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Science 1 November 1996:
Vol. 274. no. 5288, pp. 790 - 792
DOI: 10.1126/science.274.5288.790
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Reports

Conditional Circadian Dysfunction of the Arabidopsis early-flowering 3 Mutant

Karen A. Hicks, Andrew J. Millar, * Isabelle A. Carré, * David E. Somers, dagger Martin Straume, D. Ry Meeks-Wagner, ddagger Steve A. Kay dagger ddagger

Photoperiodic responses, such as the daylength-dependent control of reproductive development, are associated with a circadian biological clock. The photoperiod-insensitive early-flowering 3 (elf3) mutant of Arabidopsis thaliana lacks rhythmicity in two distinct circadian-regulated processes. This defect was apparent only when plants were assayed under constant light conditions. elf3 mutants retain rhythmicity in constant dark and anticipate light/dark transitions under most light/dark regimes. The conditional arrhythmic phenotype suggests that the circadian pacemaker is intact in darkness in elf3 mutant plants, but the transduction of light signals to the circadian clock is impaired.

K. A. Hicks and D. R. Meeks-Wagner, Institute of Molecular Biology, University of Oregon, Eugene, OR 97403, USA.
A. J. Millar, I. A. Carré, D. E. Somers, S. A. Kay, Department of Biology, NSF Center for Biological Timing, Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA.
M. Straume, Department of Medicine, NSF Center for Biological Timing, University of Virginia, Charlottesville, VA 22908, USA.
*   Present address: Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK.

dagger    Present address: Department of Cell Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

ddagger    To whom correspondence should be addressed.

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