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Science 20 September 1996:
Vol. 273. no. 5282, pp. 1709 - 1714
DOI: 10.1126/science.273.5282.1709
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Reports

Small-Conductance, Calcium-Activated Potassium Channels from Mammalian Brain

M. Köhler, B. Hirschberg, C. T. Bond, J. M. Kinzie, N. V. Marrion, J. Maylie, J. P. Adelman *

Members of a previously unidentified family of potassium channel subunits were cloned from rat and human brain. The messenger RNAs encoding these subunits were widely expressed in brain with distinct yet overlapping patterns, as well as in several peripheral tissues. Expression of the messenger RNAs in Xenopus oocytes resulted in calcium-activated, voltage-independent potassium channels. The channels that formed from the various subunits displayed differential sensitivity to apamin and tubocurare. The distribution, function, and pharmacology of these channels are consistent with the SK class of small-conductance, calcium-activated potassium channels, which contribute to the afterhyperpolarization in central neurons and other cell types.

M. Köhler, B. Hirschberg, C. T. Bond, J. M. Kinzie, N. V. Marrion, J. P. Adelman, Vollum Institute, L-474, Oregon Health Sciences University, 3181 Southwest Sam Jackson Road, Portland, OR 97201, USA.
J. Maylie, Department of Obstetrics and Gynecology, Oregon Health Sciences University, Portland, OR 97201, USA.
*   To whom correspondence should be addressed.

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   Abstract »    Full Text »    PDF »
Contribution of BK Ca2+-Activated K+ Channels to Auditory Neurotransmission in the Guinea Pig Cochlea.
L. J. Skinner, V. Enee, M. Beurg, H. H. Jung, A. F. Ryan, A. Hafidi, J.-M. Aran, and D. Dulon (2003)
J Neurophysiol 90, 320-332
   Abstract »    Full Text »    PDF »
Modeling of Ca2+ flux in pancreatic {beta}-cells: role of the plasma membrane and intracellular stores.
L. E. Fridlyand, N. Tamarina, and L. H. Philipson (2003)
Am J Physiol Endocrinol Metab 285, E138-E154
   Abstract »    Full Text »    PDF »
The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells.
J. F. Hoffman, W. Joiner, K. Nehrke, O. Potapova, K. Foye, and A. Wickrema (2003)
PNAS 100, 7366-7371
   Abstract »    Full Text »    PDF »
Active K+ secretion through multiple KCa-type channels and regulation by IKCa channels in rat proximal colon.
W. J. Joiner, S. Basavappa, S. Vidyasagar, K. Nehrke, S. Krishnan, H. J. Binder, E. L. Boulpaep, and V. M. Rajendran (2003)
Am J Physiol Gastrointest Liver Physiol 285, G185-G196
   Abstract »    Full Text »    PDF »
Calcium-Activated Potassium Channels: Multiple Contributions to Neuronal Function.
E. S. L. Faber and P. Sah (2003)
Neuroscientist 9, 181-194
   Abstract »    PDF »
Bikunin Target Genes in Ovarian Cancer Cells Identified by Microarray Analysis.
M. Suzuki, H. Kobayashi, Y. Tanaka, Y. Hirashima, N. Kanayama, Y. Takei, Y. Saga, M. Suzuki, H. Itoh, and T. Terao (2003)
J. Biol. Chem. 278, 14640-14646
   Abstract »    Full Text »    PDF »
Distinct contributions of small and large conductance Ca2+-activated K+ channels to rat Purkinje neuron function.
J. R Edgerton and P. H Reinhart (2003)
J. Physiol. 548, 53-69
   Abstract »    Full Text »    PDF »
Afterhyperpolarization Regulates Firing Rate in Neurons of the Suprachiasmatic Nucleus.
R. K. Cloues and W. A. Sather (2003)
J. Neurosci. 23, 1593-1604
   Abstract »    Full Text »    PDF »
Maurotoxin: A Potent Inhibitor of Intermediate Conductance Ca2+-Activated Potassium Channels.
N. A. Castle, D. O. London, C. Creech, Z. Fajloun, J. W. Stocker, and J.-M. Sabatier (2003)
Mol. Pharmacol. 63, 409-418
   Abstract »    Full Text »    PDF »
SK4/IK1-like channels mediate TEA-insensitive, Ca2+-activated K+ currents in bovine parotid acinar cells.
T. Takahata, M. Hayashi, and T. Ishikawa (2003)
Am J Physiol Cell Physiol 284, C127-C144
   Abstract »    Full Text »    PDF »
Small Conductance Ca2+-Activated K+ Channels Modulate Synaptic Plasticity and Memory Encoding.
R. W. Stackman, R. S. Hammond, E. Linardatos, A. Gerlach, J. Maylie, J. P. Adelman, and T. Tzounopoulos (2002)
J. Neurosci. 22, 10163-10171
   Abstract »    Full Text »    PDF »
Maxi K+ channel mediates regulatory volume decrease response in a human bronchial epithelial cell line.
J. M. Fernandez-Fernandez, M. Nobles, A. Currid, E. Vazquez, and M. A. Valverde (2002)
Am J Physiol Cell Physiol 283, C1705-C1714
   Abstract »    Full Text »    PDF »
Tamapin, a Venom Peptide from the Indian Red Scorpion (Mesobuthus tamulus) That Targets Small Conductance Ca2+-activated K+ Channels and Afterhyperpolarization Currents in Central Neurons.
P. Pedarzani, D. D'hoedt, K. B. Doorty, J. D. F. Wadsworth, J. S. Joseph, K. Jeyaseelan, R. M. Kini, S. V. Gadre, S. M. Sapatnekar, M. Stocker, et al. (2002)
J. Biol. Chem. 277, 46101-46109
   Abstract »    Full Text »    PDF »
Regional Differences in Distribution and Functional Expression of Small-Conductance Ca2+-Activated K+ Channels in Rat Brain.
C. A. Sailer, H. Hu, W. A. Kaufmann, M. Trieb, C. Schwarzer, J. F. Storm, and H.-G. Knaus (2002)
J. Neurosci. 22, 9698-9707
   Abstract »    Full Text »    PDF »


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