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Science 4 October 1996:
Vol. 274. no. 5284, pp. 106 - 108
DOI: 10.1126/science.274.5284.106
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Reports

Requirement for Invariant Chain in B Cell Maturation and Function

Idit Shachar and Richard A. Flavell *

Previously the role of invariant chain (Ii) had been described only as a chaperone that facilitates folding and transport of major histocompatability complex class II molecules; here it is shown that Ii is required for B cell development. B cells from mice lacking Ii were found to have a low response to T-independent type II antigen and could not proliferate after the mice were injected with antigen. Study of cell surface markers revealed a developmental arrest that prevented immature virgin B cells from becoming mature B cells in the periphery. This block was independent of major histocompatability complex class II expression and was an intrinsic feature of B cells that correlated with the amount of Ii. Thus, Ii participates by an unknown mechanism in B cell maturation.

I. Shachar, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.
R. A. Flavell, Section of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.
*   To whom correspondence should be addressed.

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