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Science 25 October 1996:
Vol. 274. no. 5287, pp. 546 - 567
DOI: 10.1126/science.274.5287.546
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Articles

Life with 6000 Genes

A. Goffeau, * B. G. Barrell, H. Bussey, R. W. Davis, B. Dujon, H. Feldmann, F. Galibert, J. D. Hoheisel, C. Jacq, M. Johnston, E. J. Louis, H. W. Mewes, Y. Murakami, P. Philippsen, H. Tettelin, S. G. Oliver

The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome shows a considerable amount of apparent genetic redundancy, and one of the major problems to be tackled during the next stage of the yeast genome project is to elucidate the biological functions of all of these genes.

A. Goffeau and H. Tettelin, Université Catholique de Louvain, Unité de Biochimie Physiologique, Place Croix du Sud, 2/20, 1348 Louvain-la-Neuve, Belgium.
B. G. Barrell, Sanger Centre, Hinxton Hall, Hinxton, Cambridge CB10 1SA, UK.
H. Bussey, Department of Biology, McGill University, 1205 Docteur Penfield Avenue, Montreal, H3A 1B1, Canada.
R. W. Davis, Department of Biochemistry, Stanford University, Beckman Center, Room B400, Stanford, CA 94305-5307, USA.
B. Dujon, Unité de Génétique Moléculaire des Levures (URA1149 CNRS and UPR927 Université Pierre et Marie Curie), Institut Pasteur, 25 Rue du Docteur Roux, 75724 Paris-Cedex 15, France.
H. Feldmann, Universität München, Institut für Physiologische Chemie, Schillerstrasse, 44, 80336 München, Germany.
F. Galibert, Laboratoire de Biochimie Moleculaire, UPR 41-Faculté de Médecine, CNRS, 2 Avenue du Professeur Léon Bernard, 35043 Rennes Cedex, France.
J. D. Hoheisel, Molecular Genetic Genome Analysis, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld, 506, 69120 Heidelberg, Germany.
C. Jacq, Génétique Moleculaire, Ecole Normale Supérieure, CNRS URA 1302, 46 Rue d'Ulm, 75230 Paris Cedex 05, France.
M. Johnston, Department of Genetics, Box 8232, Washington University Medical School, 4566 Scott Avenue, St. Louis, MO 63110, USA.
E. J. Louis, Yeast Genetics, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DU, UK.
H. W. Mewes, Max-Planck-Institut für Biochemie, Martinsried Institute for Protein Sciences (MIPS), Am Klopferspitz 18A, 82152 Martinsried, Germany.
Y. Murakami, Tsukuba Life Science Center, Division of Human Genome Research, RIKEN, Koyaday Tsukuba Science City 3-1-1, 305 Ibaraki, Japan.
P. Philippsen, Institute for Applied Microbiology, Universität Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland.
S. G. Oliver, Department of Biochemistry and Applied Molecular Biology, University of Manchester Institute of Science and Technology (UMIST), Post Office Box 88, Manchester M60 1QD, UK.
*   To whom correspondence should be addressed.

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Conserved and Nonconserved Proteins for Meiotic DNA Breakage and Repair in Yeasts.
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Genetics 167, 593-605
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Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome.
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MrpL36p, a Highly Diverged L31 Ribosomal Protein Homolog With Additional Functional Domains in Saccharomyces cerevisiae Mitochondria.
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Genetics 167, 65-75
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The Ashbya gossypii Genome as a Tool for Mapping the Ancient Saccharomyces cerevisiae Genome.
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Lessons from the Genome Sequence of Neurospora crassa: Tracing the Path from Genomic Blueprint to Multicellular Organism.
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