Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 18 October 1996:
Vol. 274. no. 5286, pp. 430 - 432
DOI: 10.1126/science.274.5286.430
Prev | Table of Contents | Next

Reports

Preferential Formation of Benzo[a]pyrene Adducts at Lung Cancer Mutational Hotspots in P53

Mikhail F. Denissenko, Annie Pao, Moon-shong Tang, * Gerd P. Pfeifer *

Cigarette smoke carcinogens such as benzo[a]pyrene are implicated in the development of lung cancer. The distribution of benzo[a]pyrene diol epoxide (BPDE) adducts along exons of the P53 gene in BPDE-treated HeLa cells and bronchial epithelial cells was mapped at nucleotide resolution. Strong and selective adduct formation occurred at guanine positions in codons 157, 248, and 273. These same positions are the major mutational hotspots in human lung cancers. Thus, targeted adduct formation rather than phenotypic selection appears to shape the P53 mutational spectrum in lung cancer. These results provide a direct etiological link between a defined chemical carcinogen and human cancer.

M. F. Denissenko and G. P. Pfeifer, Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
A. Pao and M.-s. Tang, M. D. Anderson Cancer Center, University of Texas, Science Park, Smithville, TX 78957, USA.
*   To whom correspondence should be addressed.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Micronuclei Related to Anti-B[a]PDE-DNA Adduct in Peripheral Blood Lymphocytes of Heavily Polycyclic Aromatic Hydrocarbon-Exposed Nonsmoking Coke-Oven Workers and Controls.
S. Pavanello, L. Kapka, E. Siwinska, D. Mielzynska, C. Bolognesi, and E. Clonfero (2008)
Cancer Epidemiol. Biomarkers Prev. 17, 2795-2799
   Abstract »    Full Text »    PDF »
Advances in Chemical Carcinogenesis: A Historical Review and Prospective.
L. A. Loeb and C. C. Harris (2008)
Cancer Res. 68, 6863-6872
   Full Text »    PDF »
Rapid repair of UVA-induced oxidized purines and persistence of UVB-induced dipyrimidine lesions determine the mutagenicity of sunlight in mouse cells.
A. Besaratinia, S.-i. Kim, and G. P. Pfeifer (2008)
FASEB J 22, 2379-2392
   Abstract »    Full Text »    PDF »
Mitogen-Activated Protein Kinase Activation in Lung Adenocarcinoma: A Comparative Study between Ever Smokers and Never Smokers.
G. Mountzios, D. Planchard, B. Besse, P. Validire, P. Girard, C. Devisme, M.-A. Dimopoulos, J.-C. Soria, and P. Fouret (2008)
Clin. Cancer Res. 14, 4096-4102
   Abstract »    Full Text »    PDF »
Effects of Tobacco Smoke on Gene Expression and Cellular Pathways in a Cellular Model of Oral Leukoplakia.
Z. H. Gumus, B. Du, A. Kacker, J. O. Boyle, J. M. Bocker, P. Mukherjee, K. Subbaramaiah, A. J. Dannenberg, and H. Weinstein (2008)
Cancer Prevention Research 1, 100-111
   Abstract »    Full Text »    PDF »
DNA Repair Capacity and Lung Cancer Risk in Never Smokers.
O. Y. Gorlova, S.-F. Weng, Y. Zhang, C. I. Amos, M. R. Spitz, and Q. Wei (2008)
Cancer Epidemiol. Biomarkers Prev. 17, 1322-1328
   Abstract »    Full Text »    PDF »
Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells.
J.-H. Park, D. Mangal, K. A. Tacka, A. M. Quinn, R. G. Harvey, I. A. Blair, and T. M. Penning (2008)
PNAS 105, 6846-6851
   Abstract »    Full Text »    PDF »
Pyrrole-imidazole hairpin polyamides with high affinity at 5'-CGCG-3' DNA sequence; influence of cytosine methylation on binding.
M. Minoshima, T. Bando, S. Sasaki, J. Fujimoto, and H. Sugiyama (2008)
Nucleic Acids Res. 36, 2889-2894
   Abstract »    Full Text »    PDF »
CYP1A1, GSTM1, and GSTT1 Polymorphisms, Smoking, and Lung Cancer Risk in a Pooled Analysis among Asian Populations.
K.-M. Lee, D. Kang, M. L. Clapper, M. Ingelman-Sundberg, M. Ono-Kihara, C. Kiyohara, S. Min, Q. Lan, L. Le Marchand, P. Lin, et al. (2008)
Cancer Epidemiol. Biomarkers Prev. 17, 1120-1126
   Abstract »    Full Text »    PDF »
Combustion-Derived Hydrocarbons Localize to Lipid Droplets in Respiratory Cells.
G. Murphy Jr., R. L. Rouse, W. W. Polk, W. G. Henk, S. A. Barker, M. J. Boudreaux, Z. E. Floyd, and A. L. Penn (2008)
Am. J. Respir. Cell Mol. Biol. 38, 532-540
   Abstract »    Full Text »    PDF »
Molecular Epidemiology and Biomarkers in Etiologic Cancer Research: The New in Light of the Old.
P. Vineis and F. Perera (2008)
Am. Assoc. Cancer Res. Educ. Book 2008, 547-567
   Abstract »    Full Text »    PDF »
Comparison of induced and cancer-associated mutational spectra using multivariate data analysis.
P.D. Lewis, B. Manshian, M.N. Routledge, G.B. Scott, and P.A. Burns (2008)
Carcinogenesis 29, 772-778
   Abstract »    Full Text »    PDF »
Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.
V. M. Arlt, M. Stiborova, C. J. Henderson, M. Thiemann, E. Frei, D. Aimova, R. Singh, G. Gamboa da Costa, O. J. Schmitz, P. B. Farmer, et al. (2008)
Carcinogenesis 29, 656-665
   Abstract »    Full Text »    PDF »
Genome-wide H3K9 Histone Acetylation Profiles Are Altered in Benzopyrene-treated MCF7 Breast Cancer Cells.
B. Sadikovic, J. Andrews, D. Carter, J. Robinson, and D. I. Rodenhiser (2008)
J. Biol. Chem. 283, 4051-4060
   Abstract »    Full Text »    PDF »
Polycyclic Aromatic Hydrocarbon-DNA Adducts in Prostate and Biochemical Recurrence after Prostatectomy.
B. A. Rybicki, C. Neslund-Dudas, C. H. Bock, A. Rundle, A. T. Savera, J. J. Yang, N. L. Nock, and D. Tang (2008)
Clin. Cancer Res. 14, 750-757
   Abstract »    Full Text »    PDF »
Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53.
S. L. Hockley, V. M. Arlt, G. Jahnke, A. Hartwig, I. Giddings, and D. H. Phillips (2008)
Carcinogenesis 29, 202-210
   Abstract »    Full Text »    PDF »
A review of conflict of interest, competing interest, and bias for toxicologists.
L. Claxton (2007)
Toxicology and Industrial Health 23, 557-571
   Abstract »    PDF »
Molecular Epidemiology and Biomarkers in Etiologic Cancer Research: The New in Light of the Old.
P. Vineis and F. Perera (2007)
Cancer Epidemiol. Biomarkers Prev. 16, 1954-1965
   Abstract »    Full Text »    PDF »
Direct evidence for the critical role of NFAT3 in benzo[a]pyrene diol-epoxide-induced cell transformation through mediation of inflammatory cytokine TNF induction in mouse epidermal Cl41 cells.
W. Ouyang, Y. Hu, J. Li, M. Ding, Y. Lu, D. Zhang, Y. Yan, L. Song, Q. Qu, D. Desai, et al. (2007)
Carcinogenesis 28, 2218-2226
   Abstract »    Full Text »    PDF »
Meta-analysis of studies of passive smoking and lung cancer: effects of study type and continent.
R. Taylor, F. Najafi, and A. Dobson (2007)
Int. J. Epidemiol. 36, 1048-1059
   Abstract »    Full Text »    PDF »
Genetic pathways and mutation profiles of human cancers: site- and exposure-specific patterns.
I.A. Lea, M.A. Jackson, X. Li, S. Bailey, S.D. Peddada, and J.K. Dunnick (2007)
Carcinogenesis 28, 1851-1858
   Abstract »    Full Text »    PDF »
Epidemiology of Lung Cancer: ACCP Evidence-Based Clinical Practice Guidelines (2nd Edition).
A. J. Alberg, J. G. Ford, and J. M. Samet (2007)
Chest 132, 29S-55S
   Abstract »    Full Text »    PDF »
Induction of Apoptosis by 9,10-Dimethyl-1,2-Benzanthracene in Cultured Preovulatory Rat Follicles Is Preceded by a Rise in Reactive Oxygen Species and Is Prevented by Glutathione.
M. Tsai-Turton, B. N Nakamura, and U. Luderer (2007)
Biol Reprod 77, 442-451
   Abstract »    Full Text »    PDF »
Activated neutrophils inhibit nucleotide excision repair in human pulmonary epithelial cells: role of myeloperoxidase.
N. Gungor, R. W.L. Godschalk, D. M. Pachen, F. J. Van Schooten, and A. M. Knaapen (2007)
FASEB J 21, 2359-2367
   Abstract »    Full Text »    PDF »
Induction of Base Damages Representing a High Risk Site for Double-strand DNA Break Formation in Genomic DNA by Exposure of Cells to DNA Damaging Agents.
E. L. Y. Ho, M. Parent, and M. S. Satoh (2007)
J. Biol. Chem. 282, 21913-21923
   Abstract »    Full Text »    PDF »
Polymorphic TP53BP1 and TP53 Gene Interactions Associated with Risk of Squamous Cell Carcinoma of the Head and Neck.
K. Chen, Z. Hu, L.-E Wang, W. Zhang, A. K. El-Naggar, E. M. Sturgis, and Q. Wei (2007)
Clin. Cancer Res. 13, 4300-4305
   Abstract »    Full Text »    PDF »
MDM2 Polymorphism, Survival, and Histology in Early-Stage Non-Small-Cell Lung Cancer.
R. S. Heist, W. Zhou, L. R. Chirieac, T. Cogan-Drew, G. Liu, L. Su, D. Neuberg, T. J. Lynch, J. C. Wain, and D. C. Christiani (2007)
J. Clin. Oncol. 25, 2243-2247
   Abstract »    Full Text »    PDF »
Epigenetics and cancer: towards an evaluation of the impact of environmental and dietary factors.
Z. Herceg (2007)
Mutagenesis 22, 91-103
   Abstract »    Full Text »    PDF »
Structure of DNA polymerase beta with a benzo[c]phenanthrene diol epoxide-adducted template exhibits mutagenic features.
V. K. Batra, D. D. Shock, R. Prasad, W. A. Beard, E. W. Hou, L. C. Pedersen, J. M. Sayer, H. Yagi, S. Kumar, D. M. Jerina, et al. (2006)
PNAS 103, 17231-17236
   Abstract »    Full Text »    PDF »
PYK2 mediates anti-apoptotic AKT signaling in response to benzo[a]pyrene diol epoxide in mammary epithelial cells.
A. D. Burdick, I. D. Ivnitski-Steele, F. T. Lauer, and S. W. Burchiel (2006)
Carcinogenesis 27, 2331-2340
   Abstract »    Full Text »    PDF »
MEF immortalization to investigate the ins and outs of mutagenesis.
J. v. Brocke, H. H. Schmeiser, M. Reinbold, and M. Hollstein (2006)
Carcinogenesis 27, 2141-2147
   Abstract »    Full Text »    PDF »
Smoking and lung cancer--a new role for an old toxicant?.
S. S. Hecht (2006)
PNAS 103, 15725-15726
   Full Text »    PDF »
From the Cover: Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair.
Z. Feng, W. Hu, Y. Hu, and M.-s. Tang (2006)
PNAS 103, 15404-15409
   Abstract »    Full Text »    PDF »
Investigating human cancer etiology by DNA lesion footprinting and mutagenicity analysis.
A. Besaratinia and G. P. Pfeifer (2006)
Carcinogenesis 27, 1526-1537
   Abstract »    Full Text »    PDF »
The association between marijuana smoking and lung cancer: a systematic review..
R. Mehra, B. A. Moore, K. Crothers, J. Tetrault, and D. A. Fiellin (2006)
Arch Intern Med 166, 1359-1367
   Abstract »    Full Text »    PDF »
Neutrophils and respiratory tract DNA damage and mutagenesis: a review.
A. M. Knaapen, N. Gungor, R. P. F. Schins, P. J. A. Borm, and F. J. Van Schooten (2006)
Mutagenesis 21, 225-236
   Abstract »    Full Text »    PDF »
Analysis of epidemiological cohort data on smoking effects and lung cancer with a multi-stage cancer model.
H. Schollnberger, M. Manuguerra, H. Bijwaard, H. Boshuizen, H.P. Altenburg, S.M. Rispens, M.J.P. Brugmans, and P. Vineis (2006)
Carcinogenesis 27, 1432-1444
   Abstract »    Full Text »    PDF »
Effects of Polycyclic Aromatic Hydrocarbons (PAHs) on Vascular Endothelial Growth Factor Induction through Phosphatidylinositol 3-Kinase/AP-1-dependent, HIF-1{alpha}-independent Pathway.
J. Ding, J. Li, J. Chen, H. Chen, W. Ouyang, R. Zhang, C. Xue, D. Zhang, S. Amin, D. Desai, et al. (2006)
J. Biol. Chem. 281, 9093-9100
   Abstract »    Full Text »    PDF »
Sequence specificity of Cr(III)-DNA adduct formation in the p53 gene: NGG sequences are preferential adduct-forming sites.
H. Arakawa, F. Wu, M. Costa, W. Rom, and M.-s. Tang (2006)
Carcinogenesis 27, 639-645
   Abstract »    Full Text »    PDF »
Red Meat Enhances the Colonic Formation of the DNA Adduct O6-Carboxymethyl Guanine: Implications for Colorectal Cancer Risk.
M. H. Lewin, N. Bailey, T. Bandaletova, R. Bowman, A. J. Cross, J. Pollock, D. E.G. Shuker, and S. A. Bingham (2006)
Cancer Res. 66, 1859-1865
   Abstract »    Full Text »    PDF »
Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection.
R. Singh and P. B. Farmer (2006)
Carcinogenesis 27, 178-196
   Abstract »    Full Text »    PDF »
3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence.
V. M. Arlt (2005)
Mutagenesis 20, 399-410
   Abstract »    Full Text »    PDF »
Mutagenesis studies with four stereoisomeric N2-dG benzo[a]pyrene adducts in the identical 5'-CGC sequence used in NMR studies: G->T mutations dominate in each case.
K.-Y. Seo, A. Nagalingam, M. Tiffany, and E. L. Loechler (2005)
Mutagenesis 20, 441-448
   Abstract »    Full Text »    PDF »
Modeling Lung Cancer Risk in Case-Control Studies Using a New Dose Metric of Smoking.
S. W. Thurston, G. Liu, D. P. Miller, and D. C. Christiani (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 2296-2302
   Abstract »    Full Text »    PDF »
Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer.
S. A. Belinsky (2005)
Carcinogenesis 26, 1481-1487
   Abstract »    Full Text »    PDF »
TP53 and KRAS Mutation Load and Types in Lung Cancers in Relation to Tobacco Smoke: Distinct Patterns in Never, Former, and Current Smokers.
F. Le Calvez, A. Mukeria, J. D. Hunt, O. Kelm, R. J. Hung, P. Taniere, P. Brennan, P. Boffetta, D. G. Zaridze, and P. Hainaut (2005)
Cancer Res. 65, 5076-5083
   Abstract »    Full Text »    PDF »
Characterization of Common CYP1B1 Variants with Different Capacity for Benzo[a]pyrene-7,8-Dihydrodiol Epoxide Formation from Benzo[a]pyrene.
E. Aklillu, S. Ovrebo, I. V. Botnen, C. Otter, and M. Ingelman-Sundberg (2005)
Cancer Res. 65, 5105-5111
   Abstract »    Full Text »    PDF »
Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case-control study.
S. Blankenburg, I. R. Konig, R. Moessner, P. Laspe, K.-M. Thoms, U. Krueger, S. G. Khan, G. Westphal, C. Berking, M. Volkenandt, et al. (2005)
Carcinogenesis 26, 1085-1090
   Abstract »    Full Text »    PDF »
Repair of cyclobutane pyrimidine dimers or dimethylsulfate damage in DNA is identical in normal or telomerase-immortalized human skin fibroblasts.
S. E. Bates, N. Y. Zhou, L. E. Federico, L. Xia, and T. R. O'Connor (2005)
Nucleic Acids Res. 33, 2475-2485
   Abstract »    Full Text »    PDF »
p53 Mutations in Benzo(a)Pyrene-Exposed Human p53 Knock-in Murine Fibroblasts Correlate with p53 Mutations in Human Lung Tumors.
Z. Liu, K.-R. Muehlbauer, H. H. Schmeiser, M. Hergenhahn, D. Belharazem, and M. C. Hollstein (2005)
Cancer Res. 65, 2583-2587
   Abstract »    Full Text »    PDF »
The p53 Codon 72 Proline Allele Is Associated with p53 Gene Mutations in Non-Small Cell Lung Cancer.
Y. Hu, M. P. McDermott, and S. A. Ahrendt (2005)
Clin. Cancer Res. 11, 2502-2509
   Abstract »    Full Text »    PDF »
Nicotine Inactivation of the Proapoptotic Function of Bax through Phosphorylation.
M. Xin and X. Deng (2005)
J. Biol. Chem. 280, 10781-10789
   Abstract »    Full Text »    PDF »
DNA Damage from Polycyclic Aromatic Hydrocarbons Measured by Benzo[a]pyrene-DNA Adducts in Mothers and Newborns from Northern Manhattan, The World Trade Center Area, Poland, and China.
F. Perera, D. Tang, R. Whyatt, S. A. Lederman, and W. Jedrychowski (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 709-714
   Abstract »    Full Text »    PDF »
Reduced nucleotide excision repair and GSTM1-null genotypes influence anti-B[a]PDE-DNA adduct levels in mononuclear white blood cells of highly PAH-exposed coke oven workers.
S. Pavanello, A. Pulliero, E. Siwinska, D. Mielzynska, and E. Clonfero (2005)
Carcinogenesis 26, 169-175
   Abstract »    Full Text »    PDF »
Quantitative Analysis of Translesion DNA Synthesis across a Benzo[a]pyrene-Guanine Adduct in Mammalian Cells: THE ROLE OF DNA POLYMERASE {kappa}.
S. Avkin, M. Goldsmith, S. Velasco-Miguel, N. Geacintov, E. C. Friedberg, and Z. Livneh (2004)
J. Biol. Chem. 279, 53298-53305
   Abstract »    Full Text »    PDF »
Clinical implications of p53 mutation analysis in bladder cancer tissue and urine sediment by functional assay in yeast.
B. Schlichtholz, M. Presler, and M. Matuszewski (2004)
Carcinogenesis 25, 2319-2323
   Abstract »    Full Text »    PDF »
Destructive cycles: the role of genomic instability and adaptation in carcinogenesis.
B. L. Schneider and M. Kulesz-Martin (2004)
Carcinogenesis 25, 2033-2044
   Abstract »    Full Text »    PDF »
Tobacco smoke induces CYP1B1 in the aerodigestive tract.
J. L. Port, K. Yamaguchi, B. Du, M. De Lorenzo, M. Chang, P. M. Heerdt, L. Kopelovich, C. B. Marcus, N. K. Altorki, K. Subbaramaiah, et al. (2004)
Carcinogenesis 25, 2275-2281
   Abstract »    Full Text »    PDF »
DNA Damage, Repair, and Mutation Induction by (+)-Syn and (-)-Anti-Dibenzo[a,l]Pyrene-11,12-Diol-13,14-Epoxides in Mouse Cells.
J.-H. Yoon, A. Besaratinia, Z. Feng, M.-s. Tang, S. Amin, A. Luch, and G. P. Pfeifer (2004)
Cancer Res. 64, 7321-7328
   Abstract »    Full Text »    PDF »
Aspen Cancer Conference Fellows.
(2004)
Toxicol Pathol 32, 749-761
   PDF »
The Spacious Active Site of a Y-Family DNA Polymerase Facilitates Promiscuous Nucleotide Incorporation Opposite a Bulky Carcinogen-DNA Adduct: ELUCIDATING THE STRUCTURE-FUNCTION RELATIONSHIP THROUGH EXPERIMENTAL AND COMPUTATIONAL APPROACHES.
R. A. Perlow-Poehnelt, I. Likhterov, D. A. Scicchitano, N. E. Geacintov, and S. Broyde (2004)
J. Biol. Chem. 279, 36951-36961
   Abstract »    Full Text »    PDF »
In silico p53 mutation hotspots in lung cancer.
P. D. Lewis and J. M. Parry (2004)
Carcinogenesis 25, 1099-1107
   Abstract »    Full Text »    PDF »
In vitro investigations into the interaction of {beta}-carotene with DNA: evidence for the role of carbon-centered free radicals.
J. C. S. Kleinjans, M. H. M. van Herwijnen, J. M. S. van Maanen, L. M. Maas, T. M. C. M. de Kok, H. J. J. Moonen, and J. J. Briede (2004)
Carcinogenesis 25, 1249-1256
   Abstract »    Full Text »    PDF »
Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: A possible mechanism for lipid peroxidation-induced carcinogenesis.
Z. Feng, W. Hu, and M.-s. Tang (2004)
PNAS 101, 8598-8602
   Abstract »    Full Text »    PDF »
Rapid and Sensitive p53 Alteration Analysis in Biopsies from Lung Cancer Patients Using a Functional Assay and A Universal Oligonucleotide Array: A Prospective Study.
C. Fouquet, M. Antoine, P. Tisserand, R. Favis, M. Wislez, F. Commo, N. Rabbe, M. F. Carette, B. Milleron, F. Barany, et al. (2004)
Clin. Cancer Res. 10, 3479-3489
   Abstract »    Full Text »    PDF »
Myeloperoxidase (MPO) -463G->A Reduces MPO Activity and DNA Adduct Levels in Bronchoalveolar Lavages of Smokers.
F. J. Van Schooten, A. W. Boots, A. M. Knaapen, R. W. L. Godschalk, L. M. Maas, P. J. A. Borm, M. Drent, and J. A. Jacobs (2004)
Cancer Epidemiol. Biomarkers Prev. 13, 828-833
   Abstract »    Full Text »    PDF »
A functional polymorphism in the SULT1A1 gene (G638A) is associated with risk of lung cancer in relation to tobacco smoking.
G. Liang, X. Miao, Y. Zhou, W. Tan, and D. Lin (2004)
Carcinogenesis 25, 773-778
   Abstract »    Full Text »    PDF »
Polycyclic aromatic hydrocarbons induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cells.
A. Solhaug, M. Refsnes, M. Lag, P. E. Schwarze, T. Husoy, and J. A. Holme (2004)
Carcinogenesis 25, 809-819
   Abstract »    Full Text »    PDF »
How Many Mutant p53 Molecules Are Needed To Inactivate a Tetramer?.
W. M. Chan, W. Y. Siu, A. Lau, and R. Y. C. Poon (2004)
Mol. Cell. Biol. 24, 3536-3551
   Abstract »    Full Text »    PDF »
PI-3K and Akt are mediators of AP-1 induction by 5-MCDE in mouse epidermal Cl41 cells.
J. Li, H. Chen, M.-S. Tang, X. Shi, S. Amin, D. Desai, M. Costa, and C. Huang (2004)
J. Cell Biol. 165, 77-86
   Abstract »    Full Text »    PDF »
S-(2-Chloroethyl)glutathione-generated p53 Mutation Spectra Are Influenced by Differential Repair Rates More than Sites of Initial DNA Damage.
J. G. Valadez and F. P. Guengerich (2004)
J. Biol. Chem. 279, 13435-13446
   Abstract »    Full Text »    PDF »
Nickel (II) enhances benzo[a]pyrene diol epoxide-induced mutagenesis through inhibition of nucleotide excision repair in human cells: a possible mechanism for nickel (II)-induced carcinogenesis.
W. Hu, Z. Feng, and M.-s. Tang (2004)
Carcinogenesis 25, 455-462
   Abstract »    Full Text »    PDF »
Alterations of p16 and Prognosis in Biliary Tract Cancers from a Population-Based Study in China.
T. Ueki, A. W. Hsing, Y.-T. Gao, B.-S. Wang, M.-C. Shen, J. Cheng, J. Deng, J. F. Fraumeni Jr., and A. Rashid (2004)
Clin. Cancer Res. 10, 1717-1725
   Abstract »    Full Text »    PDF »
Methylation of Cytochrome P4501A1 Promoter in the Lung Is Associated with Tobacco Smoking.
S. Anttila, J. Hakkola, P. Tuominen, E. Elovaara, K. Husgafvel-Pursiainen, A. Karjalainen, A. Hirvonen, and T. Nurminen (2003)
Cancer Res. 63, 8623-8628
   Abstract »    Full Text »    PDF »
Enhancement of the Mutagenicity of Benzo(a)pyrene Diol Epoxide by a Nonmutagenic Dose of Ultraviolet A Radiation.
A. Besaratinia and G. P. Pfeifer (2003)
Cancer Res. 63, 8708-8716
   Abstract »    Full Text »    PDF »
Benzo(a)pyrene Quinones Increase Cell Proliferation, Generate Reactive Oxygen Species, and Transactivate the Epidermal Growth Factor Receptor in Breast Epithelial Cells.
A. D. Burdick, J. W. Davis II, K. J. Liu, L. G. Hudson, H. Shi, M. L. Monske, and S. W. Burchiel (2003)
Cancer Res. 63, 7825-7833
   Abstract »    Full Text »    PDF »
p53 Mutations in Bladder Cancer: Evidence for Exogenous versus Endogenous Risk Factors.
J. C. Schroeder, K. Conway, Y. Li, K. Mistry, D. A. Bell, and J. A. Taylor (2003)
Cancer Res. 63, 7530-7538
   Abstract »    Full Text »    PDF »
P53 alterations in bladder tumors from arsenic and tobacco exposed patients.
L. E. Moore, A. H. Smith, C. Eng, S. DeVries, D. Kalman, V. Bhargava, K. Chew, C. Ferreccio, O. A. Rey, C. Hopenhayn, et al. (2003)
Carcinogenesis 24, 1785-1791
   Abstract »    Full Text »    PDF »
Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: Implications for interactions with intercalating anticancer agents.
Q. A. Khan, G. Kohlhagen, R. Marshall, C. A. Austin, G. P. Kalena, H. Kroth, J. M. Sayer, D. M. Jerina, and Y. Pommier (2003)
PNAS 100, 12498-12503
   Abstract »    Full Text »    PDF »
Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer.
W.-M. Gao, M. Romkes, R. D. Day, J. M. Siegfried, J. D. Luketich, H. H. Mady, M. F. Melhem, and P. Keohavong (2003)
Carcinogenesis 24, 1671-1676
   Abstract »    Full Text »    PDF »
Australia's National Tobacco Campaign.
D Hill and T Carroll (2003)
Tob. Control 12, ii9-14
   Full Text »
The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting.
G. Fingerle-Rowson, O. Petrenko, C. N. Metz, T. G. Forsthuber, R. Mitchell, R. Huss, U. Moll, W. Muller, and R. Bucala (2003)
PNAS 100, 9354-9359
   Abstract »    Full Text »    PDF »
Screening of Homologous Recombination Gene Polymorphisms in Lung Cancer Patients Reveals an Association of the NBS1-185Gln Variant and p53 Gene Mutations.
P. P. Medina, S. A. Ahrendt, M. Pollan, P. Fernandez, D. Sidransky, and M. Sanchez-Cespedes (2003)
Cancer Epidemiol. Biomarkers Prev. 12, 699-704
   Abstract »    Full Text »    PDF »
Tobacco Smoke-induced Lung Cell Proliferation Mediated by Tumor Necrosis Factor {alpha}-converting Enzyme and Amphiregulin.
H. Lemjabbar, D. Li, M. Gallup, S. Sidhu, E. Drori, and C. Basbaum (2003)
J. Biol. Chem. 278, 26202-26207
   Abstract »    Full Text »    PDF »
p53 Mutations and Survival in Stage I Non-Small-Cell Lung Cancer: Results of a Prospective Study.
S. A. Ahrendt, Y. Hu, M. Buta, M. P. McDermott, N. Benoit, S. C. Yang, L. Wu, and D. Sidransky (2003)
J Natl Cancer Inst 95, 961-970