Involvement of the TNF Receptor-Associated Factor Binding Domain of the TNF Receptor 75.
W. Declercq, G. Denecker, W. Fiers, and P. Vandenabeele (1998)
J. Immunol. 161, 390-399
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Differential Expression of a Tumor Necrosis Factor Receptor-Related Transcript in Gestational Trophoblastic Diseases in Women.
C. I. Dumur, N. P. Koritschoner, A. Flury, G. Panzetta-Dutari, J. L. Bocco, and L. C. Patrito (1998)
Biol Reprod 59, 621-625
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Dissection of Pathways Leading to Antigen Receptor-Induced and Fas/CD95-Induced Apoptosis in Human B Cells.
S. M. A. Lens, B. F. A. den Drijver, A. J. G. Potgens, K. Tesselaar, M. H. J. van Oers, and R. A. W. van Lier (1998)
J. Immunol. 160, 6083-6092
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Apoptosis : Basic Mechanisms and Implications for Cardiovascular Disease.
A. Haunstetter and S. Izumo (1998)
Circ. Res. 82, 1111-1129
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Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL.
J. G. Emery, P. McDonnell, M. B. Burke, K. C. Deen, S. Lyn, C. Silverman, E. Dul, E. R. Appelbaum, C. Eichman, R. DiPrinzio, et al. (1998)
J. Biol. Chem. 273, 14363-14367
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Proteases to die for.
V. Cryns and J. Yuan (1998)
Genes & Dev. 12, 1551-1570
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Cloning and Characterization of Two Toll/Interleukin-1 Receptor-Like Genes TIL3 and TIL4: Evidence for a Multi-Gene Receptor Family in Humans.
P. M. Chaudhary, C. Ferguson, V. Nguyen, O. Nguyen, H. F. Massa, M. Eby, A. Jasmin, B. J. Trask, L. Hood, and P. S. Nelson (1998)
Blood 91, 4020-4027
   Abstract »    Full Text »    PDF »


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