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Science 27 September 1996:
Vol. 273. no. 5283, pp. 1853 - 1856
DOI: 10.1126/science.273.5283.1853
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Reports

Initiation of Runaway Cell Death in an Arabidopsis Mutant by Extracellular Superoxide

Thorsten Jabs, * Robert A. Dietrich, Jeffery L. Dangl dagger

Reactive oxygen intermediates (ROIs) regulate apoptosis during normal development and disease in animals. ROIs are also implicated in hypersensitive resistance responses of plants against pathogens. Arabidopsis lsd1 mutants exhibited impaired control of cell death in the absence of pathogen and could not control the spread of cell death once it was initiated. Superoxide was necessary and sufficient to initiate lesion formation; it accumulated before the onset of cell death and subsequently in live cells adjacent to spreading lsd1 lesions. Thus, runaway cell death seen in lsd1 plants reflected abnormal accumulation of superoxide and lack of responsiveness to signals derived from it.

T. Jabs, Max-Delbrück Laboratory, Carl von Linné Weg 10, 50829 Köln, Germany.
R. A. Dietrich and J. L. Dangl, Department of Biology and Curricula in Genetics and Molecular Biology, Coker Hall 108, CB 3280, University of North Carolina, Chapel Hill, NC 27599-3280, USA, and Max-Delbrück Laboratory, Carl von Linné Weg 10, 50829 Köln, Germany.
*   Present address: Institut für Biologie III (Pflanzenphysiologie), Rheinisch-Westfälisch Technische Hochschule Aachen, Worringer Weg 1, 52074 Aachen, Germany.

dagger    To whom correspondence should be addressed at Department of Biology, Coker Hall 108, CB 3280, University of North Carolina, Chapel Hill, NC 27599-3280, USA. E-mail: dangl{at}email.unc.edu

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M. A. Torres, J. L. Dangl, and J. D. G. Jones (2002)
PNAS 99, 517-522
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Essential role of the small GTPase Rac in disease resistance of rice.
E. Ono, H. L. Wong, T. Kawasaki, M. Hasegawa, O. Kodama, and K. Shimamoto (2001)
PNAS 98, 759-764
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The Arabidopsis-accelerated cell death gene ACD2 encodes red chlorophyll catabolite reductase and suppresses the spread of disease symptoms.
J. M. Mach, A. R. Castillo, R. Hoogstraten, and J. T. Greenberg (2001)
PNAS 98, 771-776
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Signal interactions between nitric oxide and reactive oxygen intermediates in the plant hypersensitive disease resistance response.
M. Delledonne, J. Zeier, A. Marocco, and C. Lamb (2001)
PNAS 98, 13454-13459
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A Small GTP-Binding Host Protein Is Required for Entry of Powdery Mildew Fungus into Epidermal Cells of Barley.
H. Schultheiss, C. Dechert, K.-H. Kogel, and R. Huckelhoven (2002)
Plant Physiology 128, 1447-1454
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Science. ISSN 0036-8075 (print), 1095-9203 (online)