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Science 25 October 1996:
Vol. 274. no. 5287, pp. 540 - 546
DOI: 10.1126/science.274.5287.540
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Articles

A Gene Map of the Human Genome

G. D. Schuler, M. S. Boguski, E. A. Stewart, L. D. Stein, G. Gyapay, K. Rice, R. E. White, P. Rodriguez-Tomé, A. Aggarwal, E. Bajorek, S. Bentolila, B. B. Birren, A. Butler, A. B. Castle, N. Chiannilkulchai, A. Chu, C. Clee, S. Cowles, P. J. R. Day, T. Dibling, N. Drouot, I. Dunham, S. Duprat, C. East, C. Edwards, J.-B. Fan, N. Fang, C. Fizames, C. Garrett, L. Green, D. Hadley, M. Harris, P. Harrison, S. Brady, A. Hicks, E. Holloway, L. Hui, S. Hussain, C. Louis-Dit-Sully, J. Ma, A. MacGilvery, C. Mader, A. Maratukulam, T. C. Matise, K. B. McKusick, J. Morissette, A. Mungall, D. Muselet, H. C. Nusbaum, D. C. Page, A. Peck, S. Perkins, M. Piercy, F. Qin, J. Quackenbush, S. Ranby, T. Reif, S. Rozen, C. Sanders, X. She, J. Silva, D. K. Slonim, C. Soderlund, W.-L. Sun, P. Tabar, T. Thangarajah, N. Vega-Czarny, D. Vollrath, S. Voyticky, T. Wilmer, X. Wu, M. D. Adams, C. Auffray, N. A. R. Walter, R. Brandon, A. Dehejia, P. N. Goodfellow, R. Houlgatte, J. R. Hudson Jr., S. E. Ide, K. R. Iorio, W. Y. Lee, N. Seki, T. Nagase, K. Ishikawa, N. Nomura, C. Phillips, M. H. Polymeropoulos, M. Sandusky, K. Schmitt, R. Berry, K. Swanson, R. Torres, J. C. Venter, J. M. Sikela, J. S. Beckmann, J. Weissenbach, R. M. Myers, D. R. Cox, M. R. James, D. Bentley, P. Deloukas, E. S. Lander, T. J. Hudson

The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have been sampled to date in the form of expressed sequence tags. An international consortium was organized to develop and map gene-based sequence tagged site markers on a set of two radiation hybrid panels and a yeast artificial chromosome library. More than 16,000 human genes have been mapped relative to a framework map that contains about 1000 polymorphic genetic markers. The gene map unifies the existing genetic and physical maps with the nucleotide and protein sequence databases in a fashion that should speed the discovery of genes underlying inherited human disease. The integrated resource is available through a site on the World Wide Web at http://www.ncbi.nlm.nih.gov/SCIENCE96/.

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Radiation hybrid mapping of the zebrafish genome.
N. A. Hukriede, L. Joly, M. Tsang, J. Miles, P. Tellis, J. A. Epstein, W. B. Barbazuk, F. N. Li, B. Paw, J. H. Postlethwait, et al. (1999)
PNAS 96, 9745-9750
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Informatic selection of a neural crest-melanocyte cDNA set for microarray analysis.
S. K. Loftus, Y. Chen, G. Gooden, J. F. Ryan, G. Birznieks, M. Hilliard, A. D. Baxevanis, M. Bittner, P. Meltzer, J. Trent, et al. (1999)
PNAS 96, 9277-9280
   Abstract »    Full Text »    PDF »
High-Resolution Landmark Framework for the Sequence-Ready Mapping of Xq23-q26.1.
H. E. Steingruber, A. Dunham, A. J. Coffey, S. M. Clegg, G. R. Howell, G. L. Maslen, C. E. Scott, R. Gwilliam, P. J. Hunt, E. C. Sotheran, et al. (1999)
Genome Res. 9, 751-762
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A 3-Mb High-Resolution BAC/PAC Contig of 12q22 Encompassing the 830-kb Consensus Minimal Deletion in Male Germ Cell Tumors.
V. V.V.S. Murty, K. Montgomery, S. Dutta, S. Bala, B. Renault, G. J. Bosl, R. Kucherlapati, and R. S.K. Chaganti (1999)
Genome Res. 9, 662-671
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A Maize Map Standard With Sequenced Core Markers, Grass Genome Reference Points and 932 Expressed Sequence Tagged Sites (ESTs) in a 1736-Locus Map.
G. L. Davis, M. D. McMullen, C. Baysdorfer, T. Musket, D. Grant, M. Staebell, G. Xu, M. Polacco, L. Koster, S. Melia-Hancock, et al. (1999)
Genetics 152, 1137-1172
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Molecular Cloning and Characterization of a Mouse Homolog of Bacterial ClpX, a Novel Mammalian Class II Member of the Hsp100/Clp Chaperone Family.
S. Santagata, D. Bhattacharyya, F.-H. Wang, N. Singha, A. Hodtsev, and E. Spanopoulou (1999)
J. Biol. Chem. 274, 16311-16319
   Abstract »    Full Text »    PDF »
The CMT2D Locus: Refined Genetic Position and Construction of a Bacterial Clone-Based Physical Map.
R. E. Ellsworth, V. Ionasescu, C. Searby, V. C. Sheffield, V. V. Braden, T. A. Kucaba, J. D. McPherson, M. A. Marra, and E. D. Green (1999)
Genome Res. 9, 568-574
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Pharmacology of the Eosinophil.
M. A. Giembycz and M. A. Lindsay (1999)
Pharmacol. Rev. 51, 213-340
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Mouse Molecular Cytogenetic Resource: 157 BACs Link the Chromosomal and Genetic Maps.
J. R. Korenberg, X.-N. Chen, K. L. Devon, D. Noya, M. L. Oster-Granite, and B. W. Birren (1999)
Genome Res. 9, 514-523
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Suggestive Evidence for a Susceptibility Gene Near the Vitamin D Receptor Locus in Idiopathic Calcium Stone Formation.
P. SCOTT, D. OUIMET, L. VALIQUETTE, G. GUAY, Y. PROULX, M.-L. TROUVE, B. GAGNON, and A. BONNARDEAUX (1999)
J. Am. Soc. Nephrol. 10, 1007-1013
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Human deafness dystonia syndrome is a mitochondrial disease.
C. M. Koehler, D. Leuenberger, S. Merchant, A. Renold, T. Junne, and G. Schatz (1999)
PNAS 96, 2141-2146
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High-Resolution Physical and Genetic Mapping of the Critical Region for Meckel Syndrome and Mulibrey Nanism on Chromosome 17q22-q23.
P. Paavola, K. Avela, N. Horelli-Kuitunen, M. Bärlund, A. Kallioniemi, N. Idänheimo, M. Kyttälä, A. de la Chapelle, A. Palotie, A.-E. Lehesjoki, et al. (1999)
Genome Res. 9, 267-276
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A Sequence-Ready BAC Clone Contig of a 2.2-Mb Segment of Human Chromosome 1q24.
D. Vollrath and V. L. Jaramillo-Babb (1999)
Genome Res. 9, 150-157
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An Effective Approach for Analyzing "Prefinished" Genomic Sequence Data.
P. M. Kuehl, J. M. Weisemann, J. W. Touchman, E. D. Green, and M. S. Boguski (1999)
Genome Res. 9, 189-194
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The Genexpress IMAGE Knowledge Base of the Human Brain Transcriptome: A Prototype Integrated Resource for Functional and Computational Genomics.
G. Piétu, R. Mariage-Samson, N.-A. Fayein, C. Matingou, E. Eveno, R. Houlgatte, C. Decraene, Y. Vandenbrouck, F. Tahi, M.-D. Devignes, et al. (1999)
Genome Res. 9, 195-209
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GLC1F, A New Primary Open-angle Glaucoma Locus, Maps to 7q35-q36.
M. K. Wirtz, J. R. Samples, K. Rust, J. Lie, L. Nordling, K. Schilling, T. S. Acott, and P. L. Kramer (1999)
Arch Ophthalmol 117, 237-241
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Confirmation of linkage of type 1 hereditary sensory neuropathy to human chromosome 9q22.
K. Bejaoui, D. McKenna-Yasek, B. A. Hosler, E. Burns-Deater, L. M. Deater, G. O'Neill, J. L. Haines, and R. H. Brown (1999)
Neurology 52, 510
   Abstract »    Full Text »    PDF »


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