Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 27 September 1996:
Vol. 273. no. 5283, pp. 1848 - 1850
DOI: 10.1126/science.273.5283.1848
Prev | Table of Contents | Next

Reports

A Trinuclear Intermediate in the Copper-Mediated Reduction of O2: Four Electrons from Three Coppers

Adam P. Cole, David E. Root, Pulakesh Mukherjee, Edward I. Solomon, T. D. P. Stack *

The reaction of metal complexes with dioxygen (O2) generally proceeds in 1:1, 2:1, or 4:1 (metal:O2) stoichiometry. A discrete, structurally characterized 3:1 product is presented. This mixed-valence trinuclear copper cluster, which contains copper in the highly oxidized trivalent oxidation state, exhibits O2 bond scission and intriguing structural, spectroscopic, and redox properties. The relevance of this synthetic complex to the reduction of O2 at the trinuclear active sites of multicopper oxidases is discussed.

Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
*   To whom correspondence should be addressed.

[Data] Suplemental information.

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Substrate and Dioxygen Binding to the Endospore Coat Laccase from Bacillus subtilis.
F. J. Enguita, D. Marcal, L. O. Martins, R. Grenha, A. O. Henriques, P. F. Lindley, and M. A. Carrondo (2004)
J. Biol. Chem. 279, 23472-23476
   Abstract »    Full Text »    PDF »
Nitrosothiol Formation Catalyzed by Ceruloplasmin. IMPLICATION FOR CYTOPROTECTIVE MECHANISM IN VIVO.
K. Inoue, T. Akaike, Y. Miyamoto, T. Okamoto, T. Sawa, M. Otagiri, S. Suzuki, T. Yoshimura, and H. Maeda (1999)
J. Biol. Chem. 274, 27069-27075
   Abstract »    Full Text »    PDF »
A Common Mechanism for the Interaction of Nitric Oxide with the Oxidized Binuclear Centre and Oxygen Intermediates of Cytochrome c Oxidase.
J. Torres, C. E. Cooper, and M. T. Wilson (1998)
J. Biol. Chem. 273, 8756-8766
   Abstract »    Full Text »    PDF »
The Independent cue and cus Systems Confer Copper Tolerance during Aerobic and Anaerobic Growth in Escherichia coli.
F. W. Outten, D. L. Huffman, J. A. Hale, and T. V. O'Halloran (2001)
J. Biol. Chem. 276, 30670-30677
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)