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Science 11 October 1996:
Vol. 274. no. 5285, pp. 259 - 262
DOI: 10.1126/science.274.5285.259
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Reports

Gastric Mucosa Abnormalities and Tumorigenesis in Mice Lacking the pS2 Trefoil Protein

Olivier Lefebvre, Marie-Pierre Chenard, Régis Masson, José Linares, Andrée Dierich, Marianne LeMeur, Corinne Wendling, Catherine Tomasetto, Pierre Chambon, Marie-Christine Rio *

To determine the function of the pS2 trefoil protein, which is normally expressed in the gastric mucosa, the mouse pS2 (mpS2) gene was inactivated. The antral and pyloric gastric mucosa of mpS2-null mice was dysfunctional and exhibited severe hyperplasia and dysplasia. All homozygous mutant mice developed antropyloric adenoma, and 30 percent developed multifocal intraepithelial or intramucosal carcinomas. The small intestine was characterized by enlarged villi and an abnormal infiltrate of lymphoid cells. These results indicate that mpS2 is essential for normal differentiation of the antral and pyloric gastric mucosa and may function as a gastric-specific tumor suppressor gene.

O. Lefebvre, R. Masson, J. Linares, A. Dierich, M. LeMeur, C. Wendling, C. Tomasetto, P. Chambon, M.-C. Rio, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université Louis Pasteur/Collège de France, Boite Postale 163, 67404 Illkirch Cedex, Communauté Urbaine de Strasbourg, France.
M.-P. Chenard, Service d'Anatomie Pathologique Générale, Centre Hospitalier Universitaire de Hautepierre, 67098 Strasbourg Cedex, France.
*   To whom correspondence should be addressed.

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