Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 6 September 1996:
Vol. 273. no. 5280, pp. 1396 - 1399
DOI: 10.1126/science.273.5280.1396
Prev | Table of Contents | Next

Reports

Bimodal Interaction of Coatomer with the p24 Family of Putative Cargo Receptors

Klaus Fiedler, Michael Veit, Mark A. Stamnes, James E. Rothman *

Cytoplasmic domains of members of the p24 family of putative cargo receptors were shown to bind to coatomer, the coat protein of COPI-coated transport vesicles. Domains that contained dilysine endoplasmic reticulum retrieval signals bound the alpha -, beta '-, and epsilon -COP subunits of coatomer, whereas other p24 domains bound the beta -, gamma -, and zeta -COP subunits and required a phenylalanine-containing motif. Transit of a CD8-p24 chimera from the endoplasmic reticulum through the Golgi complex was slowed when the phenylalanine motif was mutated, suggesting that this motif may function as an anterograde transport signal. The either-or bimodal binding of coatomer to p24 tails suggests models for how coatomer can potentially package retrograde-directed and anterograde-directed cargo into distinct COPI-coated vesicles.

Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
*   To whom correspondence should be addressed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Comprehensive Overview of the Vertebrate p24 Family: Identification of a Novel Tissue-Specifically Expressed Member.
J. R.P.M. Strating, N. H.M. van Bakel, J. A.M. Leunissen, and G. J.M. Martens (2009)
Mol. Biol. Evol. 26, 1707-1714
   Abstract »    Full Text »    PDF »
Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction.
A. Bremond, O. Meynet, K. Mahiddine, S. Coito, M. Tichet, K. Scotlandi, J.-P. Breittmayer, P. Gounon, P. A. Gleeson, A. Bernard, et al. (2009)
Blood 113, 347-357
   Abstract »    Full Text »    PDF »
Depletion of {beta}-COP reveals a role for COP-I in compartmentalization of secretory compartments and in biosynthetic transport of caveolin-1.
M. L. Styers, A. K. O'Connor, R. Grabski, E. Cormet-Boyaka, and E. Sztul (2008)
Am J Physiol Cell Physiol 294, C1485-C1498
   Abstract »    Full Text »    PDF »
The Cargo Receptors Surf4, Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)-53, and p25 Are Required to Maintain the Architecture of ERGIC and Golgi.
S. Mitrovic, H. Ben-Tekaya, E. Koegler, J. Gruenberg, and H.-P. Hauri (2008)
Mol. Biol. Cell 19, 1976-1990
   Abstract »    Full Text »    PDF »
Transmembrane domain-dependent partitioning of membrane proteins within the endoplasmic reticulum.
P. Ronchi, S. Colombo, M. Francolini, and N. Borgese (2008)
J. Cell Biol. 181, 105-118
   Abstract »    Full Text »    PDF »
p24A, a Type I Transmembrane Protein, Controls ARF1-dependent Resensitization of Protease-activated Receptor-2 by Influence on Receptor Trafficking.
W. Luo, Y. Wang, and G. Reiser (2007)
J. Biol. Chem. 282, 30246-30255
   Abstract »    Full Text »    PDF »
Regulation of Anterograde Transport of {alpha}2-Adrenergic Receptors by the N Termini at Multiple Intracellular Compartments.
C. Dong and G. Wu (2006)
J. Biol. Chem. 281, 38543-38554
   Abstract »    Full Text »    PDF »
Coatomer, the Coat Protein of COPI Transport Vesicles, Discriminates Endoplasmic Reticulum Residents from p24 Proteins.
J. Bethune, M. Kol, J. Hoffmann, I. Reckmann, B. Brugger, and F. Wieland (2006)
Mol. Cell. Biol. 26, 8011-8021
   Abstract »    Full Text »    PDF »
Glutamate Receptors and Endoplasmic Reticulum Quality Control: Looking beneath the Surface.
M. W. Fleck (2006)
Neuroscientist 12, 232-244
   Abstract »    PDF »
Selective Export of HLA-F by Its Cytoplasmic Tail..
L. H. Boyle, A. K. Gillingham, S. Munro, and J. Trowsdale (2006)
J. Immunol. 176, 6464-6472
   Abstract »    Full Text »    PDF »
Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER.
V. Gupta and G. Swarup (2006)
J. Cell Sci. 119, 1703-1714
   Abstract »    Full Text »    PDF »
An Aberrant Sequence in a Connexin46 Mutant Underlies Congenital Cataracts.
P. J. Minogue, X. Liu, L. Ebihara, E. C. Beyer, and V. M. Berthoud (2005)
J. Biol. Chem. 280, 40788-40795
   Abstract »    Full Text »    PDF »
Assembly-dependent Surface Targeting of the Heterodimeric GABAB Receptor Is Controlled by COPI but Not 14-3-3.
C. Brock, L. Boudier, D. Maurel, J. Blahos, and J.-P. Pin (2005)
Mol. Biol. Cell 16, 5572-5578
   Abstract »    Full Text »    PDF »
CrebA regulates secretory activity in the Drosophila salivary gland and epidermis.
E. W. Abrams and D. J. Andrew (2005)
Development 132, 2743-2758
   Abstract »    Full Text »    PDF »
A Novel C-terminal Motif Is Necessary for the Export of the Vasopressin V1b/V3 Receptor to the Plasma Membrane.
J. Robert, E. Clauser, P. X. Petit, and M. A. Ventura (2005)
J. Biol. Chem. 280, 2300-2308
   Abstract »    Full Text »    PDF »
Generation of nonidentical compartments in vesicular transport systems.
R. Heinrich and T. A. Rapoport (2005)
J. Cell Biol. 168, 271-280
   Abstract »    Full Text »    PDF »
ARFGAP1 plays a central role in coupling COPI cargo sorting with vesicle formation.
S. Y. Lee, J.-S. Yang, W. Hong, R. T. Premont, and V. W. Hsu (2005)
J. Cell Biol. 168, 281-290
   Abstract »    Full Text »    PDF »
Sorting Signals in the Cytosolic Tail of Plant p24 Proteins Involved in the Interaction with the COPII Coat.
I. Contreras, Y. Yang, D. G. Robinson, and F. Aniento (2004)
Plant Cell Physiol. 45, 1779-1786
   Abstract »    Full Text »    PDF »
COPII Coat Assembly and Selective Export from the Endoplasmic Reticulum.
K. Sato (2004)
J. Biochem. 136, 755-760
   Abstract »    Full Text »    PDF »
The Transmembrane Domains of the prM and E Proteins of Yellow Fever Virus Are Endoplasmic Reticulum Localization Signals.
A. Op De Beeck, Y. Rouille, M. Caron, S. Duvet, and J. Dubuisson (2004)
J. Virol. 78, 12591-12602
   Abstract »    Full Text »    PDF »
Proteomics of Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membranes from Brefeldin A-treated HepG2 Cells Identifies ERGIC-32, a New Cycling Protein That Interacts with Human Erv46.
L. Breuza, R. Halbeisen, P. Jeno, S. Otte, C. Barlowe, W. Hong, and H.-P. Hauri (2004)
J. Biol. Chem. 279, 47242-47253
   Abstract »    Full Text »    PDF »
Localization of GDP-mannose transporter in the Golgi requires retrieval to the endoplasmic reticulum depending on its cytoplasmic tail and coatomer.
M. Abe, Y. Noda, H. Adachi, and K. Yoda (2004)
J. Cell Sci. 117, 5687-5696
   Abstract »    Full Text »    PDF »
Sorting Competition with Membrane-permeable Peptides in Intact Epithelial Cells Revealed Discrimination of Transmembrane Proteins Not Only at the trans-Golgi Network but Also at Pre-Golgi Stages.
A. Soza, A. Norambuena, J. Cancino, E. de la Fuente, P. Henklein, and A. Gonzalez (2004)
J. Biol. Chem. 279, 17376-17383
   Abstract »    Full Text »    PDF »
A Cell-Specific Transgenic Approach in Xenopus Reveals the Importance of a Functional p24 System for a Secretory Cell.
G. Bouw, R. Van Huizen, E. J.R. Jansen, and G. J.M. Martens (2004)
Mol. Biol. Cell 15, 1244-1253
   Abstract »    Full Text »    PDF »
Dsl1p, an Essential Component of the Golgi-Endoplasmic Reticulum Retrieval System in Yeast, Uses the Same Sequence Motif to Interact with Different Subunits of the COPI Vesicle Coat.
U. Andag and H. D. Schmitt (2003)
J. Biol. Chem. 278, 51722-51734
   Abstract »    Full Text »    PDF »
The trans-membrane protein p25 forms highly specialized domains that regulate membrane composition and dynamics.
G. Emery, R. G. Parton, M. Rojo, and J. Gruenberg (2003)
J. Cell Sci. 116, 4821-4832
   Abstract »    Full Text »    PDF »
ER export of ERGIC-53 is controlled by cooperation of targeting determinants in all three of its domains.
O. Nufer, F. Kappeler, S. Guldbrandsen, and H.-P. Hauri (2003)
J. Cell Sci. 116, 4429-4440
   Abstract »    Full Text »    PDF »
Endoplasmic Reticulum Export of Glycosyltransferases Depends on Interaction of a Cytoplasmic Dibasic Motif with Sar1.
C. G. Giraudo and H. J.F. Maccioni (2003)
Mol. Biol. Cell 14, 3753-3766
   Abstract »    Full Text »    PDF »
Cell Surface Expression of 5-Hydroxytryptamine Type 3 Receptors Is Controlled by an Endoplasmic Reticulum Retention Signal.
G. W. Boyd, A. I. Doward, E. F. Kirkness, N. S. Millar, and C. N. Connolly (2003)
J. Biol. Chem. 278, 27681-27687
   Abstract »    Full Text »    PDF »
Identification of Interdependent Signals Required for Anterograde Traffic of the ATP-binding Cassette Transporter Protein Yor1p.
E. A. Epping and W. S. Moye-Rowley (2002)
J. Biol. Chem. 277, 34860-34869
   Abstract »    Full Text »    PDF »
Role of cytoplasmic C-terminal amino acids of membrane proteins in ER export.
O. Nufer, S. Guldbrandsen, M. Degen, F. Kappeler, J.-P. Paccaud, K. Tani, and H.-P. Hauri (2002)
J. Cell Sci. 115, 619-628
   Abstract »    Full Text »    PDF »
Regulation of GTP Hydrolysis on ADP-ribosylation Factor-1 at the Golgi Membrane.
E. Szafer, M. Rotman, and D. Cassel (2001)
J. Biol. Chem. 276, 47834-47839
   Abstract »    Full Text »    PDF »
Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus.
F. A. Barr, C. Preisinger, R. Kopajtich, and R. Korner (2001)
J. Cell Biol. 155, 885-892
   Abstract »    Full Text »    PDF »
Sorting Functions of the Individual Cytoplasmic Domains of the G Protein-Coupled Vasopressin V2 Receptor in Madin Darby Canine Kidney Epithelial Cells.
R. Hermosilla and R. Schulein (2001)
Mol. Pharmacol. 60, 1031-1039
   Abstract »    Full Text »
Adaptins. The Final Recount.
M. Boehm and J. S. Bonifacino (2001)
Mol. Biol. Cell 12, 2907-2920
   Abstract »    Full Text »    PDF »
Quantitative ER {left-right-arrow} Golgi Transport Kinetics and Protein Separation upon Golgi Exit Revealed by Vesicular Integral Membrane Protein 36 Dynamics in Live Cells.
T. Dahm, J. White, S. Grill, J. Füllekrug, and E. H.K. Stelzer (2001)
Mol. Biol. Cell 12, 1481-1498
   Abstract »    Full Text »
Rer1p, a Retrieval Receptor for Endoplasmic Reticulum Membrane Proteins, Is Dynamically Localized to the Golgi Apparatus by Coatomer.
K. Sato, M. Sato, and A. Nakano (2001)
J. Cell Biol. 152, 935-944
   Abstract »    Full Text »    PDF »
Lst1p and Sec24p Cooperate in Sorting of the Plasma Membrane Atpase into Copii Vesicles in Saccharomyces cerevisiae.
Y. Shimoni, T. Kurihara, M. Ravazzola, M. Amherdt, L. Orci, and R. Schekman (2000)
J. Cell Biol. 151, 973-984
   Abstract »    Full Text »    PDF »
RGS4 and RGS2 Bind Coatomer and Inhibit COPI Association with Golgi Membranes and Intracellular Transport.
B. M. Sullivan, K. J. Harrison-Lavoie, V. Marshansky, H. Y. Lin, J. H. Kehrl, D. A. Ausiello, D. Brown, and K. M. Druey (2000)
Mol. Biol. Cell 11, 3155-3168
   Abstract »    Full Text »
Identification of a Lumenal Sequence Specifying the Assembly of Emp24p into p24 Complexes in the Yeast Secretory Pathway.
L. F. Ciufo and A. Boyd (2000)
J. Biol. Chem. 275, 8382-8388
   Abstract »    Full Text »    PDF »
The Emp24 Complex Recruits a Specific Cargo Molecule into Endoplasmic Reticulum-Derived Vesicles.
M. Muniz, C. Nuoffer, H.-P. Hauri, and H. Riezman (2000)
J. Cell Biol. 148, 925-930
   Abstract »    Full Text »    PDF »
Sec24p and Iss1p Function Interchangeably in Transport Vesicle Formation from the Endoplasmic Reticulum in Saccharomyces cerevisiae.
T. Kurihara, S. Hamamoto, R. E. Gimeno, C. A. Kaiser, R. Schekman, and T. Yoshihisa (2000)
Mol. Biol. Cell 11, 983-998
   Abstract »    Full Text »
Retention of Subunits of the Oligosaccharyltransferase Complex in the Endoplasmic Reticulum.
J. Fu and G. Kreibich (2000)
J. Biol. Chem. 275, 3984-3990
   Abstract »    Full Text »    PDF »
Molecular and Conformational Features of a Transport-Relevant Domain in the C-Terminal Tail of the Vasopressin V2 Receptor.
G. Krause, R. Hermosilla, A. Oksche, C. Rutz, W. Rosenthal, and R. Schülein (2000)
Mol. Pharmacol. 57, 232-242
   Abstract »    Full Text »
Coupled transport of p24 family members.
G Emery, M Rojo, and J Gruenberg (2000)
J. Cell Sci. 113, 2507-2516
   Abstract »    PDF »
Talin controls the exit of the integrin alpha 5 beta 1 from an early compartment of the secretory pathway.
V Martel, L Vignoud, S Dupe, P Frachet, M. Block, and C Albiges-Rizo (2000)
J. Cell Sci. 113, 1951-1961
   Abstract »    PDF »
The transmembrane protein p23 contributes to the organization of the Golgi apparatus.
M Rojo, G Emery, V Marjomaki, A. McDowall, R. Parton, and J Gruenberg (2000)
J. Cell Sci. 113, 1043-1057
   Abstract »    PDF »
Efficient Export of the Vesicular Stomatitis Virus G Protein from the Endoplasmic Reticulum Requires a Signal in the Cytoplasmic Tail That Includes Both Tyrosine-based and Di-acidic Motifs.
C. S. Sevier, O. A. Weisz, M. Davis, and C. E. Machamer (2000)
Mol. Biol. Cell 11, 13-22
   Abstract »    Full Text »
Differential Induction of Two p24delta Putative Cargo Receptors upon Activation of a Prohormoneproducing Cell.
R. P. Kuiper, H. R. Waterham, J. Rötter, G. Bouw, and G. J. M. Martens (2000)
Mol. Biol. Cell 11, 131-140
   Abstract »    Full Text »
Shr3p Mediates Specific COPII Coatomer-Cargo Interactions Required for the Packaging of Amino Acid Permeases Into ER-derived Transport Vesicles.
C. F. Gilstring, M. Melin-Larsson, and P. O. Ljungdahl (1999)
Mol. Biol. Cell 10, 3549-3565
   Abstract »    Full Text »
MAL, an Integral Element of the Apical Sorting Machinery, Is an Itinerant Protein That Cycles between the Trans-Golgi Network and the Plasma Membrane.
R. Puertollano and M. A. Alonso (1999)
Mol. Biol. Cell 10, 3435-3447
   Abstract »    Full Text »
The KDEL Receptor Regulates a GTPase-activating Protein for ADP-ribosylation Factor 1 by Interacting with Its Non-catalytic Domain.
T. Aoe, I. Huber, C. Vasudevan, S. C. Watkins, G. Romero, D. Cassel, and V. W. Hsu (1999)
J. Biol. Chem. 274, 20545-20549
   Abstract »    Full Text »    PDF »
p24 Proteins and Quality Control of LIN-12 and GLP-1 Trafficking in Caenorhabditis elegans.
C. Wen and I. Greenwald (1999)
J. Cell Biol. 145, 1165-1175
   Abstract »    Full Text »    PDF »
Erp1p and Erp2p, Partners for Emp24p and Erv25p in a Yeast p24 Complex.
M. Marzioch, D. C. Henthorn, J. M. Herrmann, R. Wilson, D. Y. Thomas, J. J. M. Bergeron, R. C. E. Solari, and A. Rowley (1999)
Mol. Biol. Cell 10, 1923-1938
   Abstract »    Full Text »
A Di-acidic (DXE) Code Directs Concentration of Cargo during Export from the Endoplasmic Reticulum.
N. Nishimura, S. Bannykh, S. Slabough, J. Matteson, Y. Altschuler, K. Hahn, and W. E. Balch (1999)
J. Biol. Chem. 274, 15937-15946
   Abstract »    Full Text »    PDF »
GTP-dependent Binding of ADP-ribosylation Factor to Coatomer in Close Proximity to the Binding Site for Dilysine Retrieval Motifs and p23.
L. Zhao, J. B. Helms, J. Brunner, and F. T. Wieland (1999)
J. Biol. Chem. 274, 14198-14203
   Abstract »    Full Text »    PDF »
A Different Intracellular Distribution of a Single Reporter Protein Is Determined at Steady State by KKXX or KDEL Retrieval Signals.
L. V. Lotti, G. Mottola, M. R. Torrisi, and S. Bonatti (1999)
J. Biol. Chem. 274, 10413-10420
   Abstract »    Full Text »    PDF »
The Transmembrane Domain of Hepatitis C Virus Glycoprotein E1 Is a Signal for Static Retention in the Endoplasmic Reticulum.
L. Cocquerel, S. Duvet, J.-C. Meunier, A. Pillez, R. Cacan, C. Wychowski, and J. Dubuisson (1999)
J. Virol. 73, 2641-2649
   Abstract »    Full Text »
Inhibition of Secretion by 1,3-Cyclohexanebis(methylamine), a Dibasic Compound That Interferes with Coatomer Function.
T. Hu, C.-Y. Kao, R. T. Hudson, A. Chen, and R. K. Draper (1999)
Mol. Biol. Cell 10, 921-933
   Abstract »    Full Text »
Two Endoplasmic Reticulum () Membrane Proteins That Facilitate ER-to-Golgi Transport of Glycosylphosphatidylinositol-anchored Proteins.
W. P. Barz and P. Walter (1999)
Mol. Biol. Cell 10, 1043-1059
   Abstract »    Full Text »
Sec24 Proteins and Sorting at the Endoplasmic Reticulum.
A. Pagano, F. Letourneur, D. Garcia-Estefania, J.-L. Carpentier, L. Orci, and J.-P. Paccaud (1999)
J. Biol. Chem. 274, 7833-7840
   Abstract »    Full Text »    PDF »
Receptor-induced polymerization of coatomer.
C. Reinhard, C. Harter, M. Bremser, B. Brugger, K. Sohn, J. B. Helms, and F. Wieland (1999)
PNAS 96, 1224-1228
   Abstract »    Full Text »    PDF »
Intracellular localization and in vivo trafficking of p24A and p23.
R Blum, F Pfeiffer, P Feick, W Nastainczyk, B Kohler, K. Schafer, and I Schulz (1999)
J. Cell Sci. 112, 537-548
   Abstract »    PDF »
Identification of Potential Regulatory Elements for the Transport of Emp24p.
N. Nakamura, S. Yamazaki, K. Sato, A. Nakano, M. Sakaguchi, and K. Mihara (1998)
Mol. Biol. Cell 9, 3493-3503
   Abstract »    Full Text »
ADP-ribosylation factor and phosphatidic acid levels in Golgi membranes during budding of coatomer-coated vesicles.
M. Stamnes, G. Schiavo, G. Stenbeck, T. H. Sollner, and J. E. Rothman (1998)
PNAS 95, 13676-13680
   Abstract »    Full Text »    PDF »
KDEL Receptor (Erd2p)-mediated Retrograde Transport of the Cholera Toxin A Subunit from the Golgi Involves COPI, p23, and the COOH Terminus of Erd2p.
I. Majoul, K. Sohn, F. T. Wieland, R. Pepperkok, M. Pizza, J. Hillemann, and H.-D. Soling (1998)
J. Cell Biol. 143, 601-612
   Abstract »    Full Text »    PDF »
Reconstitution of Retrograde Transport from the Golgi to the ER In Vitro.
A. Spang and R. Schekman (1998)
J. Cell Biol. 143, 589-599
   Abstract »    Full Text »    PDF »
The Carboxyl-terminal Tail of Kinase Splitting Membranal Proteinase/Meprin beta  Is Involved in Its Intracellular Trafficking.
L. Litovchick, A. Chestukhin, and S. Shaltiel (1998)
J. Biol. Chem. 273, 29043-29051
   Abstract »    Full Text »    PDF »
A single binding site for dilysine retrieval motifs and p23 within the gamma  subunit of coatomer.
C. Harter and F. T. Wieland (1998)
PNAS 95, 11649-11654
   Abstract »    Full Text »    PDF »
A Dileucine Sequence and an Upstream Glutamate Residue in the Intracellular Carboxyl Terminus of the Vasopressin V2 Receptor Are Essential for Cell Surface Transport in COS.M6 Cells.
R. Schülein, R. Hermosilla, A. Oksche, M. Dehe, B. Wiesner, G. Krause, and W. Rosenthal (1998)
Mol. Pharmacol. 54, 525-535
   Abstract »    Full Text »
Nucleation of COPII Vesicular Coat Complex by Endoplasmic Reticulum to Golgi Vesicle SNAREs.
S. Springer and R. Schekman (1998)
Science 281, 698-700
   Abstract »    Full Text »
Cargo Selection by the COPII Budding Machinery during Export from the ER.
M. Aridor, J. Weissman, S. Bannykh, C. Nuoffer, and W. E. Balch (1998)
J. Cell Biol. 141, 61-70
   Abstract »    Full Text »    PDF »
Specific Interaction of Golgi Coatomer Protein alpha -COP with Phosphatidylinositol 3,4,5-Trisphosphate.
A. Chaudhary, Q.-M. Gu, O. Thum, A. A. Profit, Y. Qi, L. Jeyakumar, S. Fleischer, and G. D. Prestwich (1998)
J. Biol. Chem. 273, 8344-8350
   Abstract »    Full Text »    PDF »
Endocrinopathies in the Family of Endoplasmic Reticulum (ER) Storage Diseases: Disorders of Protein Trafficking and the Role of ER Molecular Chaperones.
P. S. Kim and P. Arvan (1998)
Endocr. Rev. 19, 173-202
   Abstract »    Full Text »
Reversible dissociation of coatomer: Functional characterization of a beta /delta -coat protein subcomplex.
J. Pavel, C. Harter, and F. T. Wieland (1998)
PNAS 95, 2140-2145
   Abstract »    Full Text »    PDF »
gp25L/emp24/p24 Protein Family Members of the cis-Golgi Network Bind Both COP I and II Coatomer.
M. Dominguez, K. Dejgaard, J. Fullekrug, S. Dahan, A. Fazel, J.-P. Paccaud, D. Y. Thomas, J. J. M. Bergeron, and T. Nilsson (1998)
J. Cell Biol. 140, 751-765
   Abstract »    Full Text »    PDF »
Alpha-COP can discriminate between distinct, functional di-lysine signals in vitro and regulates access into retrograde transport.
S Schroder-Kohne, F Letourneur, and H Riezman (1998)
J. Cell Sci. 111, 3459-3470
   Abstract »    PDF »
Protein transport from the endoplasmic reticulum to the Golgi apparatus.
W Hong (1998)
J. Cell Sci. 111, 2831-2839
   Abstract »    PDF »
Three distinct steps in transport of vesicular stomatitis virus glycoprotein from the ER to the cell surface in vivo with differential sensitivities to GTP gamma S.
R Pepperkok, M Lowe, B Burke, and T. Kreis (1998)
J. Cell Sci. 111, 1877-1888
   Abstract »    PDF »
Inhibition of Endosome Function in CHO Cells Bearing a Temperature-sensitive Defect in the Coatomer (COPI) Component {varepsilon}-COP.
E. Daro, D. Sheff, M. Gomez, T. Kreis, and I. Mellman (1997)
J. Cell Biol. 139, 1747-1759
   Abstract »    Full Text »    PDF »
Proper sorting of the cation-dependent mannose 6-phosphate receptor in endosomes depends on a pair of aromatic amino acids in its cytoplasmic tail.
A. Schweizer, S. Kornfeld, and J. Rohrer (1997)
PNAS 94, 14471-14476
   Abstract »    Full Text »    PDF »
The Recycling of ERGIC-53 in the Early Secretory Pathway. ERGIC-53 CARRIES A CYTOSOLIC ENDOPLASMIC RETICULUM-EXIT DETERMINANT INTERACTING WITH COPII.
F. Kappeler, D. R. Ch. Klopfenstein, M. Foguet, J.-P. Paccaud, and H.-P. Hauri (1997)
J. Biol. Chem. 272, 31801-31808
   Abstract »    Full Text »    PDF »
Involvement of the Transmembrane Protein p23 in Biosynthetic Protein Transport.
M. Rojo, R. Pepperkok, G. Emery, R. Kellner, E. Stang, R. G. Parton, and J. Gruenberg (1997)
J. Cell Biol. 139, 1119-1135
   Abstract »    Full Text »    PDF »
Functional Dissection of COP-I Subunits in the Biogenesis of Multivesicular Endosomes.
F. Gu, F. Aniento, R. G. Parton, and J. Gruenberg (1997)
J. Cell Biol. 139, 1183-1195
   Abstract »    Full Text »    PDF »
The Coatomer Protein beta '-COP, a Selective Binding Protein (RACK) for Protein Kinase Cepsilon.
M. Csukai, C.-H. Chen, M. A. De Matteis, and D. Mochly-Rosen (1997)
J. Biol. Chem. 272, 29200-29206
   Abstract »    Full Text »    PDF »
Thyroglobulin Transport along the Secretory Pathway. INVESTIGATION OF THE ROLE OF MOLECULAR CHAPERONE, GRP94, IN PROTEIN EXPORT FROM THE ENDOPLASMIC RETICULUM.
Z. Muresan and P. Arvan (1997)
J. Biol. Chem. 272, 26095-26102
   Abstract »    Full Text »    PDF »
p23, a major COPI-vesicle membrane protein, constitutively cycles through the early secretory pathway.
W. Nickel, K. Sohn, C. Bunning, and F. T. Wieland (1997)
PNAS 94, 11393-11398
   Abstract »    Full Text »    PDF »
Sorting Determinants in the Transmembrane Domain of p24 Proteins.
K. Fiedler and J. E. Rothman (1997)
J. Biol. Chem. 272, 24739-24742
   Abstract »    Full Text »    PDF »
Interaction of Coatomer with Aminoglycoside Antibiotics: Evidence That Coatomer Has at Least Two Dilysine Binding Sites.
R. T. Hudson and R. K. Draper (1997)
Mol. Biol. Cell 8, 1901-1910
   Abstract »    Full Text »
Membrane Dynamics at the Endoplasmic Reticulum-Golgi Interface.
S. I. Bannykh and W. E. Balch (1997)
J. Cell Biol. 138, 1-4
   Full Text »    PDF »
p53/58 Binds COPI and Is Required for Selective Transport through the Early Secretory Pathway.
E. J. Tisdale, H. Plutner, J. Matteson, and W. E. Balch (1997)
J. Cell Biol. 137, 581-593
   Abstract »    Full Text »    PDF »
Dissociation of Coatomer from Membranes Is Required for Brefeldin A-induced Transfer of Golgi Enzymes to the Endoplasmic Reticulum.
J. Scheel, R. Pepperkok, M. Lowe, G. Griffiths, and T. E. Kreis (1997)
J. Cell Biol. 137, 319-333
   Abstract »    Full Text »    PDF »
Mannose 6-Phosphate Receptors Regulate the Formation of Clathrin-coated Vesicles in the TGN.
R. L. Borgne and B. Hoflack (1997)
J. Cell Biol. 137, 335-345
   Abstract »    Full Text »    PDF »
COPI-independent Anterograde Transport: Cargo-selective ER to Golgi Protein Transport in Yeast COPI Mutants.
E. C. Gaynor and S. D. Emr (1997)
J. Cell Biol. 136, 789-802
   Abstract »    Full Text »    PDF »
Sec12p requires Rer1p for sorting to coatomer (COPI)-coated vesicles and retrieval to the ER.
J Boehm, F Letourneur, W Ballensiefen, D Ossipov, C Demolliere, and H. Schmitt (1997)
J. Cell Sci. 110, 991-1003
   Abstract »    PDF »
Herp, a New Ubiquitin-like Membrane Protein Induced by Endoplasmic Reticulum Stress.
K. Kokame, K. L. Agarwala, H. Kato, and T. Miyata (2000)
J. Biol. Chem. 275, 32846-32853
   Abstract »    Full Text »    PDF »
Membrane Recruitment of Coatomer and Binding to Dilysine Signals Are Separate Events.
M. Gomez, S. J. Scales, T. E. Kreis, and F. Perez (2000)
J. Biol. Chem. 275, 29162-29169
   Abstract »    Full Text »    PDF »
Localization of Sequences within the C-terminal Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Which Impact Maturation and Stability.
M. Gentzsch and J. R. Riordan (2001)
J. Biol. Chem. 276, 1291-1298
   Abstract »    Full Text »    PDF »
The Carboxyl-terminal Valine Is Required for Transport of Glycoprotein CD8alpha from the Endoplasmic Reticulum to the Intermediate Compartment.
L. Iodice, S. Sarnataro, and S. Bonatti (2001)
J. Biol. Chem. 276, 28920-28926
   Abstract »    Full Text »    PDF »
Sorting of Golgi resident proteins into different subpopulations of COPI vesicles: a role for ArfGAP1.
J. Lanoix, J. Ouwendijk, A. Stark, E. Szafer, D. Cassel, K. Dejgaard, M. Weiss, and T. Nilsson (2001)
J. Cell Biol. 155, 1199-1212
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)