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Science 20 September 1996:
Vol. 273. no. 5282, pp. 1722 - 1725
DOI: 10.1126/science.273.5282.1722
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Reports

Neurogenic Amplification of Immune Complex Inflammation

Carmen R. Bozic, * Bao Lu, * Uta E. Höpken, Craig Gerard, Norma P. Gerard dagger

The formation of intrapulmonary immune complexes in mice generates a vigorous inflammatory response characterized by microvascular permeability and polymorphonuclear neutrophil influx. Gene-targeted disruption of the substance P receptor (NK-1R) protected the lung from immune complex injury, as did disruption of the C5a anaphylatoxin receptor. Immunoreactive substance P was measurable in fluids lining the lung at time points before neutrophil influx and may thus be involved in an early step in the inflammatory response to immune complexes in the lung.

Perlmutter Laboratory, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
*   These authors contributed equally to this work.

dagger    To whom correspondence should be addressed.

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