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Science 4 October 1996:
Vol. 274. no. 5284, pp. 94 - 96
DOI: 10.1126/science.274.5284.94
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Reports

Phenotypic Analysis of Antigen-Specific T Lymphocytes

John D. Altman, Paul A. H. Moss, Philip J. R. Goulder, Dan H. Barouch, Michael G. McHeyzer-Williams, * John I. Bell, Andrew J. McMichael, Mark M. Davis dagger

Identification and characterization of antigen-specific T lymphocytes during the course of an immune response is tedious and indirect. To address this problem, the peptide-major histocompatability complex (MHC) ligand for a given population of T cells was multimerized to make soluble peptide-MHC tetramers. Tetramers of human lymphocyte antigen A2 that were complexed with two different human immunodeficiency virus (HIV)-derived peptides or with a peptide derived from influenza A matrix protein bound to peptide-specific cytotoxic T cells in vitro and to T cells from the blood of HIV-infected individuals. In general, tetramer binding correlated well with cytotoxicity assays. This approach should be useful in the analysis of T cells specific for infectious agents, tumors, and autoantigens.

J. D. Altman and M. G. McHeyzer-Williams, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5428, USA.
P. A. H. Moss, P. J. R. Goulder, D. H. Barouch, J. I. Bell, A. J. McMichael, Institute for Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK.
M. M. Davis, The Howard Hughes Medical Institute, Department of Microbiology and Immunology, Beckman Center, Room B221, Stanford University, Stanford, CA 94305-5428, USA.
*   Present address: Department of Immunology, Duke University Medical Center, Durham, NC 27707, USA.

dagger    To whom correspondence should be addressed.

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   Abstract »    Full Text »    PDF »
Disulfide Bond Engineering to Trap Peptides in the MHC Class I Binding Groove.
S. M. Truscott, L. Lybarger, J. M. Martinko, V. E. Mitaksov, D. M. Kranz, J. M. Connolly, D. H. Fremont, and T. H. Hansen (2007)
J. Immunol. 178, 6280-6289
   Abstract »    Full Text »    PDF »
Comparative Seroprevalence and Immunogenicity of Six Rare Serotype Recombinant Adenovirus Vaccine Vectors from Subgroups B and D.
P. Abbink, A. A. C. Lemckert, B. A. Ewald, D. M. Lynch, M. Denholtz, S. Smits, L. Holterman, I. Damen, R. Vogels, A. R. Thorner, et al. (2007)
J. Virol. 81, 4654-4663
   Abstract »    Full Text »    PDF »
Effective graft depletion of MiHAg T-cell specificities and consequences for graft-versus-host disease.
M. A. de Witte, M. Toebes, J.-Y. Song, M. C. Wolkers, and T. N. M. Schumacher (2007)
Blood 109, 3830-3838
   Abstract »    Full Text »    PDF »
Multiple myeloma-reactive T cells recognize an activation-induced minor histocompatibility antigen encoded by the ATP-dependent interferon-responsive (ADIR) gene.
C. A. M. van Bergen, M. G. D. Kester, I. Jedema, M. H. M. Heemskerk, S. A. P. van Luxemburg-Heijs, F. M. Kloosterboer, W. A. E. Marijt, A. H. de Ru, M. R. Schaafsma, R. Willemze, et al. (2007)
Blood 109, 4089-4096
   Abstract »    Full Text »    PDF »
Vaccine-Induced T Cells Control Reversion of AIDS Virus Immune Escape Mutants.
C. S. Fernandez, M. Z. Smith, C. J. Batten, R. De Rose, J. C. Reece, E. Rollman, V. Venturi, M. P. Davenport, and S. J. Kent (2007)
J. Virol. 81, 4137-4144
   Abstract »    Full Text »    PDF »
Selective deletion of antigen-specific CD8+ T cells by MHC class I tetramers coupled to the type I ribosome-inactivating protein saporin.
P. R. Hess, C. Barnes, M. D. Woolard, M. D. L. Johnson, J. M. Cullen, E. J. Collins, and J. A. Frelinger (2007)
Blood 109, 3300-3307
   Abstract »    Full Text »    PDF »
Detection of Human Papillomavirus Type 16-Specific T Lymphocytes by a Recombinant Vaccinia Virus-Based Enzyme-Linked Immunospot Assay.
K. H. Kim, W. Greenfield, E. Shotts, and M. Nakagawa (2007)
Clin. Vaccine Immunol. 14, 362-368
   Abstract »    Full Text »    PDF »
Four Functionally Distinct Populations of Human Effector-Memory CD8+ T Lymphocytes.
P. Romero, A. Zippelius, I. Kurth, M. J. Pittet, C. Touvrey, E. M. Iancu, P. Corthesy, E. Devevre, D. E. Speiser, and N. Rufer (2007)
J. Immunol. 178, 4112-4119
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Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation.
J. Zhu, D. M. Koelle, J. Cao, J. Vazquez, M. L. Huang, F. Hladik, A. Wald, and L. Corey (2007)
J. Exp. Med. 204, 595-603
   Abstract »    Full Text »    PDF »
Analysis of TCR{alpha}beta Combinations used by Simian Immunodeficiency Virus-Specific CD8+ T Cells in Rhesus Monkeys: Implications for CTL Immunodominance.
A. Hasegawa, C. Moriya, H. Liu, W. A. Charini, H. C. Vinet, R. A. Subbramanian, P. Sen, N. L. Letvin, and M. J. Kuroda (2007)
J. Immunol. 178, 3409-3417
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IL-12 Controls Cytotoxicity of a Novel Subset of Self-Antigen-Specific Human CD28+ Cytolytic T Cells.
C. Barbey, P. Baumgaertner, E. Devevre, V. Rubio-Godoy, L. Derre, G. Bricard, P. Guillaume, I. F. Luescher, D. Lienard, J.-C. Cerottini, et al. (2007)
J. Immunol. 178, 3566-3574
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Facilitating matched pairing and expression of TCR chains introduced into human T cells.
J. Kuball, M. L. Dossett, M. Wolfl, W. Y. Ho, R.-H. Voss, C. Fowler, and P. D. Greenberg (2007)
Blood 109, 2331-2338
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Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8+ T cells.
C. Petrovas, Y. M. Mueller, I. D. Dimitriou, S. R. Altork, A. Banerjee, P. Sklar, K. C. Mounzer, J. D. Altman, and P. D. Katsikis (2007)
Blood 109, 2505-2513
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Impaired NFAT nuclear translocation results in split exhaustion of virus-specific CD8+ T cell functions during chronic viral infection.
P. Agnellini, P. Wolint, M. Rehr, J. Cahenzli, U. Karrer, and A. Oxenius (2007)
PNAS 104, 4565-4570
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Stable masking by H-2Dd cis ligand limits Ly49A relocalization to the site of NK cell/target cell contact.
J. Back, A. Chalifour, L. Scarpellino, and W. Held (2007)
PNAS 104, 3978-3983
   Abstract »    Full Text »    PDF »
Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients.
M. Raki, L.-E. Fallang, M. Brottveit, E. Bergseng, H. Quarsten, K. E. A. Lundin, and L. M. Sollid (2007)
PNAS 104, 2831-2836
   Abstract »    Full Text »    PDF »


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